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| 1 | 中国老年心房颤动优化抗凝管理注册研究一年结果显示文摘目的研究旨在探讨合并多种疾病的老年心房颤动(房颤)患者的优化抗凝管理策略。方法中国老年房颤患者优化抗栓管理注册研究(ChiOTEAF研究)是一项前瞻性、多中心、真实世界的注册研究。2014年10月至2018年12月在全国44家中心招募老年房颤患者,随访1年的血栓栓塞、出血、急性冠状动脉综合征和全因死亡发生情况。使用Cox风险比例模型分析抗凝治疗对血栓、出血及全因死亡复合临床事件的影响。结果本研究共招募7073例房颤患者,其中6148例完成1年随访,年龄(74.3±10.5)岁,年龄范围65~92岁,其中女患者占39.4%(2422/6148)。非维生素K拮抗剂口服抗凝药(NOACs)、华法林和抗血小板药物的使用率分别为23.5%(1444/6148)、21.1%(1300/6148)和41.0%(2521/6148)。48.6%(2988/6148)患者同时存在CHA2DS2-VASc和HAS-BLED评分高危,49.6%(3052/6148)患者HAS-BLED评分≥3。42.3%(2601/6148)患者有跌倒风险,34.2%(2102/6148)患者合并心力衰竭,17.3%(1064/6148)患者年龄≥85岁,14.3%(878/6148)合并慢性肾脏病/肝病,9.0%(555/6148)合并恶性肿瘤。校正基线特征后,房颤合并CHA2DS2-VASc和HAS-BLED高危、HAS-BLED≥3、跌倒风险、慢性肾脏病/肝病、年龄≥85岁等患者,抗凝治疗较抗血小板治疗降低急性心肌梗死、缺血性脑卒中、脑出血和全因死亡的复合终点事件风险(均P<0.05)。结论权衡血栓及出血风险后,老年高危房颤患者抗凝治疗降低临床不良事件。 | 郭豫涛 王玉堂 单兆亮 时向民 奚国荣 王浩 Lip Gregory Y H | 2020 | 中华心律失常学杂志2020，24，4： | 13 |
| 2 | Factors predicting survival in patients with proximal gastric carcinoma involving the esophagus显示文摘AIM:To investigate the clinicopathologic features which predict surgical overall survival in patients with proximal gastric carcinoma involving the esophagus (PGCE).METHODS:Electronic pathology database established in the Department of Pathology of the Nanjing Drum Tower Hospital was searched for consecutive resection cases of proximal gastric carcinoma over the period from May 2004 through July 2009.Each retrieved pathology report was reviewed and the cases with tumors crossing the gastroesophageal junction line were selected as PGCE.Each tumor was re-staged,following the guidelines on esophageal adenocarcinoma,according to the 7th edition of the American Joint Commission on Cancer Staging Manual.All histology slides were studied along with the pathology report for a retrospective analysis of 13 clinicopathologic features,i.e.,age,gender,Helicobacter pylori (H.pylori ) infection,surgical modality,Siewert type,tumor Bormann's type,size,differentiation,histology type,surgical margin,lymphovascular and perineural invasion,and pathologic stage in relation to survival after surgical resection.Prognostic factors for overall survival were assessed with uniand multi-variate analyses.RESULTS:Patients' mean age was 65 years (range:47-90 years).The male:female ratio was 3.3.The 1-,3and 5-year overall survival rates were 87%,61% and 32%,respectively.By univariate analysis,age,male gender,H.pylori ,tumor Bormann's type,size,histology type,surgical modality,positive surgical margin,lymphovascular invasion,and pT stage were not predictive for overall survival;in contrast,perineural invasion (P = 0.003),poor differentiation (P = 0.0003),> 15 total lymph nodes retrieved (P = 0.008),positive lymph nodes (P = 0.001),and distant metastasis (P = 0.005) predicted poor post-operative overall survival.Celiac axis nodal metastasis was associated with significantly worse overall survival (P = 0.007).By multivariate analysis,≥ 16 positive nodes (P = 0.018),lymph node ratio > 0.2 (P = 0.003),and overall pathologic stage (P = 0.002) were independent predictors for poor overall survival after resection.CONCLUSION:Patients with PGCE showed worse overall survival in elderly,high nodal burden and advanced pathologic stage.This cancer may be more accurately staged as gastric,than esophageal,cancer. | Yi-Fen Zhang Jiong Shi Hui-Ping Yu An-Ning Feng Xiang-Shan Fan Gregory Y Lauwers Hiroshi Mashimo Jason S Gold Gang Chen Qin Huang | 2012 | World Journal of Gastroenterology2012，18，27： | 12 |
