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| 1 | 蛋白酶激活受体2在载脂蛋白E缺陷小鼠的血管炎症和动脉粥样硬化中发挥关键作用显示文摘凝血系统与血管炎症密切相关,尽管其潜在机制仍不清楚。最近的研究结果表明,蛋白酶激活受体(protease-activated receptor,PAR)2——活化因子X(activated factor X,FXa)的主要受体之一——在血管细胞和白细胞中均有表达,这提示PAR-2可能参与炎症性疾病的发病机制。 | Hara T Phuong PT Fukuda D Yamaguchi K Murata C Nishimoto S Yagi S Kusunose K Yamada H Soeki T Wakatsuki T Imoto I Shimabukuro M Sata M 刘青 叶鹏 | 2018 | 中华高血压杂志2018，26，6： | 11 |
| 2 | Significance of postoperative follow-up of patients with metastatic colorectal cancer using circulating tumor DNA显示文摘BACKGROUND One of the most notable applications for circulating tumor DNA(ctDNA)detection in peripheral blood of patients with metastatic colorectal cancer(mCRC)is a long-term postoperative follow-up.Sometimes referred to as a“liquid(re)biopsy”it is a minimally invasive procedure and can be performed repeatedly at relatively short intervals(months or even weeks).The presence of the disease and the actual extent of the tumor burden(tumor mass)within the patient’s body can be monitored.This is of particular importance,especially when evaluating radicality of surgical treatment as well as for early detection of disease progression or recurrence.AIM To confirm the radicality of surgery using ctDNA and compare available methods for detection of recurrence in metastatic colorectal cancer.METHODSA total of 47 patients with detected ctDNA and indications for resection of mCRC were enrolled in the multicenter study involving three surgical centers.Standard postoperative follow-ups using imaging techniques and the determination of tumor markers were supplemented by ctDNA sampling.In addition to the baseline ctDNA testing prior to surgery,a postoperative observation was conducted by evaluating ctDNA presence up to a week after surgery and subsequently at approximately three-month intervals.The presence of ctDNA was correlated with radicality of surgical treatment and the actual clinical status of the patient.RESULTS Among the monitored patients,the R0(curative)resection correlated with postoperative ctDNA negativity in 26 out of 28 cases of surgical procedures(26/28,93%).In the remaining cases of R0 surgeries that displayed ctDNA,both patients were diagnosed with a recurrence of the disease after 6 months.In 7 patients who underwent an R1 resection,4 ctDNA positivities(4/7,57%)were detected after surgery and associated with the confirmation of early disease recurrence(after 3 to 7 months).All 15 patients(15/15,100%)undergoing R2 resection remained constantly ctDNA positive during the entire follow-up period.In 22 cases of recurrence,ctDNA positivity was detected 22 times(22/22,100%)compared to 16 positives(16/22,73%)by imaging methods and 15 cases(15/22,68%)of elevated tumor markers.CONCLUSION ctDNA detection in patients with mCRC is a viable tool for early detection of disease recurrence as well as for confirmation of the radicality of surgical treatment. | Lucie Benešová Tereza Hálková Renata Ptáčková Anastasiya Semyakina Kateřina Menclová JiříPudil Miroslav Ryska Miroslav Levý JaromírŠimša Filip Pazdírek JiříHoch Milan Blaha Marek Minárik | 2019 | World Journal of Gastroenterology2019，25，48： | 3 |
