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| 1 | Helicobacter pylori seropositivity in diabetic patients is associated with microalbuminuria显示文摘AIM:To investigate the relationship between Helicobacter pylori(H.pylori) seropositivity and the presence of microalbuminuria.METHODS:Between December 2003 and February 2010,asymptomatic individuals who visited the Seoul National University Healthcare System Gangnam Center for a routine check-up and underwent tests for H.pylori immunoglobulin G antibodies and urinary albumin to creatinine ratio(UACR) were included.All study subjects completed a structured questionnaire,anthropometric measurements and laboratory tests.Anti-H.pylori immunoglobulin G was identified using an enzyme-linked immunosorbent assay kit.A random single-void urine sample,collected using a clean-catch technique,was obtained to determine the UACR.The presence of microalbuminuria was defined as a UACR from 30 to 300 μg/mg.The presence of diabetes mellitus(DM) was defined as either a fasting serum glucose level greater than or equal to 126 mg/dL or taking anti-diabetic medication.Multiple logistic regression analysis was performed to identify the risk factors.The dependent variable was microalbuminuria,and the independent variables were the other study variables.RESULTS:A total of 2716 subjects(male,71.8%;mean age,54.9 years) were included.Among them,224 subjects(8.2%) had microalbuminuria and 324 subjects(11.9%) had been diagnosed with DM.Subjects with microalbuminuria had a significantly higher H.pylori seropositivity rate than subjects without microalbuminuria(60.7% vs 52.8%,P = 0.024).Multivariate analysis after adjustment for age,body mass index(BMI),waist circumference,and glucose and triglyceride levels showed that H.pylori seropositivity was significantly associated with microalbuminuria [odds ratio(OR),1.40,95% CI,1.05-1.89,P = 0.024].After the data were stratified into cohorts by glucose levels(≤ 100 mg/dL,100 mg/dL < glucose < 126 mg/dL,and ≥ 126 mg/dL or history of DM),H.pylori seropositivity was found to be significantly associated with microalbuminuria in diabetic subjects after adjusting for age,BMI and serum creatinine level(OR,2.21,95% CI,1.20-4.08,P = 0.011).In addition,the subjects were divided into five groups.Those without microalbuminuria(an UACR of < 30 μg/mg) were divided into four groups in accordance with their UACR values,and subjects with microalbuminuria comprised their own group.Notably,H.pylori seropositivity gradually increased with an increase in UACR(P = 0.001) and was highest in subjects with microalbuminuria(OR,2.41,95% CI,1.14-5.11).This suggests that H.pylori seropositivity is positively associated with microalbuminuria in diabetic subjects.CONCLUSION:H.pylori seropositivity was independently associated with microalbuminuria,and the prevalence of H.pylori seropositivity was associated with the severity of UACR in diabetic subjects. | Goh Eun Chung Nam Ju Heo Min Jung Park Su Jin Chung Hae Yeon Kang Seung Joo Kang | 2013 | World Journal of Gastroenterology2013，19，1： | 11 |
