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| 1 | Cold expansion technology of connection holes in aircraft structures:A review and prospect显示文摘As one kind of key anti-fatigue manufacture approaches with simplicity and effectiveness, the hole cold expansion technology satisfies the increasing needs for light weight and durability of aircraft structures.It can improve the fatigue life by several times at no additional weight conditions.The hole cold expansion technology has been widely used in manufacturing and repairing of both fighters and commercial aircraft, and has become a research hotspot in the strengthening technology.In recent years, hole cold expansion process methods, residual stress around expanded holes, the behavior of fatigue crack initiation and propagation, and fatigue lives after cold expansion are researched extensively through lots of experiments and finite element simulations.A review on the hole cold expansion technology research status in the last twenty years is presented in this paper.Via the analysis of the current characteristics and defects of the hole cold expansion technology, combined with the actual needs in design and manufacture of new-generation aircraft, development trends and novel research directions are presented for realizing precise and high-efficiency anti-fatigue manufacture. | Fu Yucan Ge Ende Su Honghua Xu Jiuhua Li Renzheng | 2015 | Chinese Journal of Aeronautics2015，28，4： | 31 |
| 2 | Structural basis of pre-mRNA recognition by the human cleavage factor Im complex显示文摘劈开因素我 m ( CF 我 m ),由 25 kDa 子单元组成( CF 我 m 25)并且三个更大的子单元之一( CF 我 m 59, CF 我 m 68, CF 我 m 72),并且一为 pre-mRNA 的必要蛋白质建筑群 3 ′ ;结束劈开和 polyadenylation 。它认出在上游的顺序 poly 以一种顺序依赖者方式的(A) 地点。这里,我们报导人的 CF 的水晶结构我 m , 包括 CF 我 m 25 和 CF 的 RNA 识别主题领域我 m 68 (CF 我 m 68RRM), 和 CF 的水晶结构我 m -RNA 建筑群。这些结构显示出那二 CF 我 m 68RRM 分子绑在 CF 我 经由形成 heterotetramer 的一个新奇 RRM 蛋白质相互作用模式更暗淡的 m 25。与反平行的取向,二 UGUAA RNA 定序的 RNA 固定的结构表演绑在一 CF 我 m 25-CF 我 m 68RRM heterotetramer,为由 CF 的机制提供结构的基础我 m 同时在 pre-mRNA 的一个分子以内绑二个 UGUAA 元素。点变化和运动分析表明那 CF 我 m 68RRM 能绑立即在上游的 flanking UGUAA 元素的区域,和 CF 我 m 68RRM 绑定显著地增加建筑群的RNA有约束力的亲密关系,建议那 CF 我 m 68 做必要贡献到 pre-mRNA 有约束力。 | Heng Li | 2011 | Cell Research2011，21，7： | 3 |
| 3 | Preparation of microporous starch by glucoamylase and ultrasound显示文摘 | Wu Yun Du Xianfeng Ge Honghua | 2011 | Starch/Starke2011，63，4： | 1 |
| 4 | Technology of modified orange peel adsorption treatment in wastewater containing zinc 显示文摘 | Xu Qunjie Ju Yanzhong Ge Honghua | 2013 | Advanced Materials Research2013，6106，： | 1 |
| 5 | 显示文摘 | Lai Chunyan Xu Qunjie Ge Honghua | 2008 | Solid State Ionies2008，，： | 1 |
| 6 | Study on adsorption property of collagen fiber loaded hyperbranched polyamideamine toward Cr(Ⅵ)显示文摘 | Xu Qunjie Ju Yanzhong Ge Honghua | 2012 | Advanced Materials Research2012，，610611612613： | 1 |
| 7 | A study of anti-corrosion behavior of octadecylaminetreated iron samples显示文摘 | Ge Honghua Zhou Guoding Liao Qiangqiang | 2000 | Applied Surface Science2000，156，： | 1 |
| 8 | Tetra-glutamic acid residues adjacent to for the ubiquitination mediated by gp78 Lys248 in HMG-CoA reductase are critical and UBE2G2显示文摘3-hydroxy-3-methylglutaryl 辅酶的调整甾醇的降级 reductase (HMGCR ) 是快速的反馈房间由采用控制胆固醇生合成的规章的机制。这个过程被在 HMGCR 和 Insig-1/gp78 之间的导致甾醇的相互作用开始,膜界限 ubiquitin ligase 建筑群。有二 Lys 残余(Lys89 和 Lys248 ) ,在 HMGCR 的膜领域面对 cytosol,并且 Lys248 是主要 ubiquitination 地点。在这研究,我们在 HMGCR 调查了 ubiquitination 地点选择的机制。我们发现到膜的 Lys248 的距离为它的 ubiquitination 是非必需的。然而,邻近在 HMGCR 的 Lys248 的保存 tetra-glutamic 酸残余是必要的。有 tetra 精氨酸的这些否定地控告的残余的代替引起 HMGCR 的抵抗到导致甾醇的 ubiquitination 和降级,这个变异的 HMGCR 罐头仍然绑在 Insig-1 的虽然。我们进一步发现 tetra-glutamic 酸残余为他们的邻近的 Lys 上的修正必要然而并非足够,自从他们不在 HMGCR 或在 SCAP 的 Lys89 上是功能的。UBE2G2, gp78 的以前已知的 E2,被表明涉及 HMGCR 的调整甾醇的 ubiquitination 和降级。在摘要,当在为 ubiquitination 反应的 HMGCR 的一个批评主题由 gp78 和 UBE2G2 调停了,这些结果识别 tetra-glutamic 酸残余。 | Honghua Miao Wei Jiang Liang Ge Boliang Li Baoliang Song | 2010 | Acta Biochimica et Biophysica Sinica2010，42，5： | 1 |
