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| 1 | Anatomical characteristics of patients with symptomatic severe aortic stenosis in China显示文摘With accumulating evidence of transcatheter aortic valve replacement(TAVR)worldwide,it is gradually realized that patients being treated are different across different coun-tries,including but not limited to their age,habitus,disease etiology,aortic valve morphology,and sizes of structures.[1]In China,the average age of TAVR patients is around 5 years younger than industrialized countries,[2]making Chinese patients a good predictive sample of what the industrialized countries might see in TAVR screening in the near future due to the expansion of this technique to younger patients,but anatomical features appreciated from multi-slice computed tomography(MSCT)in the Chinese patient population have not been well demonstrated. | Tian-Yuan Xiong Yi-Ming Li Yi-Jun Yao Yu-Heng Jia Kai Xu Zhen-Fei Fang Jun Jin Guo-Sheng Fu Yi-Ning Yang Lei Jiang Wei-Dong Li Yan-Qing Wu Yan-Song Guo Ran Guo Yun-Dai Chen Yi Li Yi-Bing Shao Yi Zhang Bo-Sen Yang Yi-Ke Zhang Jing-Jing He Kai-Yu Jia Sheng-Hu He Fa-Xin Ren Jian-Cheng Xiu Xing-Hua Gu Liang-Long Chen Ke Han Yuan Feng Mao Chen | 2021 | Chinese Medical Journal2021，，22： | 5 |
| 2 | Malnutrition Increases the Risk of Mortality in Hospitalized Lung Cancer Patients显示文摘Background The Global Leadership Initiative on Malnutrition(GLIM)recently developed a new set of diagnostic criteria for identifying patients with malnutrition.Because the GLIM criteria were only introduced a little over 3 years ago,additional validation and reliability testing are needed in a variety of populations.Methods We performed an observational,multicenter cohort study.From July 2013 to October 2018,lung cancer patients were recruited from the Daping Hospital of Army Medical University and the First Hospital of Jilin University as part of the INSCOC project.Previously-established cut-off values for the calf circumference(CC,male<30 cm,female<29.5 cm)were applied as the reduced muscal mass of phenotypic criteria to establish the GLIM diagnosis.Multivariate Cox regression analyses were performed to analyze the association between the GLIM criteria and survival.Results A total of 1219 patients with lung cancer were studied as subjects.Their age was 58.81±9.92 years old,and 820 were male and 399 were female.According to the GLIM diagnostic criteria using the CC as a muscle mass measurement,303 patients(24.9%)were categorized as malnourished,142 patients(23.1%)in the adult group(18≤age<60)and 161 patients(26.7%)in the older group(age≥60 years).The patients with malnutrition had a higher incidence of anemia than the nourished patients(P=0.012).The QLQ-C30 score and KPS score indicating that the malnourished patients had a consistently worse quality of life compared to the nourished group(all P<0.001).The median survival of the malnutrition group was 42(95%CI:34-50)months,which was much shorter than the 62(95%CI:57-66)months in the nourished group(P<0.001).In the adult group,the median survival decreased from 65(95%CI:55-72)months in nourished group to 34(95%CI:25-48)months in the patients with malnutrition(P<0.001).In the older group,it decreased from 61(95%CI:55-67)months to 48(95%CI:39-59)months(P=0.001).A Cox regression analysis showed that