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| 1 | Blockade of cholecystokinin-2 receptor and cyclooxygenase-2 synergistically induces cell apoptosis, and inhibits the proliferation of human gastric cancer cells in vitro显示文摘Gastrin and cyclooxygenase-2(COX-2) playimportant roles in the carcinogenesis and progression ofgastric cancer.However,it remains unknown whether the combination of cholecystokinin-2(CCK-2) receptor antagonist plus COX-2 inhibitor exerts synergistic anti-tumor effects on human gastric cancer.Here,we demonstrated that the combination of AG-041R(a CCK-2 receptor antagonist) plus NS-398(a selective COX-2 inhibitor) treatment had synergistic effects on proliferation inhibition,apoptosis induction,down-regulation of Bcl-2 and up-regulation of Bax expression in MKN-45 cells.These results indicate that simultaneous targeting of CCK-2 receptor and COX-2 may inhibit gastric cancer development more effectively than targeting either molecule alone.(C)2008 Elsevier Ireland Ltd.All rights reserved. | Sun, W. H. | 2008 | 南京医科大学学报(自然科学版)2008，28，9： | 30 |
| 2 | Aquaporin-4 deficiency down-regulates glutamate uptake and GLT-1 expression in astrocytes显示文摘 | Zeng, X. N. Sun, X. L. Gao, L. Fan, Y. Ding, J. H. Hu, G. | 2007 | 南京医科大学学报(自然科学版)2007，27，5： | 20 |
| 3 | Chemical vapor deposition growth of large-scale hexagonal boron nitride with controllable orientation显示文摘有一致厚度的大域的六角形的硼氮化物(h-BN ) 的化学蒸汽免职(CVD ) 合成是很挑战性的,主要由于这材料的极其高的成核密度。此处,我们报导晶片规模的成功的生长,有大单人赛水晶的领域尺寸的高质量的 h-BN 单层电影,吗直到~ 72 ??????????????????????????慮潮档湡敮獬???????慮潮畴敢??洠獥灯牯???? ?? | Xiuju Song Junfeng Gao Yufeng Nie Teng Gao Jingyu Sun Donglin Ma Qiucheng Li Yubin Chen Chuanhong Jin Alicja Bachmatiuk Mark H. Rummeli Feng Ding Yanfeng Zhang Zhongfan Liu | 2015 | Nano Research2015，8，10： | 12 |
| 4 | Polymorphisms of MTHFD,plasma homocysteine levels, and risk of gastric cancer in ahigh-risk Chinese population显示文摘Purpose:Accumulative evidence suggests that folate has a protective effect on gastric cancer. The methylenetetrahyd-rofolate dlehydrogenase(MTHFD) plays an important role in folate and homocysteine metabolisms, and polymorphisms of MTHFD may result in disturbance of the folate-mediated homocysteine pathway. The aim of this study is to test the hypothesis that genetic variants of MTHFD and plasma homocysteine levels are associated with risk of gastric cancer and modulated by genotypes of methylenetetrahydrofolate reductase(MTHFR). Experimental Design: We genotyped G1958A and T401C in MTHFD and C677T in MTHFR and detected total plasma homocysteine(tHcy) levels in a case-control study of 589 gastric cancer cases and 635 cancer-free controls in a high-risk Chinese population. Results:The variant genotypes of MTHFD 1958AA and 401CC were associated with a significantly increased risk of gastric canceradjusted odds ratio(OR), 2.05; 95% confidence interval(95% CI),1.34-3.13 for 1958AA; adjusted OR,1.43; 95% CI,1.14-1.80 for 401CC compared with 1958GG/GA and 401TT/TC genotypes, respectively. Both of the effects were more evident in the subjects carrying MTHFR 677CT/TT genotypes. The average tHcy level was significantly higher in gastric cancer cases than in controls(P < 0.01), and the upper quartile of tHcy (> 13.6 mu mol/L) was associated with an 82% significantly increased risk of gastric cancer, compared with the lowest quartile of tHcy(<= 8.0 pmol/L;adjusted OR,1.82; 95% CI,1.20-2.75). Conclusions:The strong associations between MTHFD variants and the plasma tHcy levels and gastric cancer risk suggest, for the first time, a possible gene-environment interaction between genetic variants of folate-metabolizing genes and high tHcy levels in gastric carcinogenesis. | Wang, L. N Ke, Q Chen, W. S Wang, J. M Tan, Y. F Zhou, Y Hua, Z. L Ding, W. L Niu, J. Y Shen, J Zhang, Z. F Wang, X. R Xu, Y. H Shen, H. B Yi Xing | 2007 | 南京医科大学学报(自然科学版)2007，27，7： | 10 |