| 2 | 2-Hydroxy-3-methoxybenzoic acid attenuates mast cell-mediated allergic reaction in mice via modulation of the FcεRI signaling pathway显示文摘桅杆房间是在免疫球蛋白(Ig ) 的重要受动器房间电子 mediated 过敏反应象气喘,遗传性过敏症的皮炎和鼻炎那样。香子兰的酸,一个自然产品,显示出抗氧化剂和反煽动性的活动。在现在的学习,我们调查了 ortho 香子兰的酸的反过敏的煽动性的效果(2-hydroxy-3-methoxybenzoic 酸,卵) 那是从 Amomum xanthioides 孤立的香子兰的酸的衍生物。在老鼠过敏性模型,卵的口头的管理(2, 10, 50 mg/kg ) dose-dependently 稀释了象降低体温,组织安版本, IgE 生产和 vasodilation 那样的导致 ovalbumin 的活跃全身的过敏性和调停 IgE 的皮肤的过敏反应;卵的管理也压制了桅杆房间 degranulator 混合物 48/80-induced 过敏性。在在 vitro 的有教养的桅杆房间线 RBL-2H3 和孤立的老鼠腹桅杆房间,有卵(1-100 mol/L ) 的预告的处理 dose-dependently 由减少禁止了桅杆房间的 DNP-HSA-induced degranulation 细胞内部的免费的钙水平,并且压制了支持 inflammatory cytokines TNF-4 和 IL-4 的表示。有卵的 RBL-2H3 房间的预告的处理压制了 Lyn, Syk, Akt,和原子 factor-B 的原子 translocation 的 DNP-HSA-induced phosphorylation。在结论,卵压制桅杆由在桅杆房间的表面上高亲密关系 IgE 受体(FcRI ) 下游地堵住发信号的小径的调停房间的过敏煽动性的反应。 | Yeon-Yong KIM In-Gyu JE Min Jong KIM Byeong-Cheol KANG Young-Ae CHOI Moon-Chang BAEK Byungheon LEE Jin Kyeong CHOI Hae Ran PARK Tae-Yong SHIN Soyoung LEE Seung-Bin YOON Sang-Rae LEE Dongwoo KHANG Sang-Hyun KIM | 2017 | Acta Pharmacologica Sinica2017，38，1： | 8 |
| 3 | Understanding microstructure and mechanical properties of(AlTa(0.76))xCoCrFeNi(2.1) eutectic high entropy alloys via thermo-physical parameters显示文摘(AlTa(0.76))xCoCrFeNi(2.1)(x values in molar ratio,x=0.1,0.3,0.5,0.7,1.0,and 1.5) alloys were designed to investigate the microstructure and mechanical properties of the eutectic high entropy alloys(EHEAs)consisting of FCC,B2,and Laves phases.Depending on the compositional variatio,clear microstructural variation was observed,as follows:(1) Group 1:FCC dendrite+Laves interdendrite(x=0.1),(2) Group 2:FCC dendrite+fine-eutectic structure consisting of FCC and Laves phases(x=0.3,0.5 and 0.7),(3) Group 3:B2 dendrite+bimodal eutectic structure [FCC/B2+Laves](x=1.0),(4) Group 4:Laves dendrite+eutectic structure consisting of B2 and Laves phases(x=1.5).As the fraction of Laves or B2 phases increases,yield stress increases from 293 to 2336 MPa,while the plastic strain decreases from 50 % to 2%.Thermo-physical parameters,such as mixing entropy(△S(mix)),mixing enthalpy(△H(mix)),valence electron concentration(VEC),and atomic size difference(δr),were calculated to understand the microstructural variation.Two criteria(δr-VEC and δr-△H(mix)) were utilized to elucidate the formation of the eutectic structures in the present EHEAs,revealing the usefulness of the thermo-physical parameters in the development of EHEAs. | Min Jung Kim Gyeol Chan Kang Sung Hwan Hong Hae Jin Park Sang Chul Muna Gian Song Ki Buem Kim | 2020 | Journal of Materials Science & Technology2020，54，22： | 3 |
| 4 | Sectoral changes of the peripapillary choroidal thickness in patients with unilateral branch retinal vein occlusion显示文摘AIM: To investigate sectoral changes in the mean peripapillary choroidal thickness(PCT) in patients with unilateral branch retinal vein occlusion(BRVO). METHODS: This retrospective, interventional study included 41 patients with acute, unilateral BRVO without macular edema. All patients completed at least a 6-month follow-up period. The PCT was measured at eight locations(temporal, superotemporal, superior, superonasal, nasal, inferonasal, inferior, and inferotemporal). In addition to calculating the average of all locations, the peripapillary choroidal area was divided into four sectors: superior(average of superotemporal PCT, superior PCT, and superonasal PCT), temporal, inferior(average of inferotemporal PCT, inferior PCT, and inferonasal PCT), and nasal. RESULTS: In the BRVO-affected eyes, the mean PCT was 177.7±69.8 μm(range, 70.1-396.0 μm) at baseline and 127.8±54.8 μm(range, 56.4-312.1 μm) at 6 mo(P<0.001). In the non-affected contralateral eyes, the mean PCT was 192.5±60.6 μm(range, 61.4-365.0 μm) at baseline and 165.9±61.1 μm(range, 56.8-326.8 μm) at 6 mo(P<0.001). In sectoral analysis, the mean PCT in each sector was significantly reduced in over 6 mo in the BRVO-affected eyes(all P<0.001). In the non-affected contralateral eyes, the mean PCT was not significantly changed in any sector over the 6-month follow-up period(superior sector, P=0.143; temporal sector, P=0.825; inferior sector, P=0.192; and nasal sector, P=0.599).CONCLUSION: Sectoral analysis shows that the mean PCTs in all sectors are reduced significantly over 6 mo in the BRVO-affected eyes, but not in the non-affected contralateral eyes. | Na Eun Lee Hae Min Kang Jeong Hoon Choi Hyoung Jun Koh Sung Chul Lee | 2019 | International Journal of Ophthalmology(English edition)2019，12，3： | 2 |
