|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Isolation of fucoxanthin from Sargassum thunbergii and preparation of microcapsules based on palm stearin solid lipid core显示文摘 | Xuanxuan WANG Hongyan LI Fangqin WANG Guixue XIA Hongjun LIU Xiaojie CHENG Ming KONG Ya LIU Chao FENG Xiguang CHEN Ying WANG | 2017 | Frontiers of Materials Science2017，11，1： | 3 |
| 2 | Development of part-dissolvable chitosan fibers with surface N-succinylation for wound care dressing显示文摘 | Guohui SUN Chao FENG Ming KONG Xiaojie CHENG Jiaojiao BING Guixue XIA Zixian BAO Hyunjin PARK Xiguang CHEN | 2015 | Frontiers of Materials Science2015，9，3： | 2 |
| 3 | Multiple MIPS 4Kc cores based interrupt controller design and its implementation on HDTV SoC platform显示文摘 | 陈颖琪 Lin Guixu Wang Feng Hu Jianling Tan Zhiming | 2007 | High Technology Letters2007，13，3： | 2 |
| 4 | Two-stage degradation and novel functional endothelium characteristics of a 3-D printed bioresorbable scaffold显示文摘Bioresorbable scaffolds have emerged as a new generation of vascular implants for the treatment of atherosclerosis,and designed to provide a temporary scaffold that is subsequently absorbed by blood vessels over time.Presently,there is insufficient data on the biological and mechanical responses of blood vessels accompanied by bioresorbable scaffolds(BRS)degradation.Therefore,it is necessary to investigate the inflexion point of degradation,the response of blood vessels,and the pathophysiological process of vascular,as results of such studies will be of great value for the design of next generation of BRS.In this study,abdominal aortas of SD rats were received 3-D printed poly-l-actide vascular scaffolds(PLS)for various durations up to 12 months.The response of PLS implanted aorta went through two distinct processes:(1)the neointima with desirable barrier function was obtained in 1 month,accompanied with slow degradation,inflammation,and intimal hyperplasia;(2)significant degradation occurred from 6 months,accompanied with decreasing inflammation and intimal hyperplasia,while the extracellular matrix recovered to normal vessels which indicate the positive remodeling.These in vivo results indicate that 6 months is a key turning point.This“two-stage degradation and vascular characteristics”is proposed to elucidate the long-term effects of PLS on vascular repair and demonstrated the potential of PLS in promoting endothelium function and positive remodeling,which highlights the benefits of PLS and shed some light in the future researches,such as drug combination coatings design. | Tieying Yin Ruolin Du Yang Wang Junyang Huang Shuang Ge Yuhua Huang Youhua Tan Qing Liu Zhong Chen Hanqing Feng Jie Du Yazhou Wang Guixue Wang | 2022 | Bioactive Materials2022，7，4： | 2 |
| 5 | Remodeling tumor immunosuppressive microenvironment via a novel bioactive nanovaccines potentiates the efficacy of cancer immunotherapy显示文摘The clinical outcomes of cancer nanovaccine have been largely impeded owing to the low antigen-specific T cell response rate and acquired resistance caused by the immunosuppressive tumor microenvironment(TME).Here,we reported a tumor acidity-responsive nanovaccine to remodel the immunosuppressive TME and expand the recruitment of tumor infiltrating lymphocytes(TILs)using hybrid micelles(HM),which encapsulated colony stimulating factor 1 receptor(CSF1-R)inhibitor BLZ-945 and indoleamine 2,3-dioxygenase(IDO)inhibitor NLG-919 in its core and displayed a model antigen ovalbumin(OVA)on its surface(denoted as BN@HM-OVA).The bioactive nanovaccine is coated with a polyethylene glycol(PEG)shell for extending nanoparticle circulation.The shell can be shed in response to the weakly acidic tumor microenvironment.The decrease in size and the increase in positive charge may cause the deep tumor penetration of drugs.We demonstrated that the bioactive nanovaccine dramatically enhance antigen presentation by dendritic cells(DCs)and drugs transportation into M1-like tumor-associated macrophages(TAMs)and tumor cells via size reduction and increasing positive charge