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| 1 | A rapid advice guideline for the diagnosis and treatment of 2019 novel coronavirus(2019-nCoV) infected pneumonia(standard version)显示文摘In December 2019, a new type viral pneumonia cases occurred in Wuhan, Hubei Province;and then named '2019 novel coronavirus(2019-nCoV)' by the World Health Organization(WHO) on 12 January 2020. For it is a never been experienced respiratory disease before and with infection ability widely and quickly, it attracted the world’s attention but without treatment and control manual. For the request from frontline clinicians and public health professionals of 2019-nCoV infected pneumonia management, an evidence-based guideline urgently needs to be developed. Therefore, we drafted this guideline according to the rapid advice guidelines methodology and general rules of WHO guideline development;we also added the first-hand management data of Zhongnan Hospital of Wuhan University. This guideline includes the guideline methodology, epidemiological characteristics, disease screening and population prevention, diagnosis, treatment and control(including traditional Chinese Medicine), nosocomial infection prevention and control, and disease nursing of the 2019-nCoV. Moreover, we also provide a whole process of a successful treatment case of the severe 2019-nCoV infected pneumonia and experience and lessons of hospital rescue for 2019-nCoV infections. This rapid advice guideline is suitable for the first frontline doctors and nurses, managers of hospitals and healthcare sections, community residents, public health persons, relevant researchers, and all person who are interested in the 2019-nCoV. | Ying-Hui Jin Lin Cai Zhen-Shun Cheng Hong Cheng Tong Deng Yi-Pin Fan Cheng Fang Di Huang Lu-Qi Huang Qiao Huang Yong Han Bo Hu Fen Hu Bing-Hui Li Yi-Rong Li Ke Liang Li-Kai Lin Li-Sha Luo Jing Ma Lin-Lu Ma Zhi-Yong Peng Yun-Bao Pan Zhen-Yu Pan Xue-Qun Ren Hui-Min Sun Ying Wang Yun-Yun Wang Hong Weng Chao-Jie Wei Dong-Fang Wu Jian Xia Yong Xiong Hai-Bo Xu Xiao-Mei Yao Yu-Feng Yuan Tai-Sheng Ye Xiao-Chun Zhang Ying-Wen Zhang Yin-Gao Zhang Hua-Min Zhang Yan Zhao Ming-Juan Zhao Hao Zi Xian-Tao Zeng Yong-Yan Wang Xing-Huan Wang 无 | 2020 | Military Medical Research2020，7，1： | 161 |
| 2 | Efficient generation of hepatocyte-like cells from human induced pluripotent stem cells显示文摘人的导致的 pluripotent 茎(iPS ) 房间类似于胚胎的茎(ES ) 房间,和罐头强烈地增殖并且区分进许多房间类型。然而,人的 iPS 房间的肝的区别还没被报导了。在这份报告,人的 iPS 房间被导致由一个逐步的协议区分进肝的房间。肝房间标记的表达式和人的 iPS 的肝相关的函数导出房间的房间被监视并且与区分的人的 ES 房间和主要人的 hepatocytes 的相比。在白天 7 点的约 60% 区分的人的 iPS 房间表示了肝的标记 alpha fetoprotein 和白长袍的。在白天 21 点的区分的房间包括白朊 Asecretion,肝糖合成,脲生产和可诱导的细胞色素 P450 活动展出了肝房间功能。肝的标记的表示和 iPS 的肝相关的功能导出房间的肝的房间比得上人的 ES 导出房间的肝的房间的。这些结果证明人的 iPS 房间,类似于人的 ES 房间,能高效地被导致区分房间进象 hepatocyte 一样。 | Zhihua Song Jun Cai Yanxia Liu Dongxin Zhao Jun Yong Shuguang Duo Xijun Song Yushan Guo Yang Zhao Han Qin Xiaolei Yin Chen Wu Jie Che Shichun Lu Mingxiao Ding Hongkui Deng | 2009 | Cell Research2009，19，11： | 63 |
| 3 | Multiple genetic alterations and behavior of cellular biology in gastric cancer and other gastric mucosal lesions:H.pylori infection,histological types and staging显示文摘AIM To investigate the expression of multiplegenes and the behavior of cellular biology ingastric cancer(GC)and other gastric mucosallesions and their relations to Helicobacter pylori(H.pylori)infection,tumor staging andhistological subtypes.METHODS Three hundred and twenty-sevenspecimens of gastric mucosa obtained viaendoscopy or surgical resection,and ABCimmunohistochemical staining were used todetect the expression of p53,p16,Bcl-2 andCOX-2 proteins.H.pylori was determined byrapid urea test combined with pathologicalstaining or14C urea breath test.Cellular image analysis was performed in 66 patients withintestinal metaplasia(IM)and/or dysplasia(Dys).In 30 of them,both cancer and theparacancerous tissues were obtained at the timeof surgery.Histological pattern,tumor staging,lymph node metastasis,grading ofdifferentiation and other