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| 1 | Essential roles of exosome and circRNA_101093 on ferroptosis desensitization in lung adenocarcinoma显示文摘Background:Resistance to ferroptosis,a regulated cell death caused by irondependent excessive accumulation of lipid peroxides,has recently been linked to lung adenocarcinoma(LUAD).Intracellular antioxidant systems are required for protection against ferroptosis.The purpose of the present studywas to investigate whether and how extracellular system desensitizes LUAD cells to ferroptosis.Methods:Established human lung fibroblasts MRC-5,WI38,and human LUAD H1650,PC9,H1975,H358,A549,and H1299 cell lines,tumor and matched normal adjacent tissues of LUAD,and plasma from healthy individuals and LUAD patients were used in this study.Immunohistochemistry and immunoblotting were used to analyze protein expression,and quantitative reverse transcription-PCR was used to analyze mRNA expression.Cell viability,cell death,and the lipid reactive oxygen species generationwere measured to evaluate the responses to ferroptosis.Exosomes were observed using transmission electron microscope.The localization of arachidonic acid(AA)was detected using click chemistry labeling followed by confocal microscopy.Interactions between RNAs and proteins were detected using RNA pull-down,RNA immunoprecipitation and photoactivatable ribonucleoside-enhanced crosslinking and immunoprecipitation methods.Proteomic analysis was used to investigate RNA-regulated proteins,and metabolomic analysis was performed to analyze metabolites.Cellderived xenograft,patient-derived xenograft,cell-implanted intrapulmonary LUAD mouse models and plasma/tissue specimens from LUAD patients were used to validate the molecular mechanism.Results:Plasma exosome from LUAD patients specifically reduced lipid peroxidation and desensitized LUAD cells to ferroptosis.A potential explanation is that exosomal circRNA_101093(cir93)maintained an elevation in intracellular cir93 in LUAD to modulate AA,a poly-unsaturated fatty acid critical for ferroptosisassociated increased peroxidation in the plasma membrane.Mechanistically,cir93 interacted with and increased fatty acid-binding protein 3(FABP3),which transported AA and facilitated its reaction with taurine.Thus,global AA was reduced,whereas N-arachidonoyl taurine(NAT,the product of AA and taurine)was induced.Notably,the role of NAT in suppressing AA incorporation into the plasma membrane was also revealed.In pre-clinical in vivo models,reducing exosome improved ferroptosis-based treatment.Conclusion:Exosome and cir93 are essential for desensitizing LUAD cells to ferroptosis,and blocking exosome may be helpful for future LUAD treatment. | Xiao Zhang Yunhua Xu Lifang Ma Keke Yu Yongjie Niu Xin Xu Yi Shi Susu Guo Xiangfei Xue Yikun Wang Shiyu Qiu Jiangtao Cui Hong Wang Xiaoting Tian Yayou Miao Fanyu Meng Yongxia Qiao Yongchun Yu Jiayi Wang | 2022 | Cancer Communications2022，42，4： | 10 |
| 2 | Cross-Scale Synthesis of Organic High-k Semiconductors Based on Spiro-Gridized Nanopolymers显示文摘High dielectric constants in organic semiconductors have been identified as a central challenge for the improvement in not only piexoelectric,preolecric,and freeltric efcts but also photoclecric conversion eficiency in OPVs,carrier mobility in OFETS,and charge density in charge-trapping memories.Herein,we report an ultralong persistence length(≈41 nm)efet of spiro-fused organic nanopolymers on dielectric properties,together with excitonic and charge carrier behaviors.The state-of-the-art nanopolymers,namely,nanopolyspirogrids(NPSGs),are synthesized via the simple crossscale Friedel-Crafts polygridlization of AjB-type nanomonomers.The high dielectric constant(k=8.43)of NPSG is firstly achieved by locking spiro-polygridization efect that results in the enhancement of dipole polarization.When doping into a polystyrene-based dielectric layer,such a high-k feature of NPSG increases the feld-ffct carrier mobility from 0.20 to 0.90cm^(2)Vl s'in pentacene OFET devices.Meanwhile,amorphous NPSG film exhibits an ultralow energy disorder(<50 meV)for an exellent zero-field hole mobility of 3.94×10^(-1)cm^(2)V^(-1)s^(-1).surpassing most of the amorphousπconjugated polymers Onganic nanopolymers with high dielectric constants open a new way to break through the bottleneck of eficiency and multifunctionality in the blueprint of the fourth generation semiconductors. | Dongqing Lin Wenhua Zhang Hang Yin Haixia Hu Yang Li He Zhang Le Wang Xinmiao Xie Hongkai Hu Yongxia Yan Haifeng Ling Jin'an Liu Yue Qian Lei Tang Yongxia Wang Chaoyang Dong Linghai Xie Hao Zhang Shasha Wang Ying Wei Xuefeng Guo Dan Lu Wei Huang | 2022 | Research2022，，2： | 3 |
