|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Nicotine attenuates beta-amyloid-induced neurotoxicity by regulating metal homeostasis.显示文摘 | Zhang J Liu Q Chen Q Liu NQ Li FL Lu ZB Qin C Zhu H Huang YY He W Zhao BL | 2006 | 中国生物学文摘2006，20，9： | 17 |
| 2 | Prevention of oxidative injury by flavonoids from stems and leaves of Scutellaria baicalensis Georgi in PC12 cells.显示文摘 | Shang YZ Qin BW Cheng JJ Miao H | 2006 | 中国生物学文摘2006，20，10： | 9 |
| 3 | Mechanosignaling activation of TGFβmaintains intervertebral disc homeostasis显示文摘Intervertebral disc(IVD) degeneration is the leading cause of disability with no disease-modifying treatment.IVD degeneration is associated with instable mechanical loading in the spine, but little is known about how mechanical stress regulates nucleus notochordal(NC) cells to maintain IVD homeostasis. Here we report that mechanical stress can result in excessive integrin α_vβ_6-mediated activation of transforming growth factor beta(TGFβ), decreased NC cell vacuoles, and increased matrix proteoglycan production, and results in degenerative disc disease(DDD). Knockout of TGFβ type II receptor(TβRII) or integrin α_v in the NC cells inhibited functional activity of postnatal NC cells and also resulted in DDD under mechanical loading.Administration of RGD peptide, TGFβ, and α_vβ_6-neutralizing antibodies attenuated IVD degeneration. Thus,integrin-mediated activation of TGFβ plays a critical role in mechanical signaling transduction to regulate IVD cell function and homeostasis. Manipulation of this signaling pathway may be a potential therapeutic target to modify DDD. | Qin Bian Lei Ma Amit Jain Janet L Crane Khaled Kebaish Mei Wan Zhengdong Zhang X Edward Guo Paul D Sponseller Cheryle A Seguin Lee H Riley Yongjun Wang Xu Cao | 2017 | Bone Research2017，5，1： | 9 |
| 4 | 东方蜜蜂高效的卫生行为机制对于西方蜜蜂抗病育种的启示显示文摘西方蜜蜂(Apismellifera)在世界各地大范围的蜂群损失现象已引起科学界和公众的广泛关注,其健康状况与东方蜜蜂(Apis cerana)相比明显较劣。东方蜜蜂群内可检测到的病原体和寄生虫相对较少,即它们对于生物威胁具有更强的抵抗力,即便是面对异种入侵的新病原(如蜜蜂残翅病毒)。 | Lin Z Page P Li L Qin Y Zhang Y Hu F Neumann P Zheng H Dietemann V 蔺哲广 郑火青 胡福良 | 2016 | 中国蜂业2016，67，12： | 5 |
| 5 | A novel membrane-dependent on/off switch mechanism of talin FERM domain at sites of cell adhesion显示文摘heterodimeric 的激活(α /β) 由 cytosolic 蛋白质 talin 的 integrin transmembrane 受体为调整多样的 cell-adhesion-dependent 过程是关键的包括血凝结,改变的组织,和癌症转移。这进程被 talin (talin-FERM ) 的 N 终端 FERM (four-point-one-protein/ezrin/radixin/moesin ) 领域的重合的绑定触发到内部膜表面和 integrin β细胞质的尾巴,但是这些有约束力的事件怎么空间与时间地被调整,仍然保持阴暗。这里,我们报导休眠 talin 的水晶结构,揭示怎么一个 C 终端 talin 杆片断(talin-RS ) 自我面具经由一个大接口的 talin-FERM 上的一个关键 integrin 有约束力的地点。出人意料地,结构也在静电地妨碍 talin-FERM 绑定到膜的 talin-RS 上揭示不同否定地控告的表面。为 talin 的如此的双禁止的拓扑学与生物化学、功能的数据一致,但是与一个以前的模型显著地不同。我们与 phosphotidylinositol-4,5-bisphosphate (PIP2 ) 在丰富之上显示出那 - 已知的 talin 使活跃之物,膜强烈在 talin-FERM 上吸引断然控告的表面并且同时在 talin-RS 上排斥否定地控告的表面。如此的静电的 “ pull-push”过程支持 talin-FERM 的双抑制的消除,它不同于经典 “位的 clash”为常规导致 PIP2 的 FERM 领域激活当模特儿。这些数据因此解开膜依赖者 FERM 领域规定的一种新类型并且说明它怎么调停 talin 开/关换到调整 integrin transmembrane 发信号和房间粘附。 | Xianqiang Song Jun Yang Jamila Hirbawi Sheng Ye H Dhanuja Perera Esen Goksoy Pallavi Dwivedi Edward F Plow Rongguang Zhang Jun Qin | 2012 | Cell Research2012，22，11： | 5 |
| 6 | Efficacy of folic acid supplementation in stroke prevention:a meta-analysis显示文摘 | Wang X Qin X Demirtas H | | The Lancet0，，： | 4 |
| 7 | Vitamin C Enhances the Generation of Mouse and Human Induced Pluripotent Stem Cells显示文摘 | Miguel Angel Esteban Tao Wang Baoming Qin Jiayin Yang Dajiang Qin Jinglei Cai Wen Li Zhihui Weng Jiekai Chen Su Ni Keshi Chen Yuan Li Xiaopeng Liu Jianyong Xu Shiqiang Zhang Feng Li Wenzhi He Krystyna Labuda Yancheng Song Anja Peterbauer Susanne Wolbank H | 2010 | Cell Stem Cell2010，，： | 3 |