| 5 | Mechanism of vascular endothelial growth factor expression mediated by cisplatin in human ovarian cancer cells显示文摘 | Zhong, X. S. Liu, L. Z. Skinner, H. D. Cao, Z. X. Ding, M. Jiang, B. H | 2007 | 南京医科大学学报(自然科学版)2007，27，10： | 8 |
| 6 | Hypersensitivity of aquaporin 4-deficient mice to 1-methyl-4-phenyl-1,2,3,6- tetrah. ydropyrindine and astrocytic modulation显示文摘 | Fan, Y. | 2008 | 南京医科大学学报(自然科学版)2008，28，12： | 7 |
| 7 | Variant alleles of TGFB1 and TGFBR2 are associated with a decreased risk of gastric cancer in a Chinese population显示文摘 | Jin, G. F. Wang, L. N. Chen, W. S. Hu, Z. B. Zhou, Y. Tan, Y. F. Wang, J. M. Hua, Z. L. Ding, W. L. Shen, J. Zhang, Z. F. Wang, X. R. Xul, Y. C. Shen, H. B. | 2007 | 南京医科大学学报(自然科学版)2007，27，5： | 7 |
| 8 | K-ATP channel openers facilitate glutamate uptake by GluTs in rat primary cultured Astrocytes显示文摘Increasing evidence, including from our laboratory, has revealed that opening of ATP sensitive potassium channels(K-ATP channels) plays the neuronal protective roles both in vivo and in vitro. Thus K-ATP channel openers(KCOs) have been proposed as potential neuroprotectants. Our previous studies demonstrated that K-ATP channels could regulate glutamate uptake activity in PC12 cells as well as in synaptosomes of rats. Since glutamate transporters(GluTs) of astrocytes play crucial roles in glutamate uptake and KATP channels are also expressed in astrocytes, the present study showed whether and how KATP channels regulated the function of GluTs in primary cultured astrocytes. The results showed that nonselective KCO pinacidil, selective mitochondrial KCO diazoxide, novel, and blood-brain barrier permeable KCO iptakalim could enhance glutamate uptake, except for the sarcolemmal KCO P1075. Moreover pinacidil, diazoxide, and iptakalim reversed the inhibition of glutamate uptake induced by 1-methyl-4-phenylpyridinium(MPP+). These potentiated effects were completely abolished by mitochondrial K-ATP blocker 5-hydroxydecanoate. Furthermore, either diazoxide or iptakalim could inhibit MPP+-induced elevation of reactive oxygen species (ROS) and phosphorylation of protein kinases C(PKC). These findings are the first to demonstrate that activation of K-ATP channel, especially mitochondrial K-ATP channel, improves the function of GluTs in astrocytes due to reducing ROS production and downregulating PKC phosphorylation. Therefore, the present study not only reveals a novel pharmacological profile of KCOs as regulators of GluTs, but also provides a new strategy for neuroprotection. | Sun, X. L. Zeng, X. N. Zhou, F. Dai, C. P. Ding, J. H. Hu, G. Nanjing Med Univ,Dept Anat Histol & Pharmacol,Neuropharmacol Lab,Nanjing 210029,Jiangsu,Peoples R China. | 2008 | 南京医科大学学报(自然科学版)2008，28，6： | 7 |
| 9 | Variant genotypes and haplotypes of the epidermal growth factor gene promoter are associated with a decreased risk of gastric cancer in a high-risk Chinese population显示文摘 | Jin, G. F. Miao, R. F. Deng, Y. M. Hu, Z. B. Zhou, Y. Tan, Y. F. Wang, J. M. Hua, Z. L. Ding, W. L. Wang, L. Chen, W. S. Shen, J. Wang, X. R. Xu, Y. C. Shen, H. B. | 2007 | 南京医科大学学报(自然科学版)2007，27，10： | 7 |
