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| 1 | Engineering Non-transgenic Gynoecious Cucumber Using an Improved Transformation Protocol and Optimized CRISPR/Cas9 System显示文摘 | Bowen Hu Dawei Li Xin Liu Jingjing Qi Dongli Gao Shuqiao Zhao Sanwen Huang Jinjing Sun Li Yang | 2017 | Molecular Plant2017，10，12： | 25 |
| 2 | The Hardy Rubber Tree Genome Provides Insights into the Evolution of Polyisoprene Biosynthesis显示文摘Eucommia ulmoides,也叫的强壮的橡胶树,是一棵经济地重要的树;然而,它的染色体顺序的缺乏 ?限制基本生物研究和这植物种的应用研究。这里,我们在场它的 1.2-Gb 染色体的一个高质量的集会(支架 N50 ?=? 1.88 Mb ) 与至少 26 ? 为 E 的 723 预言的基因。ulmoides,顺序 Garryales 的首先定序的染色体,它用联合定序的 Illumina 的综合策略被获得,定序的 PacBio,和印射的 BioNano。作为到 lamiids 和 campanulids 的姐妹 taxon, E。ulmoides 经历了三倍由核心 eudicots 而是没有进一步整个染色体的复制分享了的一个古老的染色体 ? 在最后 1.25 亿年里。E。ulmoides 为涉及压力回答和第二等的代谢物的生合成的多重基因展出高表达式层次或基因数字扩大,它可以说明它的可观的环境适应性。与橡胶树(Hevea brasiliensis ) 相对照,它生产 cis 聚异式戊二我烯, E。ulmoides 演变综合经由 farnesyl diphosphate synthases (FPS ) 的长链的 trans 聚异式戊二我烯。而且, FPS 和橡胶延伸 factor/small 橡胶粒子蛋白质基因家庭从 H 独立地被扩展。brasiliensis 系。这些结果提供新卓见进 E. 的生物学 ? ulmoides 和聚异式戊二我烯生合成的起源。 | Ta-na Wuyun Lin Wang Huimin Liu Xuewen Wang Liangsheng Zhang Jeffrey L. Bennetzen Tiezhu Li Lirong Yang Panfeng Liu Lanying Du Lu Wang Mengzhen Huang Jun Qing Iili Zhu Wenquan Bao Hongguo Li Qingxin Du Jingle Zhu Hong Yang Shuguang Yang Hui Liu Hui Yue Jiang Hu Suoliang Yu Yu Tian Fan Liang Jingjing Hu Depeng Wang Ruiwen Gao Dejun Li Hongyan Du | 2018 | Molecular Plant2018，11，3： | 24 |
| 3 | The Antagonistic Action of Abscisic Acid and Cytokinin Signaling Mediates Drought Stress Response in Arabidopsis显示文摘 | Xiaozhen Huang Lingyan Hou Jingjing Meng Huiwen You Zhen Li Zhizhong Gong Shuhua Yang Yiting Shi | 2018 | Molecular Plant2018，11，7： | 15 |
| 4 | Weldability, microstructure and mechanical properties of laser-welded selective laser melted 304 stainless steel joints显示文摘Laser welding is a promising process for joining small components produced by selective laser melting (SLM) to fabricate the large-scale and complex-shaped parts. In the work, the morphology, microstructure, microhardness, tensile properties and corrosion resistance of the laser welded stress-relieved SLMed 304 stainless steel joints are investigated, as the different sections of stress-relieved SLMed 304 stainless steel are joined. Results show that the SLMed 304 stainless steel plates have a good laser weldability. The microstructure of laser-welded joints consists of the cellular dendrites in austenite matrix within columnar grains, exhibiting a coarser dendrite structure, lower microhardness (~220HV) and tensile properties (tensile strength of ~750 MPa, and area reduction of ~27.6%), but superior corrosion resistance to those of SLMed plates. The dendrite arm spacing of the joints varies from ~3.7μm in center zone, to ~5.0 (xm in fusion zone, to ~2.5 in epitaxial zone. The SLMed anisotropy shows a negligible effect on the microstructure and performance of the laser-welded joints. The laser welding along the building directions of the SLMed base plates can induce a slightly finer dendritic structure and higher tensile properties. | Jingjing Yang Yun Wang Fangzhi Li Wenpu Huang Guanyi Jing Zemin Wang Xiaoyan Zeng | 2019 | Journal of Materials Science & Technology2019，35，9： | 14 |