| 3 | 静脉血栓栓塞显示文摘静脉血栓栓塞,包括深静脉血栓形成与肺动脉栓塞,普通可见,在医院和院外均可进行治疗主要危险因素包括年龄、近期手术(特别是整形手术)、癌症及血栓形成倾向已确立的治疗有普通肝素、低分子量肝素。 | Andrew D Blann Gregory Y H Lip 刘仁斌(译) 王深明(校) | 2006 | 英国医学杂志中文版2006，9，5： | 6 |
| 4 | Reproducibility of the diagnosis of dysplasia in Barrett esophagus: A reaffirmation显示文摘 | Elizabeth Montgomery Mary P Bronner John R Goldblum Joel K Greenson Marian M Haber John Hart Laura W Lamps Gregory Y Lauwers Audrey J Lazenby David N Lewin Marie E Robert Alicia Y Toledano Yu Shyr Kay Washington | 2001 | Human Pathology2001，，4： | 3 |
| 5 | Mucin Expression in Gastric Cancer: Reappraisal of Its Clinicopathologic and Prognostic Significance显示文摘 | Kim Dae Hwan Shin Nari Kim Gwang Ha Song Geum Am Jeon Tae-Yong Kim Dong-Heon Lauwers Gregory Y Park Do Youn | 2013 | Archives of Pathology & Laboratory Medicine2013，，8： | 2 |
| 6 | Electrochemcal study on microbiology-related corrosion of metallic dental materials显示文摘 | Chang JC Oshida Y Gregory RL | 2003 | Biomed Mater Eng2003，13，3： | 1 |
| 7 | Diffusion of ions in sea water and in deep-sea sediments显示文摘 | Li Y H Gregory S | 1974 | Geochimica et Cosmochimica Acta1974，38，5： | 1 |
| 8 | Brand and product integration in horizontal mergers and ~quisitions 显示文摘 | VU D A SHI Y J GREGORY M | 2010 | European Journal of International Management2010，4，1： | 1 |
| 9 | Indigenous bacteria from the gut microbiota regulate host serotonin biosynthesis显示文摘 | Jessica MY Kristie Y Gregory PD | 2015 | Cell2015，161，2： | 1 |
| 10 | The Significance of 'Indefinite for Dysplasia' Grading in Barrett Metaplasia显示文摘 | Younes Mamoun Lauwers Gregory Y Ertan Atilla Ergun Gulchin Verm Ray Bridges Margaret Woods Karen Meriano Frank Schmulen Carl Johnson Craig Barroso Alberto Schwartz Jim McKechnie John Lechago Juan | 2011 | Archives of Pathology & Laboratory Medicine2011，，： | 1 |
| 11 | Disk arrays: high- performance, high- reliability storage subsystems 显示文摘 | Gregory R Ganger Bruce L Worthington Robert Y | 1994 | Computer1994，27，3： | 1 |
| 12 | Cold-formed steel channels subjected to concentrated load 显示文摘 | Ben Y Gregory J H | 2003 | Journal of Structural Engineering2003，129，8： | 1 |
| 13 | Fructose-1,6- bisphosphate reduces infarct volume after reversible middle cerebral artery occlusion in rats显示文摘 | Kuluz J W Gregory G A Han Y | 1993 | Stroke1993，24，10： | 1 |
| 14 | Diffusion of ions in sea water and in deep-sea sediments 显示文摘 | Li Y -H Gregory S | 1974 | Geochimica et Cosmochimica Acta1974，38，： | 1 |
| 15 | Some new models for financial distress pre-diction in the UK 显示文摘 | Christidis A C Y Gregory A | 2010 | Working paper2010，，： | 1 |
| 16 | Upregulation of inflammatory mediators in a model of chronic pain after spinal cord injury 显示文摘 | Sandhir R Gregory E He Y Y | 2011 | Neurochem Res2011，36，5： | 1 |
| 17 | Avian-to-human transmission of H9N2 subtype influenza A viruses: Re- lationship between H9N2 and H5N1 human isolates 显示文摘 | Lin Y P Shaw M Gregory V | 2000 | PNAS2000，97，17： | 1 |
| 18 | Avian-to-human transmission of HgN2 subtype influenza A viruses: Relationship between H9N2 and H5N1 hmnan isolates 显示文摘 | Lin Y P Shaw M Gregory V | 2000 | PNAS2000，97，17： | 1 |
| 19 | Optimal shared-savings contracts in supply chains:linear contracts and double moral hazard显示文摘 | Charles J Corbett Gregory A Decroix Albert Y Ha | 2005 | European Journal of Operational Research2005，163，3： | 1 |
| 20 | yon Willebrand factor:a marker of endothelial dysfunction in vascular disorders显示文摘 | Gregory Y Lip H Andren B | 1997 | Cardiovasc Res1997，34，2： | 1 |
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