| 3 | A comprehensive review of medical image enhancement technologies显示文摘Image enhancement plays an important role in many applications of medical imaging.Image enhancement technologies can improve the qualities of medical images with low contrast and high level noise by stretching contrast,suppressing noise and so on.Such images processed by image enhancement technologies are helpful to doctors in analyses and diagnoses.In this paper,we present a technical review of various existing image enhancement methodologies which are often employed. | ZHANG Yongxia GUO Fenghua ZHAO Guoling LIU Qian ZHANG Xin | 2012 | Computer Aided Drafting,Design and Manufacturing2012，22，3： | 2 |
| 4 | Lin28 promotes Her2 expression and Lin28/Her2 predicts poorer survival in gastric cancer显示文摘 | Qinchuan Wang Jichun Zhou Jufeng Guo Rongyue Teng Jianguo Shen Yasheng Huang Shuduo Xie Qun Wei Wenhe Zhao Wenjun Chen Xiaoming Yuan Yongxia Chen Linbo Wang | 2014 | Tumor Biology2014，，11： | 1 |
| 5 | The feasibility of synthetic surfactant as an air entraining agent for the cement matrix 显示文摘 | Ouyang Xinping Guo Yongxia Qiu Xueqing | 2008 | Construction and Building Materials2008，，22： | 1 |
| 6 | Endothelial progenitor cells derived from CD34+ cells formcooperative vascular networks 显示文摘 | Guo Sufen Cheng Yongxia Ma Ying | 2010 | Cell Physiol Biochem2010，26，45： | 1 |
| 7 | Isolation of trichogin, an antifungal protein from fresh fruiting bodies of the edible mushroom Tricholoma giganteum显示文摘 | GUO Yongxia WANG Hexiang NG T B | 2005 | Peptides2005，26，4： | 1 |
| 8 | The feasibility of synthetic surfactant as an air entraining agent for the cement matrix 显示文摘 | Xinping Ouyang Yongxia Guo Xueqing Qiu | 2008 | Construction and Building Materials2008，22，： | 1 |
| 9 | The feasibility of synthetic surfactant as an air entraining agent for the cement matrix 显示文摘 | Xinping Ouyang Yongxia Guo Xueqing Qiu | 2008 | Construction and Building Materials2008，，22： | 1 |
| 10 | The feasibili- ty of synthetic surfactant as an air entraining agent for the cement matrix显示文摘 | Ouyang Xinping Guo Yongxia Qiu Xueqing | 2008 | Constr Build Mater2008，22，8： | 1 |
| 11 | The feasibility of synthetic surfactant as an air entraining agent for the cement matrix显示文摘 | XinpingOuyang Yongxia Guo Xueqing Qiu | 2008 | Construction and Building Materials2008，，22： | 1 |
| 12 | Research on Crowdsourcing Price Game Model in Crowd Sensing显示文摘Crowd-Sensing is an innovative data acquisition method that combines the perception of mobile devices with the idea of crowdsourcing.It is a new application mode under the development of the Internet of Things.The perceptual data that mobile users can provide is limited.Multiple crowdsourcing parties will share this limited data,but the cost that the crowdsourcing party can pay is limited,and enough mobile users are needed to complete the perceptual task,making the group wisdom is really played.In this process,there is bound to be a game between the crowds and the mobile users.Most of the existing researches consider a group-aware system.A group of mobile users will directly share or compete for the opportunity of the crowd-holders to do tasks and get paid,the behavior of multiple crowd-source parties,and their bilateral interaction with mobile users.The research is not clear enough and there is no targeted research.This paper will model and analyze the dynamic evolution process of crowd sensing perception.Based on the unique characteristics of crowd-source non-cooperative game and crowd-sourced Nash equilibrium,we will develop a perceptual plan for mobile users and use the stability analysis of iterative algorithms to explore a way to better match the capabilities of mobile users and the needs of crowdsourced parties.Our theoretical analysis and simulation results verify the dynamic evolution model of crowdsourcing in group perception and propose a method to improve the efficiency of crowdsourcing. | Weijin Jiang Xiaoliang Liu Dejia Shi Junpeng Chen Yongxia Sun Liang Guo | 2021 | Computers, Materials & Continua2021，，8： | 0 |
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