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| 1 | Deoxynivalenol accumulation and detoxification in cereals and its potential role in wheat-Fusarium graminearum interactions显示文摘Deoxynivalenol(DON)is a prominent mycotoxin showing significant accumulation in cereal plants during infection by the phytopathogen Fusarium graminearum.It is a virulence factor that is important in the spread of F.graminearum within cereal heads,and it causes serious yield losses and significant contamination of cereal grains.In recent decades,genetic and genomic studies have facilitated the characterization of the molecular pathways of DON biosynthesis in F.graminearum and the environmental factors that influence DON accumulation.In addition,diverse scab resistance traits related to the repression of DON accumulation in plants have been identified,and experimental studies of wheat–pathogen interactions have contributed to understanding detoxification mechanisms in host plants.The present review illustrates and summarizes the molecular networks of DON mycotoxin production in F.graminearum and the methods of DON detoxification in plants based on the current literature,which provides molecular targets for crop improvement programs.This review also comprehensively discusses recent advances and challenges related to genetic engineering-mediated cultivar improvements to strengthen scab resistance.Furthermore,ongoing advancements in genetic engineering will enable the application of these molecular targets to develop more scab-resistant wheat cultivars with DON detoxification traits. | Kun Luo Jiao Guo Dejia He Guangwei Li Thérèse Ouellet | 2023 | aBIOTECH2023，4，2： | 2 |
| 2 | 术中应用荧光素钠有利于胶质母细胞瘤浸润边缘的手术切除(英文)显示文摘Objective Extent of resection is an important prognostic factor in patients undergoing surgery for glioblastoma( GBM).Recent evidence suggests that intravenously administered fluorescein sodium associates with tumor tissue,facilitating safe maximal resection of GBM. In this study,the authors evaluate the safety and utility of intraoperative fluorescein guidance for the prediction of histopathological alteration both in the contrast-enhancing( CE) regions,where this relationship has been established,and into the nonCE( NCE),diffusely infiltrated margins. Methods Thirty-two patients received fluorescein sodium( 3 mg/kg) intravenously prior to resection. Fluorescence was intraoperatively visualized using a Zeiss Pentero surgical microscope equipped with a YELLOW 560 filter.Stereotactically localized biopsy specimens were acquired from CE and NCE regions based on preoperative MRI in conjunction with neuronavigation. The fluorescence intensity of these specimens was subjectively classified in real time with subsequent quantitative image analysis,histopathological evaluation of localized biopsy specimens,and radiological volumetric assessment of the extent of resection.Results Bright fluorescence was observed in all GBMs and localized to the CE regions and portions of the NCE margins of the tumors,thus serving as a visual guide during resection. Gross-total resection( GTR) was achieved in 84% of the patients with an average resected volume of 95%,and this rate was higher among patients for whom GTR was the surgical goal( GTR achieved in 93. 1% of patients,average resected volume of 99. 7%). Intraoperative fluorescein staining correlated with histopathological alteration in both CE and NCE regions,with positive predictive values by subjective fluorescence evaluation greater than 96% in NCE regions. Conclusions Intraoperative administration of fluorescein provides an easily visualized marker for glioma pathology in both CE and NCE regions of GBM. These findingssupport the use of fluorescein as a microsurgical adjunct for guiding GBM resection to facilitate safe maximal removal. | Neira JA Ung TH Sims J Malone HR Chow DS Samanamud JL Zanazzi GJ Guo X Bowden SG Zhao B Sheth SA McKhann GM 2nd Sisti MB Canoll P D'Amico RS Bruce JN | 2016 | 中华神经外科疾病研究杂志2016，15，5： | 2 |
| 3 | Further Remarks on Rates of Stretch Tensors显示文摘 | Guo Z H Lehmann Th Liang H | 1991 | Transactions of the CSME1991，15，2： | 1 |
| 4 | Identification of a human brain- specific isoform of mammalian STE20-like kinase 3 that is regulated by cAMP-dependent protein kinase显示文摘 | Zhou TH Ling K Guo J | 2000 | J Biol Chem2000，275，： | 1 |
