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| 1 | A complete sequence and comparative analysis of a SARS-associated virus(Isolate BJ01)显示文摘The genome sequence of the Severe Acute Respiratory Syndrome (SARS)-associated virus provides essential information for the identification of pathogen(s), exploration of etiology and evolution, interpretation of transmission and pathogenesis, development of diagnostics, prevention by future vaccination, and treatment by developing new drugs. We report the complete genome sequence and comparative analysis of an isolate (BJ01) of the coronavirus that has been recognized as a pathogen for SARS. The genome is 29725 nt in size and has 11 ORFs (Open Reading Frames). It is composed of a stable region encoding an RNA-dependent RNA polymerase (composed of 2 ORFs) and a variable region representing 4 CDSs (coding sequences) for viral structural genes (the S, E, M, N proteins) and 5 PUPs (putative uncharacterized proteins). Its gene order is identical to that of other known coronaviruses. The sequence alignment with all known RNA viruses places this virus as a member in the family of Coronaviridae. Thirty putative substitutions have been identified by comparative analysis of the 5 SARS- associated virus genome sequences in GenBank. Fifteen of them lead to possible amino acid changes (non-synonymous mutations) in the proteins. Three amino acid changes, with predicted alteration of physical and chemical features, have been detected in the S protein that is postulated to beinvolved in the immunoreactions between the virus and its host. Two amino acid changes have been detected in the Mprotein, which could be related to viral envelope formation. Phylogenetic analysis suggests the possibility of non-human origin of the SARS-associated viruses but provides noevidence that they are man-made. Further efforts should focus on identifying the etiology of the SARS-associated virus and ruling out conclusively the existence of otherpossible SARS-related pathogen(s). | QIN E'de ZHU Qingyu YU Man FAN Baochang CHANG Guohui SI Bingyin YANG Bao PENG Wenming JIANG Tao LIU Bohua DENG Yongqiang LIU Hong ZHANG Yu WANG Cui LI Yuquan GAN Yonghua LI Xiaoyu L Fushuang TAN Gang CAO Wuchun, YANG Ruifu Institute of Microbiology and Epidemiology, Chinese Academy of Military Medical Sciences, Beijing 100071, China WANG Jian, LI Wei, XU Zuyuan, LI Yan, WU Qingfa, LIN Wei, CHEN Weijun, TANG Lin, DENG Yajun, HAN Yujun, LI Changfeng, LEI Meng, LI Guoqing, LI Wenjie, L Hong, SHI Jianping, TONG Zongzhong, ZHANG Feng, LI Songgang, LIU Bin, LIU Siqi, DONG Wei, WANG Jun, Gane K-S Wong, YU Jun & YANG Huanming* Beijing Genomics Institute, Chinese Academy of Sciences, Beijing 101300 National Center for Genome Information, Beijing 101300, China | 2003 | Chinese Science Bulletin2003，48，10： | 121 |
| 2 | The Genome of Artemisia annua Provides Insight into the Evolution of Asteraceae Family and Artemisinin Biosynthesis显示文摘Artemisia annua,通常已知的同样香甜的苦恼或 Qinghao,是到中国的一个灌木土著人并且长被用于药用的目的。A。annua 现在作为有势力抗疟药混合物的唯一的生来的来源全球性被栽培, artemisinin。这里,我们报导 A 的 1.74-gigabase 染色体的一个高质量的草稿集会。annua,高度异质接合,富于重复定序,并且包含 63 ? 226 编码蛋白质的基因,在定序的植物种类之中的最大的数字之一。我们发现了那,作为在 Asteraceae 的一些定序的染色体之一, A。annua 染色体包含对这大被子植物 clade 特定的很多基因。尤其是,扩大和编码涉及萜烯生合成的酶的基因的功能的多样化与 artemisinin biosynthetic 小径的进化一致。我们进一步由介绍那 A 的 transcriptome 揭示了。annua 发展了复杂 transcriptional 规章的网络位于 \O 下面 artemisinin 生合成。把转基因的 A 基于我们产生了的全面 genomic 和 transcriptomic 分析。artemisinin 高级的生产的 annua 线,它现在为大规模生产准备好了并且将从而帮助遇见增加 artemisinin 的全球需求的挑战。 | Qian Shen Lida Zhang Zhihua Liao Shengyue Wang Tingxiang Yan Pu Shi Meng Liu Xueqing Fu Qifang Pan Yuliang Wang Zongyou Lv Xu Lu Fangyuan Zhang Weimin Jiang Yanan Ma Minghui Chen Xiaolong Hao Ling Li Yueli Tang Gang Lv Yan Zhou Xiaofen Sun Peter E. Brodelius Jocelyn K.C. Rose Kexuan Tang | 2018 | Molecular Plant2018，11，6： | 47 |
