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| 1 | Chinese Society of Clinical Oncology (CSCO) diagnosis and treatment guidelines for persistent/recurrent and metastatic differentiated thyroid cancer 2018 (English version)显示文摘Contents1. Diagnosis and dynamic assessment of persistent/recurrent and metastatic differentiated thyroid cancer (prmDTC)1.1 Basic principles of diagnosis1.2 Diagnostic methods1.3 Ongoing assessment of response to therapy2. Multidisciplinary treatment of prmDTC2.1 Basic principles of treatment2.2 Surgical management2.2.1 Preoperative clinical assessment2.2.2 Principles of surgical treatment for prmDTC. | Yansong Lin Huiqiang Huang Ye Guo Libo Chen | 2019 | Chinese Journal of Cancer Research2019，31，1： | 11 |
| 2 | First light of the 1.8-m solar telescope–CLST显示文摘Large-aperture solar telescopes play an important role in solar observations and research,and require high temporal and spatial resolution[1].To solve some fundamental problems such as the solar dynamo,coronal heating,and the triggering of major solar eruptions,the spatial resolution for solar-atmosphere observation should reach at least 0.1 arcsec[2]. | ChangHui Rao NaiTing Gu XueJun Rao Cheng Li LanQiang Zhang JinLong Huang Lin Kong Ming Zhang YunTao Cheng Yi Pu Hua Bao YouMing Guo YangYi Liu JinSheng Yang LiBo Zhong ChangJun Wang Kai Fang XiaoJun Zhang DongHong Chen Cheng Wang XinLong Fan ZhiWu Yan KeLe Chen XiYa Wei Lei Zhu Hong Liu YongJian Wan Hao Xian WenLi Ma | 2020 | Science China(Physics,Mechanics & Astronomy)2020，63，10： | 6 |
| 3 | Adaptive optics based on machine learning: a review显示文摘Adaptive optics techniques have been developed over the past half century and routinely used in large ground-based telescopes for more than 30 years.Although this technique has already been used in various applications,the basic setup and methods have not changed over the past 40 years.In recent years,with the rapid development of artificial in-telligence,adaptive optics will be boosted dramatically.In this paper,the recent advances on almost all aspects of adapt-ive optics based on machine learning are summarized.The state-of-the-art performance of intelligent adaptive optics are reviewed.The potential advantages and deficiencies of intelligent adaptive optics are also discussed. | Youming Guo Libo Zhong Lei Min Jiaying Wang Yu Wu Kele Chen Kai Wei Changhui Rao | 2022 | Opto-Electronic Advances2022，5，7： | 6 |
| 4 | The enhanced protective effects of salvianic acid A: A functionalized nanoparticles against ischemic stroke through increasing the permeability of the blood-brain barrier显示文摘Ischemic stroke is the leading cause of disability and death worldwide. Currently, the only proven treatment for ischemic stroke is restoring the cerebral blood supply. In addition, some of the tissue is damaged during the subsequent reperfusion because of the overproduction of reactive oxygen species (ROS). Furthermore, antioxidant therapies have shown promise in preclinical studies for the treatment of ischemia-reperfusion injury. However, their therapeutic efficacy has been limited because of their low bioavailability in brain. To resolve this issue, we synthesized ROS-responsive, fan-shaped dendrimer nanoparticles (NPs) and conjugated them with a blood-brain barrier (BBB)-targeting peptide, COG1410, and salvianic acid A (SA), which is an effective antioxidant in ischemic stroke. The BBB targeting peptide acts as a ligand of the nanocarrier system and penetrates the BBB through the endocytosis of the ligand receptor. The results showed that T-SA-NPs not only target and accumulate in the infarct area, they also reduce over 2 times of the infarct area and reverse the behavioral deficits in MCAO mice, which illustrates that these NPs have an effective therapeutic effect on the ischemic stroke. In addition, these NPs had no toxicity in any organs of the body. Importantly, the present study provides an alternative strategy for delivering antioxidants to the brain and achieving targeted therapy of ischemic stroke. | Yaru Li Xiaojie Zhang Zhifeng Qi Xueling Guo Xiaopeng Liu Wenjuan Shi Yang Liu Libo Du | 2020 | Nano Research2020，13，10： | 4 |
