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| 1 | Response of runoff in the headwater region of the Yellow River to climate change and its sensitivity analysis显示文摘在到气候变化和它的敏感的黄河的 headwater 区域的流量的反应在时期期间在四个水文学车站和十个气象站基于测量数据被分析 19592008。结果显示在这个区域的温度的那个变化与全球温暖和在在这个区域的每个分区的温度一直在介绍的年度一般水准的变化有一种明显的相应关系过去的 50 年里的一个变动、升起的状态。因为不同地理位置和环境的影响,然而,降水的变化在总体上生产流量的区域一直在介绍的年度降水的各种各样的区域,和变化是比在这个区域的温度的变化更复杂的过去的 50 年里的一个变动、减少的状态。并且在这个区域在流量和降水和温度之间有一种显著非线性的相互关系。因为,自从 1990,在这个区域的流量连续地一直在减少降水总体上生产流量的区域显然减少,年度平均温度连续地升起。总体上,当在在 Jimai 上面的分区的流量相应地在在这个区域的其它比那对温度变化更敏感时,在黄河的 headwater 区域的每个分区的流量对降水变化相当敏感。 | LAN Yongchao ZHAO Guohui ZHANG Yaonan WEN Jun HU Xinglin LIU Jinqi GU Minglin CHANG Junjie MA Jianhua | 2010 | Journal of Geographical Sciences2010，20，6： | 20 |
| 2 | Colorectal cancer burden and trends:Comparison between China and major burden countries in the world显示文摘Objective:To summarize the colorectal cancer(CRC)burden and trend in the world,and compare the difference of CRC burden between other countries and China.Methods:Incidence and mortality data were extracted from the GLOBOCAN2018 and Cancer Incidence in Five Continents.Age-specific incidence trend was conducted by Joinpoint analysis and average annual percent changes were calculated.Results:About 1.85 million new cases and 0.88 million deaths were expected in 2018 worldwide,including 0.52 million(28.20%)new cases and 0.25 million(28.11%)deaths in China.Hungary had the highest age-standardized incidence and mortality rates in the world,while for China,the incidence and mortality rates were only half of that.CRC incidence and mortality were highly correlated with human development index(HDI).Unlike the rapid increase in Republic of Korea and the downward trend in Canada and Australia,the age-standardized incidence rates by world standard population in China and Norway were rising gradually.The age-specific incidence rate in the age group of 50-59 years in China was increasing rapidly,while in Republic of Korea and Canada,the fastest growing age group was 30-39 years.Conclusions:The variations of CRC burden reflect the difference of risk factors,as well as levels of HDI and screening(early detection activities).The burden of CRC in China is high,and the incidence of CRC continues to increase,which may lead to a sustained increase in the burden of CRC in China in the future.Screening should be expanded to control CRC,and focused on young people in China. | Jiachen Zhou Rongshou Zheng Siwei Zhang Hongmei Zeng Shaoming Wang Ru Chen Kexin Sun Minjuan Li Jianhua Gu Guihua Zhuang Wenqiang Wei | 2021 | Chinese Journal of Cancer Research2021，33，1： | 16 |
| 3 | Total mesopancreas excision for pancreatic head cancer: analysis of 120 cases显示文摘Objective: To evaluate the feasibility and safety of total mesopancreas excision(TMpE) in the treatment of pancreatic head cancer. Methods: The clinical and pathological data of 120 patients with pancreatic head cancer who had undergone TMpE in our center from May 2010 to January 2014 were retrospectively analyzed. Results: The mean operative time was(275.0±50.2) min and the average intra-operative blood loss was(390.0±160.5) mL. Post-operative complications were reported in 45 patients, while no peri-operative death was noted. The specimen margins were measured in three dimensions, and 86 patients(71.6%) achieved R0 resection. Conclusions: TMpE is safe and feasible for pancreatic head cancer and is particularly helpful to increase the R0 resection rate. | Wenguang Wu Xu'an Wang Xiangsong Wu Maolan Li Hao Weng Yang Cao Ruifa Bao Sijun Su Jianhua Lu Wei Gong Weibin Shi Jun Gu Xuefeng Wang Yingbin Liu Zhiwei Quan Shuyou Peng | 2016 | Chinese Journal of Cancer Research2016，28，4： | 10 |
| 4 | Brassinosteroids function in spikelet differentiation and degeneration in rice显示文摘Brassinosteroids(BRs) play crucial roles in many aspects of plant development. However, their function in spikelet differentiation and degeneration in rice(Oryza sativa L.) remains unclear. Here, we investigated the roles of these phytohormones in spikelet development in fieldgrown rice subjected to five different nitrogen(N)fertilization treatments during panicle differentiation. BR levels and expression of genes involved in BR biosynthesis and signal transduction were measured in spikelets. Pollen fertility and the number of differentiated spikelets were closely associated with 24-epicastasterone(24-epiCS) and 28-homobrassinolide(28-homoBL) levels in spikelets.Enhanced BR biosynthesis and signal transduction, in response to N treatment, enhanced spikelet differentiation, reduced spikelet degeneration, and increased grain yield. Increases in proton-pumping ATPase activity, ATPconcentration, energy charge, and antioxidant system(AOS) levels were consistent with 24-epiCS and28-homoBL concentrations. Exogenous application of 24-epiCS or 28-homoBL on young panicles induced a marked increase in endogenous 24-epiCS or 28-homoBL levels, energy charge, AOS levels, spikelet differentiation, and panicle weight. The opposite effects were observed following treatment with a BR biosynthesis inhibitor. Our findings indicate that, in rice, BRs mediate the effects of N fertilization on spikelet development and play a role in promoting spikelet development through increasing AOS levels and energy charge during panicle development. | Weiyang Zhang Kuanyu Zhu Zhiqin Wang Hao Zhang Junfei Gu Lijun Liu Jianchang Yang Jianhua Zhang | 2019 | Journal of Integrative Plant Biology2019，61，8： | 10 |
| 5 | Power electronic transformer with adaptive PLL technique for voltage-disturbance ride through显示文摘The power electronic transformer(PET) has recently emerged as a type of power converter. It features the basic functions of power conversion and isolation as well as additional functions related to power quality control. A novel PET for a distribution grid called a flexible power distribution unit is proposed in this paper, and the energy exchange mechanism between the network and the load is revealed. A 30 kW 600 VAC/220 VAC/110 VDC medium-frequency isolated prototype is developed and demonstrated. This paper also presents key control strategies of the PET for electrical distribution grid applications,especially under grid voltage disturbance conditions.Moreover, stability issues related to the grid-connected three-phase PET are discussed and verified with an impedance-based analysis. The PET prototype is tested, and it passes the voltage-disturbance ride-through function. The experimental results verify the power quality control abilities of the PET. | Jianhua WANG Fangfang LUO Qing DUAN Zhendong JI Binshi GU Jun YOU Wei GU Jianfeng ZHAO | 2018 | Journal of Modern Power Systems and Clean Energy2018，6，5： | 7 |
| 6 | Effect of irrigation regime on grain yield,water productivity,and methane emissions in dry direct-seeded rice grown in raised beds with wheat straw incorporation显示文摘Dry direct-seeded rice grown in raised beds is becoming an important practice in the wheat–rice rotation system in China.However,little information has been available on the effect of various irrigation regimes on grain yield,water productivity(WP),nitrogen use efficiency(NUE),and greenhouse gas emission in this practice.This study investigated the question using two rice cultivars in 2015 and 2016 grown in soil with wheat straw incorporated into it.Rice seeds were directly seeded into raised beds,which were maintained under aerobic conditions during the early seedling period.Three irrigation regimes:continuous flooding(CF),alternate wetting and drying(AWD),and furrow irrigation(FI),were applied from 4.5-leaf-stage to maturity.Compared with CF,both AWD and FI significantly increased grain yield,WP,and internal NUE,with greater increases under the FI regime.The two cultivars showed the same tendency in both years.Both AWD and FI markedly increased soil redox potential,root and shoot biomass,root oxidation activity,leaf photosynthetic NUE,and harvest index and markedly decreased global warming potential,owing to substantial reduction in seasonalThe results demonstrate that adoption of either AWD or FI could increase grain yield and resource-use efficiency and reduce environmental risks in dry direct-seeded rice grown on raised beds with wheat straw incorporation in the wheat–rice rotation system. | Zhiqin Wang Daojian Gu Sarah S.Beebout Hao Zhang Lijun Liu Jianchang Yang Jianhua Zhang | 2018 | The Crop Journal2018，6，5： | 6 |
| 7 | The heterogeneity of islet autoantibodies and the progression of islet failure in type 1 diabetic patients显示文摘Type 1 diabetes mellitus is heterogeneous in many facets. The patients suffered from type 1 diabetes present several levels of islet function as well as variable number and type of islet-specific autoantibodies. This study was to investigate prevalence and heterogeneity of the islet autoantibodies and clinical phenotypes of type 1 diabetes mellitus; and also discussed the process of islet failure and its risk factors in Chinese type 1 diabetic patients. A total of 1,291 type 1 diabetic patients were enrolled in this study. Demographic information was collected. Laboratory tests including mixed-meal tolerance test, human leukocyte antigen alleles, hemoglobin A1 c, lipids, thyroid function and islet autoantibodies were conducted. The frequency of islet-specific autoantibody in newly diagnosed T1 DM patients(duration shorter than half year) was 73% in East China. According to binary logistic regressions, autoantibody positivity, longer duration and lower Body Mass Index were the risk factors of islet failure. As the disease developed, autoantibodies against glutamic acid decarboxylase declined as well as the other two autoantibodies against zinc transporter 8 and islet antigen 2. The decrease of autoantibodies was positively correlated with aggressive beta cell destruction. Autoantibodies can facilitate the identification of classic T1 DM from other subtypes and predict the progression of islet failure. As there were obvious heterogeneity in autoantibodies and clinical manifestation in different phenotypes of the disease, we should take more factors into consideration when identifying type 1 diabetes mellitus. | Jin Liu Lingling Bian Li Ji Yang Chen Heng Chen Yong Gu Bingqin Ma Wei Gu Xinyu Xu Yun Shi Jian Wang Dalong Zhu Zilin Sun Jianhua Ma Hui Jin Xing Shi Heng Miao Bing Xin Yan Zhu Zhenwen Zhang Ruifang Bu Lan Xu Guangde Shi Wei Tang Wei Li Dongmei Zhou Jun Liang Xingbo Cheng Bimin Shi Jixiang Dong Ji Hu Chen Fang Shao Zhong Weinan Yu Weiping Lu Chenguang Wu Li Qian Jiancheng Yu Jialin Gao Xiaoqiang Fei Qingqing Zhang Xueqin Wang Shiwei Cui Jinluo Cheng Ning Xu Guofeng Wang Guoqing Han Chunrong Xu Yun Xie Minmin An Wei Zhang Zhixiao Wang Yun Cai Qi Fu Yu Fu Shuai Zheng Fan Yang Qingfang Hu Hao Dai Yu Jin Zheng Zhang Kuanfeng Xu Yifan Li Jie Shen Hongwen Zhou Wei He Xuqin Zheng Xiao Han Liping Yu Jinxiong She Mei Zhang Tao Yang | 2016 | Science China(Life Sciences)2016，59，9： | 5 |
| 8 | Primary closure versus T-tube drainage in laparoscopic common bile duct exploration: a meta-analysis of randomized clinical trials显示文摘 | Xiangsong Wu Yong Yang Ping Dong Jun Gu Jianhua Lu Maolan Li Jiasheng Mu Wenguang Wu Jiahua Yang Lin Zhang Qichen Ding Yingbin Liu | 2012 | Langenbeck’s Archives of Surgery2012，，6： | 4 |
| 9 | Signatures within esophageal microbiota with progression of esophageal squamous cell carcinoma显示文摘Objective: Esophageal squamous cell carcinoma(ESCC) is one of the dominant malignances worldwide, but currently there is less focus on the microbiota with ESCC and its precancerous lesions.Methods: Paired esophageal biopsy and swab specimens were obtained from 236 participants in Linzhou, China.Data from 16 S ribosomal RNA gene sequencing were processed using quantitative insights into microbial ecology(QIIME2) and R Studio to evaluate differences. The Wilcoxon rank sum test and Kruskal-Wallis rank sum test were used to compare diversity and characteristic genera by specimens and participant groups. Ordinal logistic regression model was used to build microbiol prediction model.Results: Microbial diversity was similar between biopsy and swab specimens, including operational taxonomic unit(OTU) numbers and Shannon index. There were variations and similarities of esophageal microbiota among different pathological characteristics of ESCC. Top 10 relative abundance genera in all groups include Streptococcus, Prevotella, Veillonella, Actinobacillus, Haemophilus, Neisseria, Alloprevotella, Rothia, Gemella and Porphyromonas. Genus Streptococcus, Haemophilus, Neisseria and Porphyromonas showed significantly difference in disease groups when compared to normal control, whereas Streptococcus showed an increasing tendency with the progression of ESCC and others showed a decreasing tendency. About models based on all combinations of characteristic genera, only taken Streptococcus and Neisseria into model, the prediction performance was the ideal one, of which the area under the curve(AUC) was 0.738.Conclusions: Esophageal biopsy and swab specimens could yield similar microbial characterization. The combination of Streptococcus and Neisseria has the potential to predict the progression of ESCC, which is needed to confirm by large-scale, prospective cohort studies. | Minjuan Li Dantong Shao Jiachen Zhou Jianhua Gu Junjie Qin Wen Chen Wenqiang Wei | 2020 | Chinese Journal of Cancer Research2020，32，6： | 4 |
| 10 | A simple model of radial nerve injury in the rhesus monkey to evaluate peripheral nerve repair显示文摘Current research on bone marrow stem cell transplantation and autologous or xenogenic nerve transplantation for peripheral nerve regeneration has mainly focused on the repair of peripheral nerve defects in rodents.In this study,we established a standardized experimental model of radial nerve defects in primates and evaluated the effect of repair on peripheral nerve injury.We repaired 2.5-cm lesions in the radial nerve of rhesus monkeys by transplantation of autografts,acellular allografts,or acellular allografts seeded with autologous bone marrow stem cells.Five months after surgery,regenerated nerve tissue was assessed for function,electrophysiology,and histomorphometry.Postoperative functional recovery was evaluated by the wrist-extension test.Compared with the simple autografts,the acellular allografts and allografts seeded with bone marrow stem cells facilitated remarkable recovery of the wrist-extension functions in the rhesus monkeys.This functional improvement was coupled with radial nerve distal axon growth,a higher percentage of neuron survival,increased nerve fiber density and diameter,increased myelin sheath thickness,and increased nerve conduction velocities and peak amplitudes of compound motor action potentials.Furthermore,the quality of nerve regeneration in the bone marrow stem cells-laden allografts group was comparable to that achieved with autografts.The wrist-extension test is a simple behavioral method for objective quantification of peripheral nerve regeneration. | Dong Wang Xijun Huang Guo Fu Liqiang Gu Xiaolin Liu Honggang Wang Jun Hu Jianhua Yi Xiaofeng Niu Qingtang Zhu | 2014 | Neural Regeneration Research2014，9，10： | 3 |
| 11 | Dosimetric parameters of palladium-103 brachytherapy source with Monte Carlo simulation显示文摘Before clinical application of a new source, the dosimetric parameters of the source should be accu- rately determined. This work is dedicated to the Monte Carlo method to calculate dosimetric parameters as recommended by the American Association of Physicists in Medicine (AAPM) TG-43 guidelines for model ADVANTAGETM palladium-103 source and, through comparison with data from another published report for the same source, presents a suggested dataset for clinical applications. From these calcula- tions, tables are presented for the radial dose function and the anisotropy function of palladium-103 brachytherapy source. The dose rate constants are found to be 0.671 (cGyh-1U-1) in liquid water and 0.673 (cGyh-1U-1) in Solid WaterTM. And the anisotropy constants in liquid water and Solid WaterTM are found to be 0.864 and 0.865 respectively. Comparison with the previous study shows that our results of dosimetric parameters are in good agreement with those measured and calculated by Meigooni et al. (2006) both in Water and Solid WaterTM. | WANG JianHua LIU Wei XU XunJiang GU JiaHui CAI Jun HUA ZhengDong XU JiaQiang | 2008 | Chinese Science Bulletin2008，53，9： | 3 |
| 12 | QTL analysis across multiple environments reveals promising chromosome regions associated with yield-related traits in maize under drought conditions显示文摘Drought is one of the most critical abiotic stresses influencing maize yield. Improving maize cultivars with drought tolerance using marker-assisted selection requires a better understanding of its genetic basis. In this study, a doubled haploid(DH) population consisting of 217 lines was created by crossing the inbred lines Han 21(drought-tolerant) and Ye 478(drought-sensitive). The population was genotyped with a 6 K SNP assay and 756 SNP(single nucleotide polymorphism) markers were used to construct a linkage map with a length of 1344 c M. Grain yield(GY), ear setting percentage(ESP), and anthesis–silking interval(ASI) were recorded in seven environments under well-watered(WW) and water-stressed(WS) regimes. High phenotypic variation was observed for all traits under both water regimes. Using the LSMEAN(least-squares mean) values from all environments for each trait, 18 QTL were detected, with 9 associated with the WW and 9 with the WS regime. Four chromosome regions,Chr. 3: 219.8–223.7 Mb, Chr. 5: 191.5–194.7 Mb, Chr. 7: 132.2–135.6 Mb, and Chr. 10: 88.2–89.4 Mb, harbored at least 2 QTL in each region, and QTL co-located in a region inherited favorable alleles from the same parent. A set of 64 drought-tolerant BC_3F_6 lines showed preferential accumulation of the favorable alleles in these four regions, supporting an association between the four regions and maize drought tolerance. QTL-by-environment interaction analysis revealed 28 ed QTL(environment-dependent QTL) associated with the WS regime and 22 associated with the WW regime for GY, ESP, and ASI. All WS QTL and55.6% of WW QTL were located in the ed QTL regions. The hotspot genomic regions identified in this work will support further fine mapping and marker-assisted breeding of drought-tolerant maize. | Xinmin Hu Guihua Wang Xuemei Du Hongwei Zhang Zhenxiang Xu Jie Wang Guo Chen Bo Wang Xuhui Li Xunji Chen Junjie Fu Jun Zheng Jianhua Wang Riliang Gu Guoying Wang | 2021 | The Crop Journal2021，9，4： | 3 |
| 13 | DNA damage repair promotion in colonic epithelial cells by andrographolide downregulated cGAS-STING pathway activation and contributed to the relief of CPT-11-induced intestinal mucositis显示文摘Gastrointestinal mucositis is one of the most debilitating side effects of the chemotherapeutic agent irinotecan(CPT-11). Andrographolide, a natural bicyclic diterpenoid lactone, has been reported to possess anti-colitis activity. In this study, andrographolide treatment was found to significantly relieve CPT-11-induced colitis in tumor-bearing mice without decreasing the tumor suppression effect of CPT-11. CPT-11 causes DNA damage and the release of double-stranded DNA(ds DNA) from the intestine, leading to cyclic-GMP-AMP synthase(c GAS)-stimulator of interferon genes(STING)-mediated colitis, which was significantly decreased by andrographolide both in vivo and in vitro. Mechanistic studies revealed that andrographolide could promote homologous recombination(HR) repair and downregulate ds DNA-c GAS-STING signaling and contribute to the improvement of CPT-11-induced gastrointestinal mucositis. These results suggest that andrographolide may be a novel agent to relieve gastrointestinal mucositis caused by CPT-11. | Yuanyuan Wang Bin Wei Danping Wang Jingjing Wu Jianhua Gao Haiqing Zhong Yang Sun Qiang Xu Wen Liu Yanhong Gu Wenjie Guo | 2022 | Acta Pharmaceutica Sinica B2022，12，1： | 3 |
| 14 | Management scheme influence and nitrogen addition effects on soil CO_(2),CH_(4),and N_(2)O fluxes in a Moso bamboo plantation显示文摘Background:It is still not clear whether the effects of N deposition on soil greenhouse gas(GHG)emissions are influenced by plantation management schemes.A field experiment was conducted to investigate the effects of conventional management(CM)versus intensive management(IM),in combination with simulated N deposition levels of control(ambient N deposition),30 kg N·ha^(−1)·year^(−1)(N30,ambient+30 kg N·ha^(−1)·year^(−1)),60 kg N·ha^(−1)·year^(−1)(N60,ambient+60 kg N·ha^(−1)·year^(−1)),or 90 kg N·ha^(−1)·year^(−1)(N90,ambient+90 kg N·ha^(−1)·year^(−1))on soil CO_(2),CH_(4),and N_(2)O fluxes.For this,24 plots were set up in a Moso bamboo(Phyllostachys edulis)plantation from January 2013 to December 2015.Gas samples were collected monthly from January 2015 to December 2015.Results:Compared with CM,IM significantly increased soil CO_(2) emissions and their temperature sensitivity(Q_(10))but had no significant effects on soil CH_(4) uptake or N_(2)O emissions.In the CM plots,N30 and N60 significantly increased soil CO_(2) emissions,while N60 and N90 significantly increased soil N_(2)O emissions.In the IM plots,N30 and N60 significantly increased soil CO_(2) and N_(2)O emissions,while N60 and N90 significantly decreased soil CH_(4) uptake.Overall,in both CM and IM plots,N30 and N60 significantly increased global warming potentials,whereas N90 did not significantly affect global warming potential.However,N addition significantly decreased the Q_(10) value of soil CO_(2) emissions under IM but not under CM.Soil microbial biomass carbon was significantly and positively correlated with soil CO_(2) and N_(2)O emissions but significantly and negatively correlated with soil CH_(4) uptake.Conclusion:Our results indicate that management scheme effects should be considered when assessing the effect of atmospheric N deposition on GHG emissions in bamboo plantations. | Junbo Zhang Quan Li Jianhua Lv Changhui Peng Zhikang Gu Lianghua Qi Xuzhong Song Xinzhang Song | 2021 | Forest Ecosystems2021，8，1： | 2 |
| 15 | Biochar amendments increase soil organic carbon storage and decrease global warming potentials of soil CH4 and N2O under N addition in a subtropical Moso bamboo plantation显示文摘Background: Nitrogen(N) deposition affects soil greenhouse gas(GHG) emissions, while biochar application reduces GHG emissions in agricultural soils. However, it remains unclear whether biochar amendment can alleviate the promoting effects of N input on GHG emissions in forest soils. Here, we quantify the separate and combined effects of biochar amendment(0, 20, and 40 t·ha) and N addition(0, 30, 60, and 90 kg N·ha·yr) on soil GHG fluxes in a long-term field experiment at a Moso bamboo(Phyllostachys edulis) plantation.Results: Low and moderate N inputs(≤60 kg N·ha·yr) significantly increase mean annual soil carbon dioxide(CO) and nitrous oxide(NO) emissions by 17.0%–25.4% and 29.8%–31.2%, respectively, while decreasing methane(CH) uptake by 12.4%–15.9%, leading to increases in the global warming potential(GWP) of soil CHand NO fluxes by 32.4%–44.0%. Moreover, N addition reduces soil organic carbon(C;SOC) storage by 0.2%–6.5%. Compared to the control treatment, biochar amendment increases mean annual soil CO2emissions, CHuptake, and SOC storage by 18.4%–25.4%, 7.6%–15.8%, and 7.1%–13.4%, respectively, while decreasing NO emissions by 17.6%–19.2%, leading to a GWP decrease of 18.4%–21.4%. Biochar amendments significantly enhance the promoting effects of N addition on soil COemissions, while substantially offsetting the promotion of N2O emissions, inhibition of CHuptake, and decreased SOC storage, resulting in a GWP decrease of 9.1%–30.3%.Additionally, soil COand CHfluxes are significantly and positively correlated with soil microbial biomass C(MBC) and pH. Meanwhile, NO emissions have a significant and positive correlation with soil MBC and a negative correlation with pH.Conclusions: Biochar amendment can increase SOC storage and offset the enhanced GWP mediated by elevated N deposition and is, thus, a potential strategy for increasing soil C sinks and decreasing GWPs of soil CHand NO under increasing atmospheric N deposition in Moso bamboo plantations. | Quan Li Kunkai Cui Jianhua Lv Junbo Zhang Changhui Peng Yongfu Li Zhikang Gu Xinzhang Song | 2022 | Forest Ecosystems2022，9，4： | 2 |
| 16 | Crop coefficient and ratio of transpiration to evapotranspiration of winter wheat and maize in a semi-humid region显示文摘 | Shaozhong Kang Binjie Gu Taisheng Du Jianhua Zhang | 2002 | Agricultural Water Management2002，，3： | 2 |
| 17 | Ultrasmall Nanoparticle ROS Scavengers Based on Polyhedral Oligomeric Silsesquioxanes显示文摘Although tremendous efforts have been devoted to the structural and functional tailoring of natural polyphenol-functionalized nan oparticles,preparing ultrasmall sized(<6 nm)particles with precisely-defined structures has remained a grand challenge.In this work,we reported the preparation of ultra-small and precisely structured polyhedral oligomeric silsesquioxanes(POSS)-based polyphenol nanopartides(T8^-,T10^-,and T12^-GAPOSS)by accurately functionalizing the POSS surface with plant polyphenol gallic acid units via thiol-Michael'click'reactions.Those polyphenol nanoparticles exhibited strong free radical scavenging capacity,good biocompatibility and ability to resist cell oxidative damage,which dem on strated great potentials in inhibiting oxidative stress in duced pathologies. | Zhan Li Haotian Li Jianhua Zhang Xianhu Liu Zhipeng Gu Yiwen Li | 2020 | Chinese Journal of Polymer Science2020，38，11： | 2 |
| 18 | Role of polymorphisms of the IGF2 and IGFBP3 genes and risk of gastric carcinoma in China显示文摘 | Gu Jun Li Maolan Dong Ping Lu Jianhua Tan Zhujun Wu Xiangsong Mu Jiasheng Zhang Lin Wu Wenguang Ding Qichen Yang Jiahua Cao Yang Ding Qian Weng Hao Liu Yingbin | 2014 | Chinese Medical Journal2014，，3： | 2 |
| 19 | Tribological Properties of Lubricating Oils with Triethanolamine Borate under Electromagnetic Field显示文摘Tribological properties of 150SN mineral oil and lubricating oils containing triethanolamine borate(TBE)with and without electromagnetic field impact were evaluated on a modified four-ball tribo-tester.The characteristics of the worn surfaces were studied by scanning electronic microscopy(SEM),energy dispersive spectrometry(EDS)and X-ray photoelectron spectroscopy(XPS).Moreover,the tribological mechanisms are discussed from the viewpoint of physical effect and chemical effect.The results indicated that the friction coefficients and wear scar diameters(WSDs)lubricated by 150SN mineral oil under electromagnetic field were higher than those without electromagnetism impact.The WSDs of steel balls lubricated by TBE-doped oils under electromagnetic field were smaller than those obtained from non-electromagnetic field,but the friction coefficients were higher than those under non-electromagnetic field.A protective coating consists of wear particles could be formed on the frictional surface due to the physical effect of electromagnetic field on wear debris.The electromagnetic field could facilitate the interaction of elemental boron and nitrogen in TBE with metal interfaces,and contributes to forming tribo-chemical reaction film to reduce friction and wear. | Wang Xin Fang Jianhua Jiang Zeqi Gu Kecheng Liu Ping | 2019 | China Petroleum Processing & Petrochemical Technology2019，21，3： | 2 |
| 20 | A spontaneous thermo-sensitive female sterility mutation in rice enables fully mechanized hybrid breeding显示文摘Male sterility enables hybrid crop breeding to increase yields and has been extensively studied. But thermo-sensitive female sterility, which is an ideal property that may enable full mechanization in hybrid rice breeding, has rarely been investigated due to the absence of such germplasm. Here we identify the spontaneous thermo-sensitive female sterility 1 (tfs1) mutation that confers complete sterility under regular/high temperature and partial fertility under low temperature as a point mutation in ARGONAUTE7 (AGO7). AGO7 associates with miR390 to form an RNA-Induced Silencing Complex (RISC), which triggers the biogenesis of small interfering RNAs (siRNAs) from TRANS-ACTING3 (TAS3) loci by recruiting SUPPRESSOR OF GENE SILENCING (SGS3) and RNA-DEPENDENT RNA POLYMERASE6 (RDR6) to TAS3 transcripts. These siRNAs are known as tasiR-ARFs as they act in trans to repress auxin response factor genes. The mutant TFS1 (mTFS1) protein is compromised in its ability to load the miR390/miR390* duplex and eject miR390* during RISC formation. Furthermore, tasiR-ARF levels are reduced in tfs1 due to the deficiency in RDR6 but not SGS3 recruitment by mTFS1 RISC under regular/high temperature, while low temperature partially restores mTFS1 function in RDR6 recruitment and tasiR-ARF biogenesis. A miR390 mutant also exhibits female sterility, suggesting that female fertility is controlled by the miR390-AGO7 module. Notably, the tfs1 allele introduced into various elite rice cultivars endows thermo-sensitive female sterility. Moreover, field trials confirm the utility of tfs1 as a restorer line in fully mechanized hybrid rice breeding. | Haoxuan Li Chenjiang You Manabu Yoshikawa Xiaoyu Yang Haiyong Gu Chuanguo Li Jie Cui Xuemei Chen Nenghui Ye Jianhua Zhang Guanqun Wang | 2022 | Cell Research2022，32，10： | 2 |
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