| 3 | Trustworthiness of Internet-based software显示文摘Recent years see an increasing concern over the trustworthiness of Inter- net-based software. By analyzing the trustworthiness of Internet-based software and the nature of the Internet applications, we point out that, on the one hand, due to the open- ness and dynamic nature of the Internet, the identity trustworthiness and the capability trustworthiness of the software are facing serious challenges; on the other hand, in order to ensure the trustworthiness of the whole system, emerging computing paradigms based on the collaboration of autonomous software need some impacts on the behavior of the software. Here we put forward a conceptual model for the trustworthiness of Inter- net-based software, and propose a trustworthy assurance framework for Internet-based virtual computing environment (iVCE). This framework deals with the trustworthy proper- ties of software on identity, capability and behavior in a combinated way. The authorization management in inter-domain computing environment, assurance on high availability of service and incentive mechanism for autonomic collaboration are taken as three core mechanisms of iVCE trustworthy assurance. | WANG Huaimin TANG Yangbin YIN Gang LI Lei | 2006 | Science in China(Series F)2006，49，6： | 28 |
| 4 | Effects of aeration method and aeration rate on greenhouse gas emissions during composting of pig feces in pilot scale显示文摘The aim of this study was to uncover ways to mitigate greenhouse gas(GHG) emissions and reduce energy consumption during the composting process. We assessed the effects of different aeration rates(0, 0.18, 0.36, and 0.54 L/(kg dry matter(dm)·min)) and methods(continuous and intermittent) on GHG emissions. Pig feces and corn stalks were mixed at a ratio of 7:1. The composting process lasted for 10 weeks, and the compost was turned approximately every 2 weeks. Results showed that both aeration rate and method significantly affected GHG emissions. Higher aeration rates increased NH3 and N2O losses,but reduced CH4 emissions. The exception is that the CH4 emission of the passive aeration treatment was lower than that of the low aeration rate treatment. Without forced aeration,the CH4 diffusion rates in the center of the piles were very low and part of the CH4 was oxidized in the surface layer. Intermittent aeration reduced NH3 and CH4 losses, but significantly increased N2 O production during the maturing periods. Intermittent aeration increased the nitrification/denitrification alternation and thus enhanced the N2 O production. Forced aeration treatments had higher GHG emission rates than the passive aeration treatment. Forced aeration accelerated the maturing process, but could not improve the quality of the end product. Compared with continuous aeration, intermittent aeration could increase the O2 supply efficiency and reduced the total GHG emission by 17.8%, and this reduction increased to 47.4% when composting was ended after 36 days. | Tao Jiang Guoxue Li Qiong Tang Xuguang Ma Gang Wang Frank Schuchardt | 2015 | Journal of Environmental Sciences2015，27，5： | 21 |
| 5 | PLP2, a potent deubiquitinase from murine hepatitis virus, strongly inhibits cellular type I interferon production显示文摘由象严重急性呼吸症候群(SARS ) 那样的 coronaviruses 的感染 coronavirus (SCoV ) 和老鼠肝炎病毒 A59 (MHV-A59 ) 导致很小的类型我干扰素(IFN ) 生产由招待细胞,它为与 SARS 联系的快速的病毒的生长和严重 immunopathology 潜在地负责。然而,为在感染 coronaviruses 的房间的低 IFN 生产的分子的机制仍然保持不清楚。这里,我们提供证据象 Papain 一样朊酶领域 2 (PLP2 ) , nonstructural 蛋白质的一个催化领域 3 (nsp3 ) MHV-A59,能绑在 IRF3,引起它的 deubiquitination 并且阻止它的原子 translocation。作为后果, PLP2 的合作表示强烈禁止 CARDIF- ,调停 TBK1 、调停 IRF3 的 IFN 记者活动。另外,我们显示出那野类型的 PLP2 然而并非缺乏 deubiquitinase 的变异的 PLP2 (称) 活动能减少感应的 IFN 并且在感染 VSV 的房间支持病毒的生长。因此,我们的学习揭开了一病毒称它 coronaviruses 可以使用逃离主人天生的抗病毒的回答。 | Dahai Zheng Gang Chen Beichu Guo Genhong Cheng Hong Tang | 2008 | Cell Research2008，18，11： | 20 |
