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| 1 | Alterations of tumor suppressor and tumor-related genes in the development and progression of gastric cancer显示文摘胃的癌症的发展和前进包含肿瘤的很多基因、渐成说的改变压制或并且肿瘤相关的基因。区分的癌的多数从肠的遇见的无形的粘膜和展览在结构上产生改变的肿瘤压制或基因,由 p53 代表了,它经由经典二点击的机制被使失去活性,即杂合现象(LOH ) 的损失和留下的等位基因的变化。在某些染色体部位的 LOH 在肿瘤前进期间积累。约 20% 区分的癌经由倡导者 CpG 岛的 hypermethylation 在激活由于 hMLH1 显示出 mutator 小径肿瘤发生的证据,并且展出高周波的微卫星不稳定性。相反,无差别的癌很少展出在结构上改变的肿瘤压制或基因。例如,当 E-cadherin 的甲基化经常在无差别的癌被观察时,这基因的变化通常与前进被联系从区分了到无差别的癌。肿瘤的 Hypermethylation 压制或并且包括 APC, CHFR, DAP-kinase,两重棉包线, E-cadherin, GSTP1, hMLH1, p16, PTEN, RASSF1A, RUNX3,和 TSLC1,肿瘤相关的基因能被检测在区分并且在改变频率的无差别的癌。然而, hypermethylation 的意义根据这些基因的分析 genomic 区域,和 hypermethylation 变化能也在非肿瘤的胃的上皮在场。特定的基因的倡导者脱甲基例如魔术师和 synuclein Y,能在两种组织学的类型的进步阶段期间发生,并且与耐心的预后被联系。因此,当胃的致癌作用的分子的小径依赖于组织学的背景时,特定的基因改变装仍然被用于风险评价,诊断,和预后。 | Gen Tamura | 2006 | World Journal of Gastroenterology2006，12，2： | 105 |
| 2 | Promoter methylation status of E-cadherin,hMLH1,and p16 genes in nonneoplastic gastric epithelia显示文摘 | Takayoshi Waki Gen Tamura Takashi Tsuchiya | 2002 | Am J Pathology2002，161，2： | 1 |
| 3 | Hypermethylation of the RUNX3 Gene Promoter in Testicular Yolk Sac Tumor of Infants显示文摘 | Noriko Kato Gen Tamura Masayuki Fukase Hiroyuki Shibuya Teiichi Motoyama | 2003 | The American Journal of Pathology2003，，2： | 1 |
| 4 | Aalysis of genetic and epigenetie alterations of the PTEN gene in gastric cancer显示文摘 | Stato K Tamura Gen Tsuchiya T | 2002 | Vircbows Arch2002，440，2： | 1 |
| 5 | Promoter methylation ststus of DAP-Kinase and RINX3 genes in neoplastic and non-neoplastic gastric epithelia显示文摘 | Takayoshi Waki Gen Tamura Makoto Sato | 2003 | Cancer Sci2003，94，： | 1 |
| 6 | Well-differentiated adenocarcinoma mimicking complete-type intestinal metaplasia in the stomach显示文摘 | Yasushi Endoh Gen Tamura Teiichi Motoyama Yoichi Ajioka Hidenobu Watanabe | 1999 | Human Pathology1999，，7： | 1 |
| 7 | Promoter hypermethylation of DAP-kinase is associated with poor survival in primary biliary tract carcinoma patients显示文摘 | Tomohiro Tozawa Gen Tamura Teiichiro Honda | 2004 | Cancer Sci2004，95，： | 1 |
| 8 | Promoter hypenmethylation of tumor suppressor and tumor-related genes in non-small cell lung cancers显示文摘 | Naoki Yanagawa Gen Tamura Hiroyuki Oizumi | 2003 | Cancer Sci2003，94，： | 1 |
| 9 | Comparison of HER2 immunohistochemical results using a monoclonal antibody (SV2‐61γ) and a polyclonal antibody (for Dako HercepTest) in advanced gastric cancer显示文摘 | Gen Tamura Mitsumasa Osakabe Naoki Yanagawa Shin‐ya Ogata Takashi Nomura Norimasa Fukushima Yoshimasa Ito Minori Tabuchi | 2012 | Pathology International2012，，8： | 1 |
| 10 | Hypermeth- ylation of the TSLCI gene promoter in primary gastric cancers and gastric cancer cell lines 显示文摘 | Teiichiro Honda Gen Tamura Takayoshi Waki | 2002 | Jpn J Cancer Res2002，93，： | 1 |
| 11 | Analysis of genetic and epigenetic alterations of the PTEN gene in gastric cancer显示文摘 | Kiyoshi Sato Gen Tamura Takashi Tsuchiya Yasushi Endoh Ken Sakata Teiichi Motoyama Osamu Usuba Wataru Kimura Masanori Terashima Satoshi Nishizuka Tongtong Zou Stephen J. Meltzer | 2002 | Virchows Archiv2002，，2： | 1 |
