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| 1 | Vitamin C alleviates aging defects in a stem cell model for Werner syndrome显示文摘沃纳症候群(WS ) 是主要影响从中层导出的纸巾的早衰混乱。我们最近用 WRN 缺乏的人的间充质的干细胞(MSC ) 开发了一个新奇人的 WS 模型。这个模型概括 WS 的许多 phenotypic 特征。基于很多化学药品的一幅屏幕,这里,我们发现维生素 C 在出现在WRN缺乏的 MSC 的早衰为许多特征施加很有效的营救包括细胞生长拘捕,增加了反应的氧种层次, telomere 摩擦,煽动性的因素的过多的分泌物,象原子薄板和 heterochromatin 的组织的破坏一样。而且,维生素 C 在一个老鼠模型在 vivo 恢复 MSC 的生存能力。定序分析的 RNA 显示维生素 C 改变涉及染色质冷凝作用,房间周期规定, DNA 复制,和 DNA 损坏的一系列基因的表示在 WRN 缺乏的 MSC 的修理小径。我们的结果为 WS MSC 作为一个恢复因素识别维生素 C,它保持作为 WS 的处理的一种新奇类型被使用的潜力。 | Ying Li Weizhou Zhang Liang Chang Yan Han Liang Sun Xiaojun Gong Hong Tang Zunpeng Liu Huichao Deng Yanxia Ye Yu Wang Jian Li Jie Qiao Jing Qu Weiqi Zhang Guang-Hui Liu | 2016 | Protein & Cell2016，7，7： | 10 |
| 2 | Effects of AlN on the densification and mechanical properties of pressureless-sintered SiC ceramics显示文摘In the present work, Si C ceramics was fabricated with Al N using B_4 C and C as sintering aids by a solid-state pressureless-sintered method. The effects of Al N contents on the densification, mechanical properties, phase compositions, and microstructure evolutions of as-obtained Si C ceramics were thoroughly investigated. Al N was found to promote further densification of the Si C ceramics due to its evaporation over 1800 °C,transportation, and solidification in the pores resulted from Si C grain coarsening. The highest relative density of 99.65% was achieved for Si C sample with 15.0 wt% Al N by the pressureless-sintered method at 2130 °C for 1 h in Ar atmosphere. Furthermore, the fracture mechanism for Si C ceramics containing Al N tended to transfer from single transgranular fracture mode to both transgranular fracture and intergranular fracture modes when the sample with 30.0 wt% Al N sintered at 1900 °C for 1 h in Ar. Also, Si C ceramics with 30.0 wt% Al N exhibited the highest fracture toughness of 5.23 MPa m^(1/2) when sintered at 1900 °C. | Qisong Li Yujun Zhang Hongyu Gong Haibin Sun Yanxia Zhai Weiya Zhu Jie Jing | 2016 | Progress in Natural Science:Materials International2016，26，1： | 2 |
| 3 | Current management of chemotherapy-induced neutropenia in adults:key points and new challenges显示文摘Chemotherapy-induced neutropenia(CIN)is a potentially fatal and common complication in myelosuppressive chemotherapy.The timing and grade of CIN may play prognostic and predictive roles in cancer therapy.CIN is associated with older age,poor functional and nutritional status,the presence of significant comorbidities,the type of cancer,previous chemotherapy cycles,the stage of the disease,specific chemotherapy regimens,and combined therapies.There are many key points and new challenges in the management of CIN in adults including:(1)Genetic risk factors to evaluate the patient’s risk for CIN remain unclear.However,these risk factors urgently need to be identified.(2)Febrile neutropenia(FN)remains one of the most common reasons for oncological emergency.No consensus nomogram for FN risk assessment has been established.(3)Different assessment tools[e.g.,Multinational Association for Supportive Care in Cancer(MASCC),the Clinical Index of Stable Febrile Neutropenia(CISNE)score model,and other tools]have been suggested to help stratify the risk of complications in patients with FN.However,current tools have limitations.The CISNE score model is useful to support decision-making,especially for patients with stable FN.(4)There are still some challenges,including the benefits of granulocyte colony stimulating factor treatment and the optimal antibiotic regimen in emergency management of FN.In view of the current reports,our group discusses the key points,new challenges,and management of CIN. | Committee of Neoplastic Supportive-Care(CONS),China Anti-Cancer Association Committee of Clinical Chemotherapy,China Anti-Cancer Association Yi Ba Yuankai Shi Wenqi Jiang Jifeng Feng Ying Cheng Li Xiao Qingyuan Zhang Wensheng Qiu Binghe Xu Ruihua Xu Bo Shen Zhiguo Luo Xiaodong Xie Jianhua Chang Mengzhao Wang Yufu Li Yuerong Shuang Zuoxing Niu Bo Liu Jun Zhang Li Zhang Herui Yao Conghua Xie Huiqiang Huang Wangjun Liao Gongyan Chen Xiaotian Zhang Hanxiang An Yanhong Deng Ping Gong Jianping Xiong Qinghua Yao Xin An Cheng Chen Yanxia Shi Jialei Wang Xiaohua Wang Zhiqiang Wang Puyuan Xing Sheng Yang Chenfei Zhou | 2020 | Cancer Biology & Medicine2020，17，4： | 2 |
