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| 1 | 利用抗高血压药相关的遗传变异发现其潜在的功效和副作用显示文摘通过研究药物靶蛋白基因的自然变异可以了解药物的功效。本研究旨在利用这种方法探索抗高血压药的潜在副作用和再利用潜力。研究者首先确定了血管紧张素转换酶抑制剂(angiotensin converting enzyme inhibitor,ACEI)、β受体阻滞剂和钙拮抗剂的合适代表基因。 | 刘青(译) 叶鹏(校) Gill D Georgakis MK Koskeridis F Jiang L Feng Q Wei WQ Theodoratou E Elliott P Denny JC Malik R Evangelou E Dehghan A Dichgans M Tzoulaki I | 2019 | 中华高血压杂志2019，0，9： | 3 |
| 2 | CD5 expression promotes IL-10 production through activation of the MAPK/Erk pathway and upregulation of TRPC1 channels in B lymphocytes显示文摘CD5 is constitutively expressed on T cells and a subset of mature normal and leukemic B cells in patients with chronic lymphocytic leukemia(CLL).Important functional properties are associated with CD5 expression in B cells,including signal transducer and activator of transcription 3 activation,IL-10 production and the promotion of B-lymphocyte survival and transformation.However,the pathway(s)by which CD5 influences the biology of B cells and its dependence on B-cell receptor(BCR)co-signaling remain unknown.In this study,we show that CD5 expression activates a number of important signaling pathways,including Erk1/2,leading to IL-10 production through a novel pathway independent of BCR engagement.This pathway is dependent on extracellular calcium(Ca2+)entry facilitated by upregulation of the transient receptor potential channel 1(TRPC1)protein.We also show that Erk1/2 activation in a subgroup of CLL patients is associated with TRPC1 overexpression.In this subgroup of CLL patients,small inhibitory RNA(siRNA)for CD5 reduces TRPC1 expression.Furthermore,siRNAs for CD5 or for TRPC1 inhibit IL-10 production.These findings provide new insights into the role of CD5 in B-cell biology in health and disease and could pave the way for new treatment strategies for patients with B-CLL. | Soizic Garaud Taher E Taher Marjolaine Debant Miguel Burgos Sarra Melayah Christian Berthou Kaushal Parikh Jacques-Olivier Pers Damien Luque-Paz Gilles Chiocchia Maikel Peppelenbosch David A Isenberg Pierre Youinou Olivier Mignen Yves Renaudineau Rizgar A Mageed | 2018 | Cellular & Molecular Immunology2018，15，2： | 2 |
| 3 | Successful anti-hepatitis C virus therapy with telaprevir in an HIV/hepatitis C virus co-infected patient with a severe recurrence of hepatitis C virus infection on the liver graft显示文摘 | Teresa M. Antonini Valerie Furlan Elina Teicher Stephanie Haim-Boukobza Mylene Sebagh Audrey Coilly Laurence Bonhomme-Faivre Gilles Peytavin Anne-Marie Roque-Afonso Daniel Vittecoq Didier Samuel Anne-Marie Taburet Jean-Charles Duclos-Vallée | 2013 | AIDS2013，，16： | 2 |
| 4 | A genetic linkage map of Triticum tauschii(DD) and its relationship to the D genome of bread wheat (AABBDD)显示文摘 | GILL K S LUBBERS E L RAUPP WJ | 1991 | Genome1991，34，： | 2 |
| 5 | Changes in efficiency and resource utilization after increasing experience with double balloon enteroscopy显示文摘AIM:To investigate changes in efficiency and resource utilization as a single endoscopist's experience increased with each subsequent 100 double balloon enteroscopy(DBE) procedures.METHODS:We reviewed consecutive DBE procedures performed by a single endoscopist at our center over 4 years.DBE was employed when the clinician deemed the procedure was needed for disease management.The approach(oral,anal or both) was chosen based on suspected location of the target lesion.All DBE was performed in a standard endoscopy room with a portable fluoroscopy unit.Fluoroscopy was used to aid in shortening the small intestine and reducing bowel loops.For oral DBE,measurements were taken from the incisors.For anal DBE,measurements were taken from the anal verge.Enteroscopy continued until the target lesion was reached,until the entire small intestine was examined,or until no further progress was deemed possible.The length of small intestine examined(cm),procedure duration(min),and fluoroscopy time(s) were analyzed for sequential groups of 100 DBE.Sub-groups of diagnostic and therapeutic procedures were analyzed using multivariable linear regression.RESULTS:802 consecutive DBE procedures were analyzed.For oral DBE,median [interquartile range(IQR)] length of small bowel examined was 230.8 cm(range:210-248 cm) and for anal DBE was 143.5 cm(range:100-180 cm).No significant increase in length examined was noted for either the oral or anal approach with advancing position in series.In terms of duration of procedure,the median(IQR) for oral DBE was 86 min(range:71-105 min) and for anal DBE was 81.3 min(range:67-105 