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| 1 | The Genome of Artemisia annua Provides Insight into the Evolution of Asteraceae Family and Artemisinin Biosynthesis显示文摘Artemisia annua,通常已知的同样香甜的苦恼或 Qinghao,是到中国的一个灌木土著人并且长被用于药用的目的。A。annua 现在作为有势力抗疟药混合物的唯一的生来的来源全球性被栽培, artemisinin。这里,我们报导 A 的 1.74-gigabase 染色体的一个高质量的草稿集会。annua,高度异质接合,富于重复定序,并且包含 63 ? 226 编码蛋白质的基因,在定序的植物种类之中的最大的数字之一。我们发现了那,作为在 Asteraceae 的一些定序的染色体之一, A。annua 染色体包含对这大被子植物 clade 特定的很多基因。尤其是,扩大和编码涉及萜烯生合成的酶的基因的功能的多样化与 artemisinin biosynthetic 小径的进化一致。我们进一步由介绍那 A 的 transcriptome 揭示了。annua 发展了复杂 transcriptional 规章的网络位于 \O 下面 artemisinin 生合成。把转基因的 A 基于我们产生了的全面 genomic 和 transcriptomic 分析。artemisinin 高级的生产的 annua 线,它现在为大规模生产准备好了并且将从而帮助遇见增加 artemisinin 的全球需求的挑战。 | Qian Shen Lida Zhang Zhihua Liao Shengyue Wang Tingxiang Yan Pu Shi Meng Liu Xueqing Fu Qifang Pan Yuliang Wang Zongyou Lv Xu Lu Fangyuan Zhang Weimin Jiang Yanan Ma Minghui Chen Xiaolong Hao Ling Li Yueli Tang Gang Lv Yan Zhou Xiaofen Sun Peter E. Brodelius Jocelyn K.C. Rose Kexuan Tang | 2018 | Molecular Plant2018，11，6： | 47 |
| 2 | An upper ocean response to Typhoon Bolaven analyzed with Argo profiling floats显示文摘In situ observations from Argo profiling floats combined with satellite retrieved SST and rain rate are used to investigate an upper ocean response to Typhoon Bolaven from 20 through 29 August 2012. After the passage of Typhoon Bolaven, the deepening of mixed layer depth(MLD), and the cooling of mixed layer temperature(MLT) were observed. The changes in mixed layer salinity(MLS) showed an equivalent number of increasing and decreasing because the typhoon-induced salinity changes in the mixed layer were influenced by precipitation, evaporation, turbulent mixing and upwelling of thermocline water. The deepening of the MLD and the cooling of the MLT indicated a significant rightward bias, whereas the MLS was freshened to the left side of the typhoon track and increased on the other side. Intensive temperature and salinity profiles observed by Iridium floats make it possible to view response processes in the upper ocean after the passage of a typhoon. The cooling in the near-surface and the warming in the subsurface were observed by two Iridium floats located to the left side of the cyclonic track during the development stage of the storm, beyond the radius of maximum winds relative to the typhoon center. Water salinity increases at the base of the mixed layer and the top of the thermocline were the most obvious change observed by those two floats. On the right side of the track and near the typhoon center when the typhoon was intensified, the significant cooling from sea surface to a depth of 200×104 Pa, with the exception of the water at the top of the thermocline, was observed by the other Iridium float. Owing to the enhanced upwelling near the typhoon center, the water salinity in the near-surface increased noticeably. The heat pumping from the mixed layer into the thermocline induced by downwelling and the upwelling induced by the positive wind stress curl are the main causes for the different temperature and salinity variations on the different sides of the track. It seems that more time is required for the anomalies in the subsurface to be restored to pretyphoon conditions than for the anomalies in the mixed layer. | LIU Zenghong XU Jianping SUN Chaohui WU Xiaofen | 2014 | Acta Oceanologica Sinica2014，33，11： | 23 |