| 3 | 遗传性肥胖与心房颤动的关系显示文摘观察性研究已经确定了体质量指数(body mass index,BMI)与心房颤动之间的关联。然而,从观察性研究中推断因果关系会受到混杂因素、逆因果关系和偏倚的影响。该研究的主要目的是应用BMI的遗传学预测因子评估BMI与心房颤动之间的因果关系。方法:纳入1987-2002年期间在美国、冰岛和荷兰实施的7个前瞻性人群队列研究中基线无心房颤动的欧洲血统个体51 646人, | 刘莉 叶鹏 Chatterjee NA Giulianini F Geelhoed B Lunetta KL Misialek JR Niemeijer MN Rienstra M Rose LM Smith AV Arking DE Ellinor PT Heeringa J Lin H Lubitz SA Soliman EZ Verweij N Alonso A Benjamin EJ Gudnason V Stricker BH van der Harst P Chasman DI Albert CM | 2017 | 中华高血压杂志2017，25，2： | 2 |
| 4 | Transcriptional co-activator PGC-1α drives the formation of slow-twitch muscle fibres 显示文摘 | Lin J Wu H Tarr PT | 2002 | Nature2002，418，6899： | 1 |
| 5 | Shooting and bouncing rays: calculating the RCS of an arbitrarily shaped cavity 显示文摘 | Ling H Chou Pt C Lee S W | 1989 | IEEE Transactions on Antennas and Propagation1989，37，2： | 1 |
| 6 | Recognition of HLA-A3 and HLA-A11 by KIR3DL2 is peptide-specific显示文摘 | Hansasuta PT Dong H Thananchai M | 2004 | Eur J Immunol2004，34，6： | 1 |
| 7 | Apoptosis in human term placenta显示文摘 | Mari PT Voravit S Kat hleen H | 2000 | Gynecol Obstet Invest2000，50，88： | 1 |
| 8 | Schistosoma mansoni genome project: an update显示文摘 | LoVerde PT Hirai H Merricka JM | 2004 | Parasitol Int2004，53，2： | 1 |
| 9 | Extracorporeal Life Support Registry Report2004显示文摘 | Conrad SA Rycus PT Dalton H | 2005 | ASAIO J2005，51，： | 1 |
| 10 | A left nonrecurrent inferior laryngealnerve in a patient with right-sided aorta,truncus rteriossus communis and anaberrant left innominate artery显示文摘 | Fellmer PT Bohner H Wolf A | 2010 | Thyroid2010，18，6： | 1 |
| 11 | HMGB1 activates nuclear factor -kappaB signaling by RAGE and in- creases the production of TNF - alpha in human um- bilical vein endothelial ceils 显示文摘 | Luan ZG Zhang H Yang PT | 2010 | Immunobiology2010，215，12： | 1 |
| 12 | Cleavage of proBDNF by tPA/plasmin is essential forlong-term hippocampal plasticity 显示文摘 | PANG PT TENG H K ZAITSEV E | 2004 | Science2004，306，5695： | 1 |
| 13 | The liver receptor homolog -1 regulates estrogen receptor expression in breast cancer cells 显示文摘 | Thiruchelvam PT Lai CF Hua H | 2011 | Breast Cancer Res Treat2011，127，2： | 1 |
| 14 | Toll-like receptor triggering of a vitamin D-mediated human antimicrobial response 显示文摘 | Liu PT Stenger S Li H | 2006 | Science2006，311，： | 1 |
| 15 | Association between complement factor H and proteoglycans in early human coronary atherosclerotic lesions: implications for local regulation of complement activation 显示文摘 | Oksjoki R Jarva H Kovanen PT | 2003 | Arterioscler Thromb Vasc Biol2003，23，4： | 1 |
| 16 | Toll-like receptor triggering of a vitamin D-mediated human antimicrobial response 显示文摘 | Liu PT Stenger S Li H | 2006 | Science2006，311，5768： | 1 |
| 17 | Biometry and primary angle-closure glaucoma among Chi- nese,white, and black populations 显示文摘 | Congdon NG Youlin Q Quigley H Hung PT Wang TH Ho TC et a/ | 1997 | Ophthalmology1997，104，9： | 1 |
| 18 | Toll-like receptor triggering of a vitamin D mediated human antimicrobial response显示文摘 | Liu PT Stenger S Li H | 2006 | Science2006，311，5768： | 1 |
| 19 | Group B streptococcal disease in infants:a case control study显示文摘 | Health PT Balfour GF Tighe H | 2009 | Arch Dis Child2009，94，： | 1 |
| 20 | Hydrogen production by sorption-enhanced steam reforming of glycerol显示文摘 | DouB L DupontV RickettG BlakemanN Williams PT Chen H S Ding Y | 2009 | Bioresource Technology2009，100，： | 1 |
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