| 5 | 3D bioprinting of a biomimetic meniscal scaffold for application in tissue engineering显示文摘Appropriate biomimetic scaffolds created via 3D bioprinting are promising methods for treating damaged menisci.However,given the unique anatomical structure and complex stress environment of the meniscus,many studies have adopted various techniques to take full advantage of different materials,such as the printing combined with infusion,or electrospining,to chase the biomimetic meniscus,which makes the process complicated to some extent.Some researchers have tried to tackle the challenges only by 3D biopringting,while its alternative materials and models have been constrained.In this study,based on a multilayer biomimetic strategy,we optimized the preparation of meniscus-derived bioink,gelatin methacrylate(GelMA)/meniscal extracellular matrix(MECM),to take printability and cytocompatibility into account together.Subsequently,a customized 3D bioprinting system featuring a dual nozzle+multitemperature printing was used to integrate the advantages of polycaprolactone(PCL)and meniscal fibrocartilage chondrocytes(MFCs)-laden GelMA/MECM bioink to complete the biomimetic meniscal scaffold,which had the best biomimetic features in terms of morphology and components.Furthermore,cell viability,mechanics,biodegradation and tissue formation in vivo were performed to ensure that the scaffold had sufficient feasibility and functionality,thereby providing a reliable basis for its application in tissue engineering. | Zhou Jian Tian Zhuang Tian Qinyu Peng Liqing Li Kun Luo Xujiang Wang Diaodiao Yang Zhen Jiang Shuangpeng Sui Xiang Huang Jingxiang Liu Shuyun Hao Libo Tang Peifu Yao Qi Guo Quanyi | 2021 | Bioactive Materials2021，6，6： | 3 |
| 6 | EAST-Educational Adaptive-optics Solar Telescope显示文摘For the public having a better understanding of solar activities,the Educational Adaptive-optics Solar Telescope(EAST)was built in July 2021 and is located at the Shanghai Astronomy Museum.The EAST consists of a 65 cm aperture solar telescope with a 177-element adaptive optics system and two-channel high resolution imaging system at the Hαand TiO bands,in addition to three full disk solar telescopes at CaK,Hαand TiO bands equipped on the tube of the main telescope.In this paper,the configuration of the EAST is described.Its performance and on-sky observational results are presented.The EAST,to our knowledge,is the most advanced solar telescope for the popularization of science in the world.Due to its excellent performance,the data acquired by the EAST can also be used for research on solar physics and space weather prediction. | Changhui Rao Xuejun Rao Zhimao Du Hua Bao Cheng Li Jinlong Huang Youming Guo Libo Zhong Qing Lin Xin Ge Jinsheng Yang Xinlong Fan Yangyi Liu Dan Jia Xin Li Mei Li Ming Zhang Yuntao Cheng Jiahui Zhou Jiawen Yao Lanqiang Zhang Naiting Gu | 2022 | Research in Astronomy and Astrophysics2022，22，6： | 3 |
| 7 | First light of solar multi-conjugate adaptive optics at the 1-m new vacuum solar telescope显示文摘Observations play a leading role in any branches of astronomy,including solar physics.In order to solve fundamental problems,such as solar dynamo[1],coronal heating[2]and the triggering of major solar eruptions[3],solar observations with spatial resolution better than 0.1 arcsec are required.Such a goal cannot be achieved without the help of adaptive optics(AO),which eliminates the wavefront distortion caused by atmosphere turbulence[4,5].However,solar observations are performed over an extended field of | ChangHui Rao LanQiang Zhang Lin Kong YouMing Guo XueJun Rao Hua Bao Lei Zhu LiBo Zhong | 2018 | Science China(Physics,Mechanics & Astronomy)2018，61，8： | 2 |
| 8 | Application of Microwave Melting for the Recovery of Tin Powder显示文摘 | Lei Xu Jinhui Peng Hailong Bai C. Srinivasakannan Libo Zhang Qingtian wu Zhaohui Han Shenghui Guo Shaohua Ju Li Yang | 2017 | Engineering2017，3，3： | 2 |