| 8 | Fen1 mutations that specifically disrupt its interaction ~vith PCNA cause aneuploidy-associated cancer显示文摘 | Li Zheng Huifang Dai Muralidhar L Hegde Mian Zhou Zhigang Guo Xiwei Wu Jun Wu Lei Su Xueyan Zhong Sankar Mitra Qin Huang Kemp H Kernstine Gerd P Pfeifer Binghui Shen | 2011 | Cell Research2011，21，7： | 3 |
| 9 | Single Nucleotide Polymorphism rs10919543 in FCGR2A/ FCGR3A Region Confers Susceptibility to Takayasu Arteritis in Chinese Population显示文摘 | Fang Qin Hu Wang Lei Song Xi-Li Lu Li-Rui Yang Er-Peng Liang Wei Wang Yu-Bao Zou Jin Bian Hai-Ying Wu Xian-Liang Zhou Ru-Tai Hui H ui--Min Zhang Xiong-Jing Jiang | 2016 | Chinese Medical Journal2016，，7： | 2 |
| 10 | Research on Service Life Prediction Model of Concrete Structure of Sea-crossing Bridge显示文摘According to the chloride corrosion environment,service life prediction model of concrete structure of sea-crossing bridge was built using modified Fick's second law and the whole probability calculation method,which was suitable for China. Furthermore,a visual service life prediction program of concrete structure was developed by optimized Monte Carlo method. Meanwhile,Life 365 program was compared,indicating reliability of the prediction program. Finally,the validity of prediction model was verified in JinTang Bridge of Zhoushan Island Mainland Linkage Project. | WANG C J ZHANG G Z LIU K X TU L Q LI J H QIN M Q | 2010 | 武汉理工大学学报2010，32，17： | 2 |
| 11 | Application of retention cardiac catheter method in the study of antibacterial/antiendotoxin peptides显示文摘 | Qin XJ Zheng J Zhou H | 2001 | Acta Acad Med Mil Tert2001，23，3： | 1 |
| 12 | Development and characterization of monoclonal antibody specific to nuclear protein of avian influenza virus type A 显示文摘 | LI N QIN A J SHAO H X | 2008 | Agricuhural Science & Technology2008，9，1： | 1 |
| 13 | Reaction of N-methyl-2-pyrrolidinone with carbon disulfide显示文摘 | Zong Z M Peng Y L Qin Z H | 2000 | Energy Fuels2000，14，3： | 1 |
| 14 | Short telomeres and prognosis of hypertension in a Chinese popula- tion显示文摘 | Yang ZW Huang X Jiang H Zhang YR Liu HX Qin C | 2009 | Hypertension2009，53，4： | 1 |
| 15 | Genetic analysis of a novel dominant rice dwarf mutant 986083D显示文摘 | Qin R Z Qiu Y Cheng Z J Shan X Y Guo X P Zhai H Q Wan J M | 2008 | Euphytica2008，160，： | 1 |
| 16 | Feelback stabilization via designed planar centre manifold显示文摘 | DONG Y L CHENG D Z QIN H S | 2004 | International Journal of Robust and Nonlinear Control2004，14，1： | 1 |
| 17 | Development and characterization of a new tropical marine fish cell line from grouper, Epinephelus coioides susceptible to iridovirus and nodavirus 显示文摘 | Qin Q W Wu T H Jia T L | 2006 | J Virol Methods2006，131，1： | 1 |
| 18 | Polyelectrolytes as in- clusions in electrorheologically active materials: Effect of chemical characteristics on ER actirity materials and mecha- nisms in electrorheology显示文摘 | BLOCK H KELLY J P QIN A | 1990 | Langmuir1990，6，： | 1 |
| 19 | Discovery of diarylpyridine deriva- tives as novel non-nucleoside HIV-1 reverse transcriptase inhibitors 显示文摘 | Tian XT Qin B J Lu H | 2009 | Bioorg Med Chem Lett2009，19，18： | 1 |
| 20 | Electroreduction of nitrate to ammonia inalkaline solution using hydrogen storage alloy cathodes显示文摘 | C Lu S A Lu W H Qin Q G Liu | 1999 | Electrochimica Acta1999，44，： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员