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| 1 | Literature-based analysis on relationship of symptoms,drugs and therapies in treatment of intestinal diseases显示文摘OBJECTIVE:To evaluate clinical articles published in the past 30 years using the Traditional Chinese Medicine(TCM)theory of the lung being connected with large intestine to treat intestinal diseases.We also analyzed the relationship between symptoms,drugs and therapies with data-excavating technology to aid management.METHODS:After retrieving relevant clinical articles,we set up a database,used Microsoft Structured Query Language Server 2005 Analysis Services as a data-excavating tool,and applied the association rule to study the relationship between the symptoms,drugs and therapies of intestinal diseases.RESULTS:The key symptoms of dyschesia,constipation,abdominal fullness,fatigue and pale tongue could be treated with Kuxingren(Semen Armeniacae Amarum),Huangqi(Radix Astragali Mongolici)and Gualou(Fructus et Semen Trichosanthis)to invigorate Qi and moisten the intestine.Among these agents,Kuxingren(Semen Armeniacae Amarum)was used most frequently.Clearing Fu-organs was the most prevalent therapy for abdominal fullness,dyschesia,constipation and red tongue.Clearing Fu-organs could be achieved with Kuxingren(Semen Armeniacae Amarum)and Gualou(Fructus et Semen Trichosanthis),whereas Qi could be invigorated using Huangqi(Radix Astragali Mongolici),Gancao(Radix Glycyrrhizae),Baizhu(Rhizoma Atractylodis Macrocephalae)and Kuxingren(Semen Armeniacae Amarum).Moistening the intestine was possible with Kuxingren(SemenArmeniacae Amarum),Huomaren(Fructus Cannabis)and Jiegeng(Radix Platycodi).Also,moistening the lungs was done with Kuxingren(Semen Armeniacae Amarum),ventilating the lungs with Kuxingren(Semen Armeniacae Amarum)and Gualou(Fructus et Semen Trichosanthis),and nourishing the lungs with Huangqi(Radix Astragali Mongolici),Gancao(Radix Glycyrrhizae)and Kuxingren(Semen Armeniacae Amarum).These data demonstrated that Kuxingren(SemenArmeniacaeAmarum)was a key agent.CONCLUSION:Our analyses of the literature showed clear relationships between symptoms(constipation,dyschesia,abdominal fullness),drugs[Gualou(Fructus et Semen Trichosanthis),Kuxingren(Semen Armeniacae Amarum),Huangqi(Radix Astragali Mongolici)]and therapies(moistening the intestine,clearing Fu-organs,invigorating Qi,ventilating the lungs). | Luan Gao Jian Wang Yong Deng Fenggang Li Sihua Gao | 2014 | Journal of Traditional Chinese Medicine2014，34，1： | 5 |
| 2 | Jiangtang Xiaoke granule attenuates glucose metabolism disorder via regulating endoplasmic reticulum stress in the liver of type 2 diabetes mellitus mice显示文摘OBJECTIVE:To observe the effect of Jiangtang Xiaoke(JTXK) granule on endoplasmic reticulum(ER)stress in high fat diet(HFD)-induced type 2 diabetes mellitus(T2 DM) KK-Ay mice.METHODS:KK-Ay mice were fed with HFD to induce the T2 DM model,while normal control C57 BL/6 J mice were given standard feed.Fasting blood glucose(FBG) in all mice was measured weekly and oral glucose tolerance tests(OGTTs) were performed at 4 and 10 weeks after start of treatment to determine glucose metabolism.Serum fasting insulin(FINS) and insulin sensitivity index(ISI) were measured to determine insulin sensitivity.m RNA expressions of eukaryotic initiation factor-2 alpha(e IF2α),glucose regulated protein 78(GRP78),activating transcription factor 4(ATF4),and C/EBP homology protein(CHOP) were assessed by reverse transcription polymerase chain reaction and the protein expressions of p-e IF2α,GRP78,and CHOP were assessed by Western blotting.RESULTS:JTXK granule significantly reduced FBG and free fatty acid levels and improved OGTT at the120 min of the 10-week treatment in T2 DM KK-Ay mice.FINS and Hb Alc levels were reduced and insulin sensitivities were increased in KK-Ay diabetic mice,which were improved with the treatment of JTXK granule,especially at the 7 and 3.5 g/kg doses.JTXK granule at the 3.5 g/kg dose was most effective in reducing both gene and protein expressions of e IF2α,GRP78,and CHOP.CONCLUSION:ER stress response is increased in T2 DM KK-Ay mice.Treatment with JTXK granule attenuates glucose disorders,improves insulin sensitivity,and reduces serum FFA in T2 DM KK-Ay mice.The mechanisms may be attributed to regulation of the signaling ER stress pathway via decreasing e IF2α phosphorylation and suppressing e IF2α-ATF4-CHOP activation. | Zhang Yi Mo Fangfang Zhang Dongwei Gao Sihua Zhao Dandan Yu Na Mu Qianqian Zuo Jiacheng Ma Yue | 2018 | Journal of Traditional Chinese Medicine2018，38，4： | 3 |
