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| 1 | Efficacy of Add-on Montelukast in Nonasthmatic Eosinophilic Bronchitis: The Additive Effect on Airway Inflammation, Cough and Life Quality显示文摘 | Wuping Bao Ping Liu Zhongmin Qiu Li Yu Jingqing Hang Xiaohua Gao Xin Zhou | 2015 | Chinese Medical Journal2015，，1： | 19 |
| 2 | Preparation and application of iron oxide/persimmon tannin/graphene oxide nanocomposites for efficient adsorption of erbium from aqueous solution显示文摘Rare earth elements(REEs)are used for the developme nt of new energy materials owing to their intrinsic physicochemical property.However,excess REEs in water threaten the safety of animals,plants and humans.An efficient way to separate REEs from the water is therefore needed.In this study,a biosorbent consisting of iron oxide(Fe3 O4),persimmon tannin(PT),and graphene oxide(GO)as Fe3 O4/PT/GO was prepared,and the adsorption of trivalent erbium(Er3+)ions from aqueous solution was investigated.The adsorption process for Er3+ions conforms to pseudo-second order kinetic and the Langmuir isotherm model behavior.Thermodynamic studies indicate that the adsorption process is spontaneous and endothermic.Scanning electron microscopy(SEM),X-ray photoelectron spectroscopy(XPS),X-ray diffraction(XRD),thermogravimetric analysis(TGA).Fourier-transform infrared(FT-IR)spectroscopy;Brunauer-Emmett-Teller(BET)analysis,and vibrating sample magnetometer(VSM)were used to assess the adsorption mechanism of Er3+ions onto the Fe3 O4/PT/GO biosorbent.A combination of electrostatic interactions,redox reactivity and chelation are responsible for adsorption of Er3+ions on the Fe3 O4/PT/GO biosorbent,The magnetic Fe3 O4/PT/GO biosorbent can be easily separated under the magnetic field for effective recycle of Er3+ions from aqueous solution.Therefore,this new biomass composite holds great promise for wastewater treatment. | Lin Gao Zhongmin Wang Chaoke Qin Zhenming Chen Mingmin Gao Na He Xi Qian Zhide Zhou Guiyin Li | 2020 | Journal of Rare Earths2020，38，12： | 3 |
| 3 | Elastohydrodynamic lubrication and wear modelling of the knee joint replacements with surface topography显示文摘This numerical study predicted wear of lubricated total knee replacements with the existing of textured surfaceand the possibility of surface designs to reduce wear.In the first part,a wear model of metal-on-polyethylene total kneereplacement was developed.The medial and lateral knee compartments was accounted for separately,with the contactforce and motion during walking cycles applied.An adapted Archard wear formula was employed where the wearfactor was an exponential function of the'Lambda ratio'(film thickness to the average roughness).Wear of the softbearing surface(polyethylene insert)was simulated with regularly geometry update until a steady-state wear observed.ln the second part,the effect of surface topography of the knee replacements was investigated.The surface texturingtechniques have shown promising benefit to machine components in many areas of engineering practice.The textureparameters were designed using the Taguchi method for the geometry,size,and distribution of the micro dimples.twas observed that the lateral compartment may benefit from surface texturing if dimples were properly designed,while the texturing showed hardly advantageous effect on the medial surface in terms of lubrication enhancement andwear reduction.Some results were presented in the 6th World Tribology Conference. | Leiming Gao Zikai Hua Robert Hewson Michael Skipper Andersen Zhongmin Jin | 2018 | Biosurface and Biotribology2018，4，1： | 2 |