| 5 | Kinetics of the accumulation of group 2 innate lymphoid cells in IL-33-induced and IL-25-induced murine models of asthma:a potential role for the chemokine CXCL16显示文摘ILC2s are implicated in asthma pathogenesis, but little is known about the mechanisms underlying their accumulation in airways.We investigated the time course of ILC2 accumulation in different tissues in murine models of asthma induced by a serial per-nasalchallenge with ovalbumin (OVA), house dust mice (HDM), IL-25 and IL-33 and explored the potential roles of ILC2-attractingchemokines in this phenomenon. Flow cytometry was used to enumerate ILC2s at various time points. The effects of cytokines andchemokines on ILC2 migration were measured in vitro using a chemotaxis assay and in vivo using small animal imaging. Comparedwith saline and OVA challenge, both IL-25 and IL-33 challenge alone induced significant accumulation of ILC2s in the mediastinallymph nodes, lung tissue and bronchoalveolar lavage fluid of challenged animals, but with a distinct potency and kinetics. In vitro,IL-33 and CXCL16, but not IL-25 or CCL25, directly induced ILC2 migration. Small animal in vivo imaging further confirmed that asingle intranasal provocation with IL-33 or CXCL16 was sufficient to induce the accumulation of ILC2s in the lungs followinginjection via the tail vein. Moreover, IL-33-induced ILC2 migration involved the activation of ERK1/2, p38, Akt, JNK and NF-κB, whileCXCL16-induced ILC2 migration involved the activation of ERK1/2, p38 and Akt. These data support the hypothesis that epitheliumderived IL-25 and IL-33 induce lung accumulation of ILC2s, while IL-33 exerts a direct chemotactic effect in this process. AlthoughILC2s express the chemokine receptors CXCR6 and CCR9, only CXCL16, the ligand of CXCR6, exhibits a direct chemoattractanteffect. | Yan Li Shihao Chen Yafei Chi Yiran Yang Xiwen Chen Huating Wang Zhe Lv Jingjing Wang Linjie Yuan Ping Huang Kewu Huang Chris JCorrigan Wei Wang Sun Ying | 2019 | Cellular & Molecular Immunology2019，16，1： | 13 |
| 6 | Onco-miR-24 regulates cell growth and apoptosis by targeting BCL2L11 in gastric cancer显示文摘胃的癌症是世界范围的最普通的恶意之一;然而,在 tumorigenesis 的分子的机制仍然需要探索。BCL2L11 属于 BCL-2 家庭,并且充当内在的 apoptotic 串联的一个中央管理者并且调停房间 apoptosis。尽管 miRNAs 被报导了涉及癌症开发的每个阶段,在 GC 的 miR-24 的角色还没被报导。在现在的学习,当 BCL2L11 的表示在 GC 的肿瘤纸巾被禁止时, miR-24 被发现起来调整。研究从在 vitro 并且在显示出的 vivo,那 miR-24 调整 BCL2L11 表示由与 mRNA 的 3UTR 直接有约束力,因此支持房间生长,移植当禁止房间 apoptosis 时。因此, miR-24 是能是为未来的潜在的药目标的新奇 onco-miRNA 临床的使用。 | Haiyang Zhang Jingjing Duan Yanjun Qu Ting Deng Rui Liu Le Zhang Ming Bai Jialu Li Tao Ning Shaohua Ge Xia Wang ZhenzhenWang~ Qian Fan Hongli Li Guoguang Ying Dingzhi Huang Yi Ba | 2016 | Protein & Cell2016，7，2： | 11 |
| 7 | Seasonal Variations of Net-Phytoplankton Community Structure in the Southern Yellow Sea显示文摘Based on the field survey data of four cruises in 2011,all phytoplankton communities in the southern Yellow Sea (SYS) were investigated for the species composition,dominant species,abundance and diversity indices.A total of 379 species belonging to9 phyla were identified,of which the most abundant group was Bacillariophyta (60.9%) ,followed by Pyrrophyta (23.7%) and Haptophyta (6.9%) .The seasonal distribution of abundance was:summer (4137.1×103ind m 3) >spring (3940.4×103ind m 3) >winter (3010.6×103ind m 3) >autumn (340.8×103ind m 3) ,while the horizontal distribution showed a decreasing tendency from inshore to offshore regions.The dominant species of phytoplankton varied in different seasons.The dominant species were Thalassiosira pacifica,Skeletoema spp.and Chaetoceros cinctus in spring,Chaetoceros debbilis,Chaetoceros pseudocurvisetus and Chaetoceros curvisetus in summer,Thalassiosira curviseriata,Alexandrium catenella and Ceratium fusus in autumn,Paralia sulcata,Phaeocystis sp.and Bacillaria paradoxa in winter,respectively.In SYS,the group of temperate coastal species was the major ecotype,and the groups of the central SYS species and oceanic species were also important constituents.The average values of Shannon-Weaver diversity index (H’) and Pielou evenness index (J) were 2.37 and 0.65 respectively.The indices H’and J in the open sea were higher than those in coastal waters.Obvious co-variation tendencies between H’and J were observed in all but the summer cruise of this survey. | GAO Yu JIANG Zhibing LIU Jingjing CHEN Quanzhen ZENG Jiangning HUANG Wei | 2013 | Journal of Ocean University of China2013，12，4： | 10 |