| 3 | Analysis on clinically drug-used law for lung-intestine related diseases显示文摘OBJECTIVE:To analyze the application laws of clinical drugs by descriptive statistical method with the clinical literatures guided by 'lung being connected with large intestine' used as the object.METHODS:Retrievepubliclypublishedclinicalliteratures about 'lung being connected with large intestine'inrecent30years,establishthedatabaseofclinical literature,and study on the clinically drug-used lawsbydescriptivestatisticalanalyticmethod.RESULTS:The common high frequent drugs used for the lung-intestine related diseases were Gualou(Ructus Trichsanthis),Dahuang(Radix et Rhizoma),Kuxingren(Semen Armeniacae Amarum),Gancao(Radix Glycyrrhizae),Houpu(Cortex Magnoliae Officinalis),Zhishi(Fructus Aurantii Immaturus).For the different clinical syndrome types,in the commonly used drugs there were different characteristics,reflecting the principle of TCM syndrome differentiation treatment.CONCLUSION:The common high frequent drugs used for the lung-intestine related diseases are Gualou(Fructus Trichsanthis),Dahuang(Radix et Rhizoma),Kuxingren(Semen Armeniacae Amarum),Gancao(Radix Glycyrrhizae),Houpu(Cortex Magnoliae Officinalis),Zhishi(Fructus Aurantii Immaturus),which are commonly-used drugs for the lung-intestine related diseases,with differences for different syndrome types. | Luan Gao Jian Wang Fenggang Li Sihua Gao Yong Deng | 2012 | Journal of Traditional Chinese Medicine2012，32，4： | 3 |
| 4 | A Hybrid Approach to Maximize Lifetime in Connected Directional Sensor Networks with Adjustable Sensing Ranges显示文摘A directional sensor network consists of numerous small sensor nodes that have limited battery power and operate within a restricted sensing range angle. Coverage and connectivity, as two important issues,are widely studied in directional sensor networks. Different from conventional directional sensor nodes in previous studies, those in the present study could adjust their sensing ranges within a range of several values. This paper addresses the Connected adjusted-ranges directional cover(CARDC) problem. The purpose is to organize the directional sensor nodes into a group of connected covers, and assign activities to them, thereby maximizing the network lifetime. We propose a hybrid approach that combines column generation with a genetic algorithm to solve the CARDC problem. The genetic algorithm is utilized to settle the auxiliary problem of column generation, which has the ability to efficiently provide attractive columns for the master problem. Compared with pure integer linear programming formulations, the proposed genetic algorithm significantly improves the speed of column generation method, especially in large-scale networks. The effect variety of number of directions, number of power levels,and communication range on the network lifetime are also investigated. | LIU Shufen GAO Sihua HAN Lu | 2018 | Chinese Journal of Electronics2018，27，1： | 3 |
| 5 | Volatile Organic Compound (VOC) measurements in the Pearl River Delta (PRD) region, China显示文摘 | Liu Ying Shao Min Lu Sihua Chang Chih-chung Wang Jia-Lin Chen Gao | 2008 | Atmospheric Chemistry and Physics2008，，119： | 2 |
| 6 | Volatile Organic Compound (VOC) measurements in the Pearl River Delta (PRD) region, China显示文摘 | Liu Ying Shao Min Lu Sihua Chang Chih-chung Wang Jia-Lin Chen Gao | 2008 | Atmospheric Chemistry and Physics2008，，119： | 1 |
