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| 1 | Superhydrophobic modification of ceramic membranes for vacuum membrane distillation显示文摘The hydrophobically modi fied ceramic membranes have great potential for energy-ef ficient membrane distillation.In this work,flat-sheet ceramic membranes with a superhydrophobic surface were fabricated by grafting 1H,1H,2H,2H-per fluorooctyltrichlorosilane or 1H,1H,2H,2H-per fluorodecyltriethoxysilane and followed by ultraviolet irradiation.The surface water contact angle was improved from 46° of original ceramic membrane to 159°,which exhibited a stable and excellent superhydrophobic effect.The modi fied membranes showed a high flux of 27.28 kg·m^(-2)·h^(-1) and simultaneously maintained an excellent retention rate of 99.99%,when used in vacuum membrane distillation process for treatment of a 1 wt% NaCl(75 °C) aqueous solution.These results suggested that superhydrophobic modi fication of ceramic surface is a facile and cost-effective way to achieve higher membrane distillation performance.The superhydrophobically-modi fied ceramic membrane with an excellent desalination capacity would show considerable potential in practical membrane distillation utilizations. | Yanhui Yang Qianqian Liu Haizhi Wang Fusheng Ding Guoshan Jin Chunxi Li Hong Meng | 2017 | Chinese Journal of Chemical Engineering2017，25，10： | 9 |
| 2 | Experimental observation of coherent interaction between laser and erbium ions ensemble doped in fiber at sub 10 mK显示文摘Rare-earth ions doped in solid-state materials are considered promising candidates for quantum information applications,especially for photonic quantum memory.Among them,erbium ions doped in an optical fiber have attracted a lot of attentions due to their ability to provide efficient photon-atom interaction on a telecom-C band compatible transition.The coherent photon-atom interaction,which is crucial for quantum memory,has not yet been investigated for erbium ions doped in fiber at the temperature of sub 10 m K with the magnetic environment.In this paper,we experimentally observe optical nutation,which results from the coherent interaction between laser and erbium ions ensemble,in a piece of 9.5-m-long fiber with the erbium concentration of 200 ppm.We also extract the transition dipole moment from the results of optical nutation and further investigate its dependence on laser wavelength and magnetic field.A transition dipole moment of(3.424±0.019)×10^-32 C·m is obtained at the wavelength of 1537 nm and magnetic field of 0.2 T.Our results could pave the way for realizing solid-state quantum networks at telecom-C band. | Qi XI Shihai WEI Chenzhi YUAN Xueying ZHANG You WANG Haizhi SONG Guangwei DENG Bo JING Daniel OBLAK Qiang ZHOU | 2020 | Science China(Information Sciences)2020，63，8： | 3 |
| 3 | Targeting lactate dehydrogenase A (LDHA) exerts antileukemic effects on T-cell acute lymphoblastic leukemia显示文摘Background:T-cell acute lymphoblastic leukemia(T-ALL)is an uncommon and aggressive subtype of acute lymphoblastic leukemia(ALL).In the serum of T-ALL patients,the activity of lactate dehydrogenase A(LDHA)is increased.We proposed that targeting LDHA may be a potential strategy to improve T-ALL outcomes.The current study was conducted to investigate the antileukemic effect of LDHA gene-targeting treatment on T-ALL and the underlying molecular mechanism.Methods:Primary T-ALL cell lines Jurkat and DU528 were treated with the LDH inhibitor oxamate.MTT,colony formation,apoptosis,and cell cycle assays were performed to investigate the effects of oxamate on T-ALL cells.Quantitative real-time PCR(qPCR)and Western blotting analyses were applied to determine the related signaling pathways.A mitochondrial reactive oxygen species(ROS)assay was performed to evaluate ROS production after T-ALL cells were treated with oxamate.A T-ALL transgenic zebrafish model with LDHA gene knockdown was established using CRISPR/Cas9 gene-editing technology,and then TUNEL,Western blotting,and T-ALL tumor progression analyses were conducted to investigate the effects of LDHA gene knockdown on T-ALL transgenic zebrafish.Results:Oxamate significantly inhibited proliferation and induced apoptosis of Jurkat and DU528 cells.It also arrested Jurkat and DU528 cells in G0/G1 phase and stimulated ROS production(all P<0.001).Blocking LDHA significantly decreased the gene and protein expression of c-Myc,as well as the levels of phosphorylated serine/threonine kinase(AKT)and glycogen synthase kinase 3 beta(GSK-3β)in the phosphatidylinositol 3′-kinase(PI3K)signaling pathway.LDHA gene knockdown delayed disease progression and down-regulated c-Myc mRNA and protein expression in T-ALL transgenic zebrafish.Conclusion:Targeting LDHA exerted an antileukemic effect on T-ALL,representing a potential strategy for T-ALL treatment. | Haizhi Yu Yafei Yin Yifang Yi Zhao Cheng Wenyong Kuang Ruijuan Li Haiying Zhong Yajuan Cui Lingli Yuan Fanjie Gong Zhihua Wang Heng Li Hongling Peng Guangsen Zhang | 2020 | Cancer Communications2020，40，10： | 2 |
