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| 1 | Interferon-armed RBD dimer enhances the immunogenicity of RBD for sterilizing immunity against SARS-CoV-2显示文摘Severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)has caused a global crisis,urgently necessitating the development of safe,efficacious,convenient-to-store,and low-cost vaccine options.A major challenge is that the receptor-binding domain(RBD)-only vaccine fails to trigger long-lasting protective immunity if used alone for vaccination. | Shiyu Sun Yueqi Cai Tian-Zhang Song Yang Pu Lin Cheng Hairong Xu Jing Sun Chaoyang Meng Yifan Lin Haibin Huang Fang Zhao Silin Zhang Yu Gao Jian-Bao Han Xiao-Li Feng Dan-Dan Yu Yalan Zhu Pu Gao Haidong Tang Jincun Zhao Zheng Zhang Jiaming Yang Zhenxiang Hu Yang-Xin Fu Yong-Tang Zheng Hua Peng | 2021 | Cell Research2021，31，9： | 7 |
| 2 | Polyacrylic acid sodium salt film entrapped Ag-nanocubes as molecule traps for SERS detection显示文摘提高表面的拉曼光谱学(重量的单位) 是为踪迹化学药品的一种快分析技术;然而,吸附 analytes 要求活跃重量的单位底层,因此为底层与需要的亲密关系限制目标种类到那些。这里我们现在的联网的 polyacrylic 酸钠盐(PAAS ) 电影骗诱 Ag-nanocubes (作为 Ag-nanocubes@PAAS 表示了) 作为为有或没有高亲密关系的 analytes 的有效重量的单位底层。一次 analyte 水的答案在干燥 Ag-nanocubes@PAAS 底层上被扔,嗜酒的 PAAS 变得肿强迫 Ag-nanocubes 松开,当时在在 Ag-nanocubes 之中的空隙弥漫的 analytes。当弄干时, PAAS 缩小并且拉 Ag-nanocubes 回到他们的以前的聚集的状态,当 PAAS 网络为重量的单位察觉在在 Ag-nanocubes 之间的小差距耽搁 analytes 时。没有强壮的亲密关系,策略为 Ag 为不仅 singleanalytes 而且 multi-analytes 被证明有效,在环境在能吸附、非能吸附的污染物质的基于重量的单位的同时的 multi-analyte 察觉显示出它的潜力。 | Zhulin Huang Guowen Meng Qing Huang Bin Chen Fei Zhou Xiaoye Hu Yiwu Qian Haibin Tang Fangming Han Zhaoqin Chu | 2014 | Nano Research2014，7，8： | 6 |
| 3 | Numerical Simulation of Characteristics of CEX Ions in Ion Thruster Optical System显示文摘Charge exchange(CEX) ions could inflict severe damages on the ion thruster optical system.This article is aimed at investigating the characteristics of the CEX ions and their influences upon the optical system by means of particle-incell(PIC) ion simulation and Monte Carlo collision(MCC) methods.The results from numerical simulation indicate that despite the fact that CEX ions appear in the entire beamlet region near the ion optical system,the ones that present themselves downstream of the accelerator grid have good reason for attracting more attention.As their trajectories are significantly affected by the local electric field,a great number of CEX ions are accelerated toward grids resulting in sputtering erosion.When the influences of the CEX ions are considered in the numerical simulation,there could hardly be observed augments in the screen grid current,but the accelerator grid current increases from zero to 1.4% of the beamlet current.It can be understood from the numerical simulation that the CEX ions formed in the region far downstream of the accelerator grid should be blamed for the erosion on the downstream surface of the accelerator grid. | Zhong Lingwei Liu Yu Li Juan Gu Zuo Jiang Haocheng Wang Haixing Tang Haibin | 2010 | Chinese Journal of Aeronautics2010，23，1： | 5 |
| 4 | Preliminary Investigation on the Main Fungal Diseases of Sugarcane in Guangxi Province of China显示文摘[Objective] The purpose was to understand species and occurrence status of major fugal diseases in sugarcane cultivation areas of Guangxi in China, so as to provide scientific references for integrated control against sugarcane diseases. [Method] Species and occurrence degrees of major fugal diseases in sugarcane cultivation areas of Guangxi were investigated through randomized surveys, farmer interviews, literature references and location investigations from 2009 to 2011. Diseased sugarcane samples were collected and their species were identified through pathogen isolated culture and other relevant methods. [Result] Thirteen species of fungal diseases were identified in the survey, including pineapple disease [Thielaviopsis paradoxa (de Seynes) V. Hohnel], smut(Ustilago scitaminea Sydow), top rot disease (Fusarium moniliforme Sheldon), rust (Puccinia melanocephala H.