| 8 | Class A scavenger receptor activation inhibits endoplasmic reticulum stress-induced autophagy in macrophage显示文摘Macrophage death in advanced atherosclerosis promotes plaque necrosis and destabilization.Involvement of autophagy in bulk degradation of cellular components has been recognized recently as an important mechanism for cell survival under endoplasmic reticulum(ER) stress.We previously found that the engagement of class A scavenger receptor(SR-A) triggered JNK-dependent apoptosis in ER-stressed macrophages.However,pro-apoptotic mechanisms mediated by SR-A are not fully understood.Therefore,we sought to see if SR-A mediated apoptosis was associated with autophagy in macrophages.Here,we showed that fucoidan inhibited microtubule-associated protein light chain 3-phospholipid conjugates(LC3-Ⅱ) formation as well as the number of autophagosomes under ER stress.The inhibition of LC3-Ⅱ formation was paralleled by the activation of the mTOR pathway,and the inhibition of mTOR allowed LC3-Ⅱ induction in macrophages treated with thapsigargin plus fucoidan.Furthermore,apoptosis induced by fucoidan was prevented under ER stress by the mTOR inhibitor.We propose that fucoidan,a SR-A agonist,may contribute to macrophage apoptosis during ER stress by inhibiting autophagy. | Hanpeng Huang Xiaoyu Li Yan Zhuang Nan Li Xudong Zhu Jin Hu Jingjing Ben Qing Yang Hui Bai Qi Chen | 2014 | The Journal of Biomedical Research2014，28，3： | 9 |
| 9 | Development and validation of an endoscopic images-based deep learning model for detection with nasopharyngeal malignancies显示文摘Background:Due to the occult anatomic location of the nasopharynx and frequent presence of adenoid hyperpla-sia,the positive rate for malignancy identification during biopsy is low,thus leading to delayed or missed diagnosis for nasopharyngeal malignancies upon initial attempt.Here,we aimed to develop an artificial intelligence tool to detect nasopharyngeal malignancies under endoscopic examination based on deep learning.Methods:An endoscopic images-based nasopharyngeal malignancy detection model(eNPM-DM)consisting of a fully convolutional network based on the inception architecture was developed and fine-tuned using separate training and validation sets for both classification and segmentation.Briefly,a total of 28,966 qualified images were collected.Among these images,27,536 biopsy-proven images from 7951 individuals obtained from January 1st,2008,to December 31st,2016,were split into the training,validation and test sets at a ratio of 7:1:2 using simple randomiza-tion.Additionally,1430 images obtained from January 1st,2017,to March 31st,2017,were used as a prospective test set to compare the performance of the established model against oncologist evaluation.The dice similarity coef-ficient(DSC)was used to evaluate the efficiency of eNPM-DM in automatic segmentation of malignant area from the background of nasopharyngeal endoscopic images,by comparing automatic segmentation with manual segmenta-tion performed by the experts.Results:All images were histopathologically confirmed,and included 5713(19.7%)normal control,19,107(66.0%)nasopharyngeal carcinoma(NPC),335(1.2%)NPC and 3811(13.2%)benign diseases.The eNPM-DM attained an overall accuracy of 88.7%(95%confidence interval(CI)87.8%-89.5%)in detecting malignancies in the test set.In the prospective comparison phase,eNPM-DM outperformed the experts:the overall accuracy was 88.0%(95%CI 86.1%-89.6%)vs.80.5%(95%CI 77.0%-84.0%).The eNPM-DM required less time(40 s vs.110.0±5.8 min)and