| 6 | The ChinaMAP analytics of deep whole genome sequences in 10,588 individuals显示文摘Metabolic diseases are the most common and rapidly growing health issues worldwide.The massive population-based human genetics is crucial for the precise prevention and intervention of metabolic disorders.The China Metabolic Analytics Project(ChinaMAP)is based on cohort studies across diverse regions and ethnic groups with metabolic phenotypic data in China.Here,we describe the centralized analysis of the deep whole genome sequencing data and the genetic bases of metabolic traits in 10,588 individuals from the ChinaMAP.The frequency spectrum of variants,population structure,pathogenic variants and novel genomic characteristics were analyzed.The individual genetic evaluations of Mendelian diseases,nutrition and drug metabolism,and traits of blood glucose and BMI were integrated.Our study establishes a large-scale and deep resource for the genetics of East Asians and provides opportunities for novel genetic discoveries of metabolic characteristics and disorders. | Yanan Cao Lin Li Min Xu Zhimin Feng Xiaohui Sun Jieli Lu Yu Xu Peina Du Tiange Wang Ruying Hu Zhen Ye Lixin Shi Xulei Tang Li Yan Zhengnan Gao Gang Chen Yinfei Zhang Lulu Chen Guang Ning Yufang Bi Weiqing Wang The ChinaMAP Consortium | 2020 | Cell Research2020，30，9： | 20 |
| 7 | The China Alzheimer Report 2022显示文摘China’s population has rapidly aged over the recent decades of social and economic development as neurodegenerative disorders have proliferated,especially Alzheimer’s disease(AD)and related dementias(ADRD).AD’s incidence rate,morbidity,and mortality have steadily increased to make it presently the fifth leading cause of death among urban and rural residents in China and magnify the resulting financial burdens on individuals,families and society.The‘Healthy China Action’plan of 2019-2030 promotes the transition from disease treatment to health maintenance for this expanding population with ADRD.This report describes related epidemiological trends,evaluates the economic burden of the disease,outlines current clinical diagnosis and treatment status and delineates existing available public health resources.More specifically,it examines the public health impact of ADRD,including prevalence,mortality,costs,usage of care,and the overall effect on caregivers and society.In addition,this special report presents technical guidance and supports for the prevention and treatment of AD,provides expertise to guide relevant governmental healthcare policy development and suggests an information platform for international exchange and cooperation. | Rujing Ren Jinlei Qi Shaohui Lin Xinya Liu Peng Yin Zhihui Wang Ran Tang Jintao Wang Qiang Huang Jianping Li Xinyi Xie Yongbo Hu Shishuang Cui Yuan Zhu Xiaoping Yu Pengfei Wang Yikang Zhu Yiran Wang Yanyan Huang Yisong Hu Ying Wang Chunbo Li Maigeng Zhou Gang Wang | 2022 | General Psychiatry2022，35，1： | 20 |
| 8 | Long noncoding RNAs in hepatocellular carcinoma: Novel insights into their mechanism显示文摘Hepatocellular carcinoma(HCC) is the predominant subject of liver malignancies which arouse global concern. Advanced studies have found that long noncoding RNAs(lnc RNAs) are differentially expressed in HCC and implicate they may play distinct roles in the pathogenesis and metastasis of HCC. However, the underlying mechanisms remain largely unclear. In this review, we summarized the functions and mechanisms of those known aberrantly expressed lncR NAs identified in human HCC tissues. We hope to enlighten more comprehensive researches on the detailed mechanisms of lncR NAs and their application in clinic, such as being used as diagnostic and prognostic biomarkers and the targets for potential therapy. Although studies on lncR NAs in HCC are still deficient, an improved understanding of the roles played by lncR NAs in HCC will lead to a much more effective utilization of those lnc RNAs as novel candidates in early detection, diagnosis, prevention and treatment of HCC. | Yong-Ru Liu Rui-Xue Tang Wen-Ting Huang Fang-Hui Ren Rong-Quan He Li-Hua Yang Dian-Zhong Luo Yi-Wu Dang Gang Chen | 2015 | World Journal of Hepatology2015，7，28： | 18 |