﹠P. Syd.), leaf scald disease (Stagonospora sacchari Lo et Ling), red rot disease (Colletotrichum falcatum Went), zonate spot disease (Phyllosticta saccharicola P. Henn.), leaf red spot disease [Pellicularia sasakii (Shirai) Ito], white rash disease (Elsinoe sacchari L.), eye spot [Helminthosporium sacchari (Breda de Haan) Butler], yellow spot [Mycovellosiella koepkei (kruger) Deighton], brown stripe [Bipolaris stenospilum (Drechs.) Shoem.]and brown spot (Cercospora longipes Butler). Smut, rust, top rot, and pineapple disease were the most rampantly detrimental to quality and yield of sugarcane. [Conclusion] Smut is the most serious sugarcane disease; it is urgent to breed sugarcane varieties with high resistance and excellent agronomic characters to replace current sugarcane varieties susceptible to diseases. | Wei Jinju Deng Zhanyun Huang Chenghua Huang Weihua Yan Meixin Liu Haibin Tang Hongqin | 2013 | Plant Diseases and Pests2013，4，1： | 3 |
| 5 | A systematic review and meta-analysis of the safety and efficacy of uterine artery embolization vs. surgery for symptomatic uterine fibroids显示文摘Purpose: The aim of this study was to systematically review the safety and efficacy of uterine artery embolization(UAE) versus surgery for symptomatic uterine fibroids. Materials and Methods: An electronic search of the Cochrane Library, PubMed, Embase and Web of Science databases was conducted from their inception to May 2017 for randomized controlled trials(RCTs) that assessed UAE versus surgery for the treatment of symptomatic uterine fibroids. The references of the included studies were also retrieved. Two reviewers independently screened the studies based on the inclusion and exclusion criteria, extracted the data, and assessed the methodological quality. The meta-analysis was conducted using RevMan 5.3 software. Results: A total of seven RCTs involving 859 patients were included. The results of the meta-analysis showed a shorter hospital stay and recovery time for UAE as compared to surgery. Surgery was not reported to be better for improving health-related quality of life in any of the included studies. There were no significant differences in patient satisfaction(1-2 and 5 years), and intra-procedural complications or major complications(1 year). However, the rates of minor complications(1 year) and further interventions(2 and 5 years) were significantly higher in patients who underwent UAE rather than surgery. The rates of pregnancy and live births were significantly lower among patients who underwent UAE than surgery. Conclusion: UAE is safe and effective, and has the advantages of shorter hospital stay and recovery time as compared to surgery. However, UAE has the risk of re-intervention, and lower pregnancy and live birth rates. | Shiwei Tang Mingxin Kong XinjianZhao Jun Chen Chen Wang Haibin Zhang Zhongmin Wang | 2018 | Journal of Interventional Medicine2018，1，2： | 3 |
