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| 1 | Non-Epstein-Barr virus associated lymphoepithelioma-like carcinoma of the inferior common bile duct显示文摘A carcinoma displaying undifferentiated features with dense lymphoplasmacytic infiltration is defined as a lymphoepithelioma-like carcinoma(LEC),and some of LEC is associated with Epstein-Barr virus(EBV).All of the 13 previously reported cases of LEC of the biliary system were intrahepatic in location.Herein,we describe the first case of LEC of the inferior common bile duct.A 68-year-old Japanese man,who had been previously treated for hepatocellular carcinoma using microwave coagulation therapy,was found to have tumors of the common bile duct and pancreas head.Histopathological study of the resected tumor showed solid or cohesive nests of large undifferentiated cells with irregular large vesicular nuclei and nucleoli.Around the tumor cell nests,dense lymphoplasmacytic infiltration was observed.Focal glandular differentiation(approximately 5%) was also present.These histopathological features corresponded morphologically to LEC.Immunohistochemically,the tumor cells were positive for cytokeratin(CK) 7,CK 19 and CA19-9,but negative for CK 20 and Hep Par 1.In situ hybridization for Epstein Barr virus early small RNAs disclosed no nuclear signal in tumor cells.Therefore,a diagnosis of non-EBV-associated LEC of the inferior common bile duct was made.Although the prognosis of the biliary LEC is thought to be better than that of conventional cholangiocarcinoma,the differences in prognosis between EBV-positive and-negative cases have not yet been established.Therefore,additional case studies will be needed to clarify the clinicopathological features of LEC of the biliary tract. | Mitsuaki Ishida Tsuyoshi Mori Hisanori Shiomi Shigeyuki Naka Tomoyuki Tsujikawa Akira Andoh Yasuharu Saito Yoshimasa Kurumi Fumiyoshi Kojima Machiko Hotta Tohru Tani Yoshihide Fujiyama Hidetoshi Okabe | 2011 | World Journal of Gastrointestinal Oncology2011，3，7： | 5 |
| 2 | IgG4-unrelated type 1 autoimmune pancreatitis显示文摘A 50-year-old male was referred to our hospital for the evaluation of hyperproteinemia.Fluorodeoxyglucose positron emission tomography revealed high fluorodeoxyglucose uptake in the pancreas,bilateral lacrimal glands,submandibular glands,parotid glands,bilateral pulmonary hilar lymph nodes,and kidneys.Laboratory data showed an elevation of hepatobiliary enzymes,renal dysfunction,and remarkably high immunoglobulin(Ig) G levels,without elevated serum IgG4.Abdominal computed tomography revealed swelling of the pancreatic head and bilateral kidneys.Endoscopic retrograde cholangiopancreatography showed an irregular narrowing of the main pancreatic duct in the pancreatic head and stricture of the lower common bile duct.Histological examination by endoscopic ultrasonography-guided fine-needle aspiration revealed findings of lymphoplasmacytic sclerosing pancreatitis without IgG4-positive plasma cells.Abnormal laboratory values and the swelling of several organs were improved by the treatment with steroids.The patient was diagnosed as having type 1 autoimmune pancreatitis(AIP) based on the International Consensus Diagnostic Criteria.Therefore,we encountered a case of compatible type 1 AIP without elevated levels of serum IgG4 or IgG4-positive plasma cells.This case suggests that AIP phenotypes are not always associated with IgG4. | Eriko Nakano Atsushi Kanno Atsushi Masamune Naoki Yoshida Seiji Hongo Shin Miura Tetsuya Takikawa Shin Hamada Kiyoshi Kume Kazuhiro Kikuta Morihisa Hirota Keisuke Nakayama Fumiyoshi Fujishima Tooru Shimosegawa | 2015 | World Journal of Gastroenterology2015，21，33： | 3 |
| 3 | Diagnosis of autoimmune pancreatitis by EUS-FNA by using a 22-gauge needle based on the International Consensus Diagnostic Criteria显示文摘 | Atsushi Kanno Kazuyuki Ishida Shin Hamada Fumiyoshi Fujishima Jun Unno Kiyoshi Kume Kazuhiro Kikuta Morihisa Hirota Atsushi Masamune Kennichi Satoh Kenji Notohara Tooru Shimosegawa | 2012 | Gastrointestinal Endoscopy2012，，3： | 3 |