caused by the weakly acidic TME.Such bioactive nanovaccine could remodel the immunosuppressive TME into an effector T cells favorable environment,leading to tumor growth inhibition in prophylactic and therapeutic E.G7-OVA tumor models.Furthermore,combining the bioactive nanovaccine with simultaneous anti-PD-1 antibody treatment leads to a long-term tumor inhibition,based on the optimal timing and sequence of PD-1 blockade against T cell receptor.This research provides a new strategy for the development of efficient cancer immunotherapy. | Xiaoxue Xie Yi Feng Hanxi Zhang Qingqing Su Ting Song Geng Yang Ningxi Li Xiaodan Wei Tingting Li Xiang Qin Shun Li Chunhui Wu Xiaojuan Zhang Guixue Wang Yiyao Liu Hong Yang | 2022 | Bioactive Materials2022，7，10： | 1 |
| 6 | Cathepsin K contributed to disturbed flow-induced atherosclerosis is dependent on integrin-actin cytoskeleton–NF–κB pathway显示文摘Atherosclerosis is a chronic inflammatory disease, occurring preferentially in bifurcation, branching, and bending of blood vessels exposed to disturbed flow. Disturbed flow in atheroprone areas activates elevated proteases, degrading elastin lamellae and collagenous matrix, resulting in endothelial dysfunction and vascular remodeling. As a mediator for extracellular matrix protein degradation, cathepsin K (CTSK) was directly regulated by hemodynamics and contributed to atherosclerosis. The mechanism of CTSK responding to disturbed flow and contributing to disturbed flow-induced atherosclerosis is unclear. In this study, the partial carotid ligation model of mice and in vitro disturbed shear stress model were constructed to explore the contribution and potential mechanism of CTSK in atherosclerosis. Our results indicated that CTSK elevated in the disturbed flow area in vivo and in vitro along with endothelial inflammation and atherogenesis. Additionally, the expression of integrin αvβ3 was upregulated in these atheroprone areas. We found that inhibition of the integrin αvβ3-cytoskeleton pathway could significantly block the activation of NF-κB and the expression of CTSK. Collectively, our findings unraveled that disturbed flow induces increased CTSK expression, and contributes to endothelial inflammation and vascular remodeling, leading to atherogenesis eventually. This study is helpful to provide new enlightenment for the therapy of atherosclerosis. | Fei Fang Tang Feng Jianwei Li Huaiyi Zhang Qin Wang Yidan Chen Guixue Wang Yang Shen Xiaoheng Liu | 2023 | Genes & Diseases2023，10，2： | 1 |
| 7 | Co - culture embedded in cumulus clumps promotes matu- ration of denuded oocytes and reconstructs gap junc- tions between oocytes and cumulus cells显示文摘 | Guixue Feng Deshun Shi Shufang Yang | 2012 | Zygote2012，3，： | 1 |
| 8 | Profiling the Bisecting N-acetylglucosamine Modification in Amniotic Membrane via Mass Spectrometry显示文摘Bisecting N-acetylglucosamine(GlcNAc),a GlcNAc linked to the coreβ-mannose residue via aβ1,4 linkage,is a special type of N-glycosylation that has been reported to be involved in various biological processes,such as cell adhesion and fetal development.This N-glycan structure is abundant in human trophoblasts,which is postulated to be resistant to natural killer cellmediated cytotoxicity,enabling a mother to nourish a fetus without rejection.In this study,we hypothesized that the human amniotic membrane,which serves as the last barrier for the fetus,may also express bisected-type glycans.To test this hypothesis,glycomic analysis of the human amniotic membrane was performed,and bisected N-glycans were detected.Furthermore,our proteomic data,which have been previously employed to explore human missing proteins,were analyzed and the presence of bisecting GlcNAc-modified peptides was confirmed.A total of 41glycoproteins with 43 glycopeptides were found to possess a bisecting GlcNAc,and 25 of these glycoproteins were reported to exhibit this type of modification for the first time.These results provide insights into the potential roles of bisecting GlcNAc modification in the human amniotic membrane,and can be beneficial to functional studies on glycoproteins with bisecting GlcNAc modifications and functional studies on immune suppression in human placenta. | Qiushi Chen Yuanliang Zhang Keren Zhang Jie Liu Huozhen Pan Xinran Wang Siqi Li Dandan Hu Zhilong Lin Yun Zhao Guixue Hou Feng Guan Hong Li Siqi Liu Yan Ren | 2022 | Genomics, Proteomics & Bioinformatics2022，20，4： | 0 |