exhibited encouraging performance in automatic segmentation of nasopharyngeal malignant area from the background,with an average DSC of 0.78±0.24 and 0.75±0.26 in the test and prospective test sets,respectively.Conclusions:The eNPM-DM outperformed oncologist evaluation in diagnostic classification of nasopharyngeal mass into benign versus malignant,and realized automatic segmentation of malignant area from the background of nasopharyngeal endoscopic images. | Chaofeng Li Bingzhong Jing Liangru Ke Bin Li Weixiong Xia Caisheng He Chaonan Qian Chong Zhao Haiqiang Mai Mingyuan Chen Kajia Cao Haoyuan Mo Ling Guo Qiuyan Chen Linquan Tang Wenze Qiu Yahui Yu Hu Liang Xinjun Huang Guoying Liu Wangzhong Li Lin Wang Rui Sun Xiong Zou Shanshan Guo Peiyu Huang Donghua Luo Fang Qiu Yishan Wu Yijun Hua Kuiyuan Liu Shuhui Lv Jingjing Miao Yanqun Xiang Ying Sun Xiang Guo Xing Lv | 2018 | Cancer Communications2018，38，1： | 9 |
| 10 | Analysis and Design of Four-Plate Capacitive Wireless Power Transfer System for Undersea Applications显示文摘This paper presents a four-plate undersea capacitive wireless power transfer(CPT)system for underwater applications such as autonomous underwater vehicles(AUVs).Generally,a CPT system transfers the power based on electric fields.The complex resonant compensation networks are used to make the CPT system work in the resonant condition.The resonant voltage is always very high.It will be a big challenge to the human safety.In this paper,a virtual electrons periodic reciprocating flow theory is proposed for the CPT system.In one switching cycle,the electrons firstly flow in the forward direction through the forward path and then flow in the inverse direction through the inverse path.The CPT system has been deeply studied with the vacuum dielectric or the air dielectric.However,for the CPT system,there are few papers to show the underwater application.In this paper,an undersea four-plate CPT system is designed and studied in the underwater condition.The two coupling capacitors and other elements of the CPT system could build a closed-loop path.A small value inductor is adapted as a resonant compensation network for the four-plate CPT system.The DC voltage is inverted to the AC voltage in the primary side with the single-phase full-bridge inverter.The resonant voltage is rectified to the DC voltage in the secondary side with the single-phase full-bridge diode rectifier.A 100 W power level CPT system is constructed to verify the theory analysis and the calculation.The theory analysis is verified by the simulated and experimental results.The stable output voltage and load power are achieved in this paper. | Lei Yang Yuanqi Zhang Xiaojie Li Jiale Jian Zhe Wang Jingjing Huang Li Ma Xiangqian Tong | 2021 | CES Transactions on Electrical Machines and Systems2021，5，3： | 9 |
| 11 | CD146 is essential for PDGFRβ-induced pericyte recruitment显示文摘 | Jianan Chen Yongting LUO Hongxin Huang Shuilong Wu Jing Feng Jingjing Zhang Xiyun Yan | 2018 | Protein & Cell2018，9，8： | 9 |
| 12 | The Damage Patterns of Retinal Nerve Fiber Layer in Acute and Chronic Intraocular Pressure Elevation in Primary Angle Closure Glaucoma显示文摘Purpose:To observe the differences of damage patterns of retinal nerve fiber layer(RNFL) between acute and chronic intraocular pressure(IOP) elevation in primary angle closure glaucoma.(PACG).using optical coherence tomography(OCT).Methods:Twenty four patients(48 eyes) with unilateral acute PACG(APACG) attack in the 6 months after remission and 36 patients(64 eyes) with chronic PACG(CPACG) were included in this prospective study.For all cases,IOP has been controlled less than 21 mmHg after treatment.Using stratus OCT,the RNFL thickness was assessed in eyes with PACG within 3 days,2 weeks,1,3 and 6 months after IOP controlled.Repeated measures ANOVA was used to examine the time course of changes after IOP controlled in RNFL thickness in both acute attack and unaffected fellow eyes of APACG and eyes with CPACG.Results:The mean RNFL thickness(μm) for the APACG-attacked eyes increased significantly within 3 days.