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| 1 | The Genome of Artemisia annua Provides Insight into the Evolution of Asteraceae Family and Artemisinin Biosynthesis显示文摘Artemisia annua,通常已知的同样香甜的苦恼或 Qinghao,是到中国的一个灌木土著人并且长被用于药用的目的。A。annua 现在作为有势力抗疟药混合物的唯一的生来的来源全球性被栽培, artemisinin。这里,我们报导 A 的 1.74-gigabase 染色体的一个高质量的草稿集会。annua,高度异质接合,富于重复定序,并且包含 63 ? 226 编码蛋白质的基因,在定序的植物种类之中的最大的数字之一。我们发现了那,作为在 Asteraceae 的一些定序的染色体之一, A。annua 染色体包含对这大被子植物 clade 特定的很多基因。尤其是,扩大和编码涉及萜烯生合成的酶的基因的功能的多样化与 artemisinin biosynthetic 小径的进化一致。我们进一步由介绍那 A 的 transcriptome 揭示了。annua 发展了复杂 transcriptional 规章的网络位于 \O 下面 artemisinin 生合成。把转基因的 A 基于我们产生了的全面 genomic 和 transcriptomic 分析。artemisinin 高级的生产的 annua 线,它现在为大规模生产准备好了并且将从而帮助遇见增加 artemisinin 的全球需求的挑战。 | Qian Shen Lida Zhang Zhihua Liao Shengyue Wang Tingxiang Yan Pu Shi Meng Liu Xueqing Fu Qifang Pan Yuliang Wang Zongyou Lv Xu Lu Fangyuan Zhang Weimin Jiang Yanan Ma Minghui Chen Xiaolong Hao Ling Li Yueli Tang Gang Lv Yan Zhou Xiaofen Sun Peter E. Brodelius Jocelyn K.C. Rose Kexuan Tang | 2018 | Molecular Plant2018，11，6： | 47 |
| 2 | Hypoxia-stressed cardiomyocytes promote early cardiac differentiation of cardiac stem cells through HIF-1α/Jagged1/Notch1 signaling显示文摘Hypoxia is beneficial for the differentiation of stem cells transplanted for myocardial injury,but mechanisms underlying this benefit remain unsolved. Here, we report the impact of hypoxia-induced Jagged1 expression in cardiomyocytes(CMs) for driving the differentiation of cardiac stem cells(CSCs).Forced hypoxia-inducible factor 1α(HIF-1α) expression and physical hypoxia(5% O_2) treatment could induce Jagged1 expression in neonatal rat CMs. Pharmacological inhibition of HIF-1α by YC-1 attenuated hypoxia-promoted Jagged1 expression in CMs. An ERK inhibitor(PD98059), but not inhibitors of JNK(SP600125), Notch(DAPT), NF-κB(PTDC), JAK(AG490), or STAT3(Stattic) suppressed hypoxiainduced Jagged1 protein expression in CMs. c-Kit^+ CSCs isolated from neonatal rat hearts using a magnetic-activated cell sorting method expressed GATA4, SM22α or vWF, but not Nkx2.5 and cTnI.Moreover, 87.3% of freshly isolated CSCs displayed Notch1 receptor expression. Direct co-culture of CMs with BrdU-labeled CSCs enhanced CSCs differentiation, as evidenced by an increased number of BrdU^+/Nkx2.5^+ cells, while intermittent hypoxia for 21 days promoted co-culture-triggered differentiation of CSCs into CM-like cells. Notably, YC-1 and DAPT attenuated hypoxia-induced differentiation.Our results suggest that hypoxia induces Jagged1 expression in CMs primarily through ERK signaling,and facilitates early cardiac lineage differentiation of CSCs in CM/CSC co-cultures via HIF-1α/Jagged1/Notch signaling. | Keke Wang Ranran Ding Yanping Ha Yanan Jia Xiaomin Liao Sisi Wang Rujia Li Zhihua Shen Hui Xiong Junli Guo Wei Jie | 2018 | Acta Pharmaceutica Sinica B2018，8，5： | 7 |
| 3 | Enhanced thermal shock and oxidation resistance of Si_2BC_3N ceramics through MWCNTs incorporation显示文摘Multi-walled carbon nanotubes(MWCNTs)reinforced Si_2BC_3N ceramics were prepared through mechanical alloying(MA)and following spark plasma sintering(SPS).The thermal shock resistance of Si_2BC_3N ceramics was evaluated comparatively through ice water quenching test and theoretical prediction.Furthermore,the oxidation resistance of MWCNTs incorporated Si_2BC_3N ceramics was evaluated under high temperature.The results show that the calculated parameters such as the critical thermal shock temperature(R)and the thermal stresses resistance(R_(st)),as well as the toughness(R'')are improved with addition of 1 vol%MWCNTs.In addition,the crack propagation