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| 1 | Outcomes of Medicare beneficiaries hospitalised with transient ischaemic attack and stratification using the ABCD^(2) score显示文摘Background Long-term outcomes for Medicare beneficiaries hospitalised with transient ischaemic attack(TIA)and role of ABCD^(2) score in identifying high-risk individuals are not studied.Methods We identified 40825 Medicare beneficiaries hospitalised from 2011 to 2014 for a TIA to a Get With The Guidelines(GWTG)-Stroke hospital and classified them using ABCD^(2)s of mortality and rehospitalisation(all-cause,ischaemic stroke,haemorrhagic stroke,myocardial infarction,and gastrointestinal and intracranial haemorrhage)for high-risk versus low-risk groups adjusted for patient and hospital characteristics.Results Of the 40825 patients,35118(86%)were high risk(ABCD^(2)≥4)and 5707(14%)were low risk(ABCD^(2)=0-3).Overall rate of mortality during 1-year follow-up after hospital discharge for the index TIA was 11.7%,44.3% were rehospitalised for any reason and 3.6%were readmitted due to stroke.Patients with ABCD^(2) score≥4 had higher mortality at 1 year than not(adjusted HR 1.18,95%CI 1.07 to 1.30).Adjusted risks for ischaemic stroke,all-cause readmission and mortality/all-cause readmission at 1 year were also significantly higher for patients with ABCD^(2) score≥4 vs 0-3.In contrast,haemorrhagic stroke,myocardial infarction,gastrointestinal bleeding and intracranial haemorrhage risk were not significantly different by ABCD^(2) score.Conclusions This study validates the use of ABCD^(2) score for long-term risk assessment after TIA in patients aged 65 years and older.Attentive efforts for community-based follow-up care after TIA are needed for ongoing prevention in Medicare beneficiaries who were hospitalised for TIA. | Shreyansh Shah Li Liang Durgesh Bhandary Saga Johansson Eric E Smith Deepak L Bhatt Gregg C Fonarow Naeem D Khan Eric Peterson Janet Prvu Bettger | 2021 | Stroke & Vascular Neurology2021，6，2： | 3 |
| 2 | Control of T H 17/T reg Balance by Hypoxia-Inducible Factor 1显示文摘 | Eric V. Dang Joseph Barbi Huang-Yu Yang Dilini Jinasena Hong Yu Ying Zheng Zachary Bordman Juan Fu Young Kim Hung-Rong Yen Weibo Luo Karen Zeller Larissa Shimoda Suzanne L. Topalian Gregg L. Semenza Chi V. Dang Drew M. Pardoll Fan Pan | 2011 | Cell2011，，5： | 3 |
| 3 | Direct measurement of ether congeners 显示文摘 | Eric B Sheryl A T Gregg T T | 2003 | Chemosphere2003，51，： | 1 |
| 4 | Discrimination of Benign and Neoplastic Mucosa with a High-Resolution Microendoscope (HRME) in Head and Neck Cancer显示文摘 | Peter Vila Chan Park Mark Pierce Gregg Goldstein Lauren Levy Vivek Gurudutt Alexandros Polydorides James Godbold Marita Teng Eric Genden Brett Miles Sharmila Anandasabapathy Ann Gillenwater Rebecca Richards-Kortum Andrew Sikora | 2012 | Annals of Surgical Oncology2012，，： | 1 |
| 5 | Diagnostic accuracy of endoscopic ultrasound-guided fine-needle aspiration in patients with presumed pancreatic cancer显示文摘 | Chandrajit P. Raut M.D. M.Sc. Ana M. Grau M.D. Gregg A. Staerkel M.D. Madhukar Kaw M.D. Eric P. Tamm M.D. Robert A. Wolff M.D. Jean-Nicolas Vauthey M.D. F.A.C.S. Jeffrey E. Lee M.D. F.A.C.S. Peter W. T. Pisters M.D. F.A.C.S. Douglas B. Evans M.D. F.A | 2003 | Journal of Gastrointestinal Surgery2003，，1： | 1 |
| 6 | Tourists and residents use of a shopping space 显示文摘 | Snepenger David J Murphy Leann O'Connell Ryan Gregg Eric | 2003 | Annals of Tourism Research2003，30，3： | 1 |
| 7 | Quality of Care and Outcomes in Patients With Diabetes Hospitalized With Ischemic Stroke: Findings From Get With the Guidelines–Stroke显示文摘 | Mathew J. Reeves Robert S. Vaidya Gregg C. Fonarow Li Liang Eric E. Smith Robert Matulonis DaiWai M. Olson Lee H. Schwamm | 2010 | Stroke2010，，5： | 1 |
