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| 1 | Serial imaging of human embryonic stem-cell engraftment and teratoma formation in live mouse models显示文摘表示为基于 radiopharmaceutical 的成像为生物体之发光成像或 HSV1 thymidine kinase (HSV1-TK ) 编码任何一个萤火虫酶(fLuc ) 的记者 transgene 的 lentiviral 向量的二种新类型被构造监视人的胚胎的干细胞(hESC ) 在在移植以后的活老鼠的嫁接和增长。任何一个 transgene 的组成的表示没在文化改变 hESCs 的性质。我们下次在 SCID 鼠标监视了 teratomas 的形成到测试(1 ) 是否修改基因的 hESCs 维持他们的发展 pluripotency,并且(2 ) 是否支撑了记者基因表示,允许 noninvasive,在一个活鼠标模型的 hESC 衍生物的整个身体的成像。我们在接种以后从修改基因的房间以及野类型的 hESCs 2-4 月的两种类型观察了 teratoma 形成。用一个光成像系统,从 fLuc-transduced hESCs 的生物体之发光容易在在摸得出的肿瘤能被检测以前,长忍受 teratomas 的老鼠被检测。开发一个 noninvasive 成像方法对诊所更容易地可译,我们也利用了 HSV1-TK 和它的特定的底层, 1-(2 鈥 ? deoxy-2 鈥 ?fluoro- 尾 - D-arabinofuranosyl )-5-[125I]iodouracil ([125I ] FIAU ) ,记者 / 探查对。在全身的管理以后,[125I ] FIAU 是仅仅由编码 transgene 的 HSV1-TK 酶的 phosphorylated 并且在 transduced 以内保留(并且移植) 房间,由单个光子的排放允许敏感、量的成像计算了断层摄影术。象这些那样的 Noninvasive 成像方法可以使我们能在实时接受者以内重复地监视移植人的干细胞的存在和分发在上一通过记者基因的表达式长期。 | Martin G Pomper Holly Hammond Xiaobing Yu Zhaohui Ye Catherine A Foss Doris D Lin James J Fox Linzhao Cheng | 2009 | Cell Research2009，19，3： | 9 |
| 2 | 急性脊髓损伤患者治疗的临床操作指南:关于MRI基线在临床治疗决策与结果预测中作用的几点建议(英文)显示文摘The objective of this guideline is to outline the role of magnetic resonance imaging(MRI) in clinical decision making and outcome prediction in patients with traumatic spinal cord injury(SCI).Methods A systematic review of the literature was conducted to address key questions related to the use of MRI in patients with traumatic SCI.This review focused on longitudinal studies that controlled for baseline neurologic status.A multidisciplinary Guideline Development Group(GDG) used this information,their clinical expertise,and patient input to develop recommendations on the use of MRI for SCI patients.Based on GRADE(Grading of Recommendation,Assessment,Development and Evaluation),a strong recommendation is worded as ' we recommend,' whereas a weaker recommendation is indicated by 'we suggest.' Results Based on the limited available evidence and the clinical expertise of the GDG,our recommendations were:(1) 'We suggest that MRI be performed in adult patients with acute SCI prior to surgical intervention,when feasible,to facilitate improved clinical decision-making'(quality of evidence,very low) and(2) 'We suggest that MRI should be performed in adult patients in the acute period following SCI,before or after surgical intervention,to improve prediction of neurologic outcome '(quality of evidence,low).Conclusions These guidelines should be implemented into clinical practice to improve outcomes and prognostication for patients with SCI. | Fehlings MG Martin AR Tetreault LA Aarabi B Anderson P Arnold PM Brodke D Burns AS Chiba K Dettori JR Furlan JC Hawryluk G Holly LT Howley S Jeji T Kalsi-Ryan S Kotter M Kurpad S Kwon BK Marino RJ Massicotte E Merli G Middleton JW Nakashima H Nagoshi N Palmieri K Singh A Skelly AC Tsai EC Vaccaro A Wilson JR Yee A Harrop JS | 2017 | 中华神经外科疾病研究杂志2017，16，6： | 8 |
| 3 | 中文迁延悲伤量表修订版的效度和信度显示文摘目的:评价中文迁延悲伤量表修订版(PG-13-R)的效度和信度。方法:招募符合DSM-5-TR迁延悲伤障碍(PGD)诊断标准的患者200例为研究对象,进行迁延悲伤量表修订版评定,计算组内相关系数(ICC)评价评定者之间的一致性;计算Cronbachα系数评价量表的内部一致性,采取主成份方法计算条目的因子载荷考评量表的结构效度。通过计算PG-13-Revised量表的评分与社会适应量表(WSAS)评分和自评抑郁量表(SDS)的相关性来考察PG-R-13效标效度。以DSM-5-TR诊断标准为依据,计算受试者可接受曲线下面积(AUC)来判断量表的区分效度以及划定量表的划界分。结果:评定者一致性系数ICC为0.97;各个分条目之间的相关系数在0.85~0.99之间。量表总Cronbachα系数为0.85。在PG-13-R的13个条目中,采用主成分分析法算出1个主因子,贡献率达78.98%,高于结构效度检验的标准50%。以临床评估标准为参考,在区分轻度迁延悲伤障碍时划界分为≥25时灵敏度和特异度最好,分别为93.3%和78.2%,AUC为0.82,区分中度迁延悲伤障碍,划界分≥37时灵敏度和特异度最高,分别为92.5%、90.7%,AUC为0.92;在区分重度迁延悲伤障碍时,划界分≥46时灵敏度和特异度最高,分别为95.47%、92.18%,AUC为0.96。结论:中文迁延悲伤量表修订版(PG-13-R)有良好的效度和信度,能够早期测评迁延悲伤障碍的严重程度。 | 霍平乐 李然立 孙芸 陈新英 PRIGERSON Holly G CHOU S Patricia 陈光东 禚传君 黄春海 | 2022 | 中国心理卫生杂志2022，36，5： | 4 |