clinical data werestudied in the medical records.RESULTS p16 expression of IM or Dys wassignificantly lower in positive H.pylori chronicatrophic gastritis(CAG)than those withnegative H.pylori(CAG:54.8% vs 88.0%,IM:34.4% vs 69.6%,Dys:23.8% vs 53.6%,allP<0.05),Bcl-2 or COX-2 expression of IM orDys in positive H.pylori cases was significantlyhigher than that without H.pylori(Bcl-2:68.8%vs23.9%,90.5% vs 60.7%;COX-2:50.0% vs10.8%,61.8% vs 17.8%;all P<0.05).Themean number of most parameters of cellularimage analysis in positive H.pylori group wassignificantly higher than that in negative H.pylori group(Ellipser:53±14,40±12μm,Area1:748±572,302±202 μm2,Area2:3050±1661,1681±1990 μm2,all P<0.05;Ellipseb:79±23,58±15 μm,Ratio1:22%±5%,13%±4%,Ratio2:79%±17%,53%±20%,all P<0.01).There was significant correlation between Bcl-2and histologic pattern of gastric carcinoma,andbetween COX-2 and tumor staging or lymph nodemetastasis(Bcl-2:75.0% vs 16.7%;COX-2:76.0% vs 20.0%,79.2% vs 16.7%;allP<0.05).CONCLUSION p1l6, Bcl-2, and COX-2 but not p53 gene may play a role in the early genesis/ progression of gastric carcinoma and are associated with H. pylori infection. p53 gene is relatively late event in gastric tumorigenesis and mainly relates to its progression. There is more cellular-biological behavior of malignant tumor in gastric mucosal lesions with H. pylori infection. Aberrant Bcl-2 protein expression appears to be preferentially associated with the intestinal type cancer. COX-2 seems to be related to tumor staging and lymph node metastasis. | Heng Jun Gao Lian Zhen Yu Jian Feng Bai Yan Shen Peng Gu Sun Han Lin Zhao Kun Miu Xiu Zhen Lü Xiao Yong Zhang Zhi Quan Zhao | 2000 | World Journal of Gastroenterology2000，6，6： | 52 |
| 4 | Distribution of Soil Organic Carbon Fractions Along the Altitudinal Gradient in Changbai Mountain,China显示文摘Understanding the responses of soil organic carbon(SOC) fractions to altitudinal gradient variation is important for understanding changes in the carbon balance of forest ecosystems.In our study the SOC and its fractions of readily oxidizable carbon(ROC),water-soluble carbon(WSC) and microbial biomass carbon(MBC) in the soil organic and mineral horizons were investigated for four typical forest types,including mixed coniferous broad-leaved forest(MCB),dark coniferous spruce-fir forest(DCSF),dark coniferous spruce forest(DCS),and Ermans birch forest(EB),along an altitudinal gradient in the Changbai Mountain Nature Reserve in Northeast China.The results showed that there was no obvious altitudinal pattern in the SOC.Similar variation trends of SOC with altitude were observed between the organic and mineral horizons.Significant differences in the contents of SOC,WSC,MBC and ROC were found among the four forest types and between horizons.The contents of ROC in the mineral horizon,WSC in the organic horizon and MBC in both horizons in the MCB and EB forests were significantly greater than those in either DCSF or DCS forest.The proportion of soil WSC to SOC was the lowest among the three main fractions.The contents of WSC,MBC and ROC were significantly correlated(P < 0.05) with SOC content.It can be concluded that vegetation types and climate were crucial factors in regulating the distribution of soil organic carbon fractions in Changbai Mountain. | ZHANG Min ZHANG Xiao-Ke LIANG Wen-Ju JIANG Yong DAI Guan-Hua WANG Xu-Gao HAN Shi-Jie | 2011 | Pedosphere2011，21，5： | 43 |
| 5 | Neurons secrete miR-132.containing exosomes to regulate brain vascular integrity显示文摘脉管的完整帮助维持大脑微型环境动态平衡,它为中央神经系统的正常开发和函数是批评的。神经房间能调整大脑,这被知道脉管的正直。由于包含的神经与血管的相互作用的高复杂性,不管多么大脑的神经规定理解脉管的正直仍然是原始的。用未经触动的 zebrafish 幼虫和有教养的啮齿类动物大脑房间,我们发现神经原转移 miR-132,一高度保存了并且充实神经原的 microRNA,经由到 endothelial 房间(EC ) 到的 secreting exosomes 维持大脑脉管的正直。后面的 translocation 到通过 exosome 成为主观的 EC, miR-132 调整脉管的 endothelial cadherin (VE-cadherin ) 的表示,重要 adherens 连接蛋白质,由直接指向真核细胞的延伸因素 2 kinase (eef2k ) 。neuronal miR-132 表示或 exosome 分泌物的混乱,或脉管的 eef2k 的 overexpression 损害 VE-cadherin 表示和大脑脉管的正直。我们的学习显示 miR-132 作为调停的一个细胞间的信号扮演大脑的神经规定脉管的完整并且建议 neuronal exosome 是为神经与血管的通讯的一条新奇大街。 | Bing Xu Yu Zhang Xu-Fei Du Jia Li Hua-Xing Zi Ji-Wen Bu Yong Yan Hua Han Jiu-Lin Du | 2017 | Cell Research2017，27，7： | 46 |