GLIM-diagnosed malnutrition was associated with an increased risk of death among adult group(HR=1.670,95%CI:1.29-2.16),older group(HR=1.332,95%CI:1.05-1.69)and overall(HR=1.453,95%CI:1.22-1.72).Conclusion All of these results demonstrate that GLIM-diagnosed malnutrition is associated with a poorer survival for all lung cancer patients,independent of age. | Fei Fei Chong Liang Yu Yin Jie Liu Na Li Jing Guo Yang Fan Meng Yuan Zhang Ling Zhang Xiu Mei He Hong Mei Zhang Mu Li Shi Wei Li Hong Xia Xu | 2022 | Journal of Nutritional Oncology2022，7，1： | 4 |
| 3 | 大豆异黄酮对Ⅰ型糖尿病甲基乙二醛水平及白内障并发症的影响显示文摘目的:甲基乙二醛(MG)是糖代谢产生的毒性副产物,本研究旨在探讨大豆异黄酮是否通过降低MG的产生而发挥对I型糖尿病的防治作用。方法:链脲佐菌素诱导I型糖尿病大鼠模型,给予含不同剂量大豆异黄酮的大鼠饲料喂养,按大豆异黄酮不同剂量随机分为3组:大豆异黄酮低剂量组(diabetes+LIS),大豆异黄酮高剂量组(diabetes+HIS)及模型组(diabetes)。治疗8周后处死大鼠,留取血清测定血糖、糖化血红蛋白、还原型谷胱甘肽(GSH)、胰岛素水平,HPLC法测定血清MG水平,免疫组化法检测胰岛β细胞胰岛素表达情况。结果:与模型组或diabetes+LIS组大鼠比较,HIS组大鼠血清胰岛素水平明显上升[(2.46±0.35)μg/L vs(0.55±0.04)μg/L or(0.39±0.04)μg/L,均P<0.01],血糖明显下降[(19.50±1.85)mol/L vs(28.24±3.56)mol/L or(26.94±1.82)mmol/L,均P<0.05]、糖化血红蛋白减低[(13.14±3.00)%vs(17.16±2.60)%or(17.29±4.12)%,均P<0.05],血清MG明显降低[(0.77±0.09)nmol/L vs(1.57±0.17)nmol/L or(1.91±0.28)nmol/L,均P<0.05],而血清GSH水平明显增加[(13.26±1.61)mmol/L vs(7.35±1.55)mmol/L or(5.54±1.10)mmol/L,均P<0.01],diabetes+HIS组大鼠胰岛β细胞中胰岛素表达水平也明显增加。Diabetes+HIS组大鼠白内障的发生率明显低于模型组(P<0.05)。模型组与diabetes+LIS组比较,上述指标均无显著差异。结论:大豆异黄酮对I型糖尿病具有治疗作用,并能降低I型糖尿病大鼠白内障的发生率,其机制可能与胰岛素水平增加、MG水平降低及抗氧化作用有关。 | 卢美萍 SONG Xiu -yuan MENG Qing- he | 2010 | 中国病理生理杂志2010，26，5： | 3 |
| 4 | Towards carbon neutrality:A study on China's long-term low-carbon transition pathways and strategies显示文摘As the world's biggest carbon dioxide(CO_(2))emitter and the largest developing country,China faces daunting challenges to peak its emissions before 2030 and achieve carbon neutrality within 40 years.This study fully considered the carbon-neutrality goal and the temperature rise constraints required by the Paris Agreement,by developing six long-term development scenarios,and conducting a quantitative evaluation on the carbon emissions pathways,energy transformation,technology,policy and investment demand for each scenario.This study combined both bottom-up and top-down methodologies,including simulations and analyses of energy consumption of end-use and power sectors(bottom-up),as well as scenario analysis,investment demand and technology evaluation at the macro level(top-down).This study demonstrates that achieving carbon neutrality before 2060 translates to significant efforts and overwhelming challenges for China.To comply with the target,a high rate of an average annual reduction of CO_(2) emissions by 9.3%from 2030 to 2050 is a necessity,which requires a huge investment demand.For example,in the 1.5℃ scenario,an investment in energy infrastructure alone equivalent to 2.6%of that year's GDP will be necessary.The technological pathway towards carbon neutrality will rely highly on both conventional emission reduction technologies and breakthrough technologies.China needs to balance a long-term development strategy of lower greenhouse gas emissions that meets both the Paris Agreement and the long-term goals for domestic economic and social development,with a phased implementation for both its five-year and long-term plans. | Jiankun He Zheng Li Xiliang Zhang Hailin Wang Wenjuan Dong Ershun Du Shiyan Chang Xunmin Ou Siyue Guo Zhiyu Tian Alun Gu Fei Teng Bin Hu Xiu Yang Siyuan Chen Mingtao Yao Zhiyi Yuan Li Zhou Xiaofan Zhao Ying Li Danwei Zhang | 2022 | Environmental Science and Ecotechnology2022，，1： | 2 |
| 5 | Comprehensive report on China's Long-Term Low-Carbon Development Strategies and Pathways显示文摘1.Introduction 2020 is an unusual year in which the COVID-19 pandemic has raged through the globe,infecting tens of millions of people and killing hundreds of thousands.The pandemic has not only wreaked havoc on public health systems,economic activities,and people's lives,but also has greatly affected and will continue to reshape the world's political,economic,and trade patterns. | Jiankun He Zheng Li Xiliang Zhang Hailin Wang Wenjuan Dong Shiyan Chang Xunmin Ou Siyue Guo Zhiyu Tian Alun Gu Fei Teng Xiu Yang Siyuan Chen Mingtao Yao Zhiyi Yuan Li Zhou Xiaofan Zhao | 2020 | Chinese Journal of Population,Resources and Environment2020，18，4： | 1 |
| 6 | Erk is involved in the differentiation induced by diallyl disulfide in the human gastric cancer cell line MGC803显示文摘 | Hui Ling Liang-Yun Zhang Qi Su Ying Song Zhao-Yang Luo Xiu Tian Zhou Xi Zeng Jie He Hui Tan Jing-Ping Yuan | 2006 | Cellular & Molecular Biology Letters2006，，3： | 1 |
| 7 | Cytotoxic Responses and Apoptosis in Rat Kidney Epithelial Cells Exposed to Lead显示文摘The toxic effects of lead on normal rat kidney epithelial cells(NRK cells)may occur via various pathways.However,the role of intrinsic mitochondrial pathway in Lead-induced apoptosis in NRK cells has not been investigated.The purpose of our study was to investigate cytotoxic responses and cell apoptosis mediated by lead in NRK cells.NRK cells were treated with | HE Xiu Yuan YUAN Li Yun LI Yong Tao LI Meng CHEN Yuan YUAN Hui WU Jing GUO Cheng Zhi LI Jing | 2016 | Biomedical and Environmental Sciences2016，29，7： | 0 |
| 8 | Chinese expert consensus on multidisciplinary diagnosis and treatment of pancreatic neuroendocrine liver metastases显示文摘Many management strategies are available for pancreatic neuroendocrine neoplasms with liver metastases.However,a lack of biological,molecular,and genomic information and an absence of data from rigorous trials limit the validity of these strategies.This review presents the viewpoints from an international conference consisting of several expert working groups.The working groups reviewed a series of questions of particular interest to clinicians taking care of patients with pancreatic neuroendocrine neoplasms with liver metastases by reviewing the existing management strategies and literature,evaluating the evidence on which management decisions were based,developing internationally acceptable recommendations for clinical practice,and making recommendations for clinical and research endeavors.The review for each question will be followed by recommendations from the panel. | Yihebali Chi Liming Jiang Susheng Shi Shun He Chunmei Bai Dan Cao Jianqiang Cai Qichen Chen Xiao Chen Yiqiao Deng Shunda Du Zhen Huang Li Huo Yuan Ji Jie Li Wenhui Lou Jie Luo Xueying Shi Lijie Song Bei Sun Huangying Tan Feng Wang Xuan Wang Zhewen Wei Wenming Wu Dianrong Xiu Jianming Xu Huadan Xue Yi Yang Fei Yin Chunhui Yuan Yefan Zhang Weixun Zhou Dongbing Zhao Hong Zhao | 2023 | Journal of Pancreatology2023，6，4： | 0 |
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