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| 1 | Comorbid Chronic Diseases and Acute Organ Injuries Are Strongly Correlated with Disease Severity and Mortality among COVID-19 Patients: A Systemic Review and Meta-Analysis显示文摘The recent outbreak of COVID-19 has been rapidly spreading on a global scale.To date,there is no specific vaccine against the causative virus,SARS-CoV-2,nor is there an effective medicine for treating COVID-19,thus raising concerns with respect to the effect of risk factors such as clinical course and pathophysiological parameters on disease severity and outcome in patients with COVID-19.By extracting and analyzing all available published clinical data,we identified several major clinical characteristics associated with increased disease severity and mortality among patients with COVID-19.Specifically,preexisting chronic conditions such as hypertension,cardiovascular disease,chronic kidney disease,and diabetes are strongly associated with an increased risk of developing severe COVID-19;surprisingly,however,we found no correlation between chronic liver disease and increased disease severity.In addition,we found that both acute cardiac injury and acute kidney injury are highly correlated with an increased risk of COVID-19-related mortality.Given the high risk of comorbidity and the high mortality rate associated with tissue damage,organ function should be monitored closely in patients diagnosed with COVID-19,and this approach should be included when establishing new guidelines for managing these high-risk patients.Moreover,additional clinical data are needed in order to determine whether a supportive therapy can help mitigate the development of severe,potentially fatal complications,and further studies are needed to identify the pathophysiology and the mechanism underlying this novel coronavirus-associated infectious disease.Taken together,these findings provide new insights regarding clinical strategies for improving the management and outcome of patients with COVID-19. | Xinhui Wang Xuexian Fang Zhaoxian Cai Xiaotian Wu Xiaotong Gao Junxia Min Fudi Wang | 2020 | Research2020，，1： | 13 |
| 2 | The zinc transporter Slc39a5 controls glucose sensing and insulin secretion in pancreatic β-cells via Sirt1- and Pgc-1α-mediated regulation of Glut2显示文摘Zinc levels are high in pancreatic β-cells, and zinc is involved in the synthesis, processing and secretion of insulin in these cells. However, precisely how cellular zinc homeostasis is regulated in pancreatic β-cells is poorly understood. By screening the expression of 14 Slc39a metal importer family member genes, we found that the zinc transporter Slc39a5 is significantly downregulated in pancreatic β-cells in diabetic db/db mice, obese ob/ob mice and high-fat diet-fed mice. Moreover,β-cell-specific Slc39a5 knockout mice have impaired insulin secretion. In addition, Slc39a5-deficient pancreatic islets have reduced glucose tolerance accompanied by reduced expression of Pgc-1α and its downstream target gene Glut2. The down-regulation of Glut2 in Slc39a5-deficient islets was rescued using agonists of Sirt1, Pgc-1α and Ppar-γ. At the mechanistic level, we found that Slc39a5-mediated zinc influx induces Glut2 expression via Sirt1-mediated Pgc-1α activation. These findings suggest that Slc39a5 may serve as a possible therapeutic target for diabetes-related conditions. | Xinhui Wang Hong Gao Wenhui Wu Enjun Xie Yingying Yu Xuyan He Jin Li Wanru Zheng Xudong Wang Xizhi Cao Zhuoxian Meng Ligong Chen Junxia Min Fudi Wang | 2019 | Protein & Cell2019，10，6： | 6 |
| 3 | Overexpression of astrocyte-elevated gene-1 is associated with cervicalcarcinoma progression and angiogenesis显示文摘 | Min Long Ke Dong Ping Gao Xi Wang Li Liu Shuhui Yang Fang Lin Junxia Wei Huizhong Zhang | 2013 | Oncology Reports2013，，3： | 2 |