| 9 | Corrigendum to “Remodeling tumor immunosuppressive microenvironment via a novel bioactive nanovaccines potentiates the efficacy of cancer immunotherapy” [Bioactive Mater. 16 107-119]显示文摘The authors regret that the published version of the above article contained two errors which were not identified during the proofing stage.Also,Figure 2A and 6C have been replaced.The authors apologize for these errors and state that these corrections do not change the scientific conclusions of the article in any way. | Xiaoxue Xie Yi Feng Hanxi Zhang Qingqing Su Ting Song Geng Yang Ningxi Li Xiaodan Wei Tingting Li Xiang Qin Shun Li Chunhui Wu Xiaojuan Zhang Guixue Wang Yiyao Liu Hong Yang | 2023 | Bioactive Materials2023，，3： | 0 |
| 10 | Exosomes from young healthy human plasma promote functional recovery from intracerebral hemorrhage via counteracting ferroptotic injury显示文摘Intracerebral hemorrhage (ICH), as a type of life-threatening and highly disabled disease, has limited therapeutic approaches. Here, we show that exosomes derived from young healthy human plasma exhibiting typical exosomes features could facilitate functional recovery of ICH mice. When these exosomes are intraventricularly delivered into the brain after ICH, they mainly distribute around the hematoma and could be internalized by neuronal cells. Strikingly, exosomes administration markedly enhanced the behavioral recovery of ICH mice through reducing brain injury and cell ferroptosis. MiRNA sequencing revealed that microRNA-25-3p (miR-25- 3p) was differentially expressed miRNA in the exosomes from young healthy human plasma, compared with exosomes from the old control. Importantly, miR-25-3p mimicked the treatment effect of exosomes on behavioral improvement, and mediated the neuroprotective effect of exosomes against ferroptosis in ICH. Furthermore, luciferase assay and western blotting data illustrated that P53 as assumed the role of a downstream effector of miR-25-3p, thereby regulating SLC7A11/GPX4 pathway to counteract ferroptosis. Taken together, these findings firstly reveal that exosomes from young healthy human plasma improve functional recovery through counteracting ferroptotic injury by regulating P53/SLC7A11/GPX4 axis after ICH. Given the easy availability of plasma exosomes, our study provides a potent therapeutic strategy for ICH patients with quick clinical translation in the near future. | Wenqin Yang Ning Ding Ran Luo Qian Zhang Zhenhua Li Fengchun Zhao Shuixian Zhang Xuyang Zhang Tengyuan Zhou Haomiao Wang Long Wang Shengli Hu Guixue Wang Hua Feng Rong Hu | 2023 | Bioactive Materials2023，，9： | 0 |
| 11 | Adsorption Characteristics of the Powdered Activated Carbon on Pesticide in the Water显示文摘The adsorption characteristics of the powdered activated carbon on four kinds of pesticides( dichlorvos,chlorothalonil,lindane and chlorphyrifos) were studied,and the influential factors of adsorption effect were discussed. Results showed that the powdered activated carbon could effectively remove the above four kinds of pesticides. It was rapid adsorption period before 30 min,and removal rate has reached 90%. Adsorption kinetics of the powdered activated carbon on pesticides corresponded with quasi-two-level kinetic equation,and both Freundlich and Langmuir adsorption isotherms could simulate the adsorption process of the activated carbon on pesticide well. Competitive adsorption between small-molecule organics in the water diverting from Yellow River and pesticides on micropore of the activated carbon would occur. | Pan Zhangbin Song Wuchang Feng Guixue Jia Ruibao Sun Shaohua | 2014 | Meteorological and Environmental Research2014，5，12： | 0 |
您所在的机构暂未开通此部分的功能，请联系管理员