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| 1 | Relationship between H_(2)O_(2) accumulation and NO synthesis during osmotic stress:promoted somatic embryogenesis of Fraxinus mandshurica显示文摘Osmotic stress promotes somatic embryogenesis of Fraxinus mandshurica,which leads to accumulation of reactive oxygen species(ROS).The single pieces of cotyledons of F.mandshurica were used as explants to induce somatic embryogenesis in osmotic-stress medium.Furthermore,the hydrogen peroxide H_(2)O_(2) content of explanted cells was varied by adding exogenous H_(2)O_(2) or catalase solution to assess the effects of the exogenous H_(2)O_(2)on somatic embryogenesis,intracellular H_(2)O_(2)accumulation,and the relationship between signaling mediated by ROS or reactive nitrogen species.The results revealed that exogenous H_(2)O_(2)(100?300μmol L^(–1))increased the number of somatic embryos.On 60th day of exogenous H_(2)O_(2)(200μmol L^(–1))treatment,the number of somatic embryos of explants treated,which was 136.54%,was higher than the control.Moreover,exogenous H_(2)O_(2)(100μmol L^(–1))significantly increased the intracellular H_(2)O_(2)content and enhanced the activities of superoxidase dismutase and peroxidase.Finally,exogenous H_(2)O_(2)(100μmol L^(–1))activated the intracellular non-enzymatic pathway for nitric oxide(NO)synthesis.The somatic embryogenesis in broadleaf trees increases with the change of endogenic ROS content,and depends on the upregulation of antioxidant enzymes.Both H_(2)O_(2)and NO,as signaling molecules,were found to be involved in the process of somatic embryogenesis in broadleaf trees.In the process of exogenous H_(2)O_(2)promoting somatic embryogenesis,NO synthesis depended on non-enzymatic reactions.These results provide a scientific basis for resolving the mechanism by which ROS levels are regulated during somatic embryogenesis of broadleaf trees and establish a reasonable and efficient technology system for regulating somatic embryogenesis of trees. | Ling Yang Hanyang Guo Yingying Liu Dongyan Zhang Hongnan Liu Hailong Shen | 2021 | Journal of Forestry Research2021，32，3： | 1 |
| 2 | 显示文摘 | Zhai Hongbo Xu Weibing Guo Hanyang | 2004 | European Polymer Journal2004，40，： | 1 |
| 3 | Numerical study of stratified oil-water two-phase turbulent flow in a horizontal tube显示文摘 | Gao Hui Gu Hanyang Guo Liejin | 2003 | International Journal of Heat and Mass Transfer2003，46，4： | 1 |
| 4 | A novel long-term intravenous combined with local treatment with human amnion-derived mesenchymal stem cells for a multidisciplinary rescued uremic calciphylaxis patient and the underlying mechanism显示文摘Calciphylaxis is a rare disease characterized histologically by microvessel calcification and microthrombosis,with high mortality and no proven therapy.Here,we reported a severe uremic calciphylaxis patient with progressive skin ischemia,large areas of painful malodorous ulcers,and mummified legs.Because of the worsening symptoms and signs refractory to conventional therapies,treatment with human amnion-derived mesenchymal stem cells(hAMSCs)was approved.Preclinical release inspections of hAMSCs,efficacy,and safety assessment,including cytokine secretory ability,immunocompetence,tumorigenicity,and genetics analysis in vitro,were introduced.We further performed acute and long-term hAMSC toxicity evaluations in C57BL/6 mice and rats,abnormal immune response tests in C57BL/6 mice,and tumorigenicity tests in neonatal Balbc-nu nude mice.After the preclinical research,the patient was treated with hAMSCs by intravenous and local intramuscular injection and external supernatant application to the ulcers.When followed up to 15 months,the blood-based markers of bone and mineral metabolism improved,with skin soft tissue regeneration and a more favorable profile of peripheral blood mononuclear cells.Skin biopsy after 1-month treatment showed vascular regeneration with mature noncalcified vessels within the dermis,and 20 months later,the re-epithelialization restored the integrity of the damaged site.No infusion or local treatment-related adverse events occurred.Thus,this novel long-term intravenous combined with local treatment with hAMSCs warrants further investigation as a potential regenerative treatment for uremic calciphylaxis due to effects of inhibiting vascular calcification,stimulating angiogenesis and myogenesis,anti-inflammatory and immune modulation,multidifferentiation,re-epithelialization,and restoration of integrity. | Lianju Qin Jing Zhang Yujie Xiao Kang Liu Yugui Cui Fangyan Xu Wenkai Ren Yanggang Yuan Chunyan Jiang Song Ning Xiaoxue Ye Ming Zeng Hanyang Qian Anning Bian Fan Li Guang Yang Shaowen Tang Zhihong Zhang Juncheng Dai Jing Guo Qiang Wang Bin Sun Yifei Ge Chun Ouyang Xueqiang Xu Jing Wang Yaoyu Huang Hongqing Cui Jing Zhou Meilian Wang Zhonglan Su Yan Lu Di Wu Jingping Shi Wei Liu Li Dong Yinbing Pan Baiqiao Zhao Ying Cui Xueyan Gao Zhanhui Gao Xiang Ma Aiqin Chen Jie Wang Meng Cao Qian Cui Li Chen Feng Chen Youjia Yu Qiang Ji Zhiwei Zhang Mufeng Gu Xiaojun Zhuang Xiaolin Lv Hui Wang Yanyan Pan Ling Wang Xianrong Xu Jing Zhao Xiuqin Wang Cuiping Liu Ningxia Liang Changying Xing Jiayin Liu Ningning Wang | 2022 | Journal of Molecular Cell Biology2022，14，2： | 1 |