| 7 | Viscoelasticity imaging of biological tissues with phase-resolved photoacoustic measure- ment显示文摘 | Gao Guodong Yang Sihua Xing Da | 2011 | Opt Lett2011，36，17： | 1 |
| 8 | Salvia miltiorrhiza : An ancient Chinese herbal medicine as a source for anti-osteoporotic drugs显示文摘 | Yubo Guo Yu Li Liming Xue Richele P. Severino Sihua Gao Jianzhao Niu Lu-Ping Qin Dongwei Zhang Dieter Br?mme | 2014 | Journal of Ethnopharmacology2014，，3： | 1 |
| 9 | Power System Fault Diag- nosis Based on Fault Information System and Forward and Backward Reasoning显示文摘 | Liu Sihua Chen Qing Gao Tipan | | IEEE Xplore: 10，2，： | 1 |
| 10 | Viral suppression of type I interferon signaling by NSs of DBV,SFSV and UUKV via NSs-mediated RIG-I degradation显示文摘Phenuiviridae,a member of the Bunyavirales order,can lead to significant human morbidity and mortality.Various phenuiviruses target specific cellular proteins and have strategies to counteract the effects of type I interferon(IFN).Previous studies have shown that phenuiviruses infection inhibits the synthesis of type I IFNs,and viral nonstructural proteins(NSs)had been further identified as an IFN antagonist.This study found that the NSs proteins of Dabie bandavirus(DBV),Sandfly fever Sicilian virus(SFSV),and Uukuniemi virus(UUKV)can inhibit Sendai virus-induced activation of IFN-βpromoter and phosphorylation of IFN regulatory factor 3(IRF3).Moreover,detailed analysis revealed that the phenuivirus NSs protein could directly interact with retinoic acid inducible gene-I(RIG-I)and degrade it via a proteasome-dependent pathway.In short,this study demonstrate a novel mechanism of phenuiviruses to resist host antiviral immunity,which may help understand these pathogens and suggest novel therapeutic approaches. | Leling Xu Xueping Li Xiaoning Gao Sihua Liu Zheng Pang Zhiyun Wang | 2022 | Biosafety and Health2022，4，4： | 0 |
| 11 | Preliminary Discussion on the Implication of Determination of Source Depth of Earthquakes显示文摘In an earthquake catalog,the source depth of earthquakes is one of the most basic parameters; however it is also one of the most difficult to measure.The source depths in the PDE bulletin,the centroid depths from CMT inversion of USGS and Harvard University,and those obtained by depth phases of broadband waveform data are not equal to each other,and they are also have different meanings.Also,the depth obtained from broadband waveform modeling is another kind of depth of different a rupture 'core.' This paper preliminarily discusses the physical implication of the source depth of earthquakes with different measuring methods. | Gao Yuan,Zhou Huilan,Zheng Sihua,Ma Lin,Che Shi,and Liu WeihongGraduate School,University of Science and Technology of China,Beijing 100039,China Center for Analysis and Prediction,SSB,Beijing 100036,China | 1998 | Earthquake Research in China1998，12，2： | 0 |
| 12 | Ginsenoside rg3 reduces body weight by regulating fat content and browning in obese mice显示文摘Objective:To determine the effects of ginsenoside rg3 on the body weight of C57BL/6J obese mice and to investigate its underlying weight loss mechanisms with a focus on white fat browning-related factors.Methods:Eight-week-old C57BL/6J male mice were fed a high-fat diet for 12 successive weeks to construct the obese model.C57BL/6J male mice were fed a standard chow diet to construct normal control group.After 8 weeks of intervention with ginsenoside rg3,the food intake,body weight,body fat mass,blood sugar,and lipid profiles of the mice in each group were detected.Hematoxylin and eosin(HE)staining was used to observe the histological morphology of the adipose tissues.Real-time polymerase chain reaction(RT-PCR)and Western blotting(WB)were applied to detect the gene and protein expression levels of peroxisome proliferators-activated receptor gama(PPARg),Peroxisome proliferatoractivated receptor-gamma coactivator-1alpha(PGC-1a),PR domain containing 16(PRDM16),and uncoupling protein 1(UCP-1).Results:Compared to normal control group mice,the body weight,food intake,body fat composition,and