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| 1 | 急性冠状动脉综合征发生1个月后的生长分化因子15水平与主要出血风险增加相关显示文摘用双重抗血小板治疗的急性冠状动脉综合征(acutecoronarysyndromes,ACS)患者在初次就诊测量的生长分化因子15(growthdifferentiationfactor-15,GDF-15)与大出血相关。 | Lindholm D Hagstrm E James SK Becker RC Cannon CP Himmelmann A Katus HA Maurer G López-Sendón JL Steg PG Storey RF Siegbahn A Wallentin L 刘莉 叶鹏 | 2017 | 中华高血压杂志2017，25，5： | 5 |
| 2 | The effect of temperature and humidity on electrospinning显示文摘 | S. Vrieze T. Camp A. Nelvig B. Hagstr?m P. Westbroek K. Clerck | 2009 | Journal of Materials Science2009，，5： | 1 |
| 3 | Fractionated phytoplankton primary production, exudate release and bacterial production in a Baltic eutrophication gradient显示文摘 | U. Larsson ?. Hagstr?m | 1982 | Marine Biology1982，，1： | 1 |
| 4 | Plasma parathyroid hormone and the risk of cardiovascular mortality in the community 显示文摘 | Hagstr'dm E Hellman P Larsson TE | 2009 | Circulation2009，119，21： | 1 |
| 5 | Biolubricant synthesis using immobilised lipase: Process optimisation of trimethylolpropane oleate production显示文摘 | Cecilia Orellana ?kerman Anna E.V. Hagstr?m M. Amin Mollaahmad Stefan Karlsson Rajni Hatti-Kaul | 2011 | Process Biochemistry2011，，12： | 1 |
| 6 | Hydraulic fracturing:identifying and managing the risks显示文摘 | Hagstr?m E L Adams J M | 2012 | Environmental Claims Journal2012，24，93： | 1 |
| 7 | Fibrosis stage is the strongest predictor for disease‐specific mortality in NAFLD after up to 33 years of follow‐up显示文摘 | Mattias Ekstedt Hannes Hagstr?m Patrik Nasr Mats Fredrikson Per St?l Stergios Kechagias Rolf Hultcrantz | 2015 | Hepatology2015，，5： | 1 |
| 8 | Plasma Parathyroid Hormone and the Risk of Cardiovascular Mortality in the Community显示文摘 | Emil Hagstr?m Per Hellman Tobias E. Larsson Erik Ingelsson Lars Berglund Johan Sundstr?m H?kan Melhus Claes Held Lars Lind Karl Micha?lsson Johan ?rnl?v | 2009 | Circulation2009，，21： | 1 |
| 9 | A two-wave theory of traveling-wave tubes and backward-wave oscillators显示文摘 | hagstr?Zm C E | 1975 | IEEE Transaction on ED1975，22，： | 1 |
| 10 | CIP2A overexpression is associated with c-Myc expression in colorectal cancer显示文摘 | B(o)ckelman C Koskensalo S Hagstr(o)m J | 2012 | Cancer Biol Ther2012，13，5： | 1 |
| 11 | Expression of matrix metalloproteinases-2, -8, -13, -26, and tissue inhibitors of metalloproteinase-1 in human osteosarcoma显示文摘 | Jarkko T. Korpi Jaana Hagstr?m Niko Lehtonen Jyrki Parkkinen Timo Sorsa Tuula Salo Minna Laitinen | 2010 | Surgical Oncology2010，，1： | 1 |
| 12 | Low trypsinogen-1 expression in pediatric ulcerative colitis patients who undergo surgery显示文摘AIM: To investigate whether matrix metalloproteinases-9 (MMP-9) or trypsinogens could serve as histological markers for an aggressive disease course in pediatric ulcerative colitis (UC). METHODS: We identified 24 patients with pediatric onset (≤ 16 years) UC who had undergone surgery during childhood/adolescence a median of 2.1 years (range 0.1-7.4 years) after the diagnosis (between 1990 and 2008) in Children's Hospital, Helsinki, Finland. We also identified 27 conservatively treated UC patients and matched them based on their age at the time of diagnosis and follow-up at a median of 6 years (range 3-11 years) to serve as disease controls. Twenty children for whom inflammatory bowel disease (IBD) had been excluded as a result of endoscopy served as non-IBD controls. Colon biopsies taken by diagnostic endoscopy before the onset of therapy were stained using immunohistochemistry to study the expression of MMP-9, trypsinogen-1 (Tryp-1), Tryp-2, and a trypsin inhibitor (TATI). The profiles of these proteases and inhibitor at diagnosis were compared between the surgery group, the conservatively treated UC patients and the non-IBD controls. RESULTS: The proportions of Tryp-1 and Tryp-2 positive samples in the colon epithelium and in the inflammatory cells of the colon stroma were comparable between the studied groups at diagnosis. Interestingly, the immunopositivity of Tryp-1 (median 1; range 0-3) was significantly lower in the epithelium of the colon in the pediatric UC patients undergoing surgery when compared to that of the conservatively treated UC patients (median 2; range 0-3; P = 0.03) and non-IBD controls (median 2; range 0-3; P = 0.04). For Tryp-2, there was no such difference. In the inflammatory cells of the colon stroma, the immunopositivities of Tryp-1 and Tryp-2 were comparable between the studied groups at diagnosis. Also, the proportion of samples positive for TATI, as well as the immunopositivity, was comparable between the studied groups in the colon epithelium. In the stromal inflammatory cells of the colon, TATI was not detected. In UC patients, there were significantly more MMP-9 positive samples and a