| 4 | A single-center retrospective study on epidemiological and Traditional Chinese Medicine syndrome characteristics of 21010 patients with reflux/heartburn symptoms显示文摘OBJECTIVE:To provide a basis for the clinical identification of true and false reflux,integrated traditional Chinese and Western medicine,and psychosomatic treatment,we conducted a retrospective study of the etiology and epidemiological and Traditional Chinese Medicine(TCM) syndrome characteristics of patients with reflux/heartburn symptoms.METHODS:The 210 10 patients with reflux/heartburn treated at Tianjin Nankai Hospital from January 1,2016,to December 31,2019,were divided into four groups according to their pathogenesis.Sex,age,course of disease,incidence rate,gastroscopy,24-h p Himpedance,esophageal manometry,Hamilton Anxiety Scale(HAMA)/Hamilton Depression Scale(HAMD) score,8-week proton pump inhibitor(PPI) treatment effect,and TCM syndrome characteristics were statistically analyzed.RESULTS:A total of 21010 patients(8864 men and 12146 women),with reflux/heartburn symptoms were screened,including 6284(29.9%) patients with reflux esophagitis(RE),10427(49.6%) patients with nonerosive reflux esophagitis(NERD),2430(11.6%) patients with reflux hypersensitivity(RH),and 1870(8.9%) patients with functional heartburn(FH).The incidence of the disease was higher in women than in men(P <0.0001).The ranking of the incidence of anxiety and depression in these four groups was FH > RH > NERD > RE(P < 0.0001).There were more women than men in the groups with anxiety and more men than women in the groups with depression(P < 0.0001),and there was no significant difference in the distribution of anxiety and depression between men and women(P = 0.5689).There were significant differences in TCM syndrome characteristics between NERD,RE,and functional esophageal diseases(P < 0.01).The highest proportion of functional esophageal disease TCM symptoms was Qi stagnation and phlegm obstruction syndrome(36.16%),and there was no significant difference between RH and FH.The effective rates of PPI treatment at 8 weeks in patients in the RE,NERD,RH,and FH groups were 89%,72%,54%,and 0%,respectively.RE was classified into grades A,B,C,and D according to the Los Angeles grading system.The ranking of the incidence of these four grades was A > B > C > D(P < 0.0001).The effective rates of PPI treatment at 8 weeks were 91%,81%,69%,and 63% in patients with grade A,B,C,and D RE,respectively(P < 0.0001).The highest proportion of TCM syndrome types of NERD and RE was the stagnated heat syndrome in the liver and stomach syndrome,38.99% and 33.90%,respectively.CONCLUSION:Reflux/heartburn symptoms are relatively common in middle-aged women,and NERD is the most common etiology,followed by RE,RH,and FH.The most common TCM syndrome characteristics in NERD and RE were stagnated heat syndrome in the liver and stomach syndrome,and Qi stagnation and phlegm obstruction syndrome in functional esophageal diseases.Most patients with reflux/heartburn symptoms also experienced anxiety and depression. | TANG Yanping LI Peicai LIU Xi LIU Lei GONG Yanxia WEI Xiaodong LIU Lina YANG Li | 2023 | Journal of Traditional Chinese Medicine2023，43，3： | 2 |
| 5 | Lipoprotein lipase and phospholipid transfer protein overexpression in human glioma cells and their effect on cell growth, apoptosis, and migration显示文摘Glioma 是在大脑的普通肿瘤之一。脂蛋白脂肪分解酵素(LPL ) 或 phospholipid 转移蛋白质(PLTP ) 的表示水平可以影响有临床、病理学的参数的 glioma 前进和它的关系。在 glioma 的 LPL 或 PLTP 表示的临床的意义没被建立。在现在的学习,在 glioma 肿瘤的 LPL 和 PLTP 层次被调查,在 LPL 和 PLTP 水平和恶意的 glioma 的等级之间的关系被分析,与提供为在临床、基本的研究背景的 gliomas 的诊断和治疗的新想法的目的。LPL 和 PLTP mRNA 和蛋白质层次比在更低的等级肿瘤的那些在等级 IV glioma 是显著地更高的(P P = 0.005 ) 。LPL 和 PLTP 的层次与 glioma 病人的弄短的幸存被增加(P LPL 和 PLTP 导致了减少的房间生长和移植,但是在 vitro 增加了 apoptosis。另外,当 cyclin 依赖的 kinase 禁止者 p16, p21,和 Rb 是起来调整的时,周期相关的 cyclins 和他们的搭挡被发现下面调整的房间。而且, LPL 或 PLTP 击倒导致了 pro-apoptotic 分子的起来规定和 anti-apoptotic 分子的下面规定。在 U251 房间的 LPL 或 PLTP 的脱离导致了上皮的间充质的转变标记和侵略分子矩阵 metalloproteinases 的下面规定。LPL 和 PLTP 看起来是新奇联系 glioma 的蛋白质并且在人的 glioma 的前进起一个作用。 | Weijiang Dong Huilin Gong Guanjun Zhang Simona Vuletic John Albers Jiaojiao Zhang Hua Liang Yanxia Sui Jin Zheng | 2017 | Acta Biochimica et Biophysica Sinica2017，49，1： | 2 |