| 6 | Straw return and appropriate tillage method improve grain yield and nitrogen efficiency of winter wheat显示文摘Straw return is an important management tool for tackling and promoting soil nutrient conservation and improving crop yield in Huang-Huai-Hai Plain, China. Although the incorporation of maize straw with deep plowing and rotary tillage practices are widespread in the region, only few studies have focused on rotation tillage. To determine the effects of maize straw return on the nitrogen(N) efficiency and grain yield of winter wheat(Triticum aestivum L.), we conducted experiments in this region for 3 years. Five treatments were tested:(i) rotary tillage without straw return(RT);(ii) deep plowing tillage without straw return(DT);(iii) rotary tillage with total straw return(RS);(iv) deep plowing tillage with total straw return(DS);(v) rotary tillage of 2 years and deep plowing tillage in the 3rd year with total straw return(TS). Treatments with straw return increased kernels no. ear^(–1), thousand-kernel weight(TKW), grain yields, ratio of dry matter accumulation post-anthesis, and nitrogen(N) efficiency whereas reduced the ears no. ha^(–1) in the 2011–2012 and 2012–2013 growing seasons. Compared with the rotary tillage, deep plowing tillage significantly increased the grain yield, yield components, total dry matter accumulation, and N efficiency in 2013–2014. RS had significantly higher straw N distribution, soil inorganic nitrogen content, and soil enzymes activities in the 0–10 cm soil layer compared with the DS and TS. However, significantly lower values were observed in the 10–20 and 20–30 cm soil layers. TS obtained approximately equal grain yield as DS, and it also reduced the resource costs. Therefore, we conclude that TS is the most economical method for increasing grain yield and N efficiency of winter wheat in Huang-Huai-Hai Plain. | CHEN Jin ZHENG Meng-jing PANG Dang-wei YIN Yan-ping HAN Ming-ming LI Yan-xia LUO Yong-li XU Xu LI Yong WANG Zhen-lin | 2017 | Journal of Integrative Agriculture2017，16，8： | 42 |
| 7 | Epidemiology and risk factors of colorectal cancer in China显示文摘In China, colorectal cancer(CRC) ranked fourth and fifth in the highest incidence and mortality rates of all malignancies in 2018, respectively. Although these rates are below the world average, China placed first worldwide in the number of new CRC cases and CRC-related deaths because of its comparatively large population. This disease represents a threat to the health of population and incurs a heavy economic burden on the society and individuals. CRC has various risk factors, including age, sex, lifestyle, genetic factors, obesity, diabetes, gut microbiota status, and precancerous lesions. Furthermore, incidence and mortality rates of CRC are closely related to socioeconomic development levels, varying according to regional and population characteristics. Prevention is the main strategy to reduce incidence and mortality rates of CRC. This can be achieved through strategies stimulating lifestyle changes, healthy diet habits, and early screening for high-risk individuals. To reduce the burden of CRC, public health officials should promote prevention and management of modifiable risk factors through national policies. The rising incidence and mortality rates of CRC in China may be timely curbed by clarifying specific epidemiological characteristics, optimizing early screening strategies, and strictly implementing diagnosis and treatment guidelines. Thus, this study aimed to collect and report the current research status on epidemiology and risk factors of CRC in China. | Yong Yang Zihan Han Xin Li An Huang Jingyi Shi Jin Gu | 2020 | Chinese Journal of Cancer Research2020，32，6： | 42 |
| 8 | Clinical implications of fatty pancreas:Correlations between fatty pancreas and metabolic syndrome显示文摘AIM:To investigate the clinical implications of lipid deposition in the pancreas(fatty pancreas). METHODS:The subjects of this study were 293 patients who had undergone abdominal computed tomography(CT)and sonography.Fatty pancreas was diagnosed by sonographic findings and subdivided into mild,moderate,and severe fatty pancreas groups comparing to the retroperitoneal fat echogenicity. RESULTS:Fatty pancreas was associated with higher levels for visceral fat,waist circumference,aspartate aminotransferase(AST),alanine aminotransferase (ALT),total cholesterol,triglyceride,high density lipoprotein,free fatty acid,γ-GTP,insulin,and the homeostasis model assessment of insulin resistance (HOMA-IR)than the control group(P<0.05).HOMAIR,visceral fat,triglyceride,and ALT also tended to increase with the degree of fat deposition in the pancreas on sonography.In a multivariate logistic regression analysis,HOMA-IR,visceral fat,and ALT level were independently related to fatty pancreas after adjustment for age,body mass index,and lipid profile.The incidence of metabolic syndrome in the fatty pancreas group was significantly higher than in the control group,and the numbers of metabolic syndrome parameters were significantly higher in the fatty pancreas group(P<0.05).CONCLUSION:Sonographic fatty pancrease showed higher insulin resistance,visceral fat area,triglyceride, and ALT levels than normal pancreases.Fatty pancreas also showed a strong correlation with metabolic syndrome. | Jun Seok Lee Sang Heum Kim Dae Won Jun Jee Hye Han Eun Chul Jang Ji Young Park Byung Kwan Son Seong Hwan Kim Yoon Ju Jo Young Sook Park Yong Soo Kim | 2009 | World Journal of Gastroenterology2009，15，15： | 40 |
| 9 | Prevalence and evolution of drug resistance HIV-1 variants in Henan, China显示文摘To understand the prevalence and evolution of drug resistant HIV strains in Henan China after the implementation of free antiretroviral therapy for AIDS patients. 45 drug nave AIDS patients, 118 AIDS patients who received three months antiretroviral therapy and 124 AIDS patients who received six months antiretroviral treatment were recruited in the southern part of Henan province. Information on general condition, antiretroviral medicines, adherence and clinical syndromes were collected by face to face interview. Meanwhile, 14ml EDTA anticoagulant blood was drawn. CD4/CD8 T cell count, viral load and genotypic drug resistance were tested. The rates of clinical improvement were 55.1% and 50.8% respectively three months and six months after antiretroviral therapy. The mean CD4 cell count after antiretroviral therapy was significantly higher than in drug nave patients. The prevalence rate of drug resistant HIV strains were 13. 9%, 45.4% and 62.7% in drug nave patients, three month treatment patients and six month treatment patients, respectively. The number of resistance mutation codons and the frequency of mutations increased significantly with continued antiretroviral therapy. The mutation sites were primarily at the 103, 106 and 215 codons in the three-month treatment group and they increased to 15 codon mutations in the six-month treatment group. From this result, the evolution of drug resistant strains was inferred to begin with the high level NNRTI resistant strain, and then develop low level resistant strains to NRTIs. The HIV strains with high level resistance to NVP and low level resistance to AZT and DDI were highly prevalent because of the AZT+DDI+NVP combination therapy. These HIV strains were also cross resistant to DLV, EFV, DDC and D4T. Poor adherence to therapy was believed to be the main reason for the emergence and prevalence of drug resistant HIV strains. The prevalence of drug resistant HIV strains was increased with the continu- ation of antiretroviral therapy in the southern part of Henan province. Measures, that could promote high level adherence, provide new drugs and change ART regimens in failing patients, should be implemented as soon as possible. | Jing Yun LI Han Ping LI Lin LI Hong LI Zhe WANG Kun YANG Zuo Yi BAO Dao Min ZHUANG Si Yang LIU Yong Jian LIU Hui XING Yi Ming SHAO | 2005 | Cell Research2005，15，11： | 34 |