resistance of 1 vol%MWCNTs incorporated Si_2BC_3N ceramics is obviously improved through generating more tortuous crack propagation paths attributing to the'crack bridging','pull-out',and'crack deflection'mechanisms of MWCNTs.Therefore,the residual strengths of 1 vol%MWCNTs containing specimens remained the highest after the thermal shock tests.Besides,the present work also reveals that the oxidation resistance is more sensitive to relative density than MWCNTs addition. | Ning LIAO Dechang JIA Zhihua YANG Yu ZHOU Yawei LI | 2018 | Journal of Advanced Ceramics2018，7，3： | 3 |
| 4 | Chaos-Based Multipurpose Image Watermarking Algorithm显示文摘To achieve the goal of image content authentication and copyright protection simultaneously, this paper presents a novel image dual watermarking method based on chaotic map. Firstly, the host image was split into many nonoverlapping small blocks, and the block-wise discrete cosine transform (DCT) is computed. Secondly, the robust watermarks, shuffled by the chaotic sequences, are embedded in the DC coefficients of blocks to achieve the goal of copyright protection. The semi-fragile watermarks, generated by chaotic map, are embedded in the AC coefficients of blocks to obtain the aim of image authentication. Both of them can be extracted without the original image. Simulation results demonstrate the effectiveness of our algorithm in terms of robustness and fragility. | ZHU Congxu LIAO Xuefeng LI Zhihua | 2006 | Wuhan University Journal of Natural Sciences2006，11，6： | 2 |
| 5 | Enhanced mechanical properties and thermal shock resistance of Si_2BC_3N ceramics with SiC coated MWCNTs显示文摘Bulk Si_2 BC_3 N ceramics were reinforced with SiC coated multi-walled carbon nanotubes(MWCNTs). The phase compositions, mechanical properties, and thermal shock resistance, as well as the oxidation resistance of the designed Si_2 BC_3 N ceramics were comparatively investigated. The results show that nano SiC coating can be formed on MWCNTs through pyrolyzing polysilazane, which improves the oxidation resistance of MWCNTs. A stronger chemical bonding is formed between the SiC coated MWCNTs and SiC particles, contributing to improved flexural strength(532.1 MPa) and fracture toughness(6.66 MPa m1/2). Besides, the 2 vol% SiC coated MWCNTs reinforced Si_2 BC_3 N ceramics maintains much higher residual strength(193.0 MPa) after thermal shock test at 1000 ℃.The enhanced properties should be attributed to:(1) the breaking of MWCNTs and the debonding between MWCNTs and SiC interfaces, which leads to more energy dissipation;(2) the rough surfaces of SiC coated MWCNTs increase the adhesion strength during the 'pull out' of MWCNTs. | Ning LIAO Dechang JIA Zhihua YANG Yu ZHOU | 2019 | Journal of Advanced Ceramics2019，8，1： | 2 |
| 6 | Clo- ning and characterisation of the gene encoding HMG- CoA reductase from Taxus media and its functional identification in yeast显示文摘 | Liao Zhihua Tan Qiumin Chai Yourong | 2004 | Functional Plant Biology2004，31，1： | 1 |
| 7 | Isomorphism Identification for Epicyclic Gear Mechanism Based on Mapping Property and Ant Algorithm显示文摘 | Yang Ping Pei Zhihua Liao Ningbo | 2007 | Engineering with Computers2007，23，： | 1 |
| 8 | Multivariate analysis of trace element concentrations in atmospheric deposition in the Yangtze River Delta, East China显示文摘 | Shunsheng Huang Jun Tu Hongying Liu Ming Hua Qilin Liao Jinshun Feng Zhihua Weng Guangming Huang | 2009 | Atmospheric Environment2009，，36： | 1 |
| 9 | Molecular cloning and expression profile of a jasmonate biosynthetic pathway gene for allene oxide cyclase from Hyoscyamus niger显示文摘 | Keji Jiang Zhihua Liao Yan Pi Zhuoshi Huang Rong Hou Ying Cao Qing Wang Xiaofen Sun Kexuan Tang | 2008 | Molecular Biology2008，，3： | 1 |