| 4 | NON-LINEAR DYNAMIC BEHAVIOR OF THERMOELASTIC CIRCULAR PLATE WITH VARYING THICKNESS SUBJECTED TO NONCONSERVATIVE LOADING显示文摘The non-linear dynamic behaviors of thermoelastic circular plate with varying thickness subjected to radially uniformly distributed follower forces are considered.Two coupled non-linear differential equations of motion for this problem are derived in terms of the transverse deflection and radial displacement component of the mid-plane of the plate.Using the Kantorovich averaging method,the differential equation of mode shape of the plate is derived;and the eigenvalue problem is solved by using shooting method.The eigencurves for frequencies and critical loads of the circular plate with unmovable simply supported edge and clamped edge are obtained.The effects of the variation of thickness and temperature on the frequencies and critical loads of the thermoelastic circular plate subjected to radially uniformly distributed follower forces are then discussed. | WANG Zhongmin GAO Jingbo LIHuixia LIU Hongzhao | 2008 | Chinese Journal of Mechanical Engineering2008，21，5： | 2 |
| 5 | Therapeutic silencing miR-146b-5p improves cardiac remodeling in a porcine model of myocardial infarction by modulating the wound reparative phenotype显示文摘Fibrotic remodeling is an adverse consequence of immune response-driven phenotypic modulation of cardiac cells following myocardial infarction(Ml).MicroRNA-146b(miR-146b)is an active regulator of immunomodulation,but its function in the cardiac inflammatory cascade and its clinical implication in fibrotic remodeling following Ml remain largely unknown.Herein,miR-146b-5p was found to be upregulated in the infarcted myocardium of mice and the serum of myocardial ischemia patients.Gain-and loss-of-function experiments demonstrated that miR-146b-5p was a hypoxia-induced regulator that governed the pro-fibrotic phenotype transition of cardiac cells.Overexpression of miR-146b-5p activated fibroblast proliferation,migration,and fibroblast-to-myofibroblast transition,impaired endothelial cell function and stress survival,and disturbed macrophage paracrine signaling.Interestingly,the opposite effects were observed when miR-146b-5p expression was inhibited.Luciferase assays and rescue studies demonstrated that the miR-146b-5p target genes mediating the above phenotypic modulations included interleukin 1 receptor associated kinase 1(IRAKI)and carcinoembryonic antigen related cell adhesion molecule 1(CEACAM1).Local delivery of a miR-146b-5p antagomir significantly reduced fibrosis and cell death,and upregulated capillary and reparative macrophages in the infarcted myocardium to restore cardiac remodeling and function in both mouse and porcine Ml models.Local inhibition of miR-146b-5p may represent a novel therapeutic approach to treat cardiac fibrotic remodeling and dysfunction following Ml. | Yiteng Liao Hao Li Hao Cao Yun Dong Lei Gao Zhongmin Liu Junbo Ge Hongming Zhu | 2021 | Protein & Cell2021，12，3： | 1 |
| 6 | 显示文摘 | Gao Hongze Su Zhongmin | 2005 | Theochem J Mol Struct2005，722，： | 1 |
| 7 | Investigation of Voids in Polyacrylonitrile Fibers by USAXS and SAXS显示文摘The void structure of polyacrylonitrile(PAN)fibers was investigated using ultra-small angle X-ray scat-tering(USAXS)and small angle X-ray scattering(SAXS).A quantitative method was developed to analyze connected USAXS/SAXS data and thus determine the void parameters of PAN fibers.The results showed that voids affected the mechanical performance of PAN fibers and were present throughout the entire wet-spinning process.When the abso-lute quantity and size of voids decreased,the tensile strength and modulus of PAN fibers increased.The void para-meters were optimized by controlling the production process,and thus the tensile strength and modulus of PAN fibers were increased.The method for analyzing the void structure developed in this study is useful for analyzing voids over with larger size range,as well as the effect of the void structure on the mechanical performance of fibers. | TANG Haitong MENG Fanling LIU Yan JIN Shi WANG Xiaodong GAO Zhongmin CHE Xiaolei | 2019 | Chemical Research in Chinese Universities2019，35，6： | 1 |