| 9 | Milling Machinability of TiC Particle and TiB Whisker Hybrid Reinforced Titanium Matrix Composites显示文摘The milling machinabilities of titanium matrix composites were comprehensively evaluated to provide a theoretical basis for cutting parameter determination.Polycrystalline diamond(PCD)tools with different grain sizes and geometries,and carbide tools with and without coatings were used in the experiments.Milling forces,milling temperatures,tool lifetimes,tool wear,and machined surface integrities were investigated.The PCD tool required a primary cutting force 15%smaller than that of the carbide tool,while the uncoated carbide tool required a primary cutting force 10% higher than that of the TiAlN-coated tool.A cutting force of 300 Nper millimeter of the cutting edge(300N/mm)was measured.This caused excessive tool chipping.The cutting temperature of the PCD tool was 20%—30%lower than that of the carbide tool,while that of the TiAlN-coated tool was 12%lower than that of the uncoated carbide tool.The cutting temperatures produced when using water-based cooling and minimal quantity lubrication(MQL)were reduced by 100°C and 200°C,compared with those recorded with dry cutting,respectively.In general,the PCD tool lifetimes were 2—3 times longer than the carbide tool lifetimes.The roughness Raof the machined surface was less than 0.6μm,and the depth of the machined surface hardened layer was in the range of 0.15—0.25 mm for all of the PCD tools before a flank wear land of 0.2mm was reached.The PCD tool with a 0.8mm tool nose radius,0°rake angle,10°flank angle,and grain size of(30+2)μm exhibited the best cutting performance.For this specific tool,a lifetime of 16 min can be expected. | Huan Haixiang Xu Jiuhua Su Honghua Ge Yingfei Liang Xinghui | 2017 | Transactions of Nanjing University of Aeronautics and Astronautics2017，34，4： | 1 |
| 10 | Improved electrochemical performance of LiFePO4/C for lithium-ion batteries with two kinds of carbon sources显示文摘 | LAI Chunyan XU Qunjie GE Honghua | 2008 | Solid State Ionics2008，，： | 1 |
| 11 | Thermogrametric kinetics of MgSO3·6H2O byproduct from magnesia wet flue gas desulfurization显示文摘 | Chen Hui Ge Honghua Dou Binlin | 2009 | Energy & Fuels2009，23，5： | 1 |
| 12 | Accelerate the Rural Ecological Environment in Dalian Actively Promote the Development of Circular Economy显示文摘 | XU QuNie GE Honghua ZHANG Junxi | 2011 | Materials Science and Engineering2011，，10： | 1 |
| 13 | Passivation model of 316 stainless steel in simulated cooling water and the effect of sulfide on the passive film显示文摘 | Ge Honghua Zhou Guoding Wu Wenquan | 2003 | Applied Surface Science2003，211，4： | 1 |
| 14 | Passivation model of 316 stainless steel in simulated cooling water and the effect of sulfide on the passive film显示文摘 | Ge Honghua Zhou Guoding Wu Wenquar | 2003 | Applied Surface Science2003，211，4： | 1 |
| 15 | The bacterial effector SidN/Lpg1083 promotes cell death by targeting Lamin-B2显示文摘To facilitate survival,replication,and dissemination,the intracellular pathogen Legionella pneumophila relies on its unique type IVB secretion system(T4SS)to deliver over 330 effectors to hijack host cell pathways in a spatiotemporal manner.The effectors and their host targets are largely unexplored due to their low sequence identity to the known proteins and functional redundancy.The T4SS effector SidN(Lpg1083)is secreted into host cells during the late infection period.However,to the best of our knowledge,the molecular characterization of SidN has not been studied.Herein,we identified SidN as a nuclear envelope-localized effector.Its structure adopts a novel fold,and the N-terminal domain is crucial for its specific subcellular localization.Furthermore,we found that SidN is transported by eukaryotic karyopherin Importin-13 into the nucleus,where it attaches to the N-terminal region of Lamin-B2 to interfere with the integrity of the nuclear envelope,causing nuclear membrane disruption and eventually cell death.Our work provides new insights into the structure and function of an L.pneumophila effector protein,and suggests a potential strategy utilized by the pathogen to promote host cell death and then escape from the host for secondary infection. | Jiajia Gao Wenwen Xu Feng Tang Minrui Xu Qin Zhou Xingyuan Yang Nannan Zhang Jinming Ma Qi Yang Xiaofang Chen Ximing Qin Honghua Ge | 2023 | Journal of Molecular Cell Biology2023，15，5： | 0 |
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