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| 1 | Enhanced mechanical properties and degradation rate of Mg-Ni-Y alloy by introducing LPSO phase for degradable fracturing ball applications显示文摘In this work,as-cast Mg-Ni-Y alloys were proposed to develop a feasible material for fracturing balls,and their mechanical performance and corrosion behavior were systematically investigated.Long period stacking order(LPSO)phase was firstly introduced to improve both the mechanical properties and degradation rate of magnesium alloys.With the increase of LPSO phase,the compressive strength was improved significantly,while the elongation of the alloys decreased owing to the relatively brittle nature of LPSO phase.Due to the higher corrosion potential of LPSO phase,the LPSO phase can accelerate the corrosion process by providing more micro-couples.However,the LPSO phase would serve as the corrosion barrier between the corrosion medium and the matrix when the contents of LPSO phase are too high in Mg92.5Ni3Y4.5 and Mg87.5Ni5Y7.5 alloys.As-cast Mg97.5Ni1Y1.5 alloy with satisfactory mechanical properties and rapid degradation rate was successfully developed,exhibiting a high degradation rate of 6675 mm/a(93℃)in 3 wt.%KCl solution and a favorable ultimate compressive strength of 410 MPa.The degradation rate of Mg97.5Ni1Y1.5 alloy is 2-5 times of the current commercial magnesium alloy fracturing materials. | Jingfeng Wang Shiqing Gao Xiuying Liu Xing Peng Kui Wang Shijie Liu Weiyan Jiang Shengfeng Guo Fusheng Pan | 2020 | Journal of Magnesium and Alloys2020，8，1： | 13 |
| 2 | Effect of Sn addition on the mechanical properties and bio-corrosion behavior of cytocompatible Mg-4Zn based alloys显示文摘The mechanical properties and bio-corrosion behaviors of as-extruded Mg-4Zn alloys after Sn addition were investigated,systemati-cally.A small amount of Sn addition to Mg-4Zn alloy slightly improved the mechanical properties for solid solution strengthening,and significantly controlled the bio-corrosion rates.Sn participating in the outer layer film formation as SnO/SnO_(2)resisted the bio-corrosion proceeding.Especially,Mg-4Zn-1.5Sn alloy,with a weight loss rate of 0.45 mm/y and hydrogen evolution rate of 0.099 mL/cm^(2)/day,showed cytotoxicity grade of 0 to MC3T3-E1 cells.The perfect alliance of cytocompatibility,suitable mechanical properties and low bio-corrosion rate demonstrates that this Mg-4Zn-1.5Sn alloy is a promising biodegradable magnesium alloy for orthopedic implants. | Weiyan Jiang Jingfeng Wang Weikang Zhao Qingshan Liu Dianming Jiang Shengfeng Guo | 2019 | Journal of Magnesium and Alloys2019，7，1： | 6 |
| 3 | Development of a machine learning model to predict early recurrence for hepatocellular carcinoma after curative resection显示文摘Background:Early recurrence is common for hepatocellular carcinoma(HCC)after surgical resection,being the leading cause of death.Traditionally,the COX proportional hazard(CPH)models based on linearity assumption have been used to predict early recurrence,but predictive performance is limited.Machine learning models offer a novel methodology and have several advantages over CPH models.Hence,the purpose of this study was to compare random survival forests(RSF)model with CPH models in prediction of early recurrence for HCC patients after curative resection.Methods:A total of 4,758 patients undergoing curative resection from two medical centers were included.Fifteen features including age,gender,etiology,platelet count,albumin,total bilirubin,AFP,tumor size,tumor number,microvascular invasion,macrovascular invasion,Edmondson-Steiner grade,tumor capsular,satellite nodules and liver cirrhosis were used to construct the RSF model in training cohort.Discrimination,calibration,clinical usefulness and