| 9 | Hybrid Dirac semimetal-based photodetector with efficient low-energy photon harvesting显示文摘Despite the considerable effort,fast and highly sensitive photodetection is not widely available at the low-photon-energy range(~meV)of the electromagnetic spectrum,owing to the challenging light funneling into small active areas with efficient conversion into an electrical signal.Here,we provide an alternative strategy by efficiently integrating and manipulating at the nanoscale the optoelectronic properties of topological Dirac semimetal PtSe_(2)and its van der Waals heterostructures.Explicitly,we realize strong plasmonic antenna coupling to semimetal states near the skin-depth regime(λ/10^(4)),featuring colossal photoresponse by in-plane symmetry breaking.The observed spontaneous and polarization-sensitive photocurrent are correlated to strong coupling with the nonequilibrium states in PtSe_(2)Dirac semimetal,yielding efficient light absorption in the photon range below 1.24 meV with responsivity exceeding∼0.2 A/W and noise-equivalent power(NEP)less than~38 pW/Hz^(0.5),as well as superb ambient stability.Present results pave the way to efficient engineering of a topological semimetal for high-speed and low-energy photon harvesting in areas such as biomedical imaging,remote sensing or security applications. | Lin Wang Li Han Wanlong Guo Libo Zhang Chenyu Yao Zhiqingzi Chen Yulu Chen Cheng Guo Kaixuan Zhang Chia-Nung Kuo Chin Shan Lue Antonio Politano Huaizhong Xing Mengjie Jiang Xianbin Yu Xiaoshuang Chen Wei Lu | 2022 | Light(Science & Applications)2022，11，3： | 2 |
| 10 | In situ atomic-scale observation of dislocation behaviors in twin-structured Pt nanocrystals显示文摘The deformation mechanisms of twin-structured metallic materials have attracted great interest.Though previous theoretical predictions have suggested that the repulsive force of the twin boundary(TB)can significantly affect the deformation of twinstructured metals,it remains unclear whether this prediction applies to experimental conditions.In this paper,the atomic-scaled deformation process of twin-structured Pt nanocrystals was in situ observed using our home-made device in a high-resolution transmission electron microscope.We have shown that the plastic deformation of the twin-structured Pt nanocrystals was governed by full dislocation generation as well as Lomer dislocation(LD)lock formation and destruction.After LD locks were destructed,these full dislocations tended to move towards the surface of the nanocrystals.The findings revealed that due to the ultra-high repulsive force of TB on dislocation,there was no dislocation-TB reaction during the deformation.These findings can enrich our understanding of the dislocation behaviors of twin-structured nanocrystals. | GUO YiZhong SUN Tao FU LiBo HAO LongHu HUANG Ming WEI RuJian LUO JunFeng HE Xin WANG XingQuan XIONG XiaoDong WANG LiHua HAN XiaoDong | 2021 | Science China(Technological Sciences)2021，64，3： | 2 |
| 11 | Determination of trace amount of antimony by adsorption voltammetry on carbon paste electrode显示文摘 | Guo Huishi Xiao Pengfeng Nie Libo | 2004 | Journal of Southeast University2004，，： | 1 |
| 12 | Ground-layer adaptive optics for the New Vacuum Solar Telescope:Instrument description and first results显示文摘Ground-layer adaptive optics(GLAO)has shown its potential for use in solar observation owing to its wide field-of-view(FOV)correction.A high-order GLAO system that consists of a multiple direction Shack-Hartmann wavefront sensor(WFS),a realtime controller with a multi-CPU processor,and a 151-element deformable mirror was developed for the 1-m New Vacuum Solar Telescope at Yunnan Observatories,Chinese Academy of Sciences.A hexagonal microlens with 9×8 subapertures is employed in the WFS.The detection FOV is 42′′×37′′,in which 9(3×3)guide regions are extracted for multiple direction wavefront sensing with a frame rate of up to 2200 Hz.To our knowledge,this is the first professional solar GLAO system used as a regularly operating instrument for scientific observations.Its installation and adjustment were performed in the summer of 2021.In this article,a detailed account of the GLAO system and its first light results and a comprehensive analysis of the performance of the GLAO system are provided.The results show that this system can effectively improve the imaging quality after compensating for the wavefront aberration due to ground-layer turbulence. | Lanqiang Zhang Hua Bao Xuejun Rao Youming Guo Libo Zhong Xian Ran Nanfei Yan Jinsheng Yang Cheng Wang Jiahui Zhou Ying Yang Yunyao Long Xinlong Fan Zhongyi Feng Donghong Chen Changhui Rao | 2023 | Science China(Physics,Mechanics & Astronomy)2023，66，6： | 1 |
