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| 1 | 最新AD研究用诊断标准:IWG-2标准显示文摘在过去的8年中,国际工作组织(IWG)和美国国立老化研究院-阿尔茨海默协会(NIA-AA)建立了阿尔茨海默病(AD)诊断标准,它能更好地定义AD的临床表型,整合了生物标记物于诊断流程中,并覆盖了疾病的全程。本意见书充分地权衡了IWG标准的优缺点,建议改进诊断框架。依据这些改进,AD的诊断变得简单,只要有恰当的AD临床表型(典型或不典型)和与AD的病理相一致的病理生理学生物标志物出现。我们认为疾病的下游的定位性生物标志,如容积性磁共振成像(MRI)和氟脱氧葡萄糖-正电子发射型计算机断层成像(FDG-PET)等,适合更好地测量和监测疾病过程。本文还详述了非典型性AD、混合性AD和AD临床前期的特异诊断标准。 | 陈刚 曹雯炜 俞羚 糜建华 Dubois B Feldman HH Jacova C Hampel H Molinuevo JL Blennow K DeK osky ST Gauthier S Selkoe D Bateman R Cappa S Crutch S Engelborghs S Frisoni GB Fox NC Galasko D Habert MO Jicha GA Nordberg A Pasquier F Rabinovici G Robert P Rowe C Salloway S Sarazin M Epelbaum S de Souza LC Vellas B Visser PJ Schneider L Stern Y Scheltens P Cummings JL | 2014 | 神经病学与神经康复学杂志2014，11，3： | 31 |
| 2 | Motives for choosing growth-enhancing hormone treatment in adolescents with idiopathic short stature: a questionnaire and structured interview study显示文摘 | Visser-van Balen H Geenen R Kamp GA | 2005 | BMC Pediatr2005，5，1： | 1 |
| 3 | Long-term psy-chosocial consequences of hormone treatment for short stature显示文摘 | Visser-van Balen H Geenen R Kamp GA | 2007 | Acta Paediatr2007，96，5： | 1 |
| 4 | CCAT2, a novel non- coding RNA mapping to 8q24, underlies metastatic pro- gression and chromosomal instability in colon cancer 显示文摘 | Ling H Spizzo R Calin GA | 2013 | Genome Res2013，23，： | 1 |
| 5 | Contribution of fibronectin-binding protein to pathogenesis of Streptococcus suis serotype 2显示文摘 | De GA Buys H Verhaar R | 2002 | Infect Immun2002，70，3： | 1 |
| 6 | In vivo effects of cardiotrophin-1显示文摘 | Jin H Yang R Keller GA | 1996 | Cytokine1996，8，12： | 1 |
| 7 | R-CHOP14 compared to R- CHOP21 in elderly patients with dif- fuse large B-cell lymphoma (DLBCL) : Final analysis of the LNHO3-6B GELA study显示文摘 | Delarue R Tilly H Salles GA | 2012 | ASCO2012，30，： | 1 |
| 8 | Fischer-Tropsch synthesis: TPR and XANES analysis of the impact of simulated regeneration cycles on the reducibility of Co/alumina catalysts with different promoters (Pt, Ru, Re, Ag, Au, Rh, Ir)显示文摘 | THANI J JACOBS G SHAFER W D PENDYALA V R R MA W P GNANAMANI M K HOPPS S THOMAS GA K/TIYANAN B KHALID S DAVIS B H | 2014 | Catal Today2014，228，： | 1 |
| 9 | Optimum (Cs,O)/GaAs interface of negative-electron-affinity GaAs photocathodes显示文摘 | Lu Q B Pan Y X Ga H R | 1990 | Journal of Applied Physics1990，68，2： | 1 |
| 10 | Phosphate solubilizing bacteria and their role in plant growth promotion 显示文摘 | RODRIGUEZ H FRA GA R | 1999 | Biotechnolo- gy Advances1999，17，： | 1 |
| 11 | Formaldehyde-protein conjugatespecific antibodies in rats exposed to formaldehyde显示文摘 | Li H Konig R Ansari GA | 2007 | J Toxicol Environ Health2007，70，13： | 1 |
| 12 | Immunization of mice with urease vaccine affords protection against Helicobacter pylori infection in the absence of antibodies and is mediated by MHC class Ⅱ-restricted responses显示文摘 | Ermak TH Gisnnasca PJ Nichols R Myers GA Nedrud J Weltzin R Lee CK Kleanthous H Monath TP | 1998 | J Exp Med1998，188，12： | 1 |
| 13 | In vivo effects of cardiotrophin-1 显示文摘 | Jin H Yang R Keller GA | 1996 | Cytokine1996，8，12： | 1 |
| 14 | VEGF receptor blockade markedly reduces retinal microgJia/macrophage infiltration into laser-induced CNV显示文摘 | Huang H Parlier R Shen JK Lutty GA Vmores SA | 2013 | PLoS 0ne2013，8，71： | 1 |
| 15 | Analysis of immunoexpression of common cancer stem cell markers in ameloblastoma 显示文摘 | Sathi GA Tamamura R Tsujigiwa H Katase N | 2012 | Exp Ther Med2012，3，3： | 1 |
| 16 | Retinal toxicity of triamcinolone acetonide in silicone- filled eyes显示文摘 | Kivilcim M Peyman GA E1-Dessouky ES Kazi AA Cheema R Hegazy H | 2000 | Ophttwtlmic Surg Lasers2000，31，6： | 1 |
| 17 | Analysis ofimmunoexpression of common cancer vStem cell markers inameloblastoma显示文摘 | Sathi GA Tamamura R Tsujigiwa H | 2012 | Exp Ther Med2012，3，3： | 1 |
| 18 | Long-term psychosocial consequences of hormone treatment for short stature 显示文摘 | Visser-van Balen H Geenen R Kamp GA | 2007 | Acta Paediatr2007，96，5： | 1 |
| 19 | Prospective study of aspirin use and risk of stroke in women 显示文摘 | Iso H Hennekens CH Stampfer MJ R exrode KM Colditz GA Speizer FE Willett WC Man Son JE | 1999 | Stroke1999，30，9： | 1 |
| 20 | Comparison of Ti/BDD and Ti/SnO2-Sb2 05 Electrodes for Pollutant Oxidation显示文摘 | Chen X M Ga F R Chen G H | 2005 | Appl Electrochem2005，，23： | 1 |
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