| 6 | Hexagonally arranged arrays of urchin-like Ag hemispheres decorated with Ag nanoparticles for surface-enhanced Raman scattering substrates显示文摘The surface topography of noble metal particles is a significant factor in tailoring surface-enhanced Raman scattering (SERS) properties. Here, we present a simple fabrication route to hexagonally arranged arrays of surface-roughened urchin- like Ag hemispheres (Ag-HSs) decorated with Ag nanoparticles (Ag-NPs) for highly active and reproducible SERS substrates. The urchin-like Ag-HS arrays are achieved by sputtering Ag onto the top surface of a highly ordered porous anodic aluminum oxide (AAO) template to form ordered arrays of smooth Ag-HSs and then by electrodepositing Ag-NPs onto the surface of each Ag-HS. Owing to the ordered arrangement of the Ag-HSs and the improved surface roughness, the urchin-like hierarchical Ag-HS arrays can provide sufficient and uniform "hot spots" for reproducible and highly active SERS effects. Using the urchin-like Ag-HS arrays as SERS substrates, 10-7 M dibutyl phthalate (a member of plasticizers family) and 1.5 × 10-5 M PCB-77 (one congener of polychlorinated biphenyl, a notorious class of pollutants) are identified, showing promising potential for these substrates in the rapid recognition of organic pollutants. | Haibin Tang Guowen Meng Zhongbo Li Chuhong Zhu Zhulin Huang Zhaoming Wang Fadi Li | 2015 | Nano Research2015，8，7： | 3 |
| 7 | Injectable kartogenin and apocynin loaded micelle enhances the alleviation of intervertebral disc degeneration by adipose-derived stem cell显示文摘Cell transplantation has been proved the promising therapeutic effects on intervertebral disc degeneration(IVDD).However,the increased levels of reactive oxygen species(ROS)in the degenerated region will impede the efficiency of human adipose-derived stem cells(human ADSCs)transplantation therapy.It inhibits human ADSCs proliferation,and increases human ADSCs apoptosis.Herein,we firstly devised a novel amphiphilic copolymer PEG-PAPO,which could self-assemble into a nanosized micelle and load lipophilic kartogenin(KGN),as a single complex(PAKM).It was an injectable esterase-responsive micelle,and showed controlled release ability of KGN and apocynin(APO).Oxidative stimulation promoted the esterase activity in human ADSCs,which accelerate degradation of esterase-responsive micelle.Compared its monomer,the PAKM micelle possessed better bioactivities,which were attributed to their synergistic effect.It enhanced the viability,autophagic activation(P62,LC3 II),ECM-related transcription factor(SOX9),and ECM(Collagen II,Aggrecan)maintenance in human ADSCs.Furthermore,it is demonstrated that the injection of PAKM with human ADSCs yielded higher disc height and water content in rats.Therefore,PAKM micelles perform promoting cell survival and differentiation effects,and may be a potential therapeutic agent for IVDD. | Chao Yu Dongdong Li Chenggui Wang Kaishun Xia Jingkai Wang Xiaopeng Zhou Liwei Ying Jiawei Shu Xianpeng Huang Haibin Xu Bin Han Qixin Chen Fangcai Li Jianbin Tang Chengzhen Liang Nigel Slater | 2021 | Bioactive Materials2021，6，10： | 3 |
| 8 | ZnO-nanotaper array sacrificial templated synthesis of noble-metal building-block assembled nanotube arrays as 3D SERS-substrates显示文摘这份报纸描述一个 ZnO-nanotaper 数组为有试管墙的 nanotubes 的数组的制造的合成途径由 Ag-nanoplates, Au-nanorods, Pt-nanothorns 或 Pd-nanopyramids 的大楼块装配了的牺牲的 templated,因此拥有高密度的 3D 在有 nano 尖端,角落或边的附近的积木的 sub-10-nm 差距的热点。另外,这些层次 nanostructure 数组与富有的表面化学拥有高表面区域,对捕获 analyte 有益。Ag-nanoplateassembled nanotube 数组能被用作散布的敏感提高表面的拉曼(重量的单位) 有好信号一致性和重制度的底层。用如此的 Ag ,层次 nanostructure 作为重量的单位底层穿,不是仅仅有 10 <啜class=“ a-plus-plus ”> 14 M 玫瑰精 6G 识别,而且 10 <啜class=“ a-plus-plus ”> 7 M polychlorinated 联本基(印刷电路板,坚持的器官的污染物质的一个臭名昭著的班)被认出,并且甚至印刷电路板的二同种的物能在混合物被识别,在环境器官的污染物质的基于重量的单位的快速的察觉显示出材料的潜在的应用。 | Chuhong Zhu Guowen Meng Qing Huang Xiujuan Wang Yiwu Qian Xiaoye Hu Haibin Tang Nianqiang Wu | 2015 | Nano Research2015，8，3： | 3 |