| 10 | Isomorphism identification for epicyclic gear mechanism based on mapping property and ant algorithm 显示文摘 | Ping Yang Zhihua Pei Ningbo Liao Bing Yang | 2007 | Engineering with Computers2007，，2007： | 1 |
| 11 | Clinical implications of the tumor-infiltrating lymphocyte subsets in colorectal cancer显示文摘 | Yunmei Liao Juanjuan Ou Jia Deng Peiliang Geng Rui Zeng Yi Tian Houjie Liang Bing Ni Zhihua Ruan | 2013 | Medical Oncology2013，，： | 1 |
| 12 | A new isopentenyl diphosphate isomerase gene from sweet potato: cloning, characterization and color complementation显示文摘 | Zhihua Liao Min Chen Yijian Yang Chunxian Yang Yufan Fu Qitang Zhang Qiang Wang | | 0，2008，： | 1 |
| 13 | Impacts of hydrogen dilution on growth and optical properties of a-SiC:H films显示文摘Hydrogenated amorphous silicon-carbon (a-SiC:H) films were deposited by plasma enhanced chemical vapor deposition (PECVD) with a fixed methane to silane ratio ([CH4]/[SiH4]) of 1.2 and a wide range of hydrogen dilution (RH=[H2]/[SiH4 + CH4]) values of 12, 22, 33, 102 and 135. The impacts of RH on the structural and optical properties of the films were investigated by using UV-VIS transmission, Fourier transform infrared (FTIR) absorption, Raman scattering and photoluminescence (PL) measur- ements. The effects of high temperature annealing on the films were also probed. It is found that with increasing hydrogen dilution, the optical band gap increases, and the PL peak blueshifts from ~1.43 to 1.62 Ev. In annealed state, the room temperature PL peak for the low RH samples disappears, while the PL peak for the high RH samples appears at ~2.08 Ev, which is attributed to nanocrystalline Si particles confined by Si-C and Si-O bonds. | HU Zhihua LIAO Xianbo DIAO Hongwei KONG Guanglin ZENG Xiangbo XU Yanyue | 2004 | Science China(Technological Sciences)2004，47，3： | 1 |
| 14 | Cloning and char- acterization of the gene encoding HMG-CoA reductase from Taxus media and its functional identification in yeast 显示文摘 | Liao Zhihua Sun Xiaofen Tang Kexuan | 2004 | Funct Plant Biol2004，31，1： | 1 |
| 15 | A Prenyltransferase Gene Confirmed to Be a Carotenogenic CRTE Gene from Sweetpotato显示文摘Sweetpotato(Ipomoea batatas L.Lam.)ranks fifth among the most important food crops,after rice,wheat,maize and cassava,on a fresh-weight basis in developing countries(Scott and Maldonado,1999).Sweetpotato cultivars have white,yellow,purple or orange flesh,but only orange-fleshed sweetpotato cultivars are the rich sources of(3-carotene,which is the precursor of vitamin A(Failla et al.,2009).Accordingly,the orange-fleshed sweetpotato is the main source of(3-carotene for the people in underdeveloped coun- | Yufan Fu Lili Ma Fei Qiu Chunxian Yang Chunxia Hu Ying Zhao Zhi Lin Min Chen Zhihua Liao Xiaozhong Lan | 2014 | Journal of Genetics and Genomics2014，41，11： | 1 |
| 16 | Genome-wide high-resolution mapping of mitotic DNA synthesis sites and common fragile sites by direct sequencing显示文摘Common fragile sites(CFSs)are genomic loci prone to the formation of breaks or gaps on metaphase chromosomes.They are hotspots for chromosome rearrangements and structural variations,which have been extensively implicated in carcinogenesis,aging,and other pathological processes.Although many CFSs were identified decades ago,a consensus is still lacking for why they are particularly unstable and sensitive to replication perturbations.This is in part due to the lack of high-resolution mapping data for the vast majority of the CFSs,which has hindered mechanistic