| 10 | Maize-soybean strip intercropping: Achieved a balance between high productivity and sustainability显示文摘Intercropping is one of the most vital practice to improve land utilization rate in China that has limited arable land resource. However, the traditional intercropping systems have many disadvantages including illogical field lay-out of crops, low economic value, and labor deficiency, which cannot balance the crop production and agricultural sustainability. In view of this, we developed a novel soybean strip intercropping model using maize as the partner, the regular maize-soybean strip intercropping mainly popularized in northern China and maize-soybean relay-strip intercropping principally extended in southwestern China. Compared to the traditional maize-soybean intercropping systems, the main innovation of field lay-out style in our present intercropping systems is that the distance of two adjacent maize rows are shrunk as a narrow strip, and a strip called wide strip between two adjacent narrow strips is expanded reserving for the growth of two or three rows of soybean plants. The distance between outer rows of maize and soybean strips are expanded enough for light use efficiency improvement and tractors working in the soybean strips. Importantly, optimal cultivar screening and increase of plant density achieved a high yield of both the two crops in the intercropping systems and increased land equivalent ratio as high as 2.2. Annually alternative rotation of the adjacent maize-and soybean-strips increased the grain yield of next seasonal maize, improved the absorption of nitrogen, phosphorus, and potasium of maize, while prevented the continuous cropping obstacles. Extra soybean production was obtained without affecting maize yield in our strip intercropping systems, which balanced the high crop production and agricultural sustainability. | DU Jun-bo HAN Tian-fu GAI Jun-yi YONG Tai-wen SUN Xin WANG Xiao-chun YANG Feng LIU Jiang SHU Kai LIU Wei-guo YANG Wen-yu | 2018 | Journal of Integrative Agriculture2018，17，4： | 34 |
| 11 | Effects of spironolactone on electrical and structural remodeling of atrium in congestive heart failure dogs显示文摘背景:Renin-angiotensin-aldosterone 系统被表明了与充血心力衰竭(CHF ) 并且在伊朗的银币纤维性颤动(AF ) 被联系。这研究调查了螺内酯的效果,一种醛固酮对手,在上在伊朗的银币,在 CHF 狗的电的改变和纤维变性导致了由长期快速的室的踱步。方法:21 条狗随机被划分成假冒操作组,控制组,和螺内酯组。在控制组和螺内酯组,狗是室的每分钟在 220 敲击踱步 6 个星期。另外,在 15 mg x kg 的螺内酯(-1) x d (-1) 1 个星期在快速的室的踱步前被给狗直到踱步停止了。经胸廓和 transoesophageal echocardiographic 考试被执行检测中庭的结构、功能的变化。Swan2 Ganz 漂浮导管被用来测量缝 adynamics 变化。房的的有效不应期(AERP ) , AERP 分散(AERPd ) , intra 中庭和内部中庭的传导时间(CT ) 和 intra 中庭传导速度(CV ) 是坚定的。AF 的 inducibility 和持续时间也在所有组被测量。最后,在伊朗的银币,纤维变性被确定,马森染色。结果:在狗是室的以后, AERP 没显著地变化踱步 6 个星期。然而,显著地增加的 AERPd, intra 中庭和内部中庭的 CT,和 CV 显然减少了,它否定地被相关到 at 伊朗的银币纤维变性(r =-0.74, P <
0.05 ) 。同时,左中庭被扩大,心脏的缝 adynamics 在在狗上踱步变得更坏。尽管螺内酯不能有效地影响心脏的缝 adynamics,它能显然在伊朗的银币喷射部分改进左(P <
0.05 ) 。螺内酯处理没改变 AERP 持续时间,但是这药戏剧性地减少 AERPd (P <
0.05 ) ,弄短的 intra 中庭和内部中庭的传导时间(P <
0.05 ) ,并且增加的中庭 CV。而且,螺内酯减少了 AF 的 inducibility 和持续时间(P <
0.05 ) ,以及在伊朗的银币,纤维变性(P< 0.01 ) 导致了由长期快速的室的踱步。结论:螺内酯在导致由的充血心力衰竭狗贡献 AF 预防长期快速的室的踱步,它在伊朗的银币纤维变性减小和缝 adynamics 的独立人士与有关。 | YANG Shu-sen HAN Wei ZHOU Hong-yan DONG Guo WANG Bai-chun HUO Hong WEI Na CAO Yong ZHOU Guo XIU Chun-hong LI Wei-min | 2008 | Chinese Medical Journal2008，，1： | 26 |