| 13 | Charmless Decays and Effects of NewStrong and Electroweak Penguins in Topcolor-assisted Technicolor Model显示文摘 | Z J Xiao W J Li Libo Guo and G R Lu | 2001 | Eur Phys J2001，18，： | 1 |
| 14 | 3D-printed cell-free PCL-MECM scaffold with biomimetic micro-structure and micro-environment to enhance in situ meniscus regeneration显示文摘Despite intensive effort was made to regenerate injured meniscus by cell-free strategies through recruiting endogenous stem/progenitor cells,meniscus regeneration remains a great challenge in clinic.In this study,we found decellularized meniscal extracellular matrix(MECM)preserved native meniscal collagen and glycosaminoglycans which could be a good endogenous regeneration guider for stem cells.Moreover,MECM significantly promoted meniscal fibrochondrocytes viability and proliferation,increased the expression of type II collagen and proteoglycans in vitro.Meanwhile,we designed 3D-printed polycaprolactone(PCL)scaffolds which mimic the circumferential and radial collagen orientation in native meniscus.Taken these two advantages together,a micro-structure and micro-environment dually biomimetic cell-free scaffold was manipulated.This cell-free PCL-MECM scaffold displayed superior biocompatibility and yielded favorable biomechanical capacities closely to native meniscus.Strikingly,neo-menisci were regenerated within PCL-MECM scaffolds which were transplanted into knee joints underwent medial meniscectomy in rabbits and sheep models.Histological staining confirmed neo-menisci showed meniscus-like heterogeneous staining.Mankin scores showed PCL-MECM scaffold could protect articular cartilage well,and knee X-ray examination revealed same results.Knee magnetic resonance imaging(MRI)scanning also showed some neo-menisci in PCL-MECM scaffold group.In conclusion,PCL-MECM scaffold appears to optimize meniscus regeneration.This could represent a promising approach worthy of further investigation in preclinical applications. | Weimin Guo Mingxue Chen Zhenyong Wang Yue Tian Jinxuan Zheng Shuang Gao Yangyang Li Yufeng Zheng Xu Li Jingxiang Huang Wei Niu Shuangpeng Jiang Chunxiang Hao Zhiguo Yuan Yu Zhang Mingjie Wang Zehao Wang Jiang Peng Aiyuan Wang Yu Wang Xiang Sui Wenjing Xu Libo Hao Xifu Zheng Shuyun Liu Quanyi Guo | 2021 | Bioactive Materials2021，6，10： | 1 |
| 15 | Kinetics and equilibrium adsorption study of lead(II) onto the low cost adsorbent— Eupatorium adenophorum spreng显示文摘 | Shenghui Guo Wei Li Libo Zhang Jinhui Peng Hongying Xia Shiming Zhang | 2009 | Process Safety and Environmental Protection2009，，5： | 1 |
| 16 | Controllable growth of type-II Dirac semimetal PtTe2 atomic layer on Au substrate for sensitive room temperature terahertz photodetection显示文摘Platinum telluride(PtTe_(2)),a member of metallic transition metal dichalcogenides,provides a new platform for investigating various properties such as type-II Dirac fermions,topological superconductivity,and wide-band photodetection.However,the study of PtTe_(2)is largely limited to exfoliated flakes,and its direct synthesis remains challenging.Herein,we report the controllable synthesis of highly crystalline 2D PtTe_(2)crystals with tunable morphology and thickness via chemical vapor deposition(CVD)growth on Au substrate.By adjusting Te amount and substrate temperature,anisotropic and isotropic growth modes of PtTe_(2)were realized on the solid and molten Au substrates,respectively.The domain size of PtTe_(2)crystal was achieved up to 30μm,and its thickness can be tuned from 5.6 to 50 nm via controlling the growth time.Furthermore,a metal–PtTe_(2)–metal structural device was fabricated to validate the wide-band terahertz(THz)photodetection from 0.04 to 0.3 THz at room temperature.Owing to the high crystallinity of PtTe_(2)crystal,the photodetector acquires high responsivity(30–250 mA W-1 from 0.12 to 0.3 THz),fast response rate(rise time:7μs,decay time:8μs),and high-quality imaging ability.Our work demonstrates the feasibility for realistic exploitation of high-performing photodetection system at THz band based on the CVDgrown 2D Dirac semimetal materials. | Yang Yang Kaixuan Zhang Libo Zhang Guo Hong Chao Chen Hongmei Jing Jiangbo Lu Peng Wang Xiaoshuang Chen Lin Wang Hua Xu | 2021 | InfoMat2021，3，6： | 1 |
