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| 1 | Helicobacter pylori upregulates prion protein expression in gastric mucosa: A possible link to prion disease显示文摘AIM: Pathological prion protein (PrPSC) is responsible for the development of transmissible spongiform encephalopathies (TSE). While PrPc enters the organism via the oral route, less data is available to know about its uptake and the role of gastrointestinal inflammation on the expression of prion precursor PrPc, which is constitutively expressed in the gastric mucosa.METHODS: We studied PrPc expression in the gastric mucosa of 10 Helicobacter pylori-positive patients before and after successful H pylori eradication compared to non-infected controls using RT-PCR and Western blotting.The effect of central mediators of gastric inflammation,i.e., gastrin, prostaglandin E2 (PGE2), tumor necrosis factor alpha (TNF-α) and interleukin 1 beta (IL-1β) on PrPc expression was analyzed in gastric cell lines.RESULTS: PrPc expression was increased in H pyloriinfection compared with non-infected controls and decreased to normal after successful eradication. Gastrin,PGE2, and IL-1β dose-dependently upregulated PrPc in gastric cells, while TNF-α had no effect.CONCLUSION: H pylori infection leads to the upregulation of gastric PrPc expression. This can be linked to H pylori induced hypergastrinemia and increased mucosal PGE2 and IL-1β synthesis.H pylori creates a milieu for enhanced propagation of prions in the gastrointestinal tract. | Peter C Konturek Karolina Bazela Vitally Kukharskyy Michael Bauer Eckhart G Hahn Detlef Schuppan | 2005 | World Journal of Gastroenterology2005，11，48： | 9 |
| 2 | Double-balloon-enteroscopy-based endoscopic retrograde cholangiopancreatography in post-surgical patients显示文摘AIM: To evaluate double balloon enteroscopy (DBE) in post-surgical patients to perform endoscopic retrograde cholangiopancreatography (ERCP) and interventions. METHODS: In 37 post-surgical patients, a stepwise approach was performed to reach normal papilla or enteral anastomoses of the biliary tract/pancreas. When conventional endoscopy failed, DBE-based ERCP was performed and standard parameters for DBE, ERCP and interventions were recorded. RESULTS: Push-enteroscopy (overall, 16 procedures) reached enteral anastomoses only in six out of 37 post-surgical patients (16.2%). DBE achieved a high rate of luminal access to the biliary tract in 23 of the remaining 31 patients (74.1%) and to the pancreatic duct (three patients). Among all DBE-based ERCPs (86 procedures), 21/23 patients (91.3%) were successfully treated. Interventions included ostium incision or papillotomy in 6/23 (26%) and 7/23 patients (30.4%), respectively. Biliary endoprosthesis insertion and regular exchange was achieved in 17/23 (73.9%) and 7/23 patients (30.4%), respectively. Furthermore, bile duct stone extraction as well as ostium and papillary dilation were performed in 5/23 (21.7%) and 3/23 patients (13.0%), respectively. Complications during DBE-based procedures were bleeding (1.1%), perforation (2.3%) and pancreatitis (2.3%), and minor complications occurred in up to 19.1%. CONCLUSION: The appropriate use of DBE yields a high rate of luminal access to papilla or enteral anastomoses in more than two-thirds of post-surgical patients, allowing important successful endoscopic therapeutic interventions. | Martin Raithel Harald Dormann Andreas Naegel Frank Boxberger Eckhart G Hahn Markus F Neurath Juergen Maiss | 2011 | World Journal of Gastroenterology2011，17，18： | 9 |
| 3 | Pioglitazone, a specific ligand of peroxisome proliferator-activated receptor-gamma, protects pancreas against acute cerulein-induced pancreatitis显示文摘ABM: To determine the effect of pioglitazone, a specific peroxisome proliferator-activated receptor-γ(PPARγ) ligand, on the development of acute pancreatitis (AP) and on the expression of heat shock protein 70 (HSP70) in the pancreas. METHODS: AP was induced in rats by subcutaneous infusion of cerulein for 5 h. Pancreatic blood flow was measured by laser Doppler flowmetry. Plasma lipase activity, interleukin-1β (IL-1β) and IL-10 were determined, Pancreatic weight and histology were evaluated and pancreatic DNA synthesis and blood flow as well as pancreatic mRNA for IL-1β and HSP70 were assessed in rats treated with pioglitazone alone or in combination with cerulein. RESULTS: Pioglitazone administered (10-100 mg/kg i.g.) 30 min before cerulein, attenuated