| 6 | Development of Operational Space Environment Technology System显示文摘With the increasing of users and the demands which are transforming from the monotonous traditional service to network service,Multiple space environment web applications including browser-client,rich-client and mobile-client applications have been developed by SEPC(Space Environment Prediction Center,NSSC,CAS)during the past few years.The architecture of Operational Space Environment Technology System(OSETS) that these applications rely on is described and the description of structural optimization of the architecture is provided.To demonstrate the evolution of the OSETS,three web application examples for e SpaceWx,Space Weather Situation Awareness Picture(SWSAP),Plug-and-Play SWx Analysis and Plotting Program(PPSWAP) are presented. | GONG Jiancun CAI Yanxia LIU Siqing SHI Liqin LU Guorui CHEN Zhaofeng BAO Lili | 2016 | 空间科学学报2016，36，5： | 1 |
| 7 | The biochemical behavior and mechanism of uranium(Ⅵ)bioreduction induced by natural Bacillus thuringiensis显示文摘For a broader understanding of uranium migration affected by microorganisms in natural anaerobic environment,the bioreduction of uranium(Ⅵ)(U(Ⅵ))was revealed in Bacillus thuringiensis,a dominant bacterium strain with potential of uranium-tolerant isolated from uranium contaminated soil.The reduction behavior was systematically investigated by the quantitative analysis of U(Ⅳ)in bacteria,and mechanism was inferred from the pathway of electron transmission.Under anaerobic conditions,appropriate biomass and sodium lactate as electron donor,reduction behavior of U(Ⅵ)induced by B.thuringiensis was restricted by the activity of lactate dehydrogenase,which was directly affected by the initial pH,temperature and initial U(Ⅵ)concentration of bioreduction system.Bioreduction of U(Ⅵ)was driven by the generation of nicotinamide adenine dinucleotide(NADH)from enzymatic reaction of sodium lactate with various dehydrogenase.The transmission of the electrons from bacteria to U(Ⅵ)was mainly supported by the intracellular NADH dehydrogenase-ubiquinone system,this process could maintain the biological activity of cells. | Shunzhang Chen Junyuan Gong Yanxia Cheng Yuqi Guo Feize Li Tu Lan Yuanyou Yang Jijun Yang Ning Liu Jiali Liao | 2024 | Journal of Environmental Sciences2024，，2： | 0 |
| 8 | Space Weather Service for Chinese Space Science Satellites显示文摘Strategic Priority Research Program on Space Science has gained remarkable achievements. Space Environment Prediction Center(SEPC) affiliated with the National Space Science Center(NSSC) has been providing space weather services and helps secure space missions. Presently, SEPC is capable to offer a variety of space weather services covering many phases of space science missions including planning, design, launch,and orbital operation. The service packages consist of space weather forecasts, warnings, and effect analysis that can be utilized to avoid potential space weather hazard or reduce the damage caused by space storms,space radiation exposure for example. Extensive solar storms that occurred over Chinese Ghost Festival(CGF)in September 2017 led to a large enhancement of the solar energetic particle flux at 1 AU, which affected the near Earth radiation environment and brought great threat to orbiting satellites. Based on the space weather service by SEPC, satellite ground support groups collaborating with the space Tracking, Telemetering and Command system(TT&C) team were able to take immediate measures to react to the CGF solar storm event. | LIU Siqing ZHONG Qiuzhen GONG Jiancun SHI Liqin CHEN Dong MIAO Juan CAI Yanxia BAI Meng MA Wenzhen LI Zhitao LIU Fanghua CHEN Yanhong | 2018 | 空间科学学报2018，38，5： | 0 |
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