(121.49±23.84).after acute strike and then became thinner along with time.(107.22±24.72 at 2 week,93.58±18.37 at 1 month,84.10±19.89 at 3 months and 78.98±19.17 at 6 months).In APACG-attacked eyes,there were significant differences of average RNFL thickness among 5 different times after IOP was controlled(P<0.001).In the APACG unaffected fellow eyes and CPACG eyes,there were no significant differences in mean RNFL thickness among 5 different times(F=0.450,P=0.104 in APACG unaffected fellow eyes and F=1.558,P=0.200 in CPACG eyes).There was significant difference for interaction between time periods and groups(F=1.912,P= 0.003).Conclusion:RNFL damage patterns are different under different IOP elevated courses.In APACG,RNFL was found to be swollen and thickening right after acute attack and then becomes thinning and atrophy along with the time,while RNFL was found to be diffused thinness in CPACG. | Xing Liu Mei Li Yimin Zhong Hui Xiao Jingjing Huang Zhen Mao | 2011 | Eye Science2011，26，3： | 8 |
| 13 | Growth and Repair Potential of Three Species of Bacteria in Reclaimed Wastewater after UV Disinfection显示文摘Objective The growth and repair potential of three typical microorganisms in reclaimed water after UV disinfection was investigated to assess the effects of photo-reactivation and dark repair of microorganisms,and the microbial safety of reclaimed water following this procedure.Methods The growth and repair potential of Escherichia coli,a fecal coliform strain and Bacillus subtilis in the effluent of a biological wastewater treatment plant disinfected by a low-pressure UV lamp were investigated.Results Any increase in bacterial numbers in the effluent after UV disinfection was due to damage repair.Exposure to photo-reactivating light for 8-10 h after UV irradiation with a dose of 5 mJ/cm 2,the highest percentage of photo-reactivation observed for E.coli and the fecal coliform strain was 29% and 15% respectively.B.subtilis showed little photo-reactivation under these conditions.The percentage of photo-reactivation was related to the UV dose and the photo-reactivating time,and a function was developed to forecast the final concentrations of E.coli and the fecal coliform strain after UV disinfection with possible photo-reactivation.Conclusion Different species of bacteria displayed different responses to UV light and different repair potentials.The repair of indigenous bacteria in wastewater needs to be investigated in future work. | GUO MeiTing HUANG JingJing HU HongYing LIU WenJun | 2011 | Biomedical and Environmental Sciences2011，24，4： | 8 |
| 14 | Developmentally Regulated Glucosylation of Bitter Triterpenoid in Cucumber by the UDP-Glucosyltransferase UGT73AM3显示文摘 | Yang Zhong Xiaofeng Xue Zhiqiang Liu Yongshuo Ma Kewu Zeng Lida Han Jingjing Qi Dae-Kyun Ro Soren Bak Sanwen Huang Yuan Zhou Yi Shang | 2017 | Molecular Plant2017，10，7： | 7 |
| 15 | Erratum to: Sn^(4+) precursor enables 12.4% efficient kesterite solar cell from DMSO solution with open circuit voltage deficit below 0.30 V (vol 64, issue 1, page 52, 2021)显示文摘In the version of the article originally published in volume 64,issue 1,2021 of Sci China Mater(2021,64(1):52–60,http://gffzzd3cc09b8251d45dfs0qwb9ckuokq96ucu.ffgz.tsg.suse.edu.cn/10.1007/s40843-020-1408-x),the chemical formula of Sn(DMSO)_(4)Cl_(4)(page 54,8^(th) line in the left column;page 56,4^(th) and 6^(th) lines from the bottom of left column and in Equations(6 and 7)in the right column)was miswritten.The correct formula should be as below:SN(DMSO)_(2)CL_(4). | Yuancai Gong Yifan Zhang Erin Jedlicka Rajiv Giridharagopal James A.Clark Weibo Yan Chuanyou Niu Ruichan Qiu Jingjing Jiang Shaotang Yu Sanping Wu Hugh W.Hillhouse David S.Ginger Wei Huang Hao Xin | 2021 | Science China Materials2021，64，5： | 7 |