dose-dependently the pancreatic tissue damage in cerulein-induced pancreatitis (CIP) as demonstrated by the improvement of pancreatic histology, reduction in plasma lipase activity, plasma concentration of pro-inflammatory IL-1β and its gene expression in the pancreas and attenuation of the pancreatitis-evoked fall in pancreatic blood flow. CIP increased pancreatic HSP70 mRNA and protein expression in the pancreas and this effect was enhanced by pioglitazone treatment. CONCLUSION: Pioglitazone attenuates CIP and the beneficial effect of this pioglitazone is multifactorial probably due to its anti-inflammatory activities, to the suppression of IL-1β and to the over-expression of HSP70. PPARγ ligands could represent a new therapeutic option in the treatment of AP. | Peter C Konturek Artur Dembinski Zygmunt Warzecha Grzegorz Burnat Piotr Ceranowicz Eckhart G Hahn Marcin Dembinski Romana Tomaszewska Stanislaw J Konturek | 2005 | World Journal of Gastroenterology2005，11，40： | 7 |
| 4 | Biomechanical and computer analysis of radial head prostheses显示文摘 | Ganesh G Gupta George Lucas Dustan L Hahn | 1997 | Journal of Shoulder and Elbow Surgery1997，，1： | 2 |
| 5 | Pressure drop caused by abrupt flow area changes in small channels显示文摘 | F F Abdelall G Hahn S M Ghiaasiaan | 2005 | Experimental Thermal and Fluid Science2005，29，： | 1 |
| 6 | Properties of TiAlN coatings synthesized by closed-field unbalanced magnetron sputtering 显示文摘 | KIM G LEE S Y HAHN J H | 2005 | Surface and Coatings Technology2005，193，13： | 1 |
| 7 | Cardiotrophic effects of protein kinase C epsilon:analysis by in vivo modulation of PKCepsilon translocation显示文摘 | Mochly-Rosen D Wu G Hahn H | 2000 | Circ Res2000，86，： | 1 |
| 8 | Genetic transmission of fibrcdysplasia ossificans progressiva显示文摘 | Kaplan FS Mccluskey W Hahn G | 1993 | The Journal of Bone and Joint Surger1993，75，8： | 1 |
| 9 | Impact of future climate and land use change on non-timber forest product provision in Benin,West Africa:Linking niche-based modeling with ecosystem service values显示文摘 | Heubes J Heubach K Schmidt M Wittig R Zizka G Nuppenau E A Hahn K | 2012 | Economic Botany2012，66，4： | 1 |
| 10 | The effect of cop- per and cadmium on 65 - zinc absorption in zinc - defi- cient and zinc supplemented rats 显示文摘 | Evans G W Grace C I and Hahn C | 1974 | Bioinorg Chem1974，3，11： | 1 |
| 11 | Elasto-plastic coupled temperature-displacement f'mite element analysis of two-dimensional rolling-sliding contact with a translating heat source 显示文摘 | Kulkami S M Rubin C A Hahn G T | 1991 | Journal of Tribology1991，113，1： | 1 |
| 12 | High-performance liquid chromatographic determination of bathmochrorne absorption shifts显示文摘 | STEIN J HAHN A REHNER G | 1995 | Journal of Chromatography B: Biomedical Sciences and Applications1995，665，1： | 1 |
| 13 | Thermal-Mechanical Modeling of the Rolling-Plus-Sliding with Frictional Heating of a Locomotive Wheel 显示文摘 | Gupta V Hahn G T Bostias P C et aI | 1995 | Transactions of ASME1995，117，8： | 1 |
| 14 | Host-pathogen in -teraetions: XXXIII A plant protein converts a fungal pathogenesis factor into an elicitor of plant defense responses显示文摘 | Cervone F Hahn M G De Lorenzo G | 1989 | Plant Physiol1989，90，2： | 1 |
| 15 | A fast algo- rithm for Euler's elastic method using augmented Lagrangian method显示文摘 | TAI X C HAHN J CHUNG G J | 2010 | SIAM J Imaging Sci2010，4，5： | 1 |
| 16 | Echo-enhanced tran-scranial color-coded duplex sonography in the diagnosis of cerebrovascular events:a validation study 显示文摘 | Kunz A Hahn G Mucha D | 2006 | AJNR Am J Neuroradiol2006，27，10： | 1 |
| 17 | Feasibility of Particle Board Production Using Bone Glue显示文摘 | KONNERTH J HAHN G GINDL W | 2009 | European Journal of Wood and Wood Products2009，67，2： | 1 |
| 18 | An apparent relationship between Eurasian snow cover and Indian monsoon rainfall 显示文摘 | Hahn D G Shukla J | 1976 | Journal of Atmos- pheric Science1976，33，： | 1 |
| 19 | S3-Leitlinie ?Exokrines Pankreaskarzinom” 2007显示文摘 | G Adler T Seufferlein S Bischoff H.-J Brambs S Feuerbach G Grabenbauer S Hahn V Heinemann W Hohenberger J Langrehr M Lutz O Micke H Neuhaus P Neuhaus H Oettle P Schlag R Schmid W Schmiegel K Schlottmann J Werner B Wiedenmann I Kopp | 2007 | Z Gastroenterol2007，，06： | 1 |
| 20 | EpsteinBarr virus BRLF1inhibits transcription of IRF3and IRF7and suppresses induction of interferon-beta显示文摘 | BENTZ G L LIU R HAHN A M | 2010 | Virology2010，402，： | 1 |
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