| 9 | Selective laser melting of dense and crack-free AlCoCrFeNi_(2.1) eutectic high entropy alloy: Synergizing strength and ductility显示文摘Additively manufactured high-entropy alloys generally suffer from low strength and/or poor ductility.In this work,by leveraging the good castability of eutectic high entropy alloys and high cooling rate of selective laser melting(SLM),we report a nearly fully dense and crack-free as-SLM AlCoCrFeNi_(2.1) eutectic high entropy alloy with an exceptional strength-ductility synergy,showing an ultrahigh yield strength of 982.1±35.2 MPa and an ultimate tensile strength of 1322.8±54.9 MPa together with an elongation to fracture of 12.3±0.5%.Such strength-ductility enhancement is owing to the heterogeneous eutectic microstructure consisting of the columnar,equiaxed,and“L-shape”cells with much refined sizes down to nanoscales.The morphology of cells in the transition zone is related to the misorientation between the growth direction of adjacent layers.This heterogeneous eutectic microstructure is the result of the graingrowth behavior dominated by the mechanisms of the epitaxial growth and growth of heterogeneous nuclei in SLM.Our current results provide a new methodology for the future design of ultrahigh-strength and ductile SLM-fabricated metallic materials including HEAs,and other printable alloys for various structural applications. | Lin He Shiwei Wu Anping Dong Haibin Tang Dafan Du Guoliang Zhu Baode Sun Wentao Yan | 2022 | Journal of Materials Science & Technology2022，，22： | 2 |
| 10 | Outcome of bystander cardiopulmonary resuscitation after out-of-hospital cardiac arrest in Beijing显示文摘Aim:We aimed to investigate the association between bystander cardiopulmonary resuscitation(CPR)and survival of patients with out-of-hospital cardiac arrests(OHCA)in Beiing.Methods:This observational study analyzed adult patients with OHCA treated by the Beiing emergency medical service(EMS)from January 2013 to December 2017.Data were collected in a Utstein style with a 1-year follow-up and a primary outcome 01 survival to hospital discharge.Secondary outcomes were return of spontaneous circulation(ROSC),survival to admission,favorable neurological outcome at hospital discharge,and survival and favorable neurological outcomes of up to 1 year.Results:A total of 5016 patients with OHCA from Beiing's urban area were recorded by EMS,wherein 765 patients(15.25%)underwent bystander CPR.The data were propensity score-matched forage,sex,location,witness,aetiology,initial rhythm,and call to EMS arrival to compare the difference between the occurrence and nonoccurrence of bystander CPR.The survival upon the discharge of patients who experienced bystander CPR was superior to that of patients who did not receive bystander CPR(3.7%vs 1.2%,respectively;P<0.001).Moreover,patients with OHCA resuscitated with bystander CPR achieved better outcomes of ROSC,survival to admission,favorable neurological outcome at hospital discharge,survival and favorable neurological outcome after 1 year compared with those who were not resuscitated with bystander CPR.Conclusion:Survival and neu rological outcome of patients who underwent bystander CPR was better than those who underwent nonbystander CPR in Beiing.However,the rate of bystander CPR was low. | Xian Shi Yang Wu Haibin Li Shengkui Ma Dou Li Ding Gao Hao Cui Changxiao Yu Song Yang Ziren Tang Fei Shao | 2021 | Emergency and Critical Care Medicine2021，1，2： | 2 |