| 8 | Synthesis of Ti_2CT_x MXene as electrode materials for symmetric supercapacitor with capable volumetric capacitance显示文摘Two-dimensional(2D)metal carbides,MXene,present the promising application for the energy storage system.Among the MXene family,Ti_2CT_xas the lightest material,shows its unique electrochemical performance.Herein,Ti_2CT_xis synthesized by selective etching Al layer from the Ti_2Al C.With the optimized HF treating condition,Ti_2CT_xdisplays high volumetric capacitance and remarkable rate ability.Moreover,the Ti_2CT_x//Ti_2CT_xsymmetric supercapacitor is designed and assembled,which presents capable capacitance,outstanding rate performance and excellent cycling performance.The remarkable electrochemical performance is attributed to its 2D structure and high electronic conductivity.This work demonstrates the potential application of the Ti_2CT_xfor the supercapacitors and provides a template to design highperformance supercapacitors with 2D electrode materials. | Kai Zhu Yuming Jin Fei Du Shuang Gao Zhongmin Gao Xing Meng Gang Chen Yingjin Wei Yu Gao | 2019 | Journal of Energy Chemistry2019，28，4： | 1 |
| 9 | Combustion synthesis of TiCx-TiB2 composites with hypoeutectic,eu-tectic and hypereutectic microstructures显示文摘 | ZOU BINGLIN SHEN PING GAO ZHONGMIN | | 0，，11： | 1 |
| 10 | Heterogeneous hydroxylation catalyzed by multi-walled carbon nanotubes at low temperature 显示文摘 | Kang Zhenhui Wang Enbo Mao Baodong Su Zhongmin Gao Lei Niu Li Shan Hongyan Xu Lin | 2006 | Applied Catalysis A: General2006，299，： | 1 |
| 11 | Immunogenic-cell-killing and immunosuppression-inhibiting nanomedicine显示文摘Combining chemo-therapeutics with immune checkpoint inhibitors facilitates killing cancer cells and activating the immune system through inhibiting immune escape.However,their treatment effects remain limited due to the compromised accumulation of both drugs and inhibitors in certain tumor tissues.Herein,a new poly(acrylamide-co-acrylonitrile-co-vinylimidazole-co-bis(2-methacryloyl)oxyethyl disulfide)(PAAVB)polymer-based intelligent platform with controllable upper critical solution temperature(UCST)was used for the simultaneous delivery of paclitaxel(PTX)and curcumin(CUR).Additionally,a hyaluronic acid(HA)layer was coated on the surface of PAAVB NPs to target the CD44-overexpressed tumor cells.The proposed nanomedicine demonstrated a gratifying accumulation in tumor tissue and uptake by cancer cells.Then,the acidic microenvironment and high level of glutathione(GSH)in cancer cells could spontaneously decrease the UCST of polymer,leading to the disassembly of the NPs and rapid drug release at body temperature without extra-stimuli.Significantly,the released PTX and CUR could induce the immunogenic cell death(ICD)to promote adaptive anti-tumor immunogenicity and inhibit immunosuppression through suppressing the activity of indoleamine 2,3-dioxygenase 1(IDO1)enzyme respectively.Therefore,the synergism of this intelligent nanomedicine can suppress primary breast tumor growth and inhibit their lung metastasis. | Ying Wang Di Gao Yan Liu Xiaoqing Guo Shuojia Chen Li Zeng Jinxuan Ma Xingcai Zhang Zhongmin Tian Zhe Yang | 2021 | Bioactive Materials2021，6，6： | 0 |
| 12 | Targeting Hypoxic Tumors with Hybrid Nanobullets for Oxygen-Independent Synergistic Photothermal and Thermodynamic Therapy显示文摘Hypoxia is a feature of solid tumors and it hinders the therapeutic efficacy of oxygen-dependent cancer treatment.Herein,we have developed all-organic oxygen-independent hybrid nanobullets ZPA@HA-ACVA-AZ for the“precise strike”of hypoxic tumors through the dual-targeting effects from surface-modified hyaluronic acid(HA)and hypoxia-dependent factor carbonic anhydrase IX(CA IX)-inhibitor acetazolamide(AZ).The core of nanobullets is the special zinc(II)phthalocyanine aggregates(ZPA)which could heat the tumor tissues upon 808-nm laser irradiation for photothermal therapy(PTT),along with the alkyl chain-functionalized thermally decomposable radical initiator ACVA-HDA on the side chain of HA for providing oxygen-independent alkyl radicals for ablating hypoxic cancer cells by thermodynamic therapy(TDT).The results provide important evidence that the combination of reverse hypoxia hallmarks CA IX as targets for inhibition by AZ and synergistic PTT/TDT possess incomparable therapeutic advantages over traditional(reactive oxygen species(ROS)-mediated)cancer treatment for suppressing the growth of both hypoxic tumors and their metastasis. | Di Gao Ting Chen Shuojia Chen Xuechun Ren Yulong Han Yiwei Li Ying Wang Xiaoqing Guo Hao Wang Xing Chen Ming Guo Yu Shrike Zhang Guosong Hong Xingcai Zhang Zhongmin Tian Zhe Yang | 2021 | Nano-Micro Letters2021，13，6： | 0 |