| 4 | Susceptibility of patients with chronic obstructive pulmonary disease to heart rate difference associated with the short-term exposure to metals in ambient fine particles:A panel study in Beijing,China显示文摘Susceptibility of patients with chronic obstructive pulmonary disease(COPD)to cardiovascular autonomic dysfunction asso-ciated with exposure to metals in ambient fine particles(PM2.5,particulate matter with aerodynamic diameter≤2.5µm)remains poorly evidenced.Based on the COPDB(COPD in Beijing)panel study,we aimed to compare the associations of heart rate(HR,an indicator of cardiovascular autonomic function)and exposure to metals in PM2.5 between 53 patients with COPD and 82 healthy controls by using linear mixed-effects models.In all participants,the HR levels were significantly associated with interquartile range increases in the average concentrations of Cr,Zn,and Pb,but the strength of the associations differed by exposure time(from 1.4%for an average 9 days(d)Cr exposure to 3.5%for an average 9 d Zn exposure).HR was positively associated with the average concentrations of PM2.5 and certain metals only in patients with COPD.Associations between HR and exposure to PM2.5,K,Cr,Mn,Ni,Cu,Zn,As,and Se in patients with COPD significantly differed from those in health controls.Furthermore,association between HR and Cr exposure was robust in COPD patients.In conclusion,our findings indicate that COPD could exacerbate difference in HR following exposure to metals in PM2.5. | Ke Gao Xi Chen Xiaoying Li Hanxiyue Zhang Mengxiao Luan Yuan Yao Yifan Xu Teng Wang Yiqun Han Tao Xue Junxia Wang Mei Zheng Xinghua Qiu Tong Zhu | 2022 | Science China(Life Sciences)2022，65，2： | 2 |
| 5 | Preparation of porous spherical α-Ni(OH) 2 and enhancement of high-temperature electrochemical performances through yttrium addition 显示文摘 | Ren Junxia Zhou Zhen Gao Xueping | 2006 | Electrochim Acta2006，52，3： | 1 |
| 6 | Electrochemical incineration of high concentration azo dye wastewater on the in situ activated platinum electrode with sustained microwave radiation显示文摘 | Guohua Zhao Junxia Gao Wei Shi | 2009 | Chemosphere2009，77，2： | 1 |
| 7 | Multiphase fuzzy control under hybrid traffic flow of single intersection显示文摘 | Gao Junxia Li Jiangeng | 2003 | IEEE Intelligent Transportation Systems2003，，2： | 1 |
| 8 | Ultrasound enhanced electrochemical oxidation of phenol and phthalie acid on boron-doped diamond electrode显示文摘 | ZHAO Guohua GAO Junxia SHEN Shihao | 2009 | Journal of Hazardous Materials2009，172，23： | 1 |
| 9 | Ultrasound enhanced electrochemical oxidation of phenol and phthalic acid on boron-doped diamond electrode显示文摘 | ZHAO GUOHUA GAO JUNXIA SHEN SHIHAO | 2009 | Journal of Hazardous Materials2009，，172： | 1 |
| 10 | 显示文摘 | Gao Junxia Zhao Guohua Shi Wei | 2009 | Chemo- sphere2009，75，4： | 1 |
| 11 | Gene therapy with RNAi targeting UHRF1 driven by tumor-specific promoter inhibits tumor growth and enhances the sensitivity of chemotherapeutic drug in breast cancer in vitro and in vivo显示文摘 | Lin Fang Li Shanqu Gao Ping He Ting Wang Xi Dong Ke Long Min Wei Junxia Zhang Huizhong | 2012 | Cancer Chemotherapy and Pharmacology2012，，： | 1 |
| 12 | Ultrasound enhanced electrochemical oxidation of phenol and phthalic acid on boron-doped diamond electrode显示文摘 | Guohua Zhao Junxia Gao Shihao Shen Meichuan Liu Dongming Li Meifen Wu Yanzhu Lei | 2009 | Journal of Hazardous Materials2009，，2： | 1 |
| 13 | Microwave activated electrochemical degradation of 2,4-dichlorophenoxyacetic acid at boron-doped diamond electrode显示文摘 | GAO Junxia ZHAO Guohua SHI Wei | 2009 | Chemosphere2009，75，4： | 1 |
| 14 | Comparison of gene expression between upland and lowland rice cultivars under water stress using cDNA microarray显示文摘 | Haiguang Wang Hongliang Zhang Fenghua Gao Junxia Li Zichao Li | 2007 | Theoretical and Applied Genetics2007，，8： | 1 |