| 4 | Hepatic reactive lymphoid hyperplasia in a patient with primary biliary cirrhosis显示文摘Reactive lymphoid hyperplasia(RLH) of the liver is an extremely rare lesion characterized by the proliferation of non-neoplastic lymphocytes forming follicles.Hepatic RLH is known to be associated with gastrointestinal carc inoma and autoimmune diseases including primary biliary cirrhosis(PBC).We report a case of hepatic RLH in a patient with PBC and gastric cancer.A 68 year old Japanese woman with a 10 year history of liver enzyme abnormality was admitted.Laboratory testing revealed that her anti-mitochondrial antibody was markedly elev ated.Five mo after the diagnosis of PBC,she was foun d to have gastric cancer.Abdominal computed tom og raphy disclosed a liver nodule in S8,suggesting metas tatic gastric carcinoma.Histopathologically,the resected liver lesion comprised of a nodular proliferation of small lym phocytes with lymphoid follicles.This is the first reported case of hepatic RLH in a patient with both PBC and gastric cancer.Pre-operative diagnosis of hepatic RLH by clinical imaging is extremely difficult.Therefore,a need le biopsy could be useful to make a diagnosis of hepat ic RLH,especially to differentiate from metastatic gastroin t estinal carcinoma. | Mitsuaki Ishida Tamio Nakahara Yousuke Mochizuki Tomoyuki Tsujikawa Akira Andoh Yasuharu Saito Hiroshi Yamamoto Fumiyoshi Kojima Machiko Hotta Tohru Tani Yoshihide Fujiyama Hidetoshi Okabe | 2010 | World Journal of Hepatology2010，2，10： | 2 |
| 5 | FDG PET/CT Findings in Malignant Intraductal Papillary Mucinous Neoplasm of the Bile Ducts显示文摘 | Kentaro Takanami Tomomichi Hiraide Tomohiro Kaneta Hiroki Hayashi Michiaki Unno Fumiyoshi Fujishima Hiroshi Fukuda Shogo Yamada Shoki Takahashi | 2010 | Clinical Nuclear Medicine2010，，2： | 1 |
| 6 | Determination of matrine in rat plasma by high-performance liquid chromatography and its application to pharmacokinetic studies 显示文摘 | Wu Xinan Fumiyoshi Yamashita Mitsuru Hashida | 2003 | Talanta2003，59，： | 1 |
| 7 | Evaluation of prestraining and dynamic loading effects on fracture toughness of structural steels by the local approach显示文摘 | Fumiyoshi Minami Takao Ochiai | 2000 | ASME2000，404，1172： | 1 |
| 8 | Pressure- regulated metabolism in microorganisms显示文摘 | FUMIYOSHI ABE CHIAKI KATO KOKI HORIKOSHI | 1999 | Trends in Microbiology1999，7，11： | 1 |
| 9 | FDG PET/CT Findings in Malignant Intraductal Papillary Mucinous Neoplasm of the Bile Ducts显示文摘 | Kentaro Takanami Tomomichi Hiraide Tomohiro Kaneta Hiroki Hayashi Michiaki Unno Fumiyoshi Fujishima Hiroshi Fukuda Shogo Yamada Shoki Takahashi | 2010 | Clinical Nuclear Medicine2010，，2： | 1 |
| 10 | Structural and magnetic properties of FePd and CoPd alloy epitaxial thin films grown on MgO single-crystal substrates with different orientations显示文摘 | Osamu Yabuhara Mitsuru Ohtake Kouske Tobari Tsutomu Nishiyama Fumiyoshi Kirino Masaaki Futamoto | 2011 | Thin Solid Films2011，，23： | 1 |
| 11 | Relationship between esophageal dysfunction and neuropathy in diabetic patients 显示文摘 | Fumihiko Kinekawa Fumiyoshi Kubo Kazuya Matsuda et at | 2001 | The American Journal of Gastroenterology2001，7，96： | 1 |
| 12 | Targeted and sustained drug delivery using PEGylated galactosylated liposomes显示文摘 | Chittima Managit Shigeru Kawakami Makiya Nishikawa Fumiyoshi Yamashita Mitsuru Hashida | 2003 | International Journal of Pharmaceutics2003，，1： | 1 |
| 13 | 查看详情显示文摘 | Fumiyoshi T Satoshi Uchida Y F Tsuneo W | | 0，，： | 1 |
| 14 | pH dependence of rnacnzscopic swelling and microscopic structures for thermo/pH-sensitive gels with different charge distributions 显示文摘 | Takuya S Takeshi K Fumiyoshi I | 2008 | Macromolecules2008，41，： | 1 |
| 15 | MR imaging of primary leiomyosarcoma of the thyroid gland显示文摘 | Fumiyoshi Takayama Shodayu Takashima Hideki Matsuba Shinya Kobayashi Nobuo Ito Shusuke Sone | 2001 | European Journal of Radiology2001，，1： | 1 |
| 16 | QSAR Analysis of the Inhibition of Recombinant CYP 3A4 Activity by Structurally Diverse Compounds Using a Genetic Algorithm-Combined Partial Least Squares Method显示文摘 | Suchada Wanchana Fumiyoshi Yamashita Mitsuru Hashida | 2003 | Pharmaceutical Research2003，，9： | 1 |
| 17 | Control of resistance switching voltages in rectifying Pt/TiOJPt trilayer显示文摘 | Hisashi Shima Fumiyoshi Takano Hidenobu Muramatsu | 2008 | Appl Phys Lett2008，92，04： | 1 |
| 18 | Long-term follow-up study of a population-based 1996–1998 mass screening programme for lung cancer using mobile low-dose spiral computed tomography显示文摘 | Shusuke Sone Tomio Nakayama Takayuki Honda Kenji Tsushima Feng Li Masayuki Haniuda Yoshiro Takahashi Takaichiro Suzuki Takeshi Yamanda Ryoichi Kondo Takaomi Hanaoka Fumiyoshi Takayama Keishi Kubo Hajime Fushimi | 2007 | Lung Cancer2007，，3： | 1 |
| 19 | Cell specific delivery of' Genes with glycosylated carriers显示文摘 | Mitsuru H Makiya NK Fumiyoshi YS | 2001 | Adv Drug Del Rev2001，52，3： | 1 |
| 20 | Determination of matrine in rat plasma by high-performance liquid chromatography and its application to pharmacokinetic studies显示文摘 | Wu Xinan Fumiyoshi Yamashita Mitsuru Hashida | 2003 | Talanta2003，59，： | 1 |
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