| 13 | Effect of early correction of anemia with erythropoietin on left ventricular mass in predialysis patients:a multi-center trial显示文摘Objective To assess the effects of early correction of anemia with recombinant human erythropoietin (rHuEPO) on the development and progression of left ventricular hypertrophy (LVH) in patients with mild-to-moderate chronic renal insufficiency (CRI) who are not on hemodialysis. Methods A total of 158 patients with serum creatinine from 147μmol/L to 400μmol/L were nrolled in this prospective, multicenter study. Eighty-six patients with hemoglobin (Hb)<110g/L received rHuEPO treatment with a target Hb of ≥110g/L (Group A). Forty patients with comparable Hb concentration (<110g/L) but did not receive rHuEPO (Group B) and 32 patients with Hb≥110g/L and without rHuEPO treatment (Group C) were served as controls. Left ventricular mass index (LVMI) was evaluated by echocardiography at baseline and every 3 months for 2 years. Results There was no difference in age, gender, etiology of renal failure, blood pressure and cardiovascular risk factors among the 3 groups. At baseline, the prevalence of LVH was 72.1% in group A,72.5% in group B and 59.4% in group C. LVMI was inversely correlated with Hb levels (r=0.70, P<0.01). During the 2-year period, the mean LVMI decreased from 142.6±25.7g/m2 to 132.4±18.5 g/m2 in group A, while increased significantly in both group B and group C. The mean Hb concentration increased from 93.8±14.6g/L to 111.2±10.3g/L (P<0.05) in group A, but tended to decrease in group B and group C. There was no significant change of the mean blood pressure, number of anti-hypertensive drugs and serum creatinine concentrations in all 3 groups. However, patients' serum creatinine doubled more often in group B and group C than in group A.Conclusions LVH was common in predialysis CRI patients and was associated with the severity of anemia. Early intervention with rHuEPO may reverse LVH in these patients. | Fanfan HOU Jianping JIANG Lizhen GAO Yangbin PAN Niansheng YANG Wei CHEN Guiyang SHU Youming CHEN Jian CHEN Weihua PENG Jianping WU Zhongmin YANG | 2005 | Journal of Geriatric Cardiology2005，2，3： | 0 |
| 14 | Diagnosis and Treatment Guidelines for Mesenchymal Stem Cell Therapy for Coronavirus Disease 2019(Beijing,2021)显示文摘The coronavirus disease 2019(COVID-19)can be caused by severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)infection,and has led to millions of deaths among more than 100 million infected people around the world according to the declaration from World Health Organization.Dysregulated immune response of both the innate and adaptive immune systems is subsistent on COVID-19 patients,of which the degree are associated with disease severity,lung damage and long term functional disability.Current treatment options have included antiretroviral drugs,anti-inflammatory factors,antibodies,immune checkpoint inhibitors,and convalescent plasma therapy.More recently,mesenchymal stem cell(MSC)therapy has been explored for the management and control of COVID-19,particularly with the aim of preventing or at least mitigating respiratory co-morbidities.Though the safety and efficacy of stem cell therapy have been validated in multiple phase I–III clinical trials,to date,no standardized stem cell preparation,administration dosage or interval,product QA/QC testing,storage,transportation,or disposal protocols have been established.The present paper proposes a systematic methodology that addresses all the foregoing process steps and evaluation criteria for the efficacious and safe administration of MSCs in the treatment of patients infected with COVID-19. | Ruonan Xu Lei Shi Wei-Fen Xie Zhe Xu Fan-Ping Meng Jun-Liang Fu Xin Yuan Lei Huang Ming Shi Yonggang Li Yuanyuan Li Chen Yao Yu Zhang Zhongmin Liu Chenyan Gao Zhaohui Wu Shufang Meng Weidong Han Charlie Xiang Gui-Qiang Wang Taisheng Li Xiaoying Wang Yunxia Sun Zunyou Wu Wenhong Zhang Chunhua Zhao Yu Hu Tao Cheng Yuquan Wei Qi Zhou Fu-Sheng Wang | 2021 | Infectious Diseases & Immunity2021，1，2： | 0 |