| 12 | Frequent epigenetic silencing of the FHIT gene in penile squamous cell carcinomas显示文摘 | Naoki Yanagawa Mitsumasa Osakabe Masahiro Hayashi Gen Tamura Teiichi Motoyama | 2008 | Virchows Archiv2008，，4： | 1 |
| 13 | Hypermethylation of the RUNX3 Gene Promoter in Testicular Rolk Sac Tumor of Infants显示文摘 | Noriko Kato Gen Tamura Masayuki Fukase | 2003 | American Journal of Pathology2003，163，： | 1 |
| 14 | Analysis of genetic and epigenetic alterations of the PTEN gene in gastric cancer显示文摘 | Kiyoshi Sato Gen Tamura Takashi Tsuchiya Yasushi Endoh Ken Sakata Teiichi Motoyama Osamu Usuba Wataru Kimura Masanori Terashima Satoshi Nishizuka Tongtong Zou Stephen J. Meltzer | 2002 | Virchows Archiv2002，，2： | 1 |
| 15 | Multiple carcinoid tumors of the rectum: Report of two cases suggesting the origin of carcinoid tumors显示文摘 | Shunichi Sasou Takeshi Suto Toshihiko Satoh Gen Tamura Norihiko Kudara | 2012 | Pathology International2012，，10： | 1 |
| 16 | OVA and Mycobacterium tuberculosis Bacilli cooperatively polarize anti -OVA T -helper cells toward a Thl -dominant phenotype and ameliorate murine tracheal eosinophilia 显示文摘 | Kunio Sano Kanna Haneda Gen Tamura | 1999 | Am J Respir Cell Mol Bio1999，20，： | 1 |
| 17 | Hypermethylation of tumor suppressor and tumor-related genes in neoplastic and non-neoplastic gastric epithelia显示文摘A number of tumor suppressor and tumor-related genes exhibit promoter hypermethylation with resultant gene silencing in human cancers.The frequencies of methylation differ among genes and genomic regions within CpG islands in different tissue types.Hypermethylation initially occurs at the edge of CpG islands and spreads to the transcription start site before ultimately shutting down gene expression.When the degree of methylation was quantitatively evaluated in neoplastic and non-neoplastic gastric epithelia using DNA microarray analysis,highlevel methylation around the transcription start site appeared to be a tumor-specific phenomenon,although multiple tumor suppressor genes became increasingly methylated with patient age in non-neoplastic gastric epithelia.Quantitative analysis of DNA methylation is a promising method for both cancer diagnosis and risk assessment. | Gen Tamura | 2009 | World Journal of Gastrointestinal Oncology2009，1，1： | 1 |
| 18 | E-Cadherin Gene Promoter Hypermethylation in Primary Human Gastric Carcinomas 显示文摘 | Gen Tamura Jing Yin Suns Wang | 2000 | J National Cancer Institute2000，92，7： | 1 |
| 19 | Prognostic impact and initial recurrence site of lymphovascular and visceral pleural invasion in surgically resected stage I non-small-cell lung carcinoma显示文摘 | Naoki Yanagawa Satoshi Shiono Masami Abiko Shin-ya Ogata Toru Sato Gen Tamura | 2013 | European Journal of Cardio-Thoracic Surgery2013，，3： | 1 |
| 20 | Hypermethylation of the RUNX3 Gene Promoter in Testicular Rolk Sac Tumor of Infants显示文摘 | Noriko Kato Gen Tamura Masayuki Fukase | 2003 | American Journal of Pathology2003，163，： | 1 |
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