| 4 | The albumin cobalt binding test:analytical performance of a new automated chemistry 0assay for the detection of ischemia modified albumin(IMA)显示文摘 | Fagan G J Hollie Wayment Deborah L | 2002 | Clin Leg Assay2002，25，5： | 1 |
| 5 | Direct wetand dry deposition of ammonia, nitric acid, ammonium and nitrate to the Tampa Bay Estuary, FL, USA 显示文摘 | NOREEN P RAY P HOLLY G | 2001 | Atmospheric Environment2001，35，23： | 1 |
| 6 | Aspartame consumption in relation to childhood brain tumour risk: results from a case-control study显示文摘 | GURNEY J G POGODA J M HOLLY E A | 1997 | J Nat Cancer Inst1997，89，14： | 1 |
| 7 | Site-specific effects of compression on macromolecular diffusionin articular cartilage显示文摘 | Holly AL Farshid G | | 0，，10： | 1 |
| 8 | Hydrological modelling and the sustainable development of the Hadejia-Nguru Wetland, Nigeria显示文摘 | Thompson J R Hollis G E | 1995 | Hydrological Sciences Journal1995，40，1： | 1 |
| 9 | PB1-F2 expedition from the whole protein through the domain to aa residue function 显示文摘 | Kosik I Holly J Russ G | 2013 | Acta Virol2013，57，： | 1 |
| 10 | The effects of urbanization on floods of different recurrence interval 显示文摘 | Hollis G E | 1975 | Water Resources Research1975，11，： | 1 |
| 11 | Comparisons of stake- holder perceptions of tourism impacts in rural eastern North Carolina显示文摘 | Erick T B Holly E B Meghan G D | 2009 | Tourism Management2009，30，5： | 1 |
| 12 | Massive pncumocephalus following Merocel nasal tamponade for epistaxis显示文摘 | HOLLIS G J | 2000 | Acad Emerg Med2000，7，9： | 1 |
| 13 | Halophilic Vibrio Species Isolated from Blood Cultures显示文摘 | Hollis D G Weaver R E Baker C N | 1976 | J Clin Microbiol1976，3，4： | 1 |
| 14 | Assessment of myocardial mechanics using speckle tracking echocardiography: fundamentals and clinical applications 显示文摘 | Holly G Giuseppe C Hamhiko A | 2010 | J Am Soc Echocardiogr2010，23，4： | 1 |
| 15 | Effects of Hatha Yago Practice on the Health-Related Aspects of Physical Fitness 显示文摘 | Tran M D Holly R G Lashbrook J | 2001 | Previous C ardiol2001，4，： | 1 |
| 16 | Clinical Lymphoma显示文摘 | MATTHEW Y HOLLY G RUBEN M | 2015 | Myeloma and Leukemia2015，15，1： | 1 |
| 17 | Vitamin D is required for IFN-gamma-mediated antimicrobial activity of human macrophages显示文摘 | Fabri M Stenger S Shin DM Yuk JM Liu PT Realegeno S Lee HM Krutzik SR Schenk M Sieling PA Teles R Montoya D Iyer SS Bruns H Lewinsohn DM Hollis BW Hewison M Adams JS Steinmeyer A Zügel U Cheng G Jo EK Bloom BR Modlin RL | | 0，，： | 1 |
| 18 | Phosphorus nuclear magnetic resonance of per fused working rat hearts显示文摘 | JACOBUS W E TAYLOR IV G J HOLLIS | 1977 | Nature1977，265，24： | 1 |
| 19 | Diagnosis and management of opioid - induced bowel dysfunction in patients with advanced cancer显示文摘 | Fredericks A Hollis G Stricker CT | 2010 | Clin J OncolNurs2010，14，6： | 1 |
| 20 | The Role of Insulin-like Growth Factor Binding Proteins显示文摘 | HOLLY J PERKS G | 2006 | Neuroendocrinology2006，83，34： | 1 |
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