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| 1 | Schistosoma japonicum infection induces macrophage polarization显示文摘The role of macrophages(Mφ)as the first line of host defense is well accepted.These cells play a central role in orchestrating crucial functions during schistosomal infection.Thus,understanding the functional diversity of these cells in the process of infection as well as the mechanisms underlying these events is crucial for developing disease control strategies.In this study,we adopted a Mφpolarization recognition system.Ml macrophage was characterized by expressing CD16/32,IL-12 and iNOS.M2 macrophage was characterized by expressing CD206,IL-10 and arg-1.In vivo(mouse peritoneal macrophages of different infection stages were obtained)and in vitro(different 5.japonicum antigens were used to stimulate RAW264.7)were characterized by using the above mentioned system.NCA and ACA stimulated RAW264.7 express significantly higher levels of IL-12 while significantly higher levels of IL-10 were detected after soluble egg antigen(SEA)stimulation.The results showed that dramatic changes of antigen in the microenvironment before and after egg production led to macrophage polarization.Furthermore,through TLR blocking experiments,the TLR4 signaling pathway was found to play a role in the process of macrophage polarization toward Ml.Our data suggest that macrophage polarization during S.japonicum infection had significant effects on host immune responses to S.japonicum. | Jingwei Xu Hao Zhang Lin Chen Donghui Zhang Minjun Ji Haiwei Wu Guanling Wu | 2014 | The Journal of Biomedical Research2014，28，4： | 20 |
| 2 | RNF2 is recruited by WASH to ubiquitinate AMBRA1 leading to downregulation of autophagy显示文摘洗(Wiskott-Aldrich 症候群蛋白质(黄蜂) 和疤相当或相同的事物) 被识别在经由 Arp2/3 激活排序的 endosomal 工作。我们以前表明了那洗在有 AMBRA1 的 BECN1-PIK3C3 建筑群是 BECN1 和现在的新 interactor。AMBRA1-DDB1-CUL4A 建筑群是为 BECN1 的连接 K63 的 ubiquitination 的 E3 ligase,它为导致饥饿的 autophagy 被要求。洗由 BECN1 ubiquitination 的抑制压制 autophagy。然而, AMBRA1 怎么在 autophagy 期间被调整,留下逃犯。这里,我们发现 RNF2 与 AMBRA1 联系经由 K48 连接充当 E3 ligase 到 ubiquitinate AMBRA1。RNF2 调停在离氨酸 45 点的 AMBRA1 的 ubiquitination。尤其是, RNF2 缺乏提高 autophagy 正式就职。在 autophagy 正式就职之上, RNF2 加强 AMBRA1 降级在的帮助下洗。洗缺乏与 AMBRA1 损害 RNF2 的协会阻碍 AMBRA1 降级。我们的调查结果揭示 autophagy 的规定的另一新奇的层通过为导致 autophagy 的 downregulation 的 AMBRA1 降级洗 RNF2 的招募。 | Pengyan Xia Shuo Wang Guanling Huang Ying Du Pingping Zhu Man Li Zusen Fan | 2014 | Cell Research2014，24，8： | 7 |
| 3 | Study of the Change in Wave Velocity Ratio before and after Two Strong Earthquakes Using Airgun Source Data显示文摘Using the signals excited by the large-volume airgun source at the Binchuan transmitting seismic station from January to June,2016,arrival-time data was acquired at four stations near the epicenter of the Eryuan MS4.5 and MS4.0 earthquakes on February 8,2016,as well as the epicenter of the Yunlong MS5.0 and Eryuan MS4.6 earthquakes on May 18,2016 through the waveform cross-correlation technique.The wave velocity ratio of the four stations was calculated using the single-station method.At the same time,the b-value and the focal mechanism consistency parameters of the study area were also calculated.The results show that:(1)the wave velocity ratio of each station experienced a process of decline-recovery-fast rise before the