| 10 | Pathological and biochemical alterations of astrocytes in ovariectomized rats injected with D-galactose:A potential contribution to Alzheimer's disease processes显示文摘Astrocytes are implicated in the pathological changes of Alzheimer's disease. Our previous studies have demonstrated that estrogen deprivation and oxidative stress act synergistically to accelerate the progress of Alzheimer's disease. Long-term D-galactose injection combined with ovariectomy may serve as a rodent model for Alzheimer's disease. To address the potential contribution of astroglia to the Alzheimer's disease pathogenesis, we investigated pathological and biochemical alterations of astrocytes under this animal model. Ovadectomized rats injected with D-galactose for 2 weeks showed extensive localization of glial fibrillary acidic protein immunoreactive astrocytes and slightly elevated glutathione levels in the hippocampus without significant impairments in the water maze test and deficits of the cholinergic analyses, compared to the saline-injected rats. Ovariectomized rats injected with D-galactose for 6 weeks, however, exhibited degeneration of astrocytes and decreased glutathione levels in the hippocampus, accompanied with severe dysfunction of behavioral test and deficiency of cholinergic terminals. Electron microscopy further confirmed the pathological changes of astrocytes, especially in the aggregated area of synapse and brain microvessels. Consistent with degeneration of perivascular astrocytic endfeet, analysis of the horseradish peroxidase demonstrated an impairment of the blood-brain barrier permeability. These findings indicate that biochemical and pathological alterations of astrocytes may partially contribute to exacerbating neuronal deficits in the course of Alzheimer's disease. Restoring neuroprotective potential of astrocytes may be a useful therapeutic target for Alzheimer's disease and other neurodegenerative diseases. | Hua, X. D. Lei, M. Ding, H. Han, Q. Y. Hu, G. Xiao, M. Nanjing Med Univ,Dept Anat Histol & Pharmacol,Jiangsu Prov Key Lab Neurodegenerat,Nanjing 210029,Peoples R China. | 2008 | 南京医科大学学报(自然科学版)2008，28，6： | 4 |
| 11 | Pan-cancer analysis of somatic mutations across 21 neuroendocrine tumor types显示文摘 | Yanan Cao Weiwei Zhou Lin Li Jiaqian Wang Zhibo Gao Yiran Jiang Xiuli Jiang Aijing Shan Matthew H. Bailey Kuan-lin Huang Sam Q. Sun Michael D. McLellan Beifang Niu Weiqing Wang Li Ding Guang Ning | 2018 | Cell Research2018，28，5： | 3 |
| 12 | Guidelines and Good Clinical Practice Recommendations for Contrast Enhanced Ultrasound (CEUS) in the Liver – Update 2012显示文摘 | M. Claudon C. Dietrich B. Choi D. Cosgrove M. Kudo C. Nols?e F. Piscaglia S. Wilson R. Barr M. Chammas N. Chaubal M.-H. Chen D. Clevert J. Correas H. Ding F. Forsberg J. Fowlkes R. Gibson B. Goldberg N. Lassau E. Leen R. Mattrey F. Moriyasu L. Solbiati H. | 2013 | Ultraschall in Med2013，，01： | 3 |
| 13 | ISOTHERMAL SECTION OF Mg-Zn-La SYSTEM IN Mg RICH CORNER AT 350℃显示文摘在在 350 点的 Mg 富有的角落的 Mg-Zn-La 系统的合金在这研究被准备了。扫描电子显微镜学(SEM ) ,有精力的电子探查微量分析散 X 光检查光谱学(EPMAedition ) ,和 X 光检查衍射(XRD ) 被用来在合金识别阶段平衡和每个阶段的作文。作为结果,在在 350 点的 Mg 富有的角落的 Mg-Zn-La 系统的等温的节被决定了。除了一些二进制阶段,在那里存在的结果表演在在 350 点的 Mg-Zn-La 系统的线性第三的复合叫的 T 阶段,在哪个 La 内容是大约 8 在。% 桴 ?敲畱獥 t? | M.L. Huang H.X. Li H. Ding Y.P. Ren S.M. Hao | 2008 | Acta Metallurgica Sinica(English Letters)2008，21，5： | 3 |
| 14 | Guidelines and Good Clinical Practice Recommendations for Contrast Enhanced Ultrasound (CEUS) in the Liver – Update 2012显示文摘 | M. Claudon C. Dietrich B. Choi D. Cosgrove M. Kudo C. Nols?e F. Piscaglia S. Wilson R. Barr M. Chammas N. Chaubal M.-H. Chen D. Clevert J. Correas H. Ding F. Forsberg J. Fowlkes R. Gibson B. Goldberg N. Lassau E. Leen R. Mattrey F. Moriyasu L. Solbiati H. | 2013 | Ultraschall in Med2013，，01： | 3 |