| 3 | China Argo project:progress in China Argo ocean observations and data applications显示文摘This paper reviews the current achievements of the China Argo project. It considers aspects of both the construction of the Argo observing array, float technology, and the quality control and sharing of its data. The developments of associated data products and data applications for use in the fields of ocean, atmosphere, and climate research are discussed, particularly those related to tropical cyclones(typhoons), ocean circulation,mesoscale eddies, turbulence, oceanic heat/salt storage and transportation, water masses, and operational oceanic/atmospheric/climatic forecasts and predictions. Finally, the challenges and opportunities involved in the long-term maintenance and sustained development of the China Argo ocean observation network are outlined.Discussion also focuses on the necessity for increasing the number of floats in the Indian Ocean and for expanding the regional Argo observation network in the South China Sea, together with the importance of promoting the use of Argo data by the maritime countries of Southeast Asia and India. | LIU Zenghong WU Xiaofen XU Jianping LI Hong LU Shaolei SUN Chaohui CAO Minjie | 2017 | Acta Oceanologica Sinica2017，36，6： | 10 |
| 4 | Diagnostic value of 5 serum biomarkers for hepatocellular carcinoma with different epidemiological backgrounds:A large-scale,retrospective study显示文摘Objective:Hepatocellular carcinoma(HCC)is a lethal global disease that requires an accurate diagnosis.We assessed the potential of 5 serum biomarkers(AFP,AFU,GGT-II,GPC3,and HGF)in the diagnosis of HCC.Methods:In this retrospective study,we measured the serum levels of each biomarker using ELISAs in 921 participants,including 298 patients with HCC,154 patients with chronic hepatitis(CH),122 patients with liver cirrhosis(LC),and 347 healthy controls from 3 hospitals.Patients negative for hepatitis B surface antigen and hepatitis C antibody(called'NBNC-HCC')and patients positive for the above indices(called'HBV-HCC and HCV-HCC')were enrolled.The selected diagnostic model was constructed using a training cohort(n=468),and a validation cohort(n=453)was used to validate our results.Receiver operating characteristic analysis was used to evaluate the diagnostic accuracy.Results:Theα-L-fucosidase(AFU)/α-fetoprotein(AFP)combination was best able to distinguish NBNC-HCC[area under the curve:0.986(95%confidence interval:0.958–0.997),sensitivity:92.6%,specificity:98.9%]from healthy controls in the test cohort.For screening populations at risk of developing HCC(CH and LC),the AFP/AFU combination improved the diagnostic specificity for early-stage HCC[area under the curve:0.776(0.712–0.831),sensitivity:52.5%,specificity:91.6%in the test group].In all-stage HBV-HCC and HCV-HCC,AFU was also the best candidate biomarker combined with AFP[area under the curve:0.835(0.784–0.877),sensitivity 69.1%,specificity:87.4%in the test group].All results were verified in the validation group.Conclusions:The AFP/AFU combination could be used to identify NBNC-HCC from healthy controls and hepatitis-related HCC from at-risk patients. | Dongming Liu Yi Luo Lu Chen Liwei Chen Duo Zuo Yueguo Li Xiaofang Zhang Jing Wu Qing Xi Guangtao Li Lisha Qi Xiaofen Yue Xiehua Zhang Zhuoyu Sun Ning Zhang Tianqiang Song Wei Lu Hua Guo | 2021 | Cancer Biology & Medicine2021，18，1： | 10 |
| 5 | Newborn screening with targeted sequencing:a multicenter investigation and a pilot clinical study in China显示文摘Different newborn screening(NBS) programs have been practiced in many countries since the 1960 s. It is of considerable interest whether next-generation sequencing is applicable in NBS. We have developed a panel of 465 causative genes for 596 early-onset, relatively high incidence, and potentially actionable severe inherited diseases in our Newborn Screening with Targeted Sequencing(NESTS) program to screen 11,484 babies in 8 Women and Children’s hospitals nationwide in China retrospectively. The positive rate from preliminary screening of NESTS was 7.85%(902/11,484). With 45.89%(414/902) follow-up