| 9 | A Review on Representative Swarm Intelligence Algorithms for Solving Optimization Problems:Applications and Trends显示文摘Swarm intelligence algorithms are a subset of the artificial intelligence(AI)field,which is increasing popularity in resolving different optimization problems and has been widely utilized in various applications.In the past decades,numerous swarm intelligence algorithms have been developed,including ant colony optimization(ACO),particle swarm optimization(PSO),artificial fish swarm(AFS),bacterial foraging optimization(BFO),and artificial bee colony(ABC).This review tries to review the most representative swarm intelligence algorithms in chronological order by highlighting the functions and strengths from 127 research literatures.It provides an overview of the various swarm intelligence algorithms and their advanced developments,and briefly provides the description of their successful applications in optimization problems of engineering fields.Finally,opinions and perspectives on the trends and prospects in this relatively new research domain are represented to support future developments. | Jun Tang Gang Liu Qingtao Pan | 2021 | IEEE/CAA Journal of Automatica Sinica2021，8，10： | 18 |
| 10 | Three-dimensional human facial morphologies as robust aging markers显示文摘老化与许多复杂疾病被联系。变老的过程的可靠预言为估计联系老化的疾病的风险是重要的。然而尽管有强烈研究,到目前为止没有可靠老化标记。这里,我们由检验人的 3D 美容成像特征是否能被用作可靠老化标记处理了这个问题。我们收集了 >300 幅 3D 人美容图象和越过 17 ~ 77 年的年龄散布得好的血侧面。由分析词法侧面,我们产生了变老的人的面部 phenome 的第一张全面地图。我们鉴别量的面部特征例如眼睛斜坡,高度与年龄联系了。我们构造了一个柔韧的年龄预言者并且发现平均,一样的按年代先后的年龄的人由 ± 不同;在美容的 6 年变老,与在年龄 40 以后增加的偏差。用这个预言者,我们识别了被健康指示物的层次显著地支持的慢、快的蒸化机。尽管有在在血的面部词法特征和健康指示物之间的一种靠近的关系,面部特征比血侧面是更可靠的老化 biomarkers 并且能更好比按年代先后的年龄反映一般健康地位。 | Weiyang Chen Wei Qian Gang Wu Weizhong Chen Bo Xian Xingwei Chen Yaqiang Cao Christopher D Green Fanghong Zhao Kun Tang Jing-Dong J Han | 2015 | Cell Research2015，25，5： | 17 |
| 11 | Self-microemulsifying drug delivery system for improving the bioavailability of huperzine A by lymphatic uptake显示文摘Huperzine A(Hup-A) is a poorly water-soluble drug with low oral bioavailability. A selfmicroemulsifying drug delivery system(SMEDDS) was used to enhance the oral bioavailability and lymphatic uptake and transport of Hup-A. A single-pass intestinal perfusion(SPIP) technique and a chylomicron flow-blocking approach were used to study its intestinal absorption, mesenteric lymph node distribution and intestinal lymphatic uptake. The value of the area under the plasma concentration–time curve(AUC) of Hup-A SMEDDS was significantly higher than that of a Hup-A suspension(P <0.01).The absorption rate constant(K_a) and the apparent permeability coefficient(P_(app)) for Hup-A in different parts of the intestine suggested a passive transport mechanism, and the values of K_a and P_(app) of Hup-A SMEDDS in the ileum were much higher than those in other intestinal segments. The determination of Hup-A concentration in mesenteric lymph nodes can be used to explain the intestinal lymphatic absorption of Hup-A SMEDDS. For Hup-A SMEDDS, the values of AUC and maximum plasma concentration(C_(max)) of the blocking model were significantly lower than those of the control model(P<0.05). The proportion of lymphatic transport of Hup-A SMEDDS and Hup-A suspension were about 40% and 5%,respectively, suggesting that SMEDDS can significantly improve the intestinal lymphatic uptake and transport of Hup-A. | Fang Li Rongfeng Hu Bin Wang Yun Gui Gang Cheng Song Gao Lei Ye Jihui Tang | 2017 | Acta Pharmaceutica Sinica B2017，7，3： | 15 |
| 12 | Optimum design of hierarchical stiffened shells for low imperfection sensitivity显示文摘A concept of hierarchical stiffened shell is proposed in this study,aiming at reducing the imperfection sensitivity without adding additional weight.Hierarchical stiffened shell is composed of major stiffeners and minor stiffeners,and the minor stiffeners are generally distributed between adjacent major stiffeners.For various types of geometric imperfections,e.g.,eigenmode-shape imperfections,hierarchical stiffened shell shows significantly low imperfection sensitivity compared to traditional stiffened shell.Furthermore,a surrogate-based optimization framework is proposed to search for the hierarchical optimum design.Then,two optimum designs based on two different optimization objectives(including the critical buckling load and the weighted sum of collapse loads of geometrically imperfect shells with small-and large-amplitude imperfections)are compared and discussed in detail.The illustrative example demonstrates the inherent superiority of hierarchical stiffened shells in resisting imperfections and the effectiveness of the proposed framework.Moreover,the decrease of imperfection sensitivity can finally be converted into a decrease of structural weight,which is particularly important in the development of large-diameter launch vehicles. | Bo Wang Peng Hao Gang Li Jia-Xin Zhang Kai-Fan Du Kuo Tian Xiao-Jun Wang Xiao-Han Tang | 2014 | Acta Mechanica Sinica2014，30，3： | 12 |
| 13 | Effects of tensile forces on serum deprivation-induced osteoblast apoptosis: expression analysis of caspases, Bcl-2, and Bax显示文摘 | LI Xuan ZHANG Xiao-ling SHEN Gang TANG Guo-hua | 2012 | Chinese Medical Journal2012，，14： | 12 |
| 14 | Synthesis and curing of a novel amino-containing phthalonitrile derivative显示文摘A novel phthalonitrile derivative containing an amino group, 3,5-bis(3,4-dicyanophenoxy)aniline (CPA), was synthesized via a nucleophilic displacement of 4-nitrophthalonitrile and 5-aminoresorcinol hydrochloride. The structure of CPA was confirmed by Fourier transform infrared spectra (FT-IR) and nuclear magnetic resonance (1H NMR). Thermal analysis performed on CPA revealed that the novel phthalonitrile derivative showed a self-promotion curing behavior and the resulting polymer exhibited outstanding heat-resistance. | Ke Zeng Ke Zhou Wen Rui Tang Yan Tang Hong Fei Zhou Tao Liu Yi Peng Wang Hai Bing Zhou Gang Yang | 2007 | Chinese Chemical Letters2007，18，5： | 12 |
| 15 | Clinical characteristics and effectiveness of antiviral agents in hospitalized children with infectious mononucleosis in China:A multicenter retrospective study显示文摘Importance:The clinical characteristics of infectious mononucleosis(IM)in Chinese children have not been evaluated in multicenter studies,and the effectiveness of antiviral treatment are controversial.Objective:To investigate the clinical characteristics of Chinese children with IM and current status of antiviral therapy for affected patients.Methods:Hospitalized patients with IM were enrolled between 2018 and 2020 in five children’s hospitals in China.The clinical characteristics were compared among four age groups:<3 years,3-<6 years,6-<10 years,and≥10 years.The clinical characteristics of IM and effectiveness of antiviral therapy were compared among patients receiving acyclovir(ACV),ganciclovir(GCV),and no antiviral therapy(i.e.,non-antiviral group).Results:In total,499 patients were analyzed;most patients were 3-<6 years of age.The most common symptoms and signs included fever(100%),lymphadenopathy(98.6%),pharyngitis(86.4%),eyelid edema(76.8%),and snoring(72.9%).There were significant differences in rash,hepatomegaly,and liver dysfunction among the four age groups.Patients aged<3 years had a lower incidence of liver dysfunction and a higher incidence of rash.Among the 499 patients,50.1%were treated with GCV,26.3%were treated with ACV,and 23.6%received no antiviral therapy.Compared with the non-antiviral group,patients in the ACV and GCV groups had longer durations of fever(P<0.001).There were no significant differences in the incidences of complications among the three treatment groups.Interpretation:The incidence of IM in Chinese children peaked at 3-<6 years of age.Clinical features of IM varied according to age.Patients receiving antiviral therapy exhibited more serious clinical manifestations than did patients without antiviral therapy.The effectiveness of antiviral therapy for IM requires further analysis. | Huili Hu Huiling Deng Jing Bi Yi Xu Shuangjie Li Yue Xie Xinrong Sun Dongmeng Wang Xufang Li Wenxian Ouyang Bing Hu Yufeng Zhang He Tang Chunxiao Fang Hui Zhang Lingyun Guo Chen Wang Tianyi Wang Fengxia Yang Tao Jiang Zhengde Xie Gang Liu | 2021 | Pediatric Investigation2021，5，3： | 12 |
| 16 | Pharmacokinetic Studies of Factor VIII in Chinese Boys with Severe Hemophilia A: A Single-Center Study显示文摘 | Zhen-Ping Chen Pei-jing Li Gang Li Ling Tang Ying-Zi Zhen Xin-Yi Wu Xiao-Ling Cheng Koon Hung Luke Victor S Blanchette Man-Chiu Poon Qiu-Lan Ding Run-Hui Wu | 2018 | Chinese Medical Journal2018，，15： | 11 |
| 17 | Ice radar investigation at Dome A, East Antarctica:Ice thickness and subglacial topography显示文摘Dome A, located in the central East Antarctic ice sheet (EAIS), is the highest summit of the Antarctic ice sheet. From ice-sheet evolution modeling results, Dome A is likely to preserve over one million years of the Earth's paleo-climatic and -environmental records, and considered an ideal deep ice core drilling site. Ice thickness and subglacial topography are critical factors for ice-sheet models to determine the timescale and location of a deep ice core. During the 21st and 24th Chinese National Antarctic Research Expedition (CHINARE 21, 2004/05; CHINARE 24, 2007/08), ground-based ice radar systems were used to a three-dimensional investigation in the central 30 km×30 km region at Dome A. The successfully obtained high resolution and accuracy data of ice thickness and subglacial topography were then interpolated into the ice thickness distribution and subglacial topography digital elevation model (DEM) with a regular grid resolution of 140.5 m×140.5 m. The results of the ice radar investigation indicate that the average ice thickness in the Dome A central 30 km×30 km region is 2233 m, with a minimal ice thickness of 1618 m and a maximal ice thickness of 3139 m at Kunlun Station. The subglacial topography is relatively sharp, with an elevation range of 949-2445 m. The typical, clear mountain glaciation morphology is likely to reflect the early evolution of the Antarctic ice sheet. Based on the ice thickness distribution and subglacial topography characteristics, the location of Kunlun Station was suggested to carry out the first high-resolution, long time-scale deep ice core drilling. However, the internal structure and basal environments at Kunlun Station still need further research to determine. | CUI XiangBin SUN Bo TIAN Gang TANG XueYuan ZHANG XiangPei JIANG YunYun GUO JingXue LI Xin | 2010 | Chinese Science Bulletin2010，55，4： | 11 |