overall performance were assessed and compared with other models.Results:Five hundred survival trees were used to generate the RFS model.The five highest Variable Importance(VIMP)were tumor size,macrovascular invasion,microvascular invasion,tumor number and AFP.In training,internal and external validation cohort,the C-index of RSF model were 0.725[standard errors(SE)=0.005],0.762(SE=0.011)and 0.747(SE=0.016),respectively;the Gönen&Heller’s K of RSF model were 0.684(SE=0.005),0.711(SE=0.008)and 0.697(SE=0.014),respectively;the time-dependent AUC(2 years)of RSF model were 0.818(SE=0.008),0.823(SE=0.014)and 0.785(SE=0.025),respectively.The RSF model outperformed early recurrence after surgery for liver tumor(ERASL)model,Korean model,American Joint Committee on Cancer tumor-node-metastasis(AJCC TNM)stage,Barcelona Clinic Liver Cancer(BCLC)stage and Chinese stage.The RSF model is capable of stratifying patients into three different risk groups(low-risk,intermediate-risk,high-risk groups)in the training and two validation cohorts(all P<0.0001).A web-based prediction tool was built to facilitate clinical application(http://gffzz8caf4f582aa3478es5pk59puu0ufn65qp.ffgz.tsg.suse.edu.cn/surgery_predict/).Conclusions:The RSF model is a reliable tool to predict early recurrence for patients with HCC after curative resection because it exhibited superior performance compared with other models.This novel model will be helpful to guide postoperative follow-up and adjuvant therapy. | Jianxing Zeng Jinhua Zeng Kongying Lin Haitao Lin Qionglan Wu Pengfei Guo Weiping Zhou Jingfeng Liu | 2022 | Hepatobiliary Surgery and Nutrition2022，11，2： | 6 |
| 4 | Chinese expert consensus on conversion therapy for hepatocellular carcinoma(2021 edition)显示文摘Recent advances in systemic and locoregional treatments for patients with unresectable or advanced hepatocellular carcinoma(HCC)have resulted in improved response rates.This has provided an opportunity for selected patients with initially unresectable HCC to achieve adequate tumor downstaging to undergo surgical resection,a‘conversion therapy’strategy.However,conversion therapy is a new approach to the treatment of HCC and its practice and treatment protocols are still being developed.Review the evidence for conversion therapy in HCC and develop consensus statements to guide clinical practice.Evidence review:Many research centers in China have accumulated significant experience implementing HCC conversion therapy.Preliminary findings and data have shown that conversion therapy represents an important strategy to maximize the survival of selected patients with intermediate stage to advanced HCC;however,there are still many urgent clinical and scientific challenges for this therapeutic strategy and its related fields.In order to summarize and learn from past experience and review current challenges,the Chinese Expert Consensus on Conversion Therapy for Hepatocellular Carcinoma(2021 Edition)was developed based on a review of preliminary experience and clinical data from Chinese and non-Chinese studies in this field and combined with recommendations for clinical practice.Sixteen consensus statements on the implementation of conversion therapy for HCC were developed.The statements generated in this review are based on a review of clinical evidence and real clinical experience and will help guide future progress in conversion therapy for patients with HCC. | Hui-Chuan Sun Jian Zhou Zheng Wang Xiufeng Liu Qing Xie Weidong Jia Ming Zhao Xinyu Bi Gong Li Xueli Bai Yuan Ji Li Xu Xiao-Dong Zhu Dousheng Bai Yajin Chen Yongjun Chen Chaoliu Dai Rongping Guo Wenzhi Guo Chunyi Hao Tao Huang Zhiyong Huang Deyu Li Gang Li Tao Li Xiangcheng Li Guangming Li Xiao Liang Jingfeng Liu Fubao Liu Shichun Lu Zheng Lu Weifu Lv