| 4 | Bank consolidation and new business formation 显示文摘 | Bill Francis Iftekhar Hasan Haizhi Wang | 2008 | Journal of Banking & Finance2008，，32： | 1 |
| 5 | The Role and Mechanism of Unfolded Protein Response Pathway in Tumor Drug Resistance显示文摘In the process of tumor proliferation and metastasis,tumor cells encounter hypoxia,low glucose,acidosis,and other stressful environments.These conditions prompt tumor cells to generate endoplasmic reticulum stress(ERS).As a signal mechanism that mitigates ERS in eukaryotic cells,the unfolded protein response(UPR)pathway can activate cells and tissues,regulating pathological activities in various cells,and maintaining ER homeostasis.It forms the most crucial adaptive and defensive mechanism for cells.However,under the continuous influence of chemotherapy drugs,the quantity of unfolded proteins and erroneous proteins produced by tumor cells significantly increases,surpassing the normal regulatory range of UPR.Consequently,ERS fails to function properly,fostering tumor cell proliferation and the development of drug resistance.This review delves into the study of three UPR pathways(PERK,IRE1,and ATF6),elucidating the mechanisms of drug resistance and research progress in the signal transduction pathway of UPR related to cancers.It provides a profound understanding of the role and relationship between UPR and anti-tumor drugs,offering a new direction for effective clinical treatment. | Yaqi Han Bingjuan Zhou Haizhi Qiao Lingyan Wang Jinku Zhang | 2023 | Proceedings of Anticancer Research2023，7，6： | 0 |
| 6 | Macrophage CCL22 Secretion Under Hypoxic Conditions Promotes the Metastasis of Triple-Negative Breast Cancer显示文摘Objective:To explore the mechanism by which macrophages secrete CCL22 to promote the metastasis of triple-negative breast cancer under hypoxic conditions.Methods:20 ng/mL mass concentration of phorbol 12-myristate 13-acetate(PMA)cell culture medium,4′,6-diamidino-2-phenylindole(DAPI),dimethyl sulfoxide(DMSO),trypsin digestion solution,CCL18 Kit,Interleukin(IL)-10 Kit,CCL17 Kit,CCL22 Kit,TRIzol^(TM)Reagent Reverse Transcriptase Polymerase Chain Reaction(RT-PCR)Kit,triple-negative breast cancer cells MDA-MB-231 and BT-549,as well as other reagents were used to culture triple-negative breast cancer(TNBC)cells MDA-MB-231 and BT-549 as well as human mononuclear cells THP-1,analyze and observe the metastasis of triple-negative breast cancer cells to the lungs,the secretion of CCL22,the migration of triple-negative breast cancer,and the situation of CCR4.Results:Compared with normal tumor-associated macrophage(TAM),hypoxic TAM further promoted the migration of tumor cells.The number of tumor metastases in the lungs,induced by hypoxic TAM,was significantly higher than that of normoxic TAM.Hypoxia can significantly stimulate the expression of CCL22.CCL22 can significantly promote the migration of MDA-MB-231 and BT-549 cells.The expressions of CCR3,CCR4,and CCR5 in tumor tissues were significantly increased compared with normal tissues,in which CCR4 showed the most significant increase.Conclusion:TAM cultured under hypoxia significantly enhanced the migration ability of TNBC cells and promoted the metastasis of cancer cells to the lungs in vivo.The hypoxic condition induced TAM to secrete CCL22;the expression of CCL22 receptor,CCR4,in breast cancer tissues was significantly higher than that in normal tissues. | Wenming Zhao Bingjuan Zhou Jirui Sun Haizhi Qiao Jinmei Li Qiushuang Ma Xu Wang Jinku Zhang | 2022 | Proceedings of Anticancer Research2022，6，6： | 0 |
| 7 | Hertz-rate metropolitan quantum teleportation显示文摘Quantum teleportation can transfer an unknown quantum state between distant quantum nodes,which holds great promise in enabling large-scale quantum networks.To advance the full potential of quantum teleportation,quantum states must be faithfully transferred at a high rate over long distance.Despite recent impressive advances,a high-rate quantum teleportation system across metropolitan fiber networks is extremely desired.Here,we demonstrate a quantum teleportation system which transfers quantum states carried by independent photons at a rate of 7.1±0.4 Hz over 64-km-long fiber channel.An average single-photon fidelity of≥90.6±2.6%is achieved,which exceeds the maximum fidelity of 2/3 in classical regime.Our result marks an important milestone towards quantum networks and opens the door to exploring quantum entanglement based informatic applications for the future quantum internet. | Si Shen Chenzhi Yuan Zichang Zhang Hao Yu Ruiming Zhang Chuanrong Yang Hao Li Zhen Wang You Wang Guangwei Deng Haizhi Song Lixing You Yunru Fan Guangcan Guo Qiang Zhou | 2023 | Light(Science & Applications)2023，12，6： | 0 |