two strong earthquakes,and a significant quasi-synchronous rapid rise occurred within 3-12 days before the earthquake;(2)the timing of the rapid rise of the wave velocity ratio of the four stations before the Yunlong MS5.0 and Eryuan MS4.6 earthquakes were related to the epicentral distance.The station which observed the earliest increase in rapid rise is the farthest one from the epicenter,and the station where the rapid rise appeared in the latest is closest to the epicenter;(3)the form of change of the wave velocity ratio before the earthquake was different between stations located at different directions in the epicenter area;(4)the b-value and the focal mechanism consistency parameter which is commonly used to characterize the stress level both showed a downward trend before the two strong earthquakes,and were consistent with the change in the wave velocity ratio.According to the preliminary analysis,the wave velocity ratio obtained by using airgun source can better reflect the change in the stress state of the underground medium. | LIU Zifeng YE Beng CHEN Jia ZHOU Qingyun WANG Guangming PENG Guanling LI Yongli | 2019 | Earthquake Research in China2019，33，2： | 4 |
| 4 | IFN-inducible p47 GTPases display differential responses to Schistosoma japonicum acute infection显示文摘Interferon gamma induced GTPase(IGTP)(also named lrgm3)and interferon gamma inducible protein 47(IRG-47)(also named lIrgd)are interferon(IFN)-inducible p47 GTPases that have been shown to regulate host resistance to intracellular pathogens.Little knowledge has been known about the role of p47 GTPases in host responses against extracellular pathogens.To investigate possible roles of IGTP and IRG-47 in the course of Schistosoma japonicum infection,IGTP and IRG-47 knockout and wild-type(WT)mice were challenged with cercariae of S.japonicum,and host responses were analyzed.At the acute stage of S.japonicum infection,mice that lacked IGTP displayed similar parasite burden and pathological damage to WT mice.Importantly,S.japonicum-infected lRG-47-deficient mice,in contrast to IGTP-deficient mice and WT mice,showed significantly reduced worms and lower egg-burden,but intense granulomatous reaction evoked by schistosome eggs in peripheral parts of liver lobes.In addition,upregulation of inflammation-related gene expression was observed in the spleen of IRG-47-deficient mice using oligonucleotide microarrays,in which multiple pathways of cytokine-cytokine receptor interaction,T-cell receptor signaling,complement,coagulation cascades and cell adhesion molecules were highlighted.Taken together,these data suggest that IGTP and IRG-47 might have distinct features that were differentially required for resistance to S.japonicum. | Xuesong Chen Xiaotang Du Meijuan Zhang Donghui Zhang Minjun Ji Guanling Wu | 2010 | Cellular & Molecular Immunology2010，7，1： | 2 |
| 5 | Characterization of a Partially Protective B-cell Epitope within the 62 kDa Antigen of Schistosoma japonicum显示文摘约 2 亿个人当前全球受不了血吸虫病,最重要的人的寄生疾病之一。尽管确定的感染能与驱虫剂和 praziquantel 被治疗,种痘将是为不可分的控制的理想的方法血吸虫病。血吸虫 mansoni IrV-5,为研究由世界健康组织 / 专辑计划推荐了为一个疫苗的候选人并且在 TropicalDiseases 训练,在动物模型的生产高保护。我们因此集中于它的相当或相同的事物,血吸虫日本嗯 62 kDa 抗原,并且为 B 房间 epitopes 的预言用 B cell/antibody-related 数据库和分析工具分析了它。Epitope B3 为进一步的调查被选择。用一个鼠科的模型的实验显示与 B3 使免疫的老鼠导致了淋巴细胞增长并且生产了特定的免疫球蛋白 G 和 G1 的高水平,但是没生产出色的 cytokines。种痘显示出部分保护的免疫,对 S 由蠕虫负担和反肥沃免疫测量了。日本嗯。这些结果显示了 epitope B3from S。日本嗯 62-kDa 抗原可能为未来 epitope 疫苗调查充当一张候选人免疫情报。 | Lei ZHANG Xue YANG Yanfen YANG Jiaqing ZHAO Jianghua YANG Feng LIU Zhaosong ZHANG Guanling WU Chuan SU | 2007 | Acta Biochimica et Biophysica Sinica2007，39，10： | 2 |
