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| 1 | dentification of TRA2B-DNAH5 fusion as a novel oncogenic driver in human lung squamous cell carcinoma显示文摘 | Fei Li Zhaoyuan Fang Jian Zhang Chen Li Hongyan Liu Jufeng Xia Hongwen Zhu Chenchen auo Zhen Qin Fuming Li Xiangkun Han Yuetong Wang Yan Feng Ye Wang Wenjing Zhang Zuoyun Wang Yujuan Jin Yihua Sun Wenyi Wei Rong Zeng Haiquan Chen Hongbin Ji | 2016 | Cell Research2016，26，10： | 9 |
| 2 | Lignin Extraction from Black Liquor and its Application Prospects in Pulp Mills显示文摘This paper summarizes the possible application of lignin extraction from black liquor and the development of lignin extraction technology.Lignin extraction from black liquor is an important,economical method to resolve the bottleneck associated with the recovery boiler and achieve the targeted capacity expansion in pulp mills.A few of key issues must be taken into cosideration when lignin extraction technology is adopted on the industrial scale. | FuMing Jin ShuBin Wu | 2016 | Paper And Biomaterials2016，1，2： | 4 |
| 3 | An enrichment model using regular health examination data for early detection of colorectal cancer显示文摘Objective: Challenges remain in current practices of colorectal cancer(CRC) screening, such as low compliance,low specificities and expensive cost. This study aimed to identify high-risk groups for CRC from the general population using regular health examination data.Methods: The study population consist of more than 7,000 CRC cases and more than 140,000 controls. Using regular health examination data, a model detecting CRC cases was derived by the classification and regression trees(CART) algorithm. Receiver operating characteristic(ROC) curve was applied to evaluate the performance of models. The robustness and generalization of the CART model were validated by independent datasets. In addition, the effectiveness of CART-based screening was compared with stool-based screening.Results: After data quality control, 4,647 CRC cases and 133,898 controls free of colorectal neoplasms were used for downstream analysis. The final CART model based on four biomarkers(age, albumin, hematocrit and percent lymphocytes) was constructed. In the test set, the area under ROC curve(AUC) of the CART model was 0.88 [95%confidence interval(95% CI), 0.87-0.90] for detecting CRC. At the cutoff yielding 99.0% specificity, this model’s sensitivity was 62.2%(95% CI, 58.1%-66.2%), thereby achieving a 63-fold enrichment of CRC cases. We validated the robustness of the method across subsets of test set with diverse CRC incidences, aging rates, genders ratio, distributions of tumor stages and locations, and data sources. Importantly, CART-based screening had the higher positive predictive value(1.6%) than fecal immunochemical test(0.3%).Conclusions: As an alternative approach for the early detection of CRC, this study provides a low-cost method using regular health examination data to identify high-risk individuals for CRC for further examinations. The approach can promote early detection of CRC especially in developing countries such as China, where annual health examination is popular but regular CRC-specific screening is rare. | Qiang Shi Zhaoya Gao Pengze Wu Fanxiu Heng Fuming Lei Yanzhao Wang Qingkun Gao Qingmin Zeng Pengfei Niu Cheng Li Jin Gu | 2019 | Chinese Journal of Cancer Research2019，31，4： | 3 |
| 4 | First-principles study on the electronic and transport properties of periodically nitrogen-doped graphene and carbon nanotube superlattices显示文摘 | Fuming Xu Zhizhou Yu Zhirui Gong Hao Jin | 2017 | Frontiers of physics2017，12，4： | 2 |
| 5 | A novel catalyst for transesterification of dimethyl carbonate with phenol to diphenyl carbonate : samarium trifluoromethanesulfnnate显示文摘 | Mei Fuming Li Guangxing Nie Jin | 2002 | J Mol Catal A Chem2002，184，： | 1 |
| 6 | A novel catalyst for transesterification of dimethyl carbonate with phenol to diphenyl carbonate : samarium trifluoromethanesulfonate 显示文摘 | Mei Fuming Li Guangxing Nie Jin | 2002 | J Mol Catal A : Chem2002，184，12： | 1 |
| 7 | A novel catalyst for transesterification of dimethyl carbonate with phenol to diphenyl carbonate samarium trifluoromethanesulfonate显示文摘 | Mei Fuming Li Guangxing Nie Jin | 2002 | J Mol Catal A2002，184，12： | 1 |
| 8 | Bioengineered production of glycosaminoglycans and their analogues显示文摘Glycosaminoglycans(GAGs)are a class of linear polysaccharides,consisting of alternating disaccharide sequences of uronic acid and hexosamines(or galactose)with and without sulfation.They can interact with various proteins,such as growth factors,receptors and cell adhesion molecules,endowing these with various biological and pharmacological activi-ties.Such activities make GAGs useful in health care products and medicines.Currently,all GAGs,with the exception of hyaluronan,are produced by extraction from animal tissues.However,limited availability,poor control of animal tissues,impurities,viruses,prions,endotoxins,contamination and other problems have increased the interest in new approaches for GAG production.These new approaches include GAGs production by chemical synthesis,chemoenzymatic synthesis and metabolic engineering.One chemically synthesized heparin pentasaccharide,fondaparinux sodium,is in clinical use.Mostly,hyaluronan today is prepared by microbial fermentation,largely replacing hyaluronan from rooster comb.The recent gram scale chemoenzymatic synthesis of a heparin dodecasaccharide suggests its potential to replace currently used animal-sourced low molecular weight heparin(LMWH).Despite these considerable successes,such high-tech approaches still cannot meet worldwide demands for GAGs.This review gives a brief introduction on the manufacturing of unfractionated and low molecular weight heparins,the chemical synthesis and chemoenzymatic synthesis of GAGs and focuses on the progress in the bioengineered preparation of GAGs,particularly heparin. | Weihua Jin Fuming Zhang Robert J.Linhardt | 2021 | Systems Microbiology and Biomanufacturing2021，1，2： | 0 |
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