| 8 | Effect of oxygen precipitates in solar grade silicon on minority carrier lifetime and efficiency of solar cells显示文摘The effect of oxygen precipitates on minority carrier lifetime and performance of solar cell was studied by means of Fourier Transform Infrared Spectroscopy (FTIR), quasi-steady state photoconductance (QSSPCD), optical microscope, spectrum response and solar cell efficiency test. The minority carrier lifetime and performance of solar cell reduced depend on oxygen precipitates. A few of oxygen precipitates have formed after single-step annealing; and they do not impact the efficiency dramatically. Pre-annealing at 650 ℃ for 4 h enhances the oxygen precipitation when it is subjected to middle temperature annealing. The solar cells performance decayed sharply. Especially annealing at 950 ℃ for 3 h, the Vos and Isc of cells decrease 12% and 25% respectively. Few oxygen precipitates have formed in silicon after high temperature annealing at about 1050 ℃ whether pre-annealing is used or not, and the performance of cells is not be affected. | SUN Haizhi LIU Caichi HAO Qiuyan WANG Lijian | 2006 | Rare Metals2006，25，z1： | 0 |
| 9 | Mechanism of Ginsenoside Rh1 in Regulating Breast Cancer Cell Extravasation Based on CCL20- CCR6显示文摘Objective:To explore the regulatory mechanism of ginsenoside Rh1 on breast cancer cell extravasation based on CCL20-CCR6.Methods:In 2021,a total of 34 patients with breast cancer were treated in Baoding First Central Hospital.During hospitalization,pathological examinations were performed,and all the patients were diagnosed with invasive ductal carcinoma.Out of the 34 cases,16 cases were found to have CCR6 expression in breast cancer tissues,in which they were recorded as the CCR6 expression group,whereas 18 cases did not have CCR6 expression;these cases were recorded as the CCR6 non-expression group.During the same period,21 normal patients were selected as the control group.The peripheral blood CCL20 level and the expression of CCR6 on the surface of CD3+T lymphocytes were analyzed.The extracts of cancer cells were collected,purified,and cultured,and the effect of ginsenoside Rh1 on the invasion and metastasis of breast cancer cells was analyzed.Results:The peripheral blood CCL20 level in the CCR6 expression group was significantly higher than that in the CCR6 non-expression group and the control group,in which p<0.05,indicating that the difference was statistically significant;at 12,24,and 48 hours,the cell survival rate of each dose group was significantly higher than that of the blank control group and the dimethyl sulfoxide(DMSO)group(p<0.05).At 48 hours,comparing the low-dose group with the high-dose group,the cell survival rate significantly decreased(p<0.05).Compared with the blank control group and DMSO group,the invasion ability of breast cancer cells could be reduced in both,high-and medium-dose groups,where p<0.05,indicating that the difference was statistically significant.Conclusion:CCL20 may play a role in the pathogenesis of certain breast cancers,and ginsenoside Rh1 can effectively regulate the invasion and migration of breast cancer cells. | Wenming Zhao Binjuan Zhou Jirui Sun Haizhi Qiao Jinmei Li Shuangqiu Ma Xu Wang Jinku Zhang | 2022 | Proceedings of Anticancer Research2022，6，5： | 0 |
| 10 | Spectrally multiplexed indistinguishable single-photon generation at telecom-band显示文摘Heralded single-photon source(HSPS)intrinsically suffers from the trade-off between the heralded single-photon rate and the single-photon purity.To break through this trade-off,one can apply multiplexing technology in different degrees of freedom that significantly improves the performance of the HSPS.Here,we propose a 1.5μm chip-scale HSPS on lithium niobate on insulator by employing spectral multiplexing and active feedforward spectral manipulating,and we demonstrate a proof-of-principle experiment with discrete fiber-based components.With continuous-wave laser pumping and three spectral modes multiplexed,our experimental results show that the spectral multiplexing improves the heralded single-photon rate by near threefold while keeping the g^((2))(0)as low as 0.0006±0.0001 at a measured single-photon rate of 3.1 kHz.By measuring the joint spectral intensity,we show that the spectral multiplexing and feed-forward control effectively erase the frequency correlation of photon pairs.Moreover,we implement the Hong-Ou-Mandel interference between the spectrally multiplexed single photons and photons from an independent weak coherence source,which indicates that the multiplexed single photons are highly indistinguishable after the spectral manipulation.Our results pave a way for on-chip scalable and high-performance HSPS with spectral multiplexing toward deterministic single-photon emission. | HAO YU CHENZHI YUAN RUIMING ZHANG ZICHANG ZHANG HAO LI YOU WANG GUANGWEI DENG LIXING YOU HAIZHI SONG ZHIMING WANG GUANG-CAN GUO QIANG ZHOU | 2022 | Photonics Research2022，10，6： | 0 |
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