| 5 | Implantation of neurotrophic factor-treated sensory nerve graft enhances survival and axonal regeneration of motoneurons after spinal root avulsion 显示文摘 | CHU TH LI SY GUO A | 2009 | Neuropathol Exp Neurol2009，68，1： | 1 |
| 6 | The diagnosis and prognosis of endometrial atypital hyperplasia and complex hyperplasia of generational women显示文摘 | GUO LN LIAN LJ LIU TH | 1993 | Chinese Journal of Obstetrics and Gynecology1993，28，12： | 1 |
| 7 | Pharma- cogenomic analysis reveals improved virologic response in all IL-28B genotypes in naive genotype 1 chronic HCV patients treated with GI-5005 therapeutic vaccine plus PEG-IFN/ ribavirin 显示文摘 | McHutchison JG Thompson AJ Jacobson IM Boyer TD Schiff ER Everson GT Vierling JM Shiffman ML Brown RS Di Bisceglie AM Gordon SC Lee WM Guo Z King TH Armstrong B Rodell TC Apelian D | 2010 | J Heoatol2010，52，： | 1 |
| 8 | Mossy fiber sprouting, hippocampal damage and spontaneous recurrent seizures in pentylenetetrazole kindling rat model 显示文摘 | Tian FF Zeng C Guo TH | 2009 | Acta Neurol Belg2009，109，4： | 1 |
| 9 | Quercetin-containing self-nanoemulsifying drug delivery system for improving oral bioavailability显示文摘 | Tran TH Guo Y Song D | 2014 | J Pharm Sci2014，103，3： | 1 |
| 10 | Mitochondrial DNA sequence variation of Japanese anchovy Engraulis japonicus from the Yellow Sea and East China Sea 显示文摘 | Yu ZN Kong XY Guo TH Jiang YY Zhuang ZM Jin XS 2005 | 2005 | Fish Sci2005，71，： | 1 |
| 11 | GDNF-treated acellular nerve graft promotes motoneuron axon regeneration after implantation into cervical root avulsed spinal cord显示文摘 | Chu TH Wang L Guo A | 2012 | Neuropath Appl Neuro2012，38，： | 1 |
| 12 | Discussion of radical operation method for osmidrosis显示文摘 | Jiang XL Tong TH Guo L | 2005 | Chinese J of Medical Aesthetic &Cosmetic2005，11，3： | 1 |
| 13 | The gennme of the mesopolyploid crop species Brassica rapa 显示文摘 | Wang X Wang H Wang J Sun R Wu J Liu S Bai Y Mun JH Bancroft I Cheng F Huang S Li X Hua W Wang J Wang X Freeling M Pires JC Paterson AH Chalhoub B Wang B Hayward A Sharpe AG Park BS Weisshaar B Liu B Li B Liu B Tong C Song C Duran C Peng C Geng C Koh C Lin C Edwards D Mu D Shen D Soumpourou E Li F Fraser F Conant G Lassalle G King G J Bonnema G Tang H Wang H Belcram H Zhou H Hirakawa H Abe I-I Guo H Wang H Jin H Parkin IA Batley J Kim JS Just J l i J Xu J Deng J Kim JA Li J Yu J Meng J Wang J Min J Poulain J Wang J Hatakeyama K Wu K Wang L Fang L Trick M Links MG Zhao M Jin M Ramchiary N Drou N Berkman PJ Cai Q Huang Q Li R Tabata S Cheng S Zhang S Zhang S Huang S Sato S Sun S Kwon SJ Choi SR Lee TH Fan W Zhao X Tan X Xu X Wang Y Qiu Y Yin Y l i Y Du Y Liao Y Lira Y Narusaka Y Wang Y Wang Z Li Z Wang Z Xiong Z Zhang Z Brassica rapa Genome Sequencing Project Consortium | 2011 | Nature Genetics2011，43，10： | 1 |
| 14 | GDNF - treated acellularnerve graft promotes motoneuron axon regeneration after im-plantation into cervical root avulsed spinal cord 显示文摘 | Chu TH Wang L Guo A | 2012 | Neuro-pathology and applied neurobiology2012，38，7： | 1 |
| 15 | Mossy fiber sprouting, hippoeampal damage and spontaneous recurrent seizures in pentylenetetrazole kindling rat model 显示文摘 | Tian FF Zeng C Guo TH | 2009 | Aeta Neurol Belg2009，109，4： | 1 |
| 16 | Enhanced ethanol production by fermentation office straw hydrolysate without detoxi? cation using a newly adapted strain ofPichia stipitis 显示文摘 | Huang CF Lin TH Guo GL | 2009 | Bioresource Technology2009，100，17： | 1 |
| 17 | Preparation and swellingproperties of crosslinkedsodiumpolyacrylate显示文摘 | LiuMZ Guo TH | 2001 | J Appl PolymSci2001，82，： | 1 |
| 18 | Comparison of friction force between corroded and noncorroded titanium nitride plating of metal brackets 显示文摘 | Kao CT Guo JU Huang TH | 2011 | Am J Orthod Dentofacial Orthop2011，139，5： | 1 |
| 19 | Basic study and clinical application of umbilical cord blood:An uptake显示文摘 | Qian ZM Guo TH Wang W | 2002 | Chin J Int Med2002，41，8： | 1 |
| 20 | GDNF-treated acellular nerve graft promotes motoneuron axon regeneration after implantation into cervi- cal root avulsed spinal cord 显示文摘 | Chu TH Wang L Guo A | 2012 | Neuropathology and applied neurobi- ology2012，38，7： | 1 |
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