| 6 | Upflow biological illtration with floating filter media显示文摘 | Xie Weimin Wang Qunhui Song Guanling | 2004 | Process Biochemistry2004，39，6： | 1 |
| 7 | Transient Activation of Autophagy via Sox2-Mediated Suppression of mTOR Is an Important Early Step in Reprogramming to Pluripotency显示文摘 | Shuo Wang Pengyan Xia Buqing Ye Guanling Huang Jing Liu Zusen Fan | 2013 | Cell Stem Cell2013，，5： | 1 |
| 8 | Efficient graph-based algorithms for discovering and maintaining association rules in large databases显示文摘 | Guanling Lee K L Lee Arbee L P Chen | 2001 | Knowledge and Information Systems2001，3，3： | 1 |
| 9 | Fast Depth Coding Techniques Using Early Termination Scheme显示文摘 | Wang Fengsui Wang Guanling | 2014 | Computer Modelling and New Technologies2014，18，12： | 1 |
| 10 | Effect of low temperature on eutrophicated waterbody restoration by Spirodela polyrhiza显示文摘 | Guanling Song Wenhua Hou Qunhui Wang Jianlong Wang Xiangcan Jin | 2005 | Bioresource Technology2005，，15： | 1 |
| 11 | Broadcast Data Allocation for Efficient Access of Multiple Data Items in Mobile Environments显示文摘 | Guanling Lee Shou-Chih Lo | 2003 | Mobile Networks and Applications2003，，4： | 1 |
| 12 | Effect of low temperature on eutrophicated waterbody restoration by Spirodela polyrhiza显示文摘 | Song Guanling Hou Wenhua Wang Qunhui | 2006 | Bioresource Technology2006，97，： | 1 |
| 13 | Design and implementation of a toolkit for usability 显示文摘 | Ma Xiaoxiao Yan Bo Chen Guanling | 2013 | Mobile Networks and Applications2013，18，1： | 1 |
| 14 | Upflowbiological filtration with floating filter media 显示文摘 | Weimin Xie Qunhui Wang Guanling Song | 2004 | ProcessBiochemistry2004，39，6： | 1 |
| 15 | A C A D system for the automatic detection of clustered microcalcification in digitized mammogram films显示文摘 | GuanL | 2000 | IEEE Trans MI2000，19，2： | 1 |
| 16 | Design and Implementation of a Toolkit for Usability Testing of Mobile Apps显示文摘 | Ma Xiaoxiao Yan Bo Chen Guanling | 2013 | Mobile Networks and Applications2013，18，： | 1 |
| 17 | Broadcast data allocation for efficient access of multiple data items in mobile environments显示文摘 | Guanling Lee Shou-Chih Lo | 2003 | ACM/Baltzer Mobile Networks and Applications2003，，： | 1 |
| 18 | Effects of copper and cadmium on heavy metal polluted waterbody restoration by duckweed ( Lemna minor )显示文摘 | Wenhua Hou Xiao Chen Guanling Song Qunhui Wang Chein Chi Chang | 2006 | Plant Physiology and Biochemistry2006，，1： | 1 |
| 19 | 人早期胚胎染色质开放性图谱及其进化的关联显示文摘文章简介发育的进行需要体内的基因能够按照设定的程序、在特定的时间和特定的地点有序地表达,这个过程称为基因表达的编程。人体设定基因表达程序的一种'编程语言'被称为'染色体开放状态'。早期胚胎发育中'染色体开放性'如何指挥人类胚胎的基因表达并不是很清楚。本研究克服研究材料缺乏的难题. | Lei Gao Keliang Wu Zhenbo Liu Xuelong Yao Shenli Yuan Wenrong Tao Lizhi Yi Guanling Yu Zhenzhen Hou Dongdong Fan Yong Tian 刘见桥 陈子江 刘江 | 2019 | 科学新闻2019，0，2： | 1 |
| 20 | Influence of pH and chloride ion oncentration on the corrosion of Mg alloy ZE41 显示文摘 | Zhao Mingchun Liu Ming Song Guanling | 2009 | Corrosion Science2009，50，11： | 1 |
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