| 11 | P2P traffic optimization显示文摘Peer-to-peer (P2P) based content distribution systems have emerged as the main form for content distribution on the Internet,which can greatly reduce the distribution cost of content providers and improve the overall system scalability.However,the mismatch between the overlay and underlay networks causes large volume of redundant traffic,which intensifies the tension between P2P content providers and ISPs.Therefore,how to efficiently use network resources to reduce the traffic burden on the ISPs is crucial for the sustainable development of P2P systems.This paper surveys the state-of-art P2P traffic optimization technologies from three perspectives:P2P cache,locality-awareness and data scheduling.Technological details,comparison between these technologies and their applicabilities are presented,followed by a discussion of the issues that remain to be addressed and the direction of future content distribution research. | ZHANG GuoQiang TANG MingDong CHENG SuQi ZHANG GuoQing SONG HaiBin CAO JiGuang YANG Jing | 2012 | Science China(Information Sciences)2012，55，7： | 2 |
| 12 | Sequential activation of uterine epithelial IGF1R by stromal IGF1 and embryonic IGF2 directs normal uterine preparation for embryo implantation显示文摘Embryo implantation in both humans and rodents is initiated by the attachment of a blastocyst to the uterine epithelium.For blastocyst attachment,the uterine epithelium needs to transform at both the structural and molecular levels first,and then initiate the interaction with trophectoderm.Any perturbation during this process will result in implantation failure or long-term adverse pregnancy outcomes.Endocrine steroid hormones,which function through nuclear receptors,combine with the local molecules produced by the uteri or embryo to facilitate implantation.The insulin-like growth factor(IGF)signaling has been reported to play a vital role during pregnancy.However,its physiological function during implantation remains elusive.This study revealed that mice with conditional deletion of Igflr gene in uteri suffered from subfertility,mainly due to the disturbed uterine receptivity and abnormal embryo implantation.Mechanistically,we uncovered that in response to the nidatory estrogen on D4 of pregnancy,the epithelial IGF1R,stimulated by the stromal cell-produced IGF1,facilitated epithelial STAT3 activation to modulate the epithelial depolarity.Furthermore,embryonic derived IGF2 could activate both the epithelial ERK1/2 and STAT3 signaling through IGF1R,which was critical for the transcription of Cox2 and normal attachment reaction.In brief,our data revealed that epithelial IGF1R was sequentially activated by the uterine stromal IGF1 and embryonic IGF2 to guarantee normal epithelium differentiation during the implantation process. | Chan Zhou Meiying Lv Peike Wang Chuanhui Guo Zhangli Ni Haili Bao Yedong Tang Han Cai Jinhua Lu Wenbo Deng Xiaoyu Yang Guoliang Xia Haibin Wang Chao Wang Shuangbo Kong | 2021 | Journal of Molecular Cell Biology2021，13，9： | 2 |
| 13 | Nonconvex plus quadratic penalized low-rank and sparse decomposition for noisy image alignment显示文摘This paper proposes a general method for dealing with the problem of recovering the low-rank structure, in which the data can be deformed by some unknown transformations and corrupted by sparse or nonsparse noises. Nonconvex penalization method is used to remedy the drawbacks of existing convex penalization method and a quadratic penalty is further used to better tackle the nonsparse noises in the data.We exploits the local linear approximation(LLA) method for turning the resulting nonconvex penalization problem into a series of weighted convex penalization problems and these subproblems are efficiently solved via the augmented Lagrange multiplier(ALM). Besides comparing with the method of robust alignment by sparse and low-rank decomposition for linearly correlated images(RASL), we also propose a nonconvex penalized lowrank and sparse decomposition(NLSD) model as comparison. Numerical experiments are conducted on both controlled and uncontrolled data to demonstrate the outperformance of the proposed method over RASL and NLSD. | Xiai CHEN Zhi HAