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| 1 | Isolation and characterization of H7N9 viruses from live poultry markets--Implication of the source of current H7N9 infection in humans显示文摘On March 31, 2013, the National Health and Family Planning Commission announced that human infections with a previously undescribed influenza A (H7N9) virus had occurred in Shanghai and Anhui Province, China. To investigate the possible origins of the H7N9 viruses causing these human infections, we collected 970 samples, including drinking water, soil, and cloacal and tracheal swabs of poultry from live poultry markets and poultry farms in Shanghai and Anhui Province. Twenty samples were positive for the H7N9 influenza virus. Notably, all 20 viruses were isolated from samples collected from live poultry markets in Shanghai. Phylogenetic analyses showed that the six internal genes of these novel human H7N9 viruses were derived from avian H9N2 viruses, but the ancestor of their HA and NA genes is uncertain. When we examined the phylogenetic relationship between the H7N9 isolates from live poultry markets and the viruses that caused the human infections, we found that they shared high homology across all eight gene segments. We thus identified the direct avian origin of the H7N9 influenza viruses that caused the human infections. Importantly, we observed that the H7N9 viruses isolated from humans had acquired critical mutations that made them more 'human-like'. It is therefore imperative to take strong measures to control the spread of H7N9 viruses in birds and humans to prevent further threats to human health. | SHI JianZhong DENG GuoHua LIU PeiHong ZHOU JinPing GUAN LiZheng LI WenHui LI XuYong GUO Jing WANG GuoJun FAN Jun WANG JinLiang LI YuanYuan JIANG YongPing LIU LiLing TIAN GuoBin LI ChengJun CHEN HuaLan | 2013 | Chinese Science Bulletin2013，58，16： | 85 |
| 2 | Progress and significance in research on the early Middle Cambrian Kaili Biota, Guizhou Province, China显示文摘Important progress in research on the Kaili Biota has been made recently. Many interesting components from Chengjiang Biota and Burgess Shale Biota have been discovered, e.g. Microdictyon of lobopodia; Ottoia, Palaeoscolex of worms; Naraoia, Marrella of Trilobitioidea, Mollisonia, anamalocarids and other non-trilobite arthropods; and new sorts of echinoder-mas, macroalage fossils and so on. Recent work on the Kaili Biota has resulted in the following developments: (i) an increase in the number of animal genera, up to more than 100 genera in total, so that the Kaili Biota has become the third most diverse of the Burgess Shale-type Biota after the Burgess Shale and Chengjiang Biotas; and (ii) the most noteworthy fossils in the Kaili Biota are echinoderms, non-trilobite arthropods and soft-bodied medusiform fossils, especially the most diverse echinoderms. The progress provides envidence for the biodiversity of marine organisms presented after the 'Cambrian Explosion' and serves as a link between the earlist Cambrian Chengjiang Biota and late early Middle Cambrian Burgess Shale Biota. It is of great significance in the reconstruction of the Cambrian palaeoplate, palaeongeography and in research on taphonomy. | ZHAO Yuanlong, YUAN Jinliang, ZHU Maoyan, YANG Ruidong, GUO Qingjun, PENG Jin and YANG Xinglian(1. Institute of Paleontology and Biomineralization, School of Resource and Environment, Guizhou University of Technology, Guiyang 550003, China: 2. Nanjing Institute of Geology and Paleontology, Chinese Academy of Sciences, Nanjing 210008, China 3. Guiyang Institute of Geochemistry, Chinese Academy of Sciences, Guiyang 550003, China) | 2002 | Progress in Natural Science:Materials International2002，12，9： | 20 |
| 3 | A new section of Kaili Formation (Cambrian) and a biostratigraphic study of the boundary interval across the undefined Cambrian Series 2 and Series 3 at Jianshan,Jianhe County,China with a discussion of global correlation based on the first appearance dat显示文摘在 Jianshan 的 Kaili 形成的新节的三叶虫 biostratigraphic 研究, Chuandong 村庄, Jianhe 县,贵州被报导。与 Ovatoryctocara granulata Bathynotus holopygus 地区和原来在 Kaili 的 Wuliu-Zengjiayan 节从三叶虫集合被定义的 overlying Oryctocephalus indicus 地区联系的关键种类的另外的出现从这新节被报导。Oryctocephalus indicus 的第一本外观资料(一度时髦的风尚) 在单位的底上面发生在 44.52 m。基于丰富的标本的学习(n = 800 ) 从 Kaili 形成,我们主张那 Oryctocephalus indicus 是普遍的税在上与全球分布。O。reticulatus (Lermontova, 1940 ) 从在西伯利亚和 O 的 Molodo 河区域的 Amganian 阶段的 Kounamkites 地区的中间的部分。americanus (Sundberg 和 McCollum, 2003 ) 从内华达,北美洲类似于 O 的代表。发生在 O 的 indicus。Kaili 形成的 indicus 地区。O。reticulatus 和 O。americanus 这里与 O 被举出。indicus (里德, 1910 ) 。这研究为未命名的寒武纪的系列 3 的底为全球 Stratotype 作为候选人节加强 Kaili 形成的 Wuliu-Zengjiayan 节。 | Yuanlong Zhao Jinliang Yuan Shanchi Peng Loren E. Babcock Jin Peng Qingjun Guo Jihpai Lin Tongshu Tai Ruidong Yang Yuxian Wang | 2008 | Progress in Natural Science:Materials International2008，18，12： | 8 |
| 4 | Diagenesis and Diagenetic Evolution of Deltaic and Neritic Gas-Bearing Sandstones in the Lower Mingyuefeng Formation of Paleogene, Lishui Sag, East China Sea Shelf Basin: Implications for Depositional Environments and Sequence Stratigraphy Controls显示文摘Gas-bearing deposits in the Lower Mingyuefeng Formation of Paleogene, Lishui Sag, East China Sea Shelf Basin consist of shoreface sandstones of the highstand systems tract(HST) and transgressive systems tract(TST), and deltaic sandstones of the lowstand systems tract(LST) and falling stage systems tract(FSST).Detailed petrographic observations suggest that the diagenetic features and related evolution of these deposits cannot be simply characterized and demonstrated in the depth domain.However, the occurrence of diagenetic minerals systematically depends on the studied interval within the HST, TST, LST, and FSST; therefore, diagenesis in this region can be better constrained when studied in the context of the depositional environments and sequence stratigraphic framework.The eogenetic processes in such settings include:(1) microcrystalline siderite precipitated as concretions in almost all environments and systems tracts, which inhibited further mechanical compaction;(2) grain dissolution and kaolinitization occurred in shoreface HST sandstones and deltaic LST and FSST sandstones;(3) glaucony was locally observed, which did not clearly reflect the controls of facies or sequence stratigraphy; and(4) cementation by pyrite aggregates occurred in the shoreface HST sandstones and deltaic LST sandstones.The mesogenetic diagenesis includes:(1) partial conversion of kaolinite into dickite in deltaic LST sandstones, and minor chlorite cementation in deltaic FSST sandstones;(2) transformation of kaolinite into illite and quartz cementation in deltaic LST and FSST sandstones;(3) frequent precipitation of ankerite and ferroan calcite in shoreface TST sandstones and early HST sandstones, forming baffles and barriers for fluid flow, with common calcite in shoreface HST sandstones as a late diagenetic cement; and(4) formation of dawsonite in the deltaic LST and FSST sandstones, which is interpreted to be a product of the invasion of a CO2-rich fluid, and acts as a good indicator of CO2-bearing reservoirs.This study has thus constructed a reliable conceptual model to describe the spatial and temporal distribution of diagenetic alterations.The results may provide an entirely new conceptual framework and methodology for successful gas exploration in the continental margins of offshore China, thus allowing us to predict and unravel the distribution and quality evolution of clastic reservoirs at a more detailed and reliable scale. | XU Fa ZHANG Penghui ZHANG Jinliang LIU Jinshui HOU Guowei ZHANG Ming LI Jingzhe LIU Shasha GUO Jiaqi MENG Ningning | 2015 | Acta Geologica Sinica(English Edition)2015，89，5： | 5 |
| 5 | A new strain of Crimean-Congo hemorrhagic fever virus isolated from Xinjiang, China显示文摘Crimean-Congo hemorrhagic fever virus(CCHFV) is a highly pathogenic tick-borne virus with a fatality rate of up to 50% in humans. CCHFV is widely distributed in countries around the world.Outbreaks of CCHFV infection in humans have occurred in prior years in Xinjiang Province, China.Epidemiological surveys have detected CCHFV RNA in ticks and animals; however, few isolates were identified. In this study, we identified and isolated a new CCHFV strain from Hyalomma asiaticum asiaticum ticks collected from north of Tarim Basin in Xinjiang, China. A preliminary investigation of infection and antigens expression of CCHFV was performed in newborn mice. The target tissues for CCHFV replication in newborn mice were identified. The analysis of the phylogenetic relationships with other Chinese strains suggested that diverse genotypes of CCHFV have circulated in Xinjiang for years. These findings provide important insights into our understanding of CCHFV infection and evolution as well as disease prevention and control for local residents. | Rong Guo Shu Shen Yanfang Zhang Junming Shi Zhengyuan Su Dan Liu Jinliang Liu Juan Yang Qiguo Wang Zhihong Hu Yujiang Zhang Fei Deng | 2017 | Virologica Sinica2017，32，1： | 5 |
| 6 | Inheritance of resistance to Helicoverpa armigera of 3 kinds of transgenic Bt strains available in upland cotton in China显示文摘There are 3 kinds of transgenic Bt strains, Shanxi 94-24, Zhongxin 94, and R19, in upland cotton in China. Their transgenic Bt insect-resistance cultivars or hybrids have been developed and grown by farmers. Genetic studies indicate that the resistance of the 3 transgenic Bt cotton strains to Helicoverpa armigera is controlled by one pair of non-allelic dominant genes. Linkage relationship between the resistant genes of R19 and Shanxi 94-24 transgenic Bt strains shows that they may be inserted in the same chromosome. FT hybrids crossed among the 3 strains show that high levels of protection from feeding damage are the same as that of their parents. Therefore, there is no co-suppression phenomenon in many transgenic plants. The results presented here afford a fundamental reliance in developing transgenic Bt insect-resistant cultivars and exploiting the heterosis of hybrids in upland cotton. | TANG Canming SUN Jing ZHU Xiefei GUO Wangzhen ZHANG Tianzhen SHEN Jinliang GAO Congfen ZHOU Weijun CHEN Zhixian GUO Sandui | 2000 | Chinese Science Bulletin2000，45，4： | 3 |
| 7 | The immune enhancement of propolis adjuvant on inactivated porcine parvovirus vaccine in guinea pig显示文摘 | Xia Ma Zhenhuan Guo Zhiqiang Shen Jinliang Wang Yuanliang Hu Deyun Wang | 2011 | Cellular Immunology2011，，1： | 2 |
| 8 | Expression of Pseudorabies Virus gE Core Epitopes in Escherichia coli Strain BL21 and Utilization of Indirect PRV gE-ELISA显示文摘Pseudorabies virus glycoprotein E( PRV gE) has been recognized as a suitable diagnostic antigen for pseudorabies. In order to produce gE antigen in large quantities and at low cost,a gene fragment encoding PRV gE core epitopes was expressed in E. coli BL21 expression system. SDS-PAGE and Western Blotting revealed that the expression product in culture supernatant of E. coli BL21 was a recombinant protein,approximately 51. 8 Kd. At 5 h post-induction,protein concentration assay showed that the expression product amounted to 1. 65 mg /ml,accounting for 24. 17% of total proteins in the culture supernatant. An indirect PRV gE-ELISA was established by using the recombinant expression product as a coating antigen. Cross-reactivity assay showed that this antigen was PRV specific. In addition,the assay was consistently reproducible. Comparison of detection results of 240 serum samples between PRV gE-ELISA and a commercially available PRV diagnostic kit showed that there was no significant difference between these two methods( P > 0. 05). | Guangjun GUO Sufang LU Guanggang QU Feng LI Lin DONG Yanli BI Jinliang WANG Feng WEI Na TANG Chunling ZHANG Zhuang DING Zhiqiang SHEN | 2014 | Agricultural Biotechnology2014，3，4： | 2 |
| 9 | Mitochondrial transcription factor A plays opposite roles in the initiation and progression of colitis-associated cancer显示文摘Background:Mitochondria are key regulators in cell proliferation and apoptosis.Alterations in mitochondrial function are closely associated with inflammation and tumorigenesis.This study aimed to investigate whether mitochondrial transcription factor A(TFAM),a key regulator of mitochondrial DNA transcription and replication,is involved in the initiation and progression of colitis-associated cancer(CAC).Methods:TFAM expression was examined in tissue samples of inflammatory bowel diseases(IBD)and CAC by immunohistochemistry.Intestinal epithelial cell(IEC)-specific TFAM-knockout mice(TFAM^(△IEC))and colorectal cancer(CRC)cells with TFAM knockdown or overexpression were used to evaluate the role of TFAMin colitis and the initiation and progression ofCAC.The underlying mechanisms of TFAMwere also explored by analyzingmitochondrial respiration function and biogenesis.Results:The expression of TFAM was downregulated in active IBD and negatively associated with the disease activity.The downregulation of TFAM in IECs was induced by interleukin-6 in a signal transducer and activator of transcription 3(STAT3)/miR-23b-dependent manner.In addition,TFAM knockout impaired IECturnover to promote dextran sulfate sodium(DSS)-induced colitis inmice.Of note,TFAMknockout increased the susceptibility of mice to azoxymethane/DSSinduced CAC and TFAM overexpression protected mice from intestinal inflammation and colitis-associated tumorigenesis.By contrast,TFAM expression was upregulated in CAC tissues and contributed to cell growth.Furthermore,it was demonstrated that β-catenin induced the upregulation of TFAM through c-Myc in CRC cells.Mechanistically,TFAMpromoted the proliferation of both IECs and CRC cells by increasing mitochondrial biogenesis and activity.Conclusions:TFAM plays a dual role in the initiation and progression of CAC,providing a novel understanding of CAC pathogenesis. | Shirong Yang Xianli He Jing Zhao Dalin Wang Shanshan Guo Tian Gao Gang Wang Chao Jin Zeyu Yan Nan Wang Yongxing Wang Yilin Zhao Jinliang Xing Qichao Huang | 2021 | Cancer Communications2021，41，8： | 2 |
| 10 | H7N9 Influenza Viruses Are Transmissible in Ferrets by Respiratory Droplet显示文摘 | Qianyi Zhang Jianzhong Shi Guohua Deng Jing Guo Xianying Zeng Xijun He Huihui Kong Chunyang Gu Xuyong Li Jinxiong Liu Guojun Wang Yan Chen Liling Liu Libin Liang Yuanyuan Li Jun Fan Jinliang Wang Wenhui Li Lizheng Guan Qimeng Li Huanliang Yang Pucheng Che | 2013 | Science2013，，6144： | 1 |
| 11 | The immune enhancement of propolis adjuvant on inactivated porcine parvovirus vaccine in guinea pig显示文摘 | Xia Ma Zhenhuan Guo Zhiqiang Shen Jinliang Wang Yuanliang Hu Deyun Wang | 2011 | Cellular Immunology2011，，1： | 1 |
| 12 | ESR studies on the interaction of calixarenes and free radicals显示文摘 | LI Yong WANG Qi GUO Jinliang | 1999 | Materials Science and Engineering1999，10，： | 1 |
| 13 | H7N9 Influenza Viruses Are Transmissible in Ferrets by Respiratory Droplet显示文摘 | Qianyi Zhang Jianzhong Shi Guohua Deng Jing Guo Xianying Zeng Xijun He Huihui Kong Chunyang Gu Xuyong Li Jinxiong Liu Guojun Wang Yan Chen Liling Liu Libin Liang Yuanyuan Li Jun Fan Jinliang Wang Wenhui Li Lizheng Guan Qimeng Li Huanliang Yang Pucheng Che | 2013 | Science2013，，6144： | 1 |
| 14 | Recent Advance in Polyolefin Technology显示文摘 | Qiao Jinliang Guo Meifang Wang Liangshi | 2011 | Polym Chem2011，2，8： | 1 |
| 15 | Recent advances in polyolefin technology显示文摘 | Qiao Jinliang Guo Meifang Wang Liangshi | 2011 | Polymer Chemistry2011，2，8： | 1 |
| 16 | Distillability sudden death for two-qutrit states under an XY quantum environment显示文摘distillability sudden death;;bound entangled states;;negativity;;realignment criterion;;entanglement | Yao Wang ChangCheng Cheng BingBing Chai JinLiang Guo | 2018 | Science China(Physics,Mechanics & Astronomy)2018，61，2： | 1 |
| 17 | ESR studies on the interaction of calixarenes and free radicals 显示文摘 | LI Yong WANG Qi GUO Jinliang | 1999 | Materials Science and Engineering: C1999，10，： | 1 |
| 18 | Mo 2 C intermediate layers for graphite–Cu system using the molten salt method显示文摘 | Jinliang Song Quangui Guo Zechao Tao Xiaoqing Gao Ping Shen Jingli Shi Lang Liu | 2011 | Fusion Engineering and Design2011，，12： | 1 |
| 19 | Recent Advances in Polyolefin Technology 显示文摘 | Qiao Jinliang Guo Meifang Wang Liangshi | 2011 | Polym Chem2011，2，8： | 1 |
| 20 | Short-Term Load Forecasting Based on Improved Gene Expression Programming 显示文摘 | Jinliang Yin Limin Huo Lirui Guo and Jie fin | 2008 | Proceedings of the 7th World Congress on Intelligent Control and Automation2008，，： | 1 |
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