| 8 | Risk adjustment for in-hospital mortality of contemporary patients with acute myocardial infarction: The Acute Coronary Treatment and Intervention Outcomes Network (ACTION) Registry ? –Get With The Guidelines (GWTG)? acute myocardial infarction mortality 显示文摘 | Chee Tang Chin Anita Y. Chen Tracy Y. Wang Karen P. Alexander Robin Mathews John S. Rumsfeld Christopher P. Cannon Gregg C. Fonarow Eric D. Peterson Matthew T. Roe | 2011 | American Heart Journal2011，，1： | 1 |
| 9 | The “Golden Hour” and Acute Brain Ischemia: Presenting Features and Lytic Therapy in >30 000 Patients Arriving Within 60 Minutes of Stroke Onset显示文摘 | Jeffrey L. Saver Eric E. Smith Gregg C. Fonarow Mathew J. Reeves Xin Zhao DaiWai M. Olson Lee H. Schwamm | 2010 | Stroke2010，，7： | 1 |
| 10 | Adherence and Persistence in the Use of Warfarin After Hospital Discharge Among Patients With Heart Failure and Atrial Fibrillation显示文摘 | Zubin J. Eapen Xiaojuan Mi Laura G. Qualls Bradley G. Hammill Gregg C. Fonarow Mintu P. Turakhia Paul A. Heidenreich Eric D. Peterson Lesley H. Curtis Adrian F. Hernandez Sana M. Al-Khatib | 2013 | Journal of Cardiac Failure2013，，： | 1 |
| 11 | Hospital-Level Variation in Mortality and Rehospitalization for Medicare Beneficiaries With Acute Ischemic Stroke显示文摘 | Gregg C. Fonarow Eric E. Smith Mathew J. Reeves Wenqin Pan DaiWai Olson Adrian F. Hernandez Eric D. Peterson Lee H. Schwamm | 2011 | Stroke2011，，1： | 1 |
| 12 | Preventing tomorrow’s sudden cardiac death today显示文摘 | Sana M. Al-Khatib Gillian D. Sanders Mark Carlson Aida Cicic Anne Curtis Gregg C. Fonarow Peter W. Groeneveld David Hayes Paul Heidenreich Daniel Mark Eric Peterson Eric N. Prystowsky Philip Sager Marcel E. Salive Kevin Thomas Clyde W. Yancy Wojciech Zare | 2008 | American Heart Journal2008，，4： | 1 |
| 13 | Diagnostic accuracy of endoscopic ultrasound-guided fine-needle aspiration in patients with presumed pancreatic cancer显示文摘 | Chandrajit P. Raut M.D. M.Sc. Ana M. Grau M.D. Gregg A. Staerkel M.D. Madhukar Kaw M.D. Eric P. Tamm M.D. Robert A. Wolff M.D. Jean-Nicolas Vauthey M.D. F.A.C.S. Jeffrey E. Lee M.D. F.A.C.S. Peter W. T. Pisters M.D. F.A.C.S. Douglas B. Evans M.D. F.A | 2003 | Journal of Gastrointestinal Surgery2003，，1： | 1 |
| 14 | Age and Gender Differences in Quality of Care and Outcomes for Patients with ST-segment Elevation Myocardial Infarction显示文摘 | Sripal Bangalore Gregg C. Fonarow Eric D. Peterson Anne S. Hellkamp Adrian F. Hernandez Warren Laskey W. Frank Peacock Christopher P. Cannon Lee H. Schwamm Deepak L. Bhatt | 2012 | The American Journal of Medicine2012，，： | 1 |
| 15 | Sex Differences in Medical Care and Early Death After Acute Myocardial Infarction显示文摘 | Hani Jneid Gregg C. Fonarow Christopher P. Cannon Adrian F. Hernandez Igor F. Palacios Andrew O. Maree Quinn Wells Biykem Bozkurt Kenneth A. LaBresh Li Liang Yuling Hong L Kristin Newby Gerald Fletcher Eric Peterson Laura Wexler | 2008 | Circulation2008，，25： | 1 |
| 16 | Patterns of antidepressant therapy and clinical outcomes among ischaemic stroke survivors显示文摘Background and purpose Depression is common after stroke and is often treated with antidepressant medications(AD).ADs have also been hypothesised to improve stroke recovery,although recent randomised trials were neutral.We investigated the patterns of in-hospital AD initiation after ischaemic stroke and association with clinical and readmission outcomes.Methods All Medicare fee-for-service beneficiaries aged 65 or older hospitalised for ischaemic stroke in participating Get With The Guidelines-Stroke hospitals between April and December 2014 were eligible for this analysis.Outcome measures included days alive and not in a healthcare institution(home time),all-cause mortality and readmission within 1-year postdischarge.Propensity score(PS)-adjusted logistic regression models were used to evaluate the associations between AD use and each outcome measure.We also compared outcomes in patients prescribed selective serotonin reuptake inhibitors(SSRIs)AD versus those prescribed non-SSRI ADs.Results Of 21805 AD naive patients included in this analysis,1835(8.4%)were started on an AD at discharge.Patients started