Yilei Mao Guoliang Shao Yinghong Shi Tianqiang Song Guang Tan Yunqiang Tang Kaishan Tao Chidan Wan Guangyi Wang Lu Wang Shunxiang Wang Tianfu Wen Baocai Xing Bangde Xiang Sheng Yan Dinghua Yang Guowen Yin Tao Yin Zhenyu Yin Zhengping Yu Bixiang Zhang Jialin Zhang Shuijun Zhang Ti Zhang Yamin Zhang Yubao Zhang Aibin Zhang Haitao Zhao Ledu Zhou Wu Zhang Zhenyu Zhu Shukui Qin Feng Shen Xiujun Cai Gaojun Teng Jianqiang Cai Minshan Chen Qiang Li Lianxin Liu Weilin Wang Tingbo Liang Jiahong Dong Xiaoping Chen Xuehao Wang Shusen Zheng Jia Fan 无 | 2022 | Hepatobiliary Surgery and Nutrition2022，11，2： | 4 |
| 5 | Influence of Ni interlayer on interfacial microstructure and mechanical properties of Ti-6Al-4V/AZ91D bimetals fabricated by a solid–liquid compound casting process显示文摘The solid–liquid compound casting of Mg-AZ91D and Ti-TC4 alloys was developed by using pure Ni electro-deposited coating.The pouring temperatures of 660℃,690℃,720℃and 750℃were chosen to investigated the effects of casting temperatures on microstructural evolution,properties,and fracture behaviors of Ni-coated TC4/AZ91D bimetals by the solid–liquid compound casting(SLCC).The scanning electron microscopy(SEM)and the energy dispersive spectroscopy(EDS)results showed that the interfacial zone mainly composed of nickel,Mg_(2)Ni and Mg-Al-Ni in the bimetals cast at 660℃.As the pouring temperature was increased to 750℃,the width of the interface zone,which mainly composed ofδ(Mg),Mg_(2)Ni,Mg-Al-Ni,Mg_(3)TiNi_(2) and Al_(3)Ni,gradually increased.The microhardness tests showed that the micro-hardness of the interface zone was smaller than that of TC4 substrate but larger than that of the cast AZ91D matrix.At the pouring temperature of 720℃,the Ni-coated TC4/AZ91D bimetals had the most typical homogeneous interface,which had granular Mg-Al-Ni ternary phase but no ribbon-like Al3Ni binary phase,and achieved the highest shear strength of 97.35MPa.Meanwhile,further fracture behavior analysis showed that most fracture failure of Ni-coated TC4/AZ91D bimetals occurred at the Mg_(2)Ni+δ(Mg)eutectic structure and Al_(3)Ni hard intermetallic. | Fulin Wen Jianhua Zhao Miaowang Yuan Jingfeng Wang Dengzhi Zheng Jinyong Zhang Ke He Jingjing Shangguan Yu Guo | 2021 | Journal of Magnesium and Alloys2021，9，4： | 3 |
| 6 | Big Data Analytics in Healthcare: Data-Driven Methods for Typical Treatment Pattern Mining显示文摘A huge volume of digitized clinical data is generated and accumulated rapidly since the widespread adoption of Electronic Medical Records (EMRs).These big data in healthcare hold the promise of propelling healthcare evolving from a proficiency-based art to a data-driven science,from a reactive mode to a proactive mode,from one-size-fits-all medicine to personalized medicine.This paper first discusses the research background-big data analytics in healthcare,the research framework of big data analytics in healthcare,analysis of medical process,and the literature summary of treatment pattern mining.Then the challenges for data-driven typical treatment pattern mining are highlighted,including similarity measure between treatment records,typical treatment pattern extraction,evaluation and recommendation,when considering the rich temporal and heterogeneous medical information in EMRs.Furthermore,three categories of typical treatment patterns are mined from doctor order content,duration,and sequence view respectively,which can provide a data-driven guideline to achieve the '5R' goal for rational drug use and clinical pathways. | Chonghui Guo Jingfeng Chen | 2019 | Journal of Systems Science and Systems Engineering2019，28，6： | 3 |