| 18 | Review and discussion on fire behavior of bridge girders显示文摘This paper presents an overview on fire behavior of bridge girders mainly including prestressed concrete(PC) bridge girders and steel bridge girders. The typical fire accidents occurred on bridges are illustrated and, the seriousness of posing threats to bridge structures resulted from increasing traffic fires, specially intense hydrocarbon fires generated from petrol-chemicals, is highlighted. The current researches, embracing high-temperature properties of constituent materials, prestress state, measurement in fire tests, numerical methods, structural fire resistance, and so forth, taken on coping with problems existing in fire behavior and structural fire behavior in bridge girders are reviewed and discussed. Further, strategies for enhancing fire resistance of bridge girders followed with failure criterion and mode in types of bridge structures are provided. Future research area along with emerging trends in structural fire behavior of bridge girders is also recommended for mitigating fire hazards occurred on bridge girders. Herein, it can be attained a conclusion from review and discussion that prestressed concrete bridge girders with thin webs, specially T-shaped bridge girder, are prone to unstable under fire exposure conditions. High-strength concrete utilized in prestressed concrete bridge girders is vulnerable to spalling at elevated temperature. Steel-truss bridge girder present a more significant fragility to fire exposure compared than other steel bridge girders. | Gang Zhang Xiaocui Zhao Zelei Lu Chaojie Song Xuyang Li Chenhao Tang | 2022 | Journal of Traffic and Transportation Engineering(English Edition)2022，9，3： | 11 |
| 19 | Effect of Morinda officinalis capsule on osteoporosis in ovariectomized rats显示文摘AIM:To explore the therapeutic effects of Morinda officinalis capsules(MOP) on osteoporosis in ovariectomized rats.METHOD:Six-month-old female Sprague–Dawley rats were induced for postmenopausal osteoporosis(PMOP) by bilateral ovariectomy and divided into seven groups as follows:sham-operated group,ovariectomized(OVX) control group,OVX treated with xianlinggubao(XLGB)(270 mg·kg-1·d-1),OVX treated with alendronate sodium(ALN)(3 mg·kg-1·d-1),and OVX treated with Morinda officinalis capsule(MOP) of graded doses(90,270 and 810 mg·kg-1·d-1) groups.Oral treatments were administered daily on the 4th week after ovariectomy and lasted for 12 weeks.The bone mineral density was evaluated by dual-energy X-ray absorptiometry.The tartrate-resistant acid phosphatase(TRAP),alkaline phosphatase(AKP),and osteocalcin(OC) levels in the serum and plasma were determined by standard colorimetric and enzyme immunoassays methods.Bone biomechanical properties and morphological parameters were analyzed by three-point bending test and histomorphometry respectively.RESULTS:Morinda officinalis capsules at all doses were able to significantly prevent the OVX-induced loss of bone mass due to diminishing serum AKP and TRAP levels while elevating OC level in the plasma.Morinda officinalis capsules also enhanced the bone strength and prevented the deterioration of trabecular microarchitecture.CONCLUSION:Morinda officinalis capsules possess potent anti-osteoporotic activity in OVX rats which could be an effective treatment for postmenopausal osteoporosis. | LI Ye Lü Shan-Shan TANG Gui-Ying HOU Min TANG Qing ZHANG Xiao-Na CHEN Wei-Hai CHEN Gang XUE Qiang ZHANG Cong-Cong ZHANG Ji-Fen CHEN Yi XU Xiao-Yu | 2014 | Chinese Journal of Natural Medicines2014，12，3： | 10 |
| 20 | Synthesis of a benzoxazine monomer containing maleimide and allyloxy groups显示文摘新奇 benzoxazine 单体 3-(4-allyloxy )phenyl-3,4-dihydro-2H-6-(N-maleimido )-1,3-benzoxazine (AMB ) 被综合,结构被英尺红外证实,(1 ) H NMR。AMB 的热分析(DSC ) 证明烯丙氧基组的介绍减少了熔点并且展出了一扇狭窄、对称的治好的发热的窗户。 | Yan Tang Qing Lai Zhao Ke Zeng Pei Kai Miao Ke Zhou Wen Rui Tang Hong Fei Zhou Tao Liu Yi Peng Wang Gang Yang | 2007 | Chinese Chemical Letters2007，18，8： | 10 |
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