| 12 | Surveillance, epidemiology, and pathogen spectrum of hand, foot, and mouth disease in mainland of China from 2008 to 2017显示文摘Hand,foot and mouth disease(HFMD)was reported in May 2,2008 to be the 38th legally notifiable disease in China's National Notifiable Disease Reporting and Surveillance System.In order to solve the infection,an extensive three-level HFMD surveillance laboratory network was established.In this study,the framework of that network is assessed and the incidence of HFMD in China from 2008 to 2017 is reported using a descriptive epidemiologic method.During these 10 years,a series of techniques have been widely applied in all the network laboratories.Using information and material obtained from the network,a virus bank and database containing 18,238 viruses were established.Nationally,18,184,834 HFMD cases,including 152,436 severe cases and 3633 fatal cases,were reported in mainland of China.The average annual incidence in the population was 133.99/100,000 people,with a maximum incidence of 205.06/100,000 people in 2014.The incidence and mortality rates of HFMD were the highest in children aged 1–2 years.The numbers of reported cases fluctuated,with a high incidence observed every 2 years.An overall increase in the number of reported cases was also observed throughout the study period.Despite this,the incidence of severe cases and the mortality rate have been decreasing.High-risk regions are located in southern,eastern,and central China.Two peaks of HFMD infection cases were observed annually except for Northeast China.Different proportions of enterovirus serotypes were observed during the studied years.The predominant enterovirus varies from year to year,but the disease severity is always closely related to the specific serotype.EV-A71 is the dominant serotype associated with severe and fatal cases,with constituent ratios of 70.03%and 92.23%,respectively.The studied highly sensitive and efficient surveillance network provides information that is critical for prevention and control of the disease.It is extremely necessary and important to continuously conduct extensive virological surveillance for HFMD. | Tianjiao Ji Taoli Han Xiaojuan Tan Shuangli Zhu Dongmei Yan Qian Yang Yang Song Aili Cui Yan Zhang Naiying Mao Songtao Xu Zhen Zhu Dandan Niu Yong Zhang Wenbo Xu | 2019 | Biosafety and Health2019，1，1： | 26 |
| 13 | Antisense telomerase RNA induced human gastric cancer cell apoptosis显示文摘INTRODUCTION Human tissue homeostasis is precisely regulated bycellular division,differentiation and death.Normalhuman somatic cells progressively lose telomererestriction fragment(TRF)length with eachsuccessive cell division,eventually leading tocellular quiescence,chromosomal end-degradationand apoptosis.On the contrary,stabilization oftelomere lengths by expressing telomerase,an RNA-dependent DNA polymerase,may be involved incellular immortality and carcinogenesis. | Fang Xin Zhang Xue Yong Zhang Dai Ming Fan Zi Yun Deng Yan Yan Han Ping Wu Jun Jie Fan | 2000 | World Journal of Gastroenterology2000，6，3： | 24 |
| 14 | Transduction of Fas gene or Bcl-2 antisense RNA sensitizes cultured drug resistant gastric cancer cells to chemotherapeutic drugs显示文摘INTRODUCTIONChemotherapyisoneofthemajormethodsintumortreatment,butitoftendoesnotworkduetomultidrugresistance(MDR).Recentstudi... | XIAO Bing, SHI Yong Quan, ZHAO Yan Qiu, YOU Han, WANG Zuo You, LIU Xian Ling, YIN Fang, QIAO Tai Dong and FAN Dai Ming | 1998 | World Journal of Gastroenterology1998，4，5： | 24 |
| 15 | Characterization of focal liver masses using acoustic radiation force impulse elastography显示文摘AIM:To investigate the diagnostic performance of acoustic radiation force impulse(ARFI) elastography for characterizing focal liver mass by quantifying their stiffness.METHODS:This prospective study included 62 patients with a focal liver mass that was well visualized on conventional ultrasonography performed in our institution from February 2011 to November 2011.Among them,12 patients were excluded for ARFI measurement failure due to a lesion that was smaller than the region of the interest and at an inaccessible location(deeper than 8 cm)(n = 7) or poor compliance to hold their breath as required(n = 5).Finally,50 patients with valid ARFI measurements were enrolled.If a patient had multiple liver masses,only one mass of interest was chosen.The masses were diagnosed by histological examination or clinical diagnostic criteria.During ultrasonographic evaluation,stiffness,expressed as velocity,was checked 10 times per focal liver mass and the surrounding liver parenchyma.RESULTS:After