on an AD had higher rates of depression and prior ischaemic stroke,presented with higher admission National Institutes of Health Stroke Scale score and were less likely to be discharged home.Similarly,patients started on an SSRI had lower rates of discharge to home.Adjusting for stroke severity,patients started on an AD had worse all-cause mortality,all-cause readmission,major adverse cardiac events,readmission for depression and decreased home-time.However,AD use was also associated with an increased risk for the sepsis,a falsification endpoint,suggesting the presence of residual confounding.Conclusions Patients with ischaemic stroke initiated on AD therapy are at increased risk of poor clinical outcomes and readmission even after PS adjustment,suggesting that poststroke depression requiring medication is a poor prognostic sign.Further research is needed to explore the reasons why depression is associated with worse outcome,and whether AD treatment modifies this risk or not. | Mark R Etherton Shreyansh Shah Xu Haolin Ying Xian Lesley Maisch Deidre Hannah Brianna Lindholm Barbara Lytle Laine Thomas Eric E Smith Gregg C Fonarow Lee H Schwamm Deepak L Bhatt Adrian F Hernandez Emily C O'Brien | 2021 | Stroke & Vascular Neurology2021，6，3： | 0 |
| 17 | Targeted PERK inhibition with biomimetic nanoclusters confers preventative and interventional benefits to elastase-induced abdominal aortic aneurysms显示文摘Abdominal aortic aneurysm(AAA)is a progressive aortic dilatation,causing~80%mortality upon rupture.Currently,there is no approved drug therapy for AAA.Surgical repairs are invasive and risky and thus not recommended to patients with small AAAs which,however,account for~90%of the newly diagnosed cases.It is therefore a compelling unmet clinical need to discover effective non-invasive strategies to prevent or slow down AAA progression.We contend that the first AAA drug therapy will only arise through discoveries of both effective drug targets and innovative delivery methods.There is substantial evidence that degenerative smooth muscle cells(SMCs)orchestrate AAA pathogenesis and progression.In this study,we made an exciting finding that PERK,the endoplasmic reticulum(ER)stress Protein Kinase R-like ER Kinase,is a potent driver of SMC degeneration and hence a potential therapeutic target.Indeed,local knockdown of PERK in elastase-challenged aorta significantly attenuated AAA lesions in vivo.In parallel,we also conceived a biomimetic nanocluster(NC)design uniquely tailored to AAA-targeting drug delivery.This NC demonstrated excellent AAA homing via a platelet-derived biomembrane coating;and when loaded with a selective PERK inhibitor(PERKi,GSK2656157),the NC therapy conferred remarkable benefits in both preventing aneurysm development and halting the progression of pre-existing aneurysmal lesions in two distinct rodent models of AAA.In summary,our current study not only establishes a new intervention target for mitigating SMC degeneration and aneurysmal pathogenesis,but also provides a powerful tool to facilitate the development of effective drug therapy of AAA. | Nisakorn Yodsanit Takuro Shirasu Yitao Huang Li Yin Zain Husain Islam Alexander Christopher Gregg Alessandra Marie Riccio Runze Tang Eric William Kent Yuyuan Wang Ruosen Xie Yi Zhao Mingzhou Ye Jingcheng Zhu Yi Huang Nicholas Hoyt Mengxue Zhang John A.Hossack Morgan Salmon K.Craig Kent Lian-Wang Guo Shaoqin Gong Bowen Wang | 2023 | Bioactive Materials2023，，8： | 0 |
| 18 | 心率变异性新指标对左室功能的评定价值显示文摘目的在已知有心脏疾病并伴有左室收缩功能降低的患者中,评定心率变异性(HRV)频域分析新指标。方法病变组:66例左室收缩功能降低者;对照组:64例心脏结构功能正常且无严重冠脉狭窄者。用5min心电图测定心率变异性频域中极高频成分并生成新指标VHF指数(VHFI)。结果病变组VHFI显著高于对照组(19.17±13.35vs11.37±10.77,p<0.05);VHFI与左室收缩功能呈负相关(R=-0.612);以VHFI>15为阳性,VHFI<15为阴性,对于左室收缩功能降低的预测敏感性和特异性分别为57.58%和78.13%。结论VHFI可以作为有价值的指标,用于急诊快速评定左室功能。 | 刘霞 Saeed Babaeizadeh Sophia Zhou 胡文瑛 Dirk Feild Eric Helfenbein James Lindauer Richard Gregg | 2008 | 临床心电学杂志2008，17，3： | 0 |
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