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| 1 | 最新AD研究用诊断标准:IWG-2标准显示文摘在过去的8年中,国际工作组织(IWG)和美国国立老化研究院-阿尔茨海默协会(NIA-AA)建立了阿尔茨海默病(AD)诊断标准,它能更好地定义AD的临床表型,整合了生物标记物于诊断流程中,并覆盖了疾病的全程。本意见书充分地权衡了IWG标准的优缺点,建议改进诊断框架。依据这些改进,AD的诊断变得简单,只要有恰当的AD临床表型(典型或不典型)和与AD的病理相一致的病理生理学生物标志物出现。我们认为疾病的下游的定位性生物标志,如容积性磁共振成像(MRI)和氟脱氧葡萄糖-正电子发射型计算机断层成像(FDG-PET)等,适合更好地测量和监测疾病过程。本文还详述了非典型性AD、混合性AD和AD临床前期的特异诊断标准。 | 陈刚 曹雯炜 俞羚 糜建华 Dubois B Feldman HH Jacova C Hampel H Molinuevo JL Blennow K DeK osky ST Gauthier S Selkoe D Bateman R Cappa S Crutch S Engelborghs S Frisoni GB Fox NC Galasko D Habert MO Jicha GA Nordberg A Pasquier F Rabinovici G Robert P Rowe C Salloway S Sarazin M Epelbaum S de Souza LC Vellas B Visser PJ Schneider L Stern Y Scheltens P Cummings JL | 2014 | 神经病学与神经康复学杂志2014，11，3： | 31 |
| 2 | Radiometric correction of visible and infrared remote sensing data at the Canada Centre for Remote Sensing显示文摘 | AHERN F J Brown R J Cihlar J Gauthier R Murphy J Neville R A and Teillet P M | 1984 | International Journal of Remote Sensing1984，8，： | 2 |
| 3 | Fractionation of whey' protein hydrolysates using charged UF/NF membranes显示文摘 | Pouliot Y Wijers M C Gauthier S F | 1999 | Journal of Membrane Science1999，158，： | 1 |
| 4 | Optimized electrochemical performance of LiFePO4 at 60℃ with purity controlled by SQUID magnetometry 显示文摘 | ZAGHIB K RAVET N GAUTHIER M GENDRON F MAUGER A GOODENOUGH J B JULIEN C M | 2006 | Journal of Power Sources2006，163，： | 1 |
| 5 | Comparison of bifidobacterial growth-promoting activity of ultrafiltered casein hydrolyzate fractions 显示文摘 | Proulx M Ward P Gauthier S F | 1994 | Lait1994，74，： | 1 |
| 6 | Comparison of bifidobacterial growth-promoting activity of ultrafihered casein hvdrolvzate fractions显示文摘 | Proulx M Ward P Gauthier S F | 1994 | Lair1994，74，2： | 1 |
| 7 | Visceral fat area as a new independent predictive factor of survival in patients with meta- static renal cell carcinoma treated with antiangiogenic agents 显示文摘 | Ladoire S Bonnetain F Gauthier M | 2011 | Oncologist2011，16，1： | 1 |
| 8 | Correlation between chain microstructura/changes and embrittle- ment of LLDPE-based fdms during photo-and thermo-oxidative degradation 显示文摘 | GAUTHIER E LAYCOCK B CUOQ F J J M | 2013 | Polym Degrad Stab2013，98，1： | 1 |
| 9 | Role of nitric oxide in antibacterial non-specific immunity:in vivo and in vitro study显示文摘 | Gauthier Y P Burckhart M F Vidal D R | 1994 | Trav Sci Chercheurs Serv Sante Armees1994，15，： | 1 |
| 10 | Phosphonate based bipyridine dyes for stable photovohaic devices 显示文摘 | Gauthier I G Odobel F Alebbi M | 2001 | Inorganic Chemistry2001，40，23： | 1 |
| 11 | Modelling evaporation of multicomponent fuel droplets under ambient temperature conditions显示文摘 | Benaissa A Gauthier J E D Bardon M F | 2002 | Journal of the Institute of Energy2002，75，3： | 1 |
| 12 | Fractionation of whey protein hydrolysates using charged UF/NF mem- branes显示文摘 | Pouliot Y Wijers M C Gauthier S F | 1999 | Journal of Membrane Science1999，158，1： | 1 |
| 13 | Optimized electrochemical performance of LiFePO4 at 60℃ with purity controlled by SQUID magnetometry显示文摘 | RAVET K N GAUTHIER M GENDRON F | 2006 | Journal of Power Sources2006，163，： | 1 |
| 14 | Shock Tube Ignition Measurements of Iso-Octane/Air and Toluene/Air at High Pressures显示文摘 | Davidson D F Gauthier B M Hanson R K | 2005 | Proceedings of the Combustion Institute2005，30，1： | 1 |
| 15 | Oxidation behavior of γ-TiAl coated with zirconia thermal barriers显示文摘 | GAUTHIER V DETTENWANGER F SCH(U)TZE M | 2002 | Intermetallics2002，10，7： | 1 |
| 16 | Effects of humidity on tomato water uptake, yield, and dehumidification cost显示文摘 | Trigui M Barrington S F Gauthier L | 1999 | Canadian Agricultural Engineering1999，41，3： | 1 |
| 17 | Purification and characterization of a new cystatin inhibitor from Taiwan cobra (Naja naja atra) venom显示文摘 | Brillard-Bourdet M Nguyen V Ferrer-di Martino M Gauthier F Moreau T | 1998 | Biochem J1998，331，： | 1 |
| 18 | Microstructural aspects of the dissolution and melting of Al2Cu phase in Al-Si alloys during solution heat treatment显示文摘 | Samuel A M Gauthier J Samuel F H | 1996 | Metallurgical and Materials Transactions A1996，27，： | 1 |
| 19 | Immigrant and refugee preschoolers'sandplay representations of the tsunami显示文摘 | Lacroix L Rousseau C Gauthier M F | 2007 | The Arts in Psychotherapy2007，34，2： | 1 |
| 20 | Shock tube determination of ignition delay times in full blend and surrogate fuel mixtures 显示文摘 | GAUTHIER B M DAVIDSON D F HANSON R K | 2004 | Combustion and Flame2004，139，4： | 1 |
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