| 5 | 16S rRNA基因测序技术在肝脓疡细菌鉴定中的作用(英文)显示文摘目的评价16S核糖体RNA(rRNA)基因测序在肝脓疡中细菌鉴定中的应用价值。方法2012年1月—2013年12月间共20例肝脓疡行经皮置管引流的患者,分别行脓液培养,血培养和16S rRNA基因测序。利用454 GS Junior System对脓液基因组DNA行PCR和16S rRNA基因测序。脓液培养,血液培养和16S rRNA基因测序结果进行分别评价。结果脓液和血液培养阳性的患者分别是9例(45%)和4例(20%)。16S rRNA基因测序细菌鉴定率为90%,明显高于传统的培养方法。结论 16S rRNA基因测序方法较传统的培养方法能更准确和有效对肝脓疡进行细菌鉴定。 | 宋伦圭 Yun Gyu Song Sang Gun Shim Kwang Min Kim Dae Soo Kim Sang Haeng Choi Jae Young Song Kon Ho Lee Hyung-Lyun Kang Seung-Chul Baik Woo-Kon Lee Myung Je Cho Kwang Ho Rhee Dong Hae Lee | 2014 | 介入放射学杂志2014，23，10： | 2 |
| 6 | Locoregional Recurrence of Breast Cancer in Patients Treated With Breast Conservation Surgery and Radiotherapy Following Neoadjuvant Chemotherapy显示文摘 | Sun Young Min Seung Ju Lee Kyung Hwan Shin In Hae Park So-Youn Jung Keun Seok Lee Jungsil Ro Seeyoun Lee Seok Won Kim Tae Hyun Kim Han-Sung Kang Kwan Ho Cho | 2011 | International Journal of Radiation Oncology Biology Physics2011，，5： | 1 |
| 7 | Characterization of a profile of the anthocyanins isolated from Vitis coignetiae Pulliat and their anti-invasive activity on HT-29 human colon cancer cells显示文摘 | Jeong Won Yun Won Sup Lee Min Jeong Kim Jing Nan Lu Myung Hee Kang Hoon Gu Kim Dong Chul Kim Eun Ju Choi Jin Young Choi Hae Gyeong Kim Yun-Kyoung Lee Chung Ho Ryu GonSup Kim Yung Hyun Choi Ock Jin Park Sung Chul Shin | 2010 | Food and Chemical Toxicology2010，，3： | 1 |
| 8 | Prevalence of focal lamina cribrosa defects in eyes with pachychoroid disease spectrum显示文摘AIM:To determine the prevalence of focal lamina cribrosa(LC)defect among patients with pachychoroid disease spectrum(PDS)in the absence of peripapillary retinoschisis.METHODS:This retrospective,cross-sectional study comprised of 180 patients with PDS,including polypoidal choroidal vasculopathy(PCV),central serous chorioretinopathy,and pachychoroidal neovasculopathy.Medical records and optic ner ve head evaluations conducted using spectral-domain optical coherence tomography with enhanced depth imaging were reviewed.As a control group,236 patients who underwent ophthalmologic evaluation for vitreous floaters,without obvious ocular disease,were also included.RESULTS:The mean age of the PDS group,which included 118 male patients(65.6%),was 57.4±11.1 y.There was no significant difference between the two groups in age(P=0.710)or sex(P=0.248).Six patients(3.3%)in the PDS group and none in the control group showed focal LC defect(P=0.318).Among the six patients with focal LC defect in the PDS group,four eyes had PCV,one eye was the fellow eye of a PCV eye,and one eye had pachychoroidal neovasculopathy.CONCLUSION:Focal LC defect can be defected in patients with PDS in the absence of peripapillar y retinoschisis.However,the prevalence of focal LC defect was not different significantly between PDS patients and those who did not have PDS. | Hae Min Kang Na Eun Lee Jeong Hoon Choi Hyoung Jun Koh Sung Chul Lee | 2022 | International Journal of Ophthalmology(English edition)2022，15，1： | 0 |
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