blood lipid levels of model group mice increased significantly.After 8 weeks of intervention with ginsenoside rg3,body weight,body fat composition,food intake,and blood lipid profiles decreased.HE staining showed that ginsenoside rg3 can improve white adipocyte hypertrophy to a certain extent.RTPCR and WB demonstrated that ginsenoside rg3 can increase the mRNA and protein expression levels of PPARg,PGC-1a,PRDM16,and UCP-1 in the adipose tissues of obese mice.Conclusion:The weight reduction effect of ginsenoside rg3 may be related to the promotion of white fat browning. | Qianqian Mu Jiacheng Zuo Dandan Zhao Xiaoshan Zhou Jing Hua Ying Bai Fangfang Mo Xin Fang Min Fu Sihua Gao | 2021 | Journal of Traditional Chinese Medical Sciences2021，8，1： | 0 |
| 13 | Loganin regulates glycolipid metabolism by influencing intestinal microbiota and AMPK signaling in obese mice显示文摘Objective: We aimed to observe the effects of loganin(Log) on serum glycolipid levels and probe the mechanisms focusing on intestinal flora and AMP-activated protein kinase(AMPK) signaling in obese mice.Methods: A high-fat diet was given for 12 consecutive weeks to generate the obesity model in institute of cancer research(ICR) mice. Body weight was measured weekly and fasting blood glucose(FBG) was determined every 2 weeks. Both the oral glucose tolerance test and the intraperitoneal insulin tolerance test were performed. The serum levels of total cholesterol(TC), triglyceride, high-density lipoproteincholesterol, low-density lipoprotein-cholesterol(LDL-C), and free fatty acids(FFA) were measured. The expression of key proteins in the AMPK signaling pathway in skeletal muscle tissue was detected by immunoblotting, and gut microbiota were characterized using 16S rDNA sequencing.Results: Log significantly decreased the body weight and the FBG in obese mice(P <.05), and it could restore FBG to normal levels. The total cholesterol, LDL-C, and FFA levels were significantly reduced by Log compared with the obese controls(TC: P =.0020;LDL-C: P =.0233;FFA: P =.0127), and the glucose tolerance of animals was significantly improved(P =.0477). The western blot results showed that Log could upregulate the protein expression of Adenosine 5‘-monophosphate(AMP)-activated protein kinase(AMPKa), Sirtuin 1(SIRT1), and peroxisome proliferator-activated receptor-gamma coactivator-1 alpha(PGC1a) in skeletal muscle tissue of obese mice. 16S rDNA sequencing indicated that Log reduced the diversity of the gut flora in feces and altered the floral composition of obese mice.Conclusions: Log was effective in reducing body weight and improving glucolipid metabolism in obese mice, probably through activating AMPK signaling and regulating intestinal microbial diversity. | Bingrui Xu Zimengwei Ye Tian Tian Ruyuan Zhu Chenyue Liu Xin Fang Dongwei Zhang Min Fu Sihua Gao Dandan Zhao | 2022 | Journal of Traditional Chinese Medical Sciences2022，9，3： | 0 |
| 14 | A Hybrid Approach to Maximize the Lifetime of Directional Sensor Networks with Smoothly Varying Sensing Ranges显示文摘The difficulty of maximizing the lifetime in directional sensor networks has gained increasing attention recently. Most of the existing studies are focused on directional sensors with single or several predefined sensing ranges. In the present study, directional sensors can change sensing ranges smoothly. We address the problem of maximizing the lifetime in directional sensor networks with such smoothly varying sensing ranges,and propose a hybrid approach that combines a column generation method with an immune genetic algorithm. We search for attractive columns with the genetic algorithm, and optimize them by designing dynamic vaccines. Computational results demonstrate the performance of the proposed approach. Meanwhile,the advantage of the mentioned sensors in terms of solution quality is also revealed. | LIU Shufen GAO Sihua BAO Tie ZHANG Yikun | 2017 | Chinese Journal of Electronics2017，26，4： | 0 |
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