| 5 | A Linearized Branch Flow Model Considering Line Shunts for Radial Distribution Systems and Its Application in Volt/VAr Control显示文摘When urban distribution systems are gradually modernized,the overhead lines are replaced by underground cables,whose shunt admittances can not be ignored.Traditional power flow(PF)model withπequivalent circuit shows non-convexity and long computing time,and most recently proposed linear PF models assume zero shunt elements.All of them are not suitable for fast calculation and optimization problems of modern distribution systems with non-negligible line shunts.Therefore,this paper proposes a linearized branch flow model considering line shunt(LBFS).The strength of LBFS lies in maintaining the linear structure and the convex nature after appropriately modeling theπequivalent circuit for network equipment like transformers.Simulation results show that the calculation accuracy in nodal voltage and branch current magnitudes is improved by considering shunt admittances.We show the application scope of LBFS by controlling the network voltages through a two-stage stochastic Volt/VAr control(VVC)problem with the uncertain active power output from renewable energy sources(RESs).Since LBFS results in a linear VVC program,the global solution is guaranteed.Case study exhibits that VVC framework can optimally dispatch the discrete control devices,viz.substation transformers and shunt capacitors,and also optimize the decision rules for real-time reactive power control of RES.Moreover,the computing efficiency is significantly improved compared with that of traditional VVC methods. | Hanyang Lin Firdous Ul Nazir Bikash C.Pal Ye Guo | 2023 | Journal of Modern Power Systems and Clean Energy2023，11，4： | 0 |
| 6 | Stability of stratified flow and slugging in horizontal gas-liquid flow显示文摘A transient one-dimensional two-fluid model is proposed to investigate numerically the interfacial instability and the onset of slugging for liquid-gas flow in a horizontal duct. In the present model, the effects of surface tension and transverse variations in dynamic pressure are taken into account. The evolution of interfacial disturbances is displayed and compared with the linear viscous KelvinHelmholtz stability analyses. It shows that interfacial wave is more instable due to the non-linear effect. The model predicts well the stability limit of stratified flow in comparison with the experimental data, and also automatically tracks the onset of slugging. The results show that the initiation of hydrodynamic slugging is related to local interfacial instability. Based on the cycle of slugging, a model for slug frequency is presented, which predicts the trends of slug frequencies with gas/liquid flow rate well in comparison with the available data. The effects of physical properties on slugging have been examined. It is found that with the increase in the gas viscosity and liquid density the slugging would be inhibited, whereas, with the increase in liquid viscosity and gas density, the slugging can be promoted. | GU Hanyang GUO Liejin | 2005 | Progress in Natural Science:Materials International2005，15，11： | 0 |
| 7 | The induction of PANoptosis in KRAS-mutant pancreatic ductal adenocarcinoma cells by a multispecific platinum complex显示文摘Oncogenic KRAS reprograms pancreatic ductal adenocarcinoma(PDAC) cells to a state that is awfully resistant to apoptosis.An alternative coping strategy is to trigger a nonapoptotic cell death.Herein,a multi specific platinum complex SEP was constructed by conjugating a quinone derivative seratrodast to a prodrug of cisplatin.Interestingly,SEP-treated KRAS-mutant PDAC cells showed the characteristics of pyroptosis,apoptosis and necroptosis,similar to PANoptosis(a newfound inflammatory cell death).Mechanistically,SEP could enter cancer cells effectively,then damage nuclear DNA,boost mitochondrial superoxide anion radicals and affect various signaling pathways related to redox homeostasis and tumor metabolism.To our best knowledge,SEP is the first metal complex,even small molecule,to elicit PANoptosis(pyroptosis,apoptosis and necroptosis) in cancer cells,providing a new strategy to overcome apoptotic resistance of KRAS-mutant PDAC. | Xin Yuan Shuren Zhang Xuanmeng Zhong Hao Yuan Dongfan Song Xiaoyu Wang Hanyang Yu Zijian Guo | 2022 | Science China Chemistry2022，65，10： | 0 |
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