| 17 | Immunosenescence:molecular mechanisms and diseases显示文摘Infection susceptibility,poor vaccination efficacy,age-related disease onset,and neoplasms are linked to innate and adaptive immune dysfunction that accompanies aging(known as immunosenescence).During aging,organisms tend to develop a characteristic inflammatory state that expresses high levels of pro-inflammatory markers,termed inflammaging.This chronic inflammation is a typical phenomenon linked to immunosenescence and it is considered the major risk factor for age-related diseases.Thymic involution,naïve/memory cell ratio imbalance,dysregulated metabolism,and epigenetic alterations are striking features of immunosenescence.Disturbed T-cell pools and chronic antigen stimulation mediate premature senescence of immune cells,and senescent immune cells develop a proinflammatory senescence-associated secretory phenotype that exacerbates inflammaging.Although the underlying molecular mechanisms remain to be addressed,it is well documented that senescent T cells and inflammaging might be major driving forces in immunosenescence.Potential counteractive measures will be discussed,including intervention of cellular senescence and metabolic-epigenetic axes to mitigate immunosenescence.In recent years,immunosenescence has attracted increasing attention for its role in tumor development.As a result of the limited participation of elderly patients,the impact of immunosenescence on cancer immunotherapy is unclear.Despite some surprising results from clinical trials and drugs,it is necessary to investigate the role of immunosenescence in cancer and other age-related diseases. | Zaoqu Liu Qimeng Liang Yuqing Ren Chunguang Guo Xiaoyong Ge Libo Wang Quan Cheng Peng Luo Yi Zhang Xinwei Han | 2023 | Signal Transduction and Targeted Therapy2023，8，6： | 1 |
| 18 | Charmless Decays B→PP,PV and Effects of New Strong and Electroweak Penguins in Topeolor-assisted Technicolor Model显示文摘 | Xiao Z J Li W J Guo Libo Lu G R | 2001 | Eur Phys J2001，18，： | 1 |
| 19 | Ultra-high strength yet superplasticity in a hetero-grain-sized nanocrystalline Au nanowire显示文摘Nanocrystalline metals often display a high strength up to the gigapascal level,yet they suffer from poor plasticity.Previous studies have shown that the development of hetero-sized grains can efficiently overcome the strength-ductility trade-off of nanocrystalline metals.However,whether this strategy can lead to the fabrication of nanocrystalline nanowires exhibiting both high strength and superplasticity is unclear,similar to the atomistic deformation mechanism.In this paper,we show that ultra-small nanocrystalline Au nanowires comprising grains in both the Hall–Petch and inverse Hall–Petch grain-size regions can exhibit extremely high uniform elongation(236%)and high strength(2.34 gigapascals)at room temperature.In situ atomic-scale observations revealed that the plastic deformation underwent two stages.In the first stage,the super-elongation ability originated from the intergrain plasticity of small grains via mechanisms such as grain boundary migration and grain rotation.This intergrain plasticity caused the grains in the heterogeneous-structured nanowires to grow very large.In the second stage,the superelongation ability originated from intragrain plasticity accompanied by the diffusion of surface atoms.Our results show that the hetero-grain-sized nanocrystalline nanowires,comprising grains with sizes both in the strongest Hall–Petch effect region and the inverse Hall–Petch effect region,were simultaneously ultrastrong and ductile.They displayed neither a strength-ductility trade-off nor plastic instability. | Libo Fu Deli Kong Chengpeng Yang Jiao Teng Yan Lu Yizhong Guo Guo Yang Xin Yan Pan Liu Mingwei Chen Ze Zhang Lihua Wang Xiaodong Han | 2022 | Journal of Materials Science & Technology2022，，6： | 1 |
| 20 | Differential expression of PTEN in hepatic tissue and hepatic stellatecells during rat liver fibrosis and its reversal显示文摘 | Libo Zheng Xiuli Chen Jinbo Guo Huicong Sun Lei Liu David Shih Xiaolan Zhang | 2012 | International Journal of Molecular Medicine2012，，6： | 1 |
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