higher immunopositivity in the stromal inflammatory cells of the colon when compared to the samples from the non-IBD patients (P = 0.006 and P = 0.002, respectively); the immunopositivity correlated with the histological grade of inflammation (95%CI: 0.22-0.62; P = 0.0002), but not with the other markers of active disease. There were no differences in the immunopositivity or in the proportions of MMP-9 positive samples when examined by epithelial staining. The staining profiles in the ileal biopsies were comparable between the studied groups for all of the studied markers.CONCLUSION: For pediatric UC patients who require surgery, the immunopositivity of Tryp-1 at diagnosis is lower when compared to that of patients with a more benign disease course. | Maija Piekkala Jaana Hagstrm Maarit Tanskanen Risto Rintala Caj Haglund Kaija-Leena Kolho | 2013 | World Journal of Gastroenterology2013，19，21： | 1 |
| 13 | Plasma parathyroid hormone and the risk of cardiovascular mortality in the community显示文摘 | Hagstr?m E Hellman P Larsson TE | | 0，，： | 1 |
| 14 | Patterns in sedentary and exercise behaviors and associations with overweight in 9-14-year-old boys and girls-a cross-sectional study显示文摘 | Saskia J te Velde Ilse De Bourdeaudhuij Inga Thorsdottir Mette Rasmussen Maria Hagstr?mer Knut-Inge Klepp and Johannes Brug | 2007 | BMC Public Health2007，7，： | 1 |
| 15 | Size-selective grazing by a microflagellate on pelagic bacteria显示文摘 | Andensson A Larsson U Hagstr M A | 1986 | Mar Ecol Prog Ser1986，33，： | 1 |
| 16 | Processing of structural composites from biobased thermoset resins and natural fibres by compression moulding显示文摘 | (A)kesson D Skrifvars M Hagstr(o)m B Walkenstr(o)m P Sepp(a)l(a) J | 2009 | Journal of Biobased Materials and Bioenergy2009，3，3： | 1 |
| 17 | CIP2A overexpression is associated with c-Myc expression in colorectal cancer显示文摘 | Bckelman C Koskensalo S Hagstrm J | | 0，，05： | 1 |
| 18 | Microbial loop in an oligotrophic pelagic marine ecosystem:possible roles of cyanobacteria and nanoflagellates in the organic fluxes显示文摘 | Hagstrǒm A Azam F Anderson A | 1988 | Mar Ecol Prog Ser1988，49，： | 1 |
| 19 | Alcohol consumption in patients with primary sclerosing cholangitis显示文摘AIM:To assess the alcohol drinking patterns in a cohort of primary sclerosing cholangitis(PSC) patients and the possible influence on the development of fibrosis.METHODS:Ninety-six patients with PSC were evaluated with a validated questionnaire about a patient's lifetime drinking habits:the lifetime drinking history(LDH) questionnaire.In addition,clinical status,transient elastography and biochemistry values were analysed and registered.Patients were defined as having either significant or non-significant fibrosis.Significant fibrosis was defined as either an elastography value of ≥ 17.3 kPa or the presence of clinical signs of cirrhosis.Patients were divided into two groups depending on their alcohol consumption patterns;no/low alcohol consumption(one drink or unit/d) and moderate/high alcohol consumption(≥ 1 drink or unit/d).LDH data were calculated to estimate lifetime alcohol intake(LAI),current alcohol intake,drinks per year before and after diagnosis of PSC.We also calculated the number of episodes of binge-drinking(defined as consuming ≥ 5 drinks per occasion) in total,before and after the diagnosis of PSC.RESULTS:The mean LAI was 3882 units of alcohol,giving a mean intake after onset of alcohol consumption of 2.6 units per week.Only 9% of patients consumed alcohol equal to or more than one unit per day.Current alcohol intake in patients with significant fibrosis(n = 26) was less than in patients without significant fibrosis(n = 70),as shown by lower values of phosphatidylethanol(B-PEth)(0.1 mol/L vs 0.33 mol/L,respectively,P = 0.002) and carbohydrate-deficient transferrin(CDT)(0.88% vs 1.06%,respectively,P = 0.02).Self-reported LAI was similar between the two groups.Patients with significant fibrosis reduced their alcohol intake after diagnosis from 103 to 88 units per year whereas patients without fibrosis increased their alcohol intake after PSC diagnosis from 111 to 151 units/year.There were no correlations between elastography values and intake of alcohol(units/year)(r =-0.036).CONCLUSION:PSC patients have low alcohol consumption.The lack of correlation between fibrosis and alcohol intake indicates that a low alcohol intake is safe in these patients. | Hannes Hagstrm Per Stl Knut Stokkeland Annika Bergquist | 2012 | World Journal of Gastroenterology2012，18，24： | 1 |
| 20 | Periodic bacterivore activity balances bacterial growth in the marine environment显示文摘 | Wikner J Rassoulzadegan F Hagstrǒm A | 1990 | Limnol Oceanogr1990，35，： | 1 |
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