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| 1 | 体内腺相关病毒-常间回文重复序列丛集及其相关蛋白9介导的基因编辑可改善家族性高胆固醇血症的动脉粥样硬化显示文摘低密度脂蛋白受体(low-density lipoprotein receptor,Ldlr)基因突变是家族性高胆固醇血症的主要原因之一,可导致动脉粥样硬化,并具有很高的终生心血管病风险。常间回文重复序列丛集(clustered regularly interspaced short palindromic repeats,CRISPR)/CRISPR相关蛋白9(CRISPR-related protein 9,Cas9)系统是基因编辑纠正基因突变从而改善疾病的有效工具。该研究的目的是通过腺相关病毒(adeno-associated virus,AAV)携带的CRISPR/Cas9系统进行体内体细胞基因编辑,以确定其能否在小鼠模型中治疗由Ldlr突变体引起的家族性高胆固醇血症。 | 刘青(译) 叶鹏(审校) Zhao H Li Y He L Pu W Yu W Li Y Wu YT Xu C Wei Y Ding Q Song BL Huang H Zhou B | 2020 | 中华高血压杂志2020，28，3： | 22 |
| 2 | Nicotine attenuates beta-amyloid-induced neurotoxicity by regulating metal homeostasis.显示文摘 | Zhang J Liu Q Chen Q Liu NQ Li FL Lu ZB Qin C Zhu H Huang YY He W Zhao BL | 2006 | 中国生物学文摘2006，20，9： | 17 |
| 3 | The signaling adaptors and pathways activated by TNF superfamily显示文摘 | Paul W Dempsey Sean E Doyle Jeannie Q He Genhong Cheng | 2003 | Cytokine and Growth Factor Reviews2003，，3： | 2 |
| 4 | Water uptake and acid doping of polybenzimidazoles as electrolyte membranes for fuel cells显示文摘 | LI Q F HE R H BERG R W | 2004 | Solid State Ionics2004，168，12： | 1 |
| 5 | TLR4 signaling promotes immune escape of human lung cancer cells by inducing immunosuppressive cytokines and apoptosis resistance显示文摘 | HE W LIU Q WANG L | 2007 | Mol Immunol2007，44，11： | 1 |
| 6 | Biomacromolecules显示文摘 | Chen Y Ding D Mao Z Q He Y F Hu Y Wu W Jiang X Q | 2008 | 9(10):2609-26142008，9，10： | 1 |
| 7 | The distributions of particulate heavy metals and its indication to the transfer of sediments in the Changjiang Estuary and Hangzhou Bay, China 显示文摘 | Che Y He Q Lin W Q | 2003 | Marine Pollution Bulletin2003，46，1： | 1 |
| 8 | Graphene oxide as a carbon source for controlled growth of carbon nanowires 显示文摘 | CAO X H HE Q Y SHI W H | 2011 | Small2011，7，9： | 1 |
| 9 | Endogenous amino acid loss at the terminal ileum of rats fed water-extractable or alkali-extractable soluble non-starch polysaccharides obtained from wheat bran when fed with and without xylanase显示文摘 | HE Y H LU W Q PIAO X S | 2006 | Journal of Animal and Veterinary Advances2006，5，8： | 1 |
| 10 | Experimental study on progressive col- lapse-resistant behavior of reinforced concrete frame structures 显示文摘 | Yi W He Q Xiao Y | 2008 | ACI Structural Journal2008，105，43： | 1 |
| 11 | 3D numerical simulation on shell-and-tube heat exchangers with middle-overlapped helical baffles and continuous baffles-Part II : Simulation results of periodic model and comparison between continuous and noncontinuous helical baffles显示文摘 | Zhang J F He Y L Tao W Q | 2009 | International Journal of Heat and Mass Transfer2009，52，2324： | 1 |
| 12 | Experimental study on the performance of CO2 residential air-conditioning system with anInternal heat exchanger显示文摘 | Tao Y B He Y L Tao W Q Wu Z G | | 0，，01： | 1 |
| 13 | 查看详情显示文摘 | Zhang J P Yang H P Han K L Deng W Q He G Z Lou N Q | | 0，，： | 1 |
| 14 | Emergence, circulation, and spatiotemporal phylogenetie analysis of eoxsaekievirus a6 - and coxsackievirus al0 - associated hand, foot, and mouth disease infections from 2008 to 2012 in shenzhen, china显示文摘 | He Y Q Chen L Xu W B | 2013 | J Clin Microbiol2013，51，11： | 1 |
| 15 | The TIL commissioning and performance显示文摘 | X Zhang W Zheng X Wei F Jing Z Sui K Zheng Q Xu X Yuan X Jiang L Yang P Ma M Li J Wang D Hu S He F Li Z Peng B Feng H Zhou L Guo X Li X Zhang J Su Q Zhu H Yu R Zhao C Ma H He D Fan W Zhang | 2008 | Journal of Physics: Conference Series2008，，3： | 1 |
| 16 | The physicochemical prop- erties of swelled maize starch granules complexed with lauric acid 显示文摘 | Chang F D He X W Huang Q | 2013 | Food Hydrocolloids2013，32，2： | 1 |
| 17 | The mechanism of starch granule reacted with OSA by phase transition catalyst in aqueous medium显示文摘 | WANG C HE X W HUANG Q | 2013 | Food Chemistry2013，141，4： | 1 |
| 18 | 2007b Mechanism of heterogeneous reaction of carbonyl sulfide on magnesium oxide 显示文摘 | Liu Y C He H Xu W Q | 2007 | J Phys Chem (A)2007，111，： | 1 |
| 19 | Use of 7Be and 137Cs measurement to document short and medium-term rates of water-induced soil erosion on agricultural land显示文摘 | Walling D E He Q Blake W H | 1999 | Water Resources Research1999，35，12： | 1 |
| 20 | Preparation of a kaolinite-poly(acrylic acid acrylamide) water superabsorbent by photopolymerization显示文摘 | Wan T Wang X Q Yuan Y He W Q | 2006 | Journal of Applied Polymer Science2006，102，： | 1 |
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