further excluding three masses that were non-diagnostic on biopsy,a total of 47 focal mass lesions were tested,including 39(83.0%) malignant masses [24 hepatocellular carcinomas(HCC),seven cholangiocellular carcinomas(CCC),and eight liver metastases] and eight(17.0%) benign masses(five hemangiomas and three focal nodular hyperplasias,FNH).Thirty-seven(74.0%) masses were confirmed by histological examination.The mean velocity was 2.48 m/s in HCCs,1.65 m/s in CCCs,2.35 m/s in metastases,1.83 m/s in hemangiomas,and 0.97 m/s in FNHs.Although considerable overlap was still noted between malignant and benign masses,significant differences in ARFI values were observed between malignant and benign masses(mean 2.31 m/s vs 1.51 m/s,P = 0.047),as well as between HCCs and benign masses(mean 2.48 m/s vs 1.51 m/s,P = 0.006).The areas under the receiver operating characteristics curves(AUROC) for discriminating the malignant masses from benign masses was 0.724(95%CI,0.566-0.883,P = 0.048),and the AUROC for discriminating HCCs from benign masses was 0.813(95%CI,0.649-0.976,P = 0.008).To maximize the sum of sensitivity and specificity,an ARFI value of 1.82 m/s was selected as the cutoff value to differentiate malignant from benign liver masses.Furthermore,the cutoff value for distinguishing HCCs from benign masses was also determined to be 1.82 m/s.The diagnostic performance of the sum of the ARFI values for focal liver masses and the surrounding liver parenchyma to differentiate liver masses improved(AUROC = 0.853;95%CI,0.745-0.960;P = 0.002 in malignant liver masses vs benign ones and AUROC = 0.948;95%CI,0.896-0.992,P < 0.001 in HCCs vs benign masses).CONCLUSION:ARFI elastography provides additional information for the differential diagnosis of liver masses.However,our results should be interpreted in clinical context,because considerable overlap in ARFI values existed among liver masses. | Hana Park Jun Yong Park Do Young Kim Sang Hoon Ahn Chae Yoon Chon Kwang-Hyub Han Seung Up Kim | 2013 | World Journal of Gastroenterology2013，19，2： | 22 |
| 16 | Temperature variation of a thermionic cathode during electron emission显示文摘It is necessary to know the actual temperature of a thermionic cathode that works as the electron source in a microwave tube. It has been found that the temperature of the cathode drops markedly during the thermionic emission. For example, the temperature could fall by about 30oC under a current density of 2.92 A/cm2. Using the molecular thermodynamics, the dependence of the cathode temperature on the emission current density has been obtained. It has been theoretically pointed out that several factors, such as heating model and temperature coefficient of resis-tance of heater, can influence the cathode temperature. These theoretical conclu-sions were supported by the experimental results. | LIU YanWen TIAN Hong HAN Yong XU ZhenYing MENG MingFeng ZHANG HongLai | 2008 | Science China(Technological Sciences)2008，51，9： | 22 |
| 17 | Hypoglycemic and Hypolipidemic Effects of Lycium barbarum Polysaccharide in Diabetic Rats显示文摘Objective To study the antidiabetic effects and the underlying molecular mechanisms of Lycium barbarum polysaccharide(LBP) and its DEAE cellulose elution fraction LBP-IV in diabetic rats induced by high fat diet(HFD) and streptozotocin(STZ). Methods After ig administration of LBP-IV [50, 100, and 200 mg/(kg·d)] and LBP [100 mg/(kg·d)] once daily for consecutive 4 weeks to diabetic rats, the glucose and lipids in blood, m RNA expression of phosphoenolpyruvate carboxykinase(PEPCK), sterol regulatory element binding-protein-1c(SREBP-1c), and fatty acid synthase(FAS) in liver were determined. Results Ig administration of LBP and LBP-IV significantly decreased the levels of blood glucose, Hb A1 c, TC, TG, and LDL-C, as well as the hepatic m RNA expression of PEPCK, SREBP-1c, and FAS, whereas significantly increased the oral glucose tolerance of diabetic rats. Conclusion The findings suggest that the antidiabetic effects of LBP and LBP-IV are associated with the decreased hepatic m RNA expression of PEPCK, SREBP-1c, and FAS in HFD-STZ induced diabetic rats. | Rong Zhao Rui Jin Yong Chen Feng-mei Han | 2015 | Chinese Herbal Medicines2015，7，4： | 22 |