| 15 | Understanding AIE and ACQ phenomenon of organometallic iridium(Ⅲ) complexes by simple cationization engineering显示文摘Understanding the relationship between structure and properties is critical to the development of solidstate luminescence materials with desired characteristics and performance optimization. In this work, we elaborately designed and synthesized a pair of mononuclear iridium(Ⅲ) complexes with similar structures but different degrees of cationization. [Ir2-f][2PF_(6)] with two counterions is obtained by simple Nmethylation of the ancillary ligand of [Ir1-f][PF_(6)] which is a classic cationic iridium(Ⅲ) complex. Such a tiny modification results in tremendously different optical properties in dilute solutions and powders.[Ir1-f][PF_(6)] exhibits weak light in solution but enhanced emission in solid-state as well as poly(methyl methacrylate) matrix, indicative of its aggregation-induced emission(AIE) activity. On the sharp contrary, [Ir2-f][2PF_(6)] is an aggregation-caused quenching(ACQ) emitter showing strong emission in the isolated state but nearly nonemissive in aggregation states. Benefiting from the appealing characteristics of mechanochromic luminescence and AIE behavior, [Ir1-f][PF_(6)] has been successfully applied in reversible re-writable data recording and cell imaging. These results might provide deep insights into AIE and ACQ phenomenon of iridium(Ⅲ) complexes and facilitate the development of phosphorescent materials with promising properties. | Weilin Song Huiting Mao Ying Gao Yaxuan Yao Guo-Gang Shan Zhongmin Su | 2024 | Chinese Chemical Letters2024，35，2： | 0 |
| 16 | Erratum to:Development of chloroplast marker for identification of Ulva species显示文摘Erratum to:http://gffzzd3cc09b8251d45dfsq6vf5xq09xbk660w.ffgz.tsg.suse.edu.cn/10.1007/s00343-022-2154-6 The financial supporting information of this article contains a mistake.The correct one is given below. | Dahai GAO Qingchun ZHANG Zhongmin SUN | 2023 | Journal of Oceanology and Limnology2023，41，1： | 0 |
| 17 | Haplotype-resolved and chromosome-level genome assembly of Colorado potato beetle显示文摘As the most important non-cereal food crop,potatoes are a staple food for 1.3 billion people(Stokstad,2019).However,these cultivated potatoes are challenged with multiple biotic stresses(i.e.,pathogens and pests),some of which can evade host resistance,leading to a serious dampening of potato yield.One of these pests is the Colorado potato beetle(hereafter referred to as CPB,Leptinotarsa decemlineata Say).CPB is a member of the order Coleoptera,and originated in the southwestern United States and Mexico(Alyokhin et al.,2008). | Ziqi Ye Ruirui Lu Chao Li Doudou Yang Zhuozhen Zeng Weichao Lin Jie Cheng Zhongmin Yang Li Wang Yulin Gao Sanwen Huang Xingtan Zhang Suhua Li | 2023 | Journal of Genetics and Genomics2023，50，7： | 0 |
| 18 | Surface Metallurgy of Nickle Base Superalloy显示文摘The Double Glow Plasma Surface Alloying Technique, the Xu-Tee Process, is a new method to produce high quality alloying layer on the surface of less expensive materials. By using thes technique, the surface alloying layer similar to superalloy Inconel 625 has been obtained on the surface of three kinds of melallic materials (low carbon steel, industrial pure iron, stainless steel Cr18Ni9). The results of the composition and microstructure analyzed by Scanning Electron Microscopy (SEM) and X-Ray Uffrachon (XRD) show that the alloying layer consistS of y matrix and several precipitates (Laves intermetallic phase and carbide etc.). The electrochemical corrosion results show that the surface alloying layer formed on the surface of stainless steel and industrial pure iron have better corrosion resistance than that of nickel base alloy inconel 625 and stainless steel Cr18Ni9 in 3.5%NaCl solution. The exper iments indicate that it is an effective way to obtain the gradient surface alloying layer on the surfaces of steels by using Double Glow Plasma Surface Alloying Technique. | Xu Zhang Zhongmin Yang Jianxin Dong Xishan Xie Yuan Gao Zhong Xu (Material Science and Engineering school, University of Science and Technology Beijing, Beijing 100083, China)(Institute of Surface Engineering, Taiyuan University of Technology, Taiyua | 1999 | International Journal of Minerals,Metallurgy and Materials1999，13，1： | 0 |