| 16 | Synthesis of low-cost porous ceramic microspheres from waste gangue for dye adsorption显示文摘Low-cost porous ceramic microspheres from waste gangue were prepared by simple spray drying and subsequent calcination. Effects of calcination temperature on phase and microstructure evolution, specific surface area, pore structure, and dye adsorption mechanism of the microspheres were investigated systematically. Results showed that the microspheres were spherical, with some mesopores both on the surface and inside the spheres. The phase kept kaolinite after calcined at 800 and 900 ℃ and transformed into mullite at 1000 ℃. The microspheres calcined at 800 ℃ showed larger adsorption capacity and removal efficiency than those calcined at higher temperatures. Methylene blue(MB) and basic fuchsin(BF) removal efficiency reached 100% and 99.9% with the microsphere dosage of 20 g/L, respectively, which was comparable to that of other low-cost waste adsorbents used to remove dyes in the literature. Adsorption kinetics data followed the pseudosecond-order kinetic model, and the isotherm data fit the Langmuir isotherm model. The adsorption process was attributed to multiple adsorption mechanisms including physical adsorption, hydrogen bonding, and electrostatic interactions between dyes and gangue microspheres. The low-cost porous microspheres with excellent cyclic regeneration properties are promising absorbent for dyes in wastewater filtration and adsorption treatment. | Shu YAN Yiming PAN Lu WANG Jingjing LIU Zaijuan ZHANG Wenlong HUO Jinlong YANG Yong HUANG | 2018 | Journal of Advanced Ceramics2018，7，1： | 6 |
| 17 | Cross-cultural adaption and psychometric properties of the Chinese version of the Diabetes Behavior Rating Scale: a pilot study显示文摘Self-care behavior plays a major role in diabetic management. However, in China, a satisfactory instrument has not yet been developed to evaluate the compliance of self-care behavior for young patients with type 1 diabetes mellitus(T1 DM). The Diabetes Behavior Rating Scale(DBRS) has a potential to be the first mature instrument. The purpose of this study is to cross-culturally adapt the DBRS, and preliminarily evaluate its psychometric properties. The instrument translation included translation, back translation and culture adaptation. Psychometric properties were assessed in a sample of 116 young patients with T1 DM adapting insulin injection therapy. The Chinese version of the DBRS was divided to four subscales. Cronbach's α for the total scale was 0.92. The mean inter-item and item-total correlations were 0.35 and 0.54 respectively. Test-retest reliability showed good temporal stability(r=0.81, P=0.001). Negative correlations were found between DBRS scores with the Diabetes Distress Scale scores(r=.0.32, P=0.003) and hemoglobin A1 c(HbA1 c) levels(r=.0.36, P=0.002). Higher DBRS scores correlated with better glycemic control. The Chinese insulin injection therapy version of the DBRS is well translated and culturally adapted. It shows good overall reliability and validity and appears to be a valuable tool for assessing the diabetic self-care behaviors for young patients with T1 DM. | Jing Zhu Jingjing Xu Yang Chen Yong Gu Li Ji Yufeng Zhou Min Zhu Hsiang-Ting Hsu Xiaoping Huang Cuiping Yuan Yun Shi Dan Yan Lili Xie Shuang Chen Tao Yang Wei He | 2018 | Science China(Life Sciences)2018，61，3： | 6 |