| 7 | Mining Typical Treatment Duration Patterns for Rational Drug Use from Electronic Medical Records显示文摘Rational drug use requires that patients receive medications for an adequate period of time.The adequate duration time of medications not only improve the therapeutic effect of medicines,but also reduce the side effects and adverse reactions of medicines.This paper proposes a data-driven method to mine typical treatment duration patterns for rational drug use from electronic medical records (EMRs).Firstly,a quintuple is defined to describe drug use duration statistics (DUDS) for each drug and treatment record is further represented with DUDS vector (DUDSV).Next a similarity measure method is adopted to compute the similarity between treatment records.Meanwhile,a clustering algorithm is used to cluster all patient treatment records to extract typical treatment duration patterns including typical drug sets,effective drug use day sets,and the DUDSs of each typical drug.Then the extracted typical treatment duration patterns are evaluated and annotated based on patients' demographic information,disease severity scores,treatment outcome and diagnostic information.Finally,a real-world EMR dataset is performed to indicate that the approach we proposed can effectively mine typical treatment duration patterns from EMRs and recommend the appropriate treatment regimens for patients based on their admission information. | Jingfeng Chen Chonghui Guo Leilei Sun Menglin Lu | 2019 | Journal of Systems Science and Systems Engineering2019，28，5： | 2 |
| 8 | EB病毒膜潜伏蛋白LMP-1筛选鼻咽癌的初步结果(英文)显示文摘Objective: Early diagnosis of nasopharyngeal carcinoma (NPC) is an important method to improve the survival rate.However,the sensitivity and specificity of the screening protocols which was widely used in clinic now are considered to be unsatisfactory.Epstein-Barr virus (EBV)-encoded latent membrane protein-1 (LMP-1) is one of the proteins that have been suggested to be a classic oncogene with transformation properties.The current study set out to discuss the clinical significance of LMP-1 on the screening of NPC.Methods: Three hundred patients who visited our institution (Department of Radiation Oncology,Fujian Provincial Cancer Hospital,Fuzhou,China) with ENT symptoms between 2007 and 2008 were involved in this study,and all of them were agreed to be involved in this investigation.Not only did they undergo nasopharyngeal swab to obtain cells for the LMP-1 polymerase chain reaction (PCR) analysis,but also nasopharyngeal biopsy were taken to identify the diagnosis.Results: An amount of DNA that was sufficient for PCR was extracted from 243 (81%) swab samples,the positive rate of LMP-1 of those with non-nasopharyngeal carcinoma was 3.85% (4/108),which was much lower than those with nasopharyngeal carcinoma (P < 0.05).By detecting LMP-1 in nasopharyngeal swabs,NPC was diagnosed with a sensitivity of 88.15% (119 of 135 patients),specificity of 96.30% (104 of 108 patients),a positive predictive value of 95.2% (119 of 123 patients),a negative predictive value of 86.67% (104 of 120 patients),accuracy of 91.77%,and Youden index of 84.45%.Conclusion: The nasopharyngeal swab coupled with PCR-based EBV LMP-1 detection have high sensitivity and specificity,and also good repeatability,it could serve as part of the screening program for high-risk populations. | Shaojun Lin Qiaojuan Guo Jin Lin Jingfeng Zong Lu Han Jianji Pan | 2011 | The Chinese-German Journal of Clinical Oncology2011，10，1： | 2 |