| 18 | Activation of aldehyde dehydrogenase 2 slows down the progression of atherosclerosis via attenuation of ER stress and apoptosis in smooth muscle cells显示文摘(ALDH2 ) 醛脱氢酶 2 是在醛的新陈代谢的关键 mitochondrial 酶并且可以为象心脏的肥大,心失败,心肌的 I/R 损害,灌注,心律不齐,冠的心疾病和动脉粥样硬化那样的条件有有益的心血管的效果。在这研究,我们在动脉粥样硬化和内在的机制的前进调查了 ALDH2 的角色,与 endoplasmic 蜂窝胃的一个焦点(嗯) 应力。临床的研究与冠的心疾病在 248 个病人被执行。病人根据他们的 ALDH2 遗传型被划分成二个组。基线临床的特征和冠的 angiography 被记录,并且冠的动脉 Gensini 分数是计算的。4-hydroxy-2-nonenal (4-HNE ) 的浆液层次被检测。临床的学习表明变异的 ALDH2 遗传型是为冠的心疾病的一个独立风险因素。ALDH2 基因多型性仔细与动脉粥样硬化和冠的动脉狭窄的严厉被联系。4-HNE 的浆液层次比在有野类型的 ALDH2 遗传型的病人在有变异的 ALDH2 遗传型的病人是显著地更高的。作为一在里面动脉粥样硬化的 vitro 模型,老鼠光滑的肌肉房间( SMC )与 oxygenized 被对待低密度的脂蛋白( ox-LDL )它显著地提高了层次嗯标记调整葡萄糖的 protein78 ( GRP78 ),蛋白质 kinase 象R一样嗯 kinase (津贴), phosphorylated 真核细胞的翻译开始因素子单元( p-eIF2 ),激活的抄写 factor-4 ( ATF-4 ), CEBP 相应蛋白质(砍)和在房间的 4-HNE 。所有 ox-LDL-induced 回答显著地面对 Alda-1 (激活代理人的 ALDH2 ) 被稀释,并且面对 daidzin (一个 ALDH2 禁止者) 加重了。而且,有 ALDH2 使活跃之物 Alda-1 的预告的处理显著地减少了 ox-LDL-induced apoptosis。同样, ALDH2 的 overexpression 保护了 SMC 免于 ox-LDL-induced 嗯应力象一样嗯导致压力的 apoptosis。这些调查结果建议 ALDH2 可以经由变细减缓动脉粥样硬化的前进嗯在光滑的肌肉房间的应力和 apoptosis。 | Mei-yan YANG Ya-bin WANG Bo HAN Bo YANG Yu-wei QIANG Yan ZHANG Zhao WANG Xu HUANG Jie LIU Yun-dai CHEN Jun REN Feng CAO Yong XU | 2018 | Acta Pharmacologica Sinica2018，39，1： | 22 |
| 19 | Biliary drainage for obstructive jaundice caused by unresectable hepatocellular carcinoma: the endoscopic versus percutaneous approach显示文摘BACKGROUND: For palliative treatment of the obstructive jaundice associated with unresectable hepatocellular carcinoma (HCC), percutaneous transhepatic biliary drainage (PTBD) or endoscopic retrograde biliary drainage (ERBD) has been performed. PTBD is preferred as an initial procedure. Little is known about the better option for patients with obstructive jaundice caused by unresectable HCC. METHODS: Sixty patients who had received ERBD or PTBD for the palliative treatment of obstructive jaundice caused by unresectable HCC between January 2006 and May 2010 were included in this retrospective study. Successful drainage, drainage patency, and the overall survival of patients were evaluated. RESULTS: Univariate analysis revealed that the overall frequency of successful drainage was higher in the ERBD group (22/29, 75.9%) than in the PTBD group (15/31, 48.4%) (P=0.029); but multivariate analysis showed marginal significance (P=0.057). The duration of drainage patency was longer in the ERBD group than in the PTBD group (82 vs 37 days, respectively, P=0.020). Regardless of what procedure was performed, the median survival time of patients who had a successful drainage was much longer than that of the patients who did not have a successful drainage (143 vs 38 days, respectively, P<0.001).CONCLUSION: Besides PTBD, ERBD may be used as the initial treatment option to improve obstructive jaundice in patients with unresectable HCC if there is a longer duration of drainage patency after a successful drainage. | Jongkyoung Choi Ji Kon Ryu Sang Hyub Lee Dong-Won Ahn Jin-Hyeok Hwang Yong-Tae Kim Yong Bum Yoon Joon Koo Han | 2012 | Hepatobiliary & Pancreatic Diseases International2012，11，6： | 17 |
| 20 | Hemodynamic variables and clinical features correlated with serum uric acid in patients with pulmonary arterial hypertension显示文摘背景浆液尿酸(UA ) ,嘌呤降级的最后的产品,被建议了是为严厉和在有肺的动脉的高血压的病人的死亡的一个可能的预言者的一个标记(哼) 。这研究的目的是阐明浆液 UA 水平是否在中国病人与临床的特征和血液动力学的变量相关与哼并且与不同病原学联系了在病人比较相互关联的差别。方法浆液 UA 与三种类型在 228 个病人被估计哼(自发哼(IPAH ) ,联系的先天的心疾病哼(CHD 哼) 并且联系的结缔组织疾病哼(CTD 哼)) 和另外的临床的特征。在为至少 6 个月的个性化的治疗以后, UA 层次和临床的特征在 88 个病人被重新估计。结果浆液 UA 显著地在病人被提高与与匹配年龄的控制题目相比哼((350.40 ???????? 僚 ?????? 隸??????? 丨吗?? | JIANG Xin HAN Zhi-yan WANG Yong XU Xi-qi MA Chuan-rong WU Yan PAN Lei JING Zhi-cheng | 2008 | Chinese Medical Journal2008，，24： | 17 |
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