| 18 | IL-17 sustains the plasma cell response via p38-mediated Bcl-xL RNA stability in lupus pathogenesis显示文摘Recent studies have demonstrated a central role for plasma cells in the development of autoimmune diseases,such as systemic lupus erythematosus(SLE).Currently,both the phenotypic features and functional regulation of autoreactive plasma cells during SLE pathogenesis remain largely unclear.In this study,we first found that a major subset of IL-17 receptor-expressing plasma cells potently produced anti-dsDNA IgG upon IL-17A(IL-17)stimulation in SLE patients and lupus mice.Using a humanized lupus mouse model,we showed that the transfer of Th17 cell-depleted PBMCs from lupus patients resulted in a significantly reduced plasma cell response and attenuated renal damage in recipient mice compared to the transfer of total SLE PBMCs.Moreover,long-term BrdU incorporation in lupus mice detected highly enriched long-lived BrdU+subsets among IL-17 receptor-expressing plasma cells.Lupus mice deficient in IL-17 or IL-17 receptor C(IL-17RC)exhibited a diminished plasma cell response and reduced autoantibody production with attenuated renal damage,while the adoptive transfer of Th17 cells triggered the plasma cell response and renal damage in IL-17-deficient lupus mice.In reconstituted chimeric mice,IL-17RC deficiency resulted in severely impaired plasma cell generation but showed no obvious effect on germinal center B cells.Further mechanistic studies revealed that IL-17 significantly promoted plasma cell survival via p38-mediated Bcl-xL transcript stabilization.Together,our findings identified a novel function of IL-17 in enhancing plasma cell survival for autoantibody production in lupus pathogenesis,which may provide new therapeutic strategies for the treatment of SLE. | Kongyang Ma Wenhan Du Fan Xiao Man Han Enyu Huang Na Peng Yuan Tang Chong Deng Lixiong Liu Yulan Chen Jingjing Li Shiwen Yuan Qin Huang Xiaoping Hong Dajun Hu Xiaoyan Cai Quan Jiang Dongzhou Liu Liwei Lu | 2021 | Cellular & Molecular Immunology2021，18，7： | 6 |
| 19 | Bismuth nanosheets as a Q-switcher for a mid-infrared erbium-doped SrF_2 laser显示文摘Bismuth nanosheets(Bi-NSs) were successfully prepared and employed as saturable absorbers to generate a diodepumped dual-wavelength Er^(3+):SrF_2 laser in the mid-infrared region. Q-switched pulses with a maximum output power of 0.226 W were obtained at an absorbed pump power of 1.97 W. A repetition rate of 56.20 kHz and a minimum pulse duration of 980 ns were achieved. To the best of our knowledge, we present the first application of Bi-NSs in a mid-infrared all-solid-state laser. The results prove that Bi-NSs may be applied as an optical modulator in mid-infrared photonic devices or as a mode-locker and Q-switcher. | JINGJING LIU HAO HUANG FENG ZHANG ZHEN ZHANG JIE LIU HAN ZHANG LIANGBI SU | 2018 | Photonics Research2018，6，8： | 6 |
| 20 | Recent advances in mammalian reproductive biology显示文摘Reproductive biology is a uniquely important topic since it is about germ cells, which are central for transmitting genetic information from generation to generation. In this review, we discuss recent advances in mammalian germ cell development,including preimplantation development, fetal germ cell development and postnatal development of oocytes and sperm. We also discuss the etiologies of female and male infertility and describe the emerging technologies for studying reproductive biology such as gene editing and single-cell technologies. | Lu Wen Qiang Liu Jingjing Xu Xixi Liu Chaoyi Shi Zuwei Yang Yili Zhang Hong Xu Jiang Liu Hui Yang Hefeng Huang Jie Qiao Fuchou Tang Zi-Jiang Chen | 2020 | Science China(Life Sciences)2020，63，1： | 6 |
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