| 15 | A study on the effect of coating's sorption capacity on the porosity in lost foam aluminum alloy casting显示文摘Effects of coating constituent, coating density, coating layer thickness and temperature on coating sorption capacity for polystyrene decomposition products have been studied systematically. It has been found that the effect of attapulgite clay on sorption capacity is the largest among coating constituents. The sorption capacity of the coating with 2% attapulgite clay is elevated by 81%. The relationship between casting porosity and coating sorption capacity has been studied. It has been pointed out that higher coating sorption capacity for polystyrene decomposition products is helpful to decrease the casting porosity. Results also show that the sorption capacity of self-developed HW-1 coating for polystyrene decomposition products is as good as that of Ashland coating from America. | ~*G. H. Wu~1, M. Xie~1, W.J. Ding~1, J.R. Luo~2(1. Shanghai Jiaotong University, Shanghai 200030, P. R. China 2. Huazhong University of Science and Technology, Wuhan 430074, Hubei, P. R. China) | 2004 | China Foundry2004，1，S1： | 2 |
| 16 | Genetic background effects on age-related hearing loss associated with Cdh23 variants in mice显示文摘 | Kelly L. Kane Chantal M. Longo-Guess Leona H. Gagnon Dalian Ding Richard J. Salvi Kenneth R. Johnson | 2011 | Hearing Research . 2011 (1-2)2011，，1： | 2 |
| 17 | Estimation of Population-Size Changes and HIV Prevalence among Female Sex Workers from 2006 to 2009 in Kaiyuan,Yunnan,China显示文摘Objective This study is to estimate the population size and prevalence of HIV and herpes simplex virus type 2(HSV-2) infections among female sex workers(FSWs) in Kaiyuan,Yunnan Province,China.Methods Eight cross-sectional studies were conducted among FSWs in Kaiyuan from 2006 to 2009.Based on the data from two study time points each year,the total numbers of FSWs and HIV positive FSWs were estimated by using the capture-recapture technique(CR).Results Estimated sizes of FSWs in Kaiyuan were 1 629,1 672,1 186,and 1 014 in the respective years from 2006 to 2009.Although the crude prevalence rates of HIV and HSV-2 varied over time,the adjusted prevalence among this population was relatively stable at 10%-12% and the adjusted HSV-2 prevalence ranged from 67% to72%.Conclusion The reason for the slight decrease of the size of the FSW population is unknown.The adjusted prevalence rates of HIV and HSV-2 among them were stable over the course of this study. | WANG Jun Jie YANG Qian FAN Pan Ying REILLY Kathleen H. DING Guo Wei WANG Ning | 2012 | Biomedical and Environmental Sciences2012，25，4： | 2 |
| 18 | Functions of autophagy in normal and diseased liver显示文摘 | Mark J. Czaja Wen-Xing Ding Terrence M. Donohue Scott L. Friedman Jae-Sung Kim Masaaki Komatsu John J. Lemasters Antoinette Lemoine Jiandie D. Lin Jing-hsiung James Ou David H. Perlmutter Glenn Randall Ratna B. Ray Allan Tsung Xiao-Ming Yin | 2013 | Autophagy2013，，8： | 2 |
| 19 | Antibacterial activity and increased bone marrow stem cell functions of Zn-incorporated TiO 2 coatings on titanium显示文摘 | H. Hu W. Zhang Y. Qiao X. Jiang X. Liu C. Ding | 2011 | Acta Biomaterialia2011，，2： | 2 |
| 20 | Ptpn11/Shp2 Acts as a Tumor Suppressor in Hepatocellular Carcinogenesis显示文摘 | Emilie A. Bard-Chapeau Shuangwei Li Jin Ding Sharon S. Zhang Helen H. Zhu Frederic Princen Diane D. Fang Tao Han Beatrice Bailly-Maitre Valeria Poli Nissi M. Varki Hongyang Wang Gen-Sheng Feng | 2011 | Cancer Cell2011，，5： | 2 |
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