| 15 | Multiphase fuzzy control under hybrid traffic flow of single intersection 显示文摘 | Junxia Gao Jiangeng Li | 2003 | IEEE Intelligent Transportation Systems2003，2，： | 1 |
| 16 | Multiphase Fuzzy Control Under Hybrid Traffic Flow of Single Intersection显示文摘 | Junxia Gao Jiangeng Li | 2003 | IEEE Trans2003，，： | 1 |
| 17 | Leucine-rich glioma-inactivated protein 1 antibody-mediated autoimmune encephalitis in a 4-year-old girl:a case report显示文摘Background:Leucine-rich glioma-inactivated protein 1(LGI1)antibody-mediated encephalitis is a rare subtype of autoimmune encephalopathy,which is associated with autoimmunity against the neuronal plasma membrane proteins.The characteristic symptoms of this disease are memory dysfunction,seizures,faciobrachial dystonic seizures,cognitive deficits,neuropsychiatric disturbances,and intractable hyponatremia.The diagnosis of this disease mainly depends on the presence of anti-LGI1 antibody in serum or cerebrospinal fluid of patients.LGI1 antibody encephalitis has been reported mostly in adults,with rare occurrences in children.Case presentation:In this report,we described a 4-year-old girl with typical seizures.Seizure types included focal seizures and generalized tonic-clonic seizures.The electroencephalogram findings showed focal discharges.Brain magnetic resonance imaging(MRI)showed normal.The cerebrospinal fluid(CSF)levels of cells,glucose,and chloride were within the normal range,and the culture did not reveal growth of any pathogen.Test of serum LGI1-Ab was positive,while the tests for autoimmune encephalitis antibody series in CSF were negative.The seizures of the patient were completely controlled after the therapy of immunoglobulin,methylprednisolone and antiepileptic drugs(AEDs),and the mental state almost returned to normal.Conclusion:To our knowledge,the patient described here may be the youngest case of LGI1 antibody encephalitis reported to date.Children with the LGI1 antibody-associated encephalitis may present only with single symptoms such as epileptic seizures and have good response to the therapy of immunoglobulin,methylprednisolone and antiepileptic drugs.Our case report will provide hints for pediatricians in the diagnosis and treatment of LGI1-antibody encephalitis. | Junxia Luo Jianguo Shi Yehong Chen Wandong Hu Yujie Guo Guangshun Hou Zaifen Gao | 2021 | Acta Epileptologica2021，3，1： | 1 |
| 18 | A new multi-turn beam dump scheme design and simulation for HIAF-BRing machine protection显示文摘Purpose To protect accelerator devices from being damaged by high-power beam,a new beam dump system is under design for HIAF-BRing.Method Based on the optical characteristics,unwanted particles are safely deflected to a specific internal absorber through a local bump orbit generated by active-discharging magnets,which is achieved by paralleling a bleeder resistor of 600 m�to two of dipole magnet power supplies.Results Taking alignment and multipolefield errors into account,discarded beam can be dumped within 5 ms with an efficiency of more than 99.8%at any operation stage.Conclusion The proposed beam dump solution satisfies the machine protection requirements for BRing and can provide a new idea for similar facilities. | Ren Hang Yang Jiancheng Shen Guodong Wang Geng Yao Liping Ruan Shuang Sheng Lina Wu Junxia Zhao He Liu Jie Cai Fucheng Gao Yunzhe Chang Mingxuan Li Minxiang | 2022 | Radiation Detection Technology and Methods2022，6，4： | 1 |
| 19 | Rapid mineralization of azo - dye wastewater by microwave synergistic Electro - Fenton oxidation process显示文摘 | Wang Yujing Zhao Hongying Gao Junxia | 2012 | The Journal of Physical Chemistry: Nano- materials and Interfaces2012，116，13： | 1 |
| 20 | The velocity synchronizing control on the electro-hydraulic load simulator显示文摘 | Jiao Zongxia Gao Junxia Hua Qing Wang Shaoping | 2004 | Chinese Jounenal of Aeronautics2004，，： | 1 |
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