of preliminary positive cases, the overall clinically confirmative diagnosis rate of monogenic disorders was 12.07%(50/414), estimating an average of 0.95%(7.85% × 12.07%) clinical diagnosis rate, suggesting that monogenic disorders account for a considerable proportion of birth defects. The disease/gene spectrum varied in different regions of China. NESTS was implemented in a hospital by screening 3923 newborns to evaluate its clinical application. The turn-around time of a primary report, including the sequencing period of < 7 days, was within 11 days by our automatic interpretation pipeline. Our results suggest that NESTS is feasible and cost-effective as a first-tier NBS program, which will change the status of current clinical practice of NBS in China. | Chanjuan Hao Ruolan Guo Xuyun Hu Zhan Qi Qi Guo Xuanshi Liu Yuanhu Liu Yanhua Sun Xiaofen Zhang Feng Jin Xiujie Wu Ren Cai Dingyuan Zeng Xijiang Hu Xiaohua Wang Xiaoping Ji Wenjie Li Quansheng Xing Lanfang Mu Xiulian Jiang Xue Yang Weimin Yang Yan Zhang Qianli Yin Xin Ni Wei Li | 2022 | Journal of Genetics and Genomics2022，49，1： | 7 |
| 6 | Current Opinions on the Functions of Tocopherol Based on the Genetic Manipulation of Tocopherol Biosynthesis in Plants显示文摘As a member of an important group of lipid soluble antioxidants, tocopherols play a paramount role in the daily diet of humans and animals. Recently, genes required for tocochromanol biosynthesis pathway have been identified and cloned with the help of genomics-based approaches and molecular manipulation in the model organisms: Arabidopsis thaliana and Synechocystis sp. PCC 6803. At the basis of these foundations, genetic manipulation of tocochromanol biosynthesis pathway can give rise to strategies that enhance the level of tocochromanol content or convert the constitution of tocochromanol. In addition, genetic manipulations of the tocochromanol biosynthesis pathway provide help for the study of the function of tocopherol in plant systems. The present article summarizes recent advances and pays special attention to the functions of tocopherol in plants. The roles of tocopherol in the network of reactive oxygen species, antioxidants and phytohormones to maintain redox homeostasis and the functions of tocopherol as a signal molecule in chloroplast-to- nucleus signaling to regulate carbohydrate metabolism are also discussed. | Yin Li Zinan Wang Xiaofen Sun Kexuan Tang | 2008 | Journal of Integrative Plant Biology2008，50，9： | 1 |
| 7 | Longitudinal virological changes and underlying pathogenesis in hospitalized COVID-19 patients in Guangzhou,China显示文摘Prolonged viral RNA shedding and recurrence of severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)in coronavirus disease 2019(COVID-19)patients have been reported.However,the clinical outcome and pathogenesis remain unclear.In this study,we recruited 43 laboratory-confirmed COVID-19 patients.We found that prolonged viral RNA shedding or recurrence mainly occurred in severe/critical patients(P<0.05).The average viral shedding time in severe/critical patients was more than 50 days,and up to 100 days in some patients,after symptom onset.However,chest computed tomography gradually improved and complete absorption occurred when SARS-CoV-2 RT-PCR was still positive,but specific antibodies appeared.Furthermore,the viral shedding time significantly decreased when the A1,430G or C12,473T mutation occurred(P<0.01 and FDR<0.01)and increased when G227A occurred(P<0.05 and FDR<0.05).High IL1R1,IL1R2,and TNFRSF21 expression in the host positively correlated with viral shedding time(P<0.05 and false discovery rate<0.05).Prolonged viral RNA shedding often occurs but may not increase disease damage.Prolonged viral RNA shedding is associated with viral mutations and host factors. | Zhengtu Li Yinhu Li Ruilin Sun Shaoqiang Li Lingdan Chen Yangqing Zhan Mingzhou Xie Jiasheng Yang Yanqun Wang Airu Zhu Guoping Gu Le Yu Shuaicheng Li Tingting Liu Zhaoming Chen Wenhua Jian Qian Jiang Xiaofen Su Weili Gu Liyan Chen Jing Cheng Jincun Zhao Wenju Lu Jinping Zheng Shiyue Li Nanshan Zhong Feng Ye | 2021 | Science China(Life Sciences)2021，64，12： | 1 |