interrogations.Here,we seek to map human CFSs with high resolution on a genome-wide scale by sequencing the sites of mitotic DNA synthesis(MiDASeq)that are specific for CFSs.We generated a nucleotide-resolution atlas of MiDAS sites(MDSs)that covered most of the known CFSs,and comprehensively analyzed their sequence characteristics and genomic features.Our data on MDSs tallied well with long-standing hypotheses to explain CFS fragility while highlighting the contributions of late replication timing and large transcription units.Notably,the MDSs also encompassed most of the recurrent double-strand break clusters previously identified in mouse neural stem/progenitor cells,thus bridging evolutionarily conserved break points across species.Moreover,MiDAseq provides an important resource that can stimulate future research on CFSs to further unravel the mechanisms and biological relevance underlying these labile genomic regions. | Fang Ji Hongwei Liao Sheng Pan Liujian Ouyang Fang Jia Zaiyang Fu Fengjiao Zhang Xinwei Geng Xinming Wang Tingting Li Shuangying Liu Madiha Zahra Syeda Haixia Chen Wen Li Zhihua Chen Huahao Shen Songmin Ying | 2020 | Cell Research2020，30，11： | 1 |
| 17 | Molecular insights into AabZIP1-mediated regulation on artemisinin biosynthesis and drought tolerance in Artemisia annua显示文摘Artemisia annua is the main natural source of artemisinin production.In A.annua,extended drought stress severely reduces its biomass and artemisinin production while short-term water-withholding or abscisic acid(ABA)treatment can increase artemisinin biosynthesis.ABA-responsive transcription factor AabZIP1 and JA signaling AaMYC2 have been shown in separate studies to promote artemisinin production by targeting several artemisinin biosynthesis genes.Here,we found AabZIP1 promote the expression of multiple artemisinin biosynthesis genes including AaDBR2 and AaALDH1,which AabZIP1 does not directly activate.Subsequently,it was found that AabZIP1 up-regulates AaMYC2expression through direct binding to its promoter,and that AaMYC2 binds to the promoter of AaALDH1to activate its transcription.In addition,AabZIP1 directly transactivates wax biosynthesis genes AaCER1and AaCYP86A1.The biosynthesis of artemisinin and cuticular wax and the tolerance of drought stress were significantly increased by AabZIP1 overexpression,whereas they were significantly decreased in RNAi-AabZIP1 plants.Collectively,we have uncovered the AabZIP1-AaMYC2 transcriptional module as a point of cross-talk between ABA and JA signaling in artemisinin biosynthesis,which may have general implications.We have also identified AabZIP1 as a promising candidate gene for the development of A.annua plants with high artemisinin content and drought tolerance in metabolic engineering breeding. | Guoping Shu Yueli Tang Mingyuan Yuan Ning Wei Fangyuan Zhang Chunxian Yang Xiaozhong Lan Min Chen Kexuan Tang Lien Xiang Zhihua Liao | 2022 | Acta Pharmaceutica Sinica B2022，12，3： | 1 |
| 18 | Isomorphism identification for epicyclic gear mechanism based on mapping property and ant algorithm显示文摘 | Ping Yang Zhihua Pei Ningbo Liao | 2007 | Engineering with Computers2007，23，： | 1 |
| 19 | Isoprenoid biosynthesis in plants : pathway, genes, regulation and metabolic engineering显示文摘 | Liao Zhihua Chen Min Gong Yifu | 2006 | J Bio Sci2006，，6： | 1 |
| 20 | Interfacial microstructure and mechanical property of Ti6Al4V/A6061 dissimilar joint by direct laser brazing without filler metal and groove显示文摘 | Zhihua Song Kazuhiro Nakata Aiping Wu Jinsun Liao | 2013 | Materials Science & Engineering A2013，，： | 1 |
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