min).When comparing by the position in series,there was a significant(P value < 0.001) decrease in procedure duration for both upper and lower procedures with increasing experience.Median(IQR) time of exposure to fluoroscopy for oral DBE was 190 s(114-275) compared to anal DBE which was 196.4 s(312-128).This represented a significant(P value < 0.001) decrease in the amount of fluoroscopy used with increasing position in series.For both oral and anal DBE,fluoroscopy time was reduced by greater than 50% over the course of 802 total procedures performed.Sub-group analysis was conducted on therapeutic and diagnostic groups.Out of 802 procedures,a total of 434 were considered therapeutic.Argon plasma coagulation was by far the most common therapeutic intervention performed.There was no evidence of a difference in length examined or fluoroscopy exposure among oral DBE for diagnostic and therapeutic procedures,P = 0.91 and P = 0.32 respectively.The median(IQR) for length was 235 cm(range:178-280 cm) for diagnostic vs 230 cm(range:180-275 cm) for therapeutic procedures;additionally,fluoroscopy time median(IQR) was 180 s(range:110-295 s) and 162 s(range:102-263 s) for no intervention and intervention.However,there was a significant difference in procedure duration among oral DBE(P < 0.001).The median(IQR) was 80 min(range:60-97 min) and 94 min(range:77-110 min) for diagnostic and therapeutic interventions respectively.CONCLUSION:For a single endoscopist,increased DBE experience with number of performed procedures is associated with increased efficiency and decreased resource utilization. | Neal C Patel William C Palmer Kanwar R Gill David Cangemi Nancy Diehl Mark E Stark | 2013 | World Journal of Gastrointestinal Endoscopy2013，5，3： | 2 |
| 6 | Some simple solutions for heat-induced tropical circulation显示文摘 | GILL A E | 1980 | Quart J Roy Meteor Soc1980，106，： | 1 |
| 7 | Hyponatremia independent of osteo- porosis is associated with fracture occurrence 显示文摘 | Sandhu HS Gilles E DeVita MV | 2010 | Clin J Am Soc Nephrol2010，5，2： | 1 |
| 8 | Enzyme activities and microbial community structure in semiarid agricultural soils 显示文摘 | Acosta-Martinez V Zobeck T M Gill T E | 2003 | Biology and Fertility of Soils2003，3，： | 1 |
| 9 | Advances in Urological Laparoscopy 显示文摘 | Gill I S Clayman R V Medougall E M | 1995 | J Urol1995，154，4： | 1 |
| 10 | A genetic linkage map of Triticum tauschii(DD) and its relationship to the D genome of bread wheat (AABBDD) 显示文摘 | GILL K S LUBBERS E L RAUPP W J | 1991 | Genome1991，34，： | 1 |
| 11 | HVAC design for isolation rooms显示文摘 | Gill K E | 1994 | Heating/Piping/Air Conditioning1994，2，7： | 1 |
| 12 | Evidence for lateral gene transfer between Archaea and Bacteria from genome sequence of Thermotoga maritime显示文摘 | NELSON K E CLAYTON R A GILL S R | 1999 | Nature1999，399，： | 1 |
| 13 | A new method of STR interpre- tation using inferential logic-development of a criminal intelli- gence database显示文摘 | Gill P Urquhart A Millican E | 1996 | Int J Legal Med1996，109，1： | 1 |
| 14 | The relative abundance of three plant functional types in temperate grassland and shurblands of north and south America:effects of projected climate cbange显示文摘 | EPSTEIN H E GILL R A PARUELO J M | 2002 | Journal of Biogcography2002，29，： | 1 |
| 15 | The effect of digestibility and forage species on the removal of digesta from the rumen and the voluntary intake of hay by sheep显示文摘 | Aitchison E Gill M Dhanoa M S | 1986 | British Journal of Nutrition1986，，： | 1 |
| 16 | Insights on evolution of virulence and resistance from the complete genome analysis of an early methicillin-resistant Staphylococcus aureus strain and a biofilm-producing methicillin-resistant Staphylococcus epidermidis strain显示文摘 | Gill S R Fouts D E Archer G L | 2005 | J Bacteriol2005，187，： | 1 |
| 17 | Surgical dislocation of the adult hip a technique with full access to the femoral head and acetabulum without the risk of avascular necrosis显示文摘 | Ganz R Gill TJ Gautier E | 2001 | J Bone Joint Surg2001，83，： | 1 |
| 18 | Hyponatremia associated with large -bone fracture in elderly patients 显示文摘 | Sandhu HS Gilles E DeVita MV | 2009 | lnt Urol Nephrol2009，41，3： | 1 |
| 19 | The mode of Actions of Bacillus Thuringiensis Endotoxins显示文摘 | GILL S S COWLES E A Pietrantonio P V | 1992 | Ann Rev Entomol1992，，37： | 1 |
| 20 | The effects of starvation on plasma free amino acid and glucose concentrations in lake sturgeon显示文摘 | Gills T E Ballantyne J S | 1996 | J Fish Biol1996，49，6： | 1 |
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