| 9 | The template-assisted zinc ion incorporation in SAPO-34 and the enhanced ethylene selectivity in MTO reaction显示文摘The SAPO-34 catalyst was fine-tuned with zinc cations through a straightforward template-assisted ion incorporation (TH) process, without the necessary template pre-removal and the preparation of NH4- SAPO-34 intermediate, which is more facile, efficient and cost-effective than the conventional ion exchange process. The template-assisted zinc cations incorporated SAPO-34 catalysts were characterized by XRD, XRF, N2 adsorption-desorption, XPS, SEM, EDX,NMR, respectively. Enhanced selectivity to ethylene and ratio of ethylene to propylene in MTO reaction are observed over the zinc cations modified SAPO-34 catalysts, due to the facilitated formation of lower methylbenzenes that favour the ethylene gen eration, as well as the increased diffusion hindrance originated from the zinc cations incorporation and the facil让ated generation of aromatics compound. | Jiawei Zhong Jingfeng Han Yingxu Wei Shutao Xu Tantan Sun Xinwen Guo Chunshan Song Zhongmin Liu | 2019 | Journal of Energy Chemistry2019，28，5： | 2 |
| 10 | RapamLycin increases pCREB, Bcl-2, and VEGF-A through ERK under normoxia显示文摘Rapamycin 可以由于它禁止 OSA 的变形行为的能力作为新 anti-osteosarcoma (OSA ) 服务代理人。然而,仅仅有限的利益在 OSA 的处理作为一个单个代理人在啮齿类动物研究和临床的 trials using rapamycin 被观察。rapamycin 的目标, rapamycin 的哺乳动物的目标有多重生物功能并且可以与 kinases 被连接调停周期的安培应答的元素绑定(CREB ) 的 phosphorylation 蛋白质,在肿瘤的一个进口因素前进。由采用 OSA 房间线 MG-63,我们调查了 rapamycin 怎么在 Ser133 和二个通常认为的 CREB 目标的表情调整 CREB (pCREB ) 的 phosphorylation, B 房间淋巴瘤 2 (Bcl-2 ) 并且脉管的 endothelial 生长因素 -- 一(VEGF -- 一) 。在 normoxia 下面,我们发现 rapamycin (100 nM ) 导致了被激活 mitogen 的蛋白质 kinase (MEK ) 阻止的 pCREB 的增加 /extracellular 调整信号的 kinase (英皇家空军之阶级最低之兵) 禁止者 U0126 或营地依赖者蛋白质 kinase (PKA ) 禁止者 H89。然而, H89 提高了 Akt phosphorylation 并且没减少在 rapamycin 处理之上的房间生存能力。相反, U0126 没提高 Akt phosphorylation 并且减少在 rapamycin 处理之上的房间生存能力。而且, U0126 阻止了 Bcl-2 和 VEGF 的导致 rapamycin 的增加 -- 一层次。在组织缺氧下面, rapamycin 有效地阻止了 pCREB, Bcl-2,和 VEGF 的导致组织缺氧的增加 -- 一。我们的学习证明 rapamycin 可能在在 normoxia 下面对待 OSA 房间是不太有效的并且在 OSA 的处理为 rapamycin 和 MEK/ERK 禁止者的联合提供基本原理。 | Yudong Liu Qixin Zheng Hongbin Wu Xiaodong Guo Jingfeng Li Shaofei Hao | 2013 | Acta Biochimica et Biophysica Sinica2013，45，4： | 1 |
| 11 | An im-proved algorithm for mining closegraph 显示文摘 | Zou Xiaohong Chen Xiao Guo Jingfeng | 2010 | ICIC ExpressLetters2010，4，4： | 1 |
| 12 | Relationships between in-flight particle characteristics and properties of HVOF sprayed WC-CoCr coatings显示文摘 | Xueping Guo Marie-Pierre Planche Jingfeng Chen | 2014 | J Mater Process Technol2014，214，： | 1 |
| 13 | Clinical application of local ultrasound hyperthermia combined with systemic chemotherapy in oral maxillofacial-head and neck malignant tumors显示文摘 | Guoxin Ren Wei Guo Yazhu Chen Guofeng Shen Dongxia Ye Jingfeng Bai | 2008 | 中国口腔颌面外科杂志2008，6，B05： | 1 |
| 14 | Study on the effects of the different polar group of EPA-enriched phospholipids on the proliferation and apoptosis in 95D cells显示文摘EPA-enriched phosphatidylcholine(EPA-PC)and EPA-enriched phosphatidylethanolamine(EPA-PE)are newly identified marine phospholipids.The polar group of phospholipids is known to influence EPA-phospholipid activity.However,the differences in anti-tumor effects between EPA-PC and EPA-PE have not been reported.In this study,we evaluated the effects of two forms of EPA on the proliferation and apoptosis in the lung-cancer cell line 95D as well as possible molecular mechanisms.Our results showed that EPA-PC effectively inhibited proliferative activity and promoted apoptosis of 95D cells in a dose-dependent manner,while EPA-PE had no effect on cell proliferation,although it slightly promoted apoptosis.Western blot results showed that EPA-PC and EPA-PE upregulated the expression of PPARy,RXRoc,and PTEN,and downregulated the PI3K/AKT signaling pathway.Furthermore,EPA-PC and EPA-PE induced the expression of the pro-apoptotic gene,Bax,and reduced the expression of the anti-apoptotic gene,Bcl-xl.Additionally,EPA-PC and EPA-PE promoted the release of cytochrome c and activated the apoptotic enzyme-cleaved caspase-3.These data suggest that the anti-tumor effect of EPA-phospholipids may be exerted via a PPARy-related mechanism.EPA-PC was more efficacious as compared to EPA-PE,which might be due to the different polar groups of phospholipids. | Yao Guo Qin Zhao Yingying Tian Yuanyuan Liu Ziyi Yan Changhu Xue Jingfeng Wang | 2021 | Marine Life Science & Technology2021，3，4： | 1 |
| 15 | Structural performance of blind bolted end plate joints to concrete-filled thin-walled steel tubular columns显示文摘 | Jingfeng Wang Shuiping Guo | 2012 | Thin-Walled Structures2012，，： | 1 |
| 16 | An advanced algorithm of frequent subgraph mining based on ADI 显示文摘 | Zou Xiaohong Zhao Li Guo Jingfeng | 2009 | ICIC Express Letters2009，3，3： | 1 |
| 17 | Impact of photogenerated charge behaviors on luminescence of Eu^(3+) -incorporated microporous titanosilicate ETS-10显示文摘A series of Eu3+ -incorporated ETS-10 samples were successfully prepared based on the traditional ion exchange method. The relationship between photogenerated charge behaviors and luminescent properties has been investigated in detail. It has been demonstrated that as a result of the charge transfer from the titanate quantum wires to Eu3+ crystal field states, the host matrix ETS-10 functions as the sensitizer of Eu3+ to enhance the red luminescence, while Eu3+ cations contribute to the recombination of photogenerated charges. The behavior of photogenerated charges has significant impact on the luminescent properties of Eu3+ -incorporated ETS-10 materials. | GUO XingXing WEI Xiao WANG KaiXue WANG JingFeng CHEN JieSheng | 2013 | Science China Chemistry2013，56，4： | 1 |
| 18 | An Advanced Algorithm of Frequent Subgraph Mining Based on ADI显示文摘 | Zou Xiaohong Zhao Li Guo Jingfeng | 2009 | ICIC Express Letters2009，3，3： | 1 |
| 19 | Memory Safety Based on Probabilistic Memory Allocation显示文摘Some unsafe languages,like C and C++,let programmers maximize performance but are vulnerable to memory errors which can lead to program crashes and unpredictable behavior.Aiming to solve the problem,traditional memory allocating strategy is improved and a new probabilistic memory allocation technology is presented.By combining random memory allocating algorithm and virtual memory,memory errors are avoided in all probability during software executing.By replacing default memory allocator to manage allocation of heap memory,buffer overflows and dangling pointers are prevented.Experiments show it is better than Diehard of the following aspects:memory errors prevention,performance in memory allocation set and ability of controlling working set.So probabilistic memory allocation is a valid memory errors prevention technology and it can tolerate memory errors and provide probabilistic memory safety effectively. | Xue Jingfeng Hu Changzhen Guo Xiaojing Leng Bingxing Ma Rui | 2012 | China Communications2012，9，4： | 0 |
| 20 | Multiple charge ion beam generation with a 2.45 GHz electron cyclotron resonance ion source显示文摘Multiple charge ions (MCIs) are necessary for increasing the output energy of particles in accelerators. In general, MCI beams are largely produced by electron beam ion source (EBIS) [1], laser ion source (LIS) [2], or high-frequency (mostly >5 GHz) electron cyclotron resonance (ECR) ion source [3]. Among these, only ECR ion source can operate in the continuous wave (CW) mode, while EBIS and LIS only support pulses. In addition, ECR ion source with lower frequency (mostly 2.45 GHz) are required primarily for generating single charge state ions, because the corresponding ECR field (875 Gs) is not sufficiently strong for MCI generation [4]. | Yuan Xu ShiXiang Peng HaiTao Ren JiaMei Wen AiLin Zhang Tao Zhang JingFeng Zhang WenBin Wu ZhiYu Guo JiaEr Chen | 2017 | Science China(Physics,Mechanics & Astronomy)2017，60，6： | 0 |
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