| 19 | Epidemiological and clinical features,treatment status,and economic burden of traumatic spinal cord injury in China:a hospital-based retrospective study显示文摘Traumatic spinal cord injury is potentially catastrophic and can lead to permanent disability or even death.China has the largest population of patients with traumatic spinal cord injury.Previous studies of traumatic spinal cord injury in China have mostly been regional in scope;national-level studies have been rare.To the best of our knowledge,no national-level study of treatment status and economic burden has been performed.This retrospective study aimed to examine the epidemiological and clinical features,treatment status,and economic burden of traumatic spinal cord injury in China at the national level.We included 13,465 traumatic spinal cord injury patients who were injured between January 2013 and December 2018 and treated in 30 hospitals in 11 provinces/municipalities representing all geographical divisions of China.Patient epidemiological and clinical features,treatment status,and total and daily costs were recorded.Trends in the percentage of traumatic spinal cord injuries among all hospitalized patients and among patients hospitalized in the orthopedic department and cost of care were assessed by annual percentage change using the Joinpoint Regression Program.The percentage of traumatic spinal cord injuries among all hospitalized patients and among patients hospitalized in the orthopedic department did not significantly change overall(annual percentage change,-0.5%and 2.1%,respectively).A total of 10,053(74.7%)patients underwent surgery.Only 2.8%of patients who underwent surgery did so within 24 hours of injury.A total of 2005(14.9%)patients were treated with high-dose(≥500 mg)methylprednisolone sodium succinate/methylprednisolone(MPSS/MP);615(4.6%)received it within 8 hours.The total cost for acute traumatic spinal cord injury decreased over the study period(-4.7%),while daily cost did not significantly change(1.0%increase).Our findings indicate that public health initiatives should aim at improving hospitals’ability to complete early surgery within 24 hours,which is associated with improved sensorimotor recovery,increasing the awareness rate of clinical guidelines related to high-dose MPSS/MP to reduce the use of the treatment with insufficient evidence. | Hengxing Zhou Yongfu Lou Lingxiao Chen Yi Kang Lu Liu Zhiwei Cai David BAnderson Wei Wang Chi Zhang Jinghua Wang Guangzhi Ning Yanzheng Gao Baorong He Wenyuan Ding Yisheng Wang Wei Mei Yueming Song Yue Zhou Maosheng Xia Huan Wang Jie Zhao Guoyong Yin Tao Zhang Feng Jing Rusen Zhu Bin Meng Li Duan Zhongmin Zhang Desheng Wu Zhengdong Cai Lin Huang Zhanhai Yin Kainan Li Shibao Lu Shiqing Feng | 2024 | Neural Regeneration Research2024，19，5： | 0 |
| 20 | Axially Chiral Dodecanuclear Lanthanide Clusters Constructed by“Bottom-Up” Self-assembly for Enantioselective Sensing显示文摘Via the bottom-up synthetic strategy,we synthesized a pair of dodecanuclear metal clusters of Eu_(12)(C_(2)O_(4))_(9)(R/S-BNP)_(18)(EtOH)_(6)-(H_(2)0)_(6)·8EtOH-7H_(2)0(complex 2),which represent the largest axial chiral lanthanide metal clusters.In the structure,rare four-pointed star coordination mode of oxalic acid is reported by this work.In addition,as a fluorescence sensor,the complex 2 exhibits high enantioselectivity for R-/S-BINOL-TF_(2)(EF=2.87)and other chiral binaphthyl derivatives. | Honglei Zhao Dongxu Cui Junning Kou Haijuan Gao Guanghui Yu Chunyi Sun Xinlong Wang Zhongmin Su | 2022 | Chinese Journal of Chemistry2022，40，10： | 0 |
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