| 8 | Chinese consensus guidelines for therapeutic drug monitoring of polymyxin B,endorsed by the Infection and Chemotherapy Committee of the Shanghai Medical Association and the Therapeutic Drug Monitoring Committee of the Chinese Pharmacological Society显示文摘Polymyxin B,which is a last-line antibiotic for extensively drug-resistant Gram-negative bacterial infections,became available in China in Dec.2017.As dose adjustments are based solely on clinical experience of risk toxicity,treatment failure,and emergence of resistance,there is an urgent clinical need to perform therapeutic drug monitoring(TDM)to optimize the use of polymyxin B.It is thus necessary to standardize operating procedures to ensure the accuracy of TDM and provide evidence for their rational use.We report a consensus on TDM guidelines for polymyxin B,as endorsed by the Infection and Chemotherapy Committee of the Shanghai Medical Association and the Therapeutic Drug Monitoring Committee of the Chinese Pharmacological Society.The consensus panel was composed of clinicians,pharmacists,and microbiologists from different provinces in China and Australia who made recommendations regarding target concentrations,sample collection,reporting,and explanation of TDM results.The guidelines provide the first-ever consensus on conducting TDM of polymyxin B,and are intended to guide optimal clinical use. | XIAOFEN LIU CHENRONG HUANG PHILLIP JBERGEN JIAN LI JINGJING ZHANG YIJIAN CHEN YONGCHUAN CHEN BEINING GUO FUPIN HU JINFANG HU LINLIN HU XIN LI HONGQIANG QIU HUA SHAO TONGWEN SUN YU WANG PING XU JING YANG YONG YANG ZHENWEI YU BIKUI ZHANG HUAIJUN ZHU XIAOCONG ZUO YI ZHANG LIYAN MIAO JING ZHANG | 2023 | Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)2023，24，2： | 1 |
| 9 | Molecular cloning and expression profile of a jasmonate biosynthetic pathway gene for allene oxide cyclase from Hyoscyamus niger显示文摘 | Keji Jiang Zhihua Liao Yan Pi Zhuoshi Huang Rong Hou Ying Cao Qing Wang Xiaofen Sun Kexuan Tang | 2008 | Molecular Biology2008，，3： | 1 |
| 10 | Transgenic rice homozygous lines expressing GNA showed enhanced resistance to rice brown planthopper显示文摘Mature seed-derived callo from two elite Chinese japonica rice (Oryza saliva L.) cultivars Eyi 105 and Ewan 5 were co-transformed with two plasmids, pWRG1515 and pRSSGNAl, containing the selectable marker hygromy-cin phosphotransferase gene (hpt), the reporter β-glu-curonidase gene (gusA) and the snowdrop (Galanthus nivalis) lectin gene (gna) via particle bombardment. 61 independent transgenic rice plants were regenerated from 329 bombarded calli. 79% transgenic plants contained all the three genes, revealed by PCR/Southern blot analysis. Western blot analysis revealed that 36 out of 48 gna-containing transgenic plants expressed GNA (75%) at various levels with the highest expression being approximately 0.5% of total soluble protein. Genetic analysis confirmed Mendelian segregation of transgenes in progeny. From the R2 generations whose R1 parent plants showing 3:1 Mendelian segregation patterns, we identified five independent homozygous lines containing and expressing all the three transgenes. Insect | SUN Xiaofen TANG Kexuan WAN Bingliang Ql Huaxiong LU Xinggui | 2001 | Chinese Science Bulletin2001，46，20： | 1 |
| 11 | Molecular cloning, characterization and expression of a novel jasmonate-dependent defensin gene from Ginkgo biloba显示文摘 | Guoan Shen Yongzhen Pang Weisheng Wu Zhiqi Miao Hongmei Qian Lingxia Zhao Xiaofen Sun Kexuan Tang | 2005 | Journal of Plant Physiology2005，，10： | 1 |
| 12 | First living target of Ce(III)action on horseradish cell proteins on/in cellmembrane显示文摘 | Guamgmei Yang Zhaoguo Sun Xiaofen Lv | | 0，，： | 1 |
| 13 | Cloning and char- acterization of the gene encoding HMG-CoA reductase from Taxus media and its functional identification in yeast 显示文摘 | Liao Zhihua Sun Xiaofen Tang Kexuan | 2004 | Funct Plant Biol2004，31，1： | 1 |
| 14 | Identification and expression profile of GbAGL2, a C-class gene from G ossypium barbadense显示文摘 | Xiang Liu Kaijing Zuo Fei Zhang Ying Li Jieting Xu Lida Zhang Xiaofen Sun Kexuan Tang | 2009 | Journal of Biosciences2009，，6： | 1 |
| 15 | Influence of ENSO Events on Tropical Cyclone Activity over the Western North Pacific显示文摘Based on an analysis of 51-year (1965 2015) data, the influence of El Ni o Southern Oscillation (ENSO) events on tropical cyclone (TC) activity is examined over the western North Pacific (WNP). The total number of TCs formed in the entire WNP reduces by about 3.4 TCs per year in La Ni a years, whereas TCs have an equivalent genesis number between El Ni o years and climatology. During El Ni o years, the frequency of TC formation increases remarkably in the southeast quadrant (140 E 180 , 0 17 N) and decreases in the northwest quadrant (120 140 E, 17 30 N). During La Ni a years, TCs tend to form in the northwest and southwest quadrants (120 140 E, 0 17 N) quadrants. TCs tend to become long-lived in the peak season (from July to Septem- ber) of El Ni o years and during strong El Ni o events. TC genesis shows a southeastward positive shift in terms of lifetime and intensity during El Ni o years, thus more super TCs (winds ≥ 58.64 m s 1) are formed in the southeast quadrant. Further analysis using the genesis potential index (GPI) indicates that the interannual variations in the TC genesis and track are significantly influenced by a combination of large-scale dynamic and thermodynamic conditions. | LIU Zenghong CHEN Xingrong SUN Chaohui CAO Minjie WU Xiaofen LU Shaolei | 2019 | Journal of Ocean University of China2019，18，4： | 1 |
| 16 | Identification and characterization of differentially expressed ESTs of Gossypium barbadense infected by Verticillium dahliae with suppression subtractive hybridization显示文摘 | Kaijing Zuo Jin Wang Weisheng Wu Yourong Chai Xiaofen Sun Kexuan Tang | 2005 | Molecular Biology2005，，2： | 1 |
| 17 | A novel pathogenesis-related protein (SsPR10) from Solanum surattense with ribonucleolytic and antimicrobial activity is stress- and pathogen-inducible显示文摘 | Xiaojun Liu Beibei Huang Juan Lin Jiong Fei Zhonghai Chen Yongzhen Pang Xiaofen Sun Kexuan Tang | 2005 | Journal of Plant Physiology2005，，5： | 1 |
| 18 | Particle-bombardment-mediated co-transformation of elite Chinese rice cultivars with genes conferring resistance to bacterial blight and sap-sucking insect pests显示文摘 | Kexuan Tang Porntip Tinjuangjun Yanan Xu Xiaofen Sun John A. Gatehouse Pamela C. Ronald Huaxiong Qi Xinggui Lu Paul Christou Ajay Kohli | 1999 | Planta1999，，4： | 1 |
| 19 | Molecular Cloning and Characterization of a Novel Dehydrin Gene from Ginkgo biloba显示文摘 | Zhongxiang Deng Yiding Wang Keji Jiang Xuefen Liu Weisheng Wu Shi Gao Juan Lin Xiaofen Sun Kexuan Tang | 2006 | Bioscience Reports2006，，3： | 1 |
| 20 | Overexpression ofGbERF confers alteration of ethylene-responsive gene expression and enhanced resistance toPseudomonas syringae in transgenic tobacco显示文摘 | Jie Qin Kaijing Zuo Jingya Zhao Hua Ling Youfang Cao Chengxiang Qiu Fupeng Li Xiaofen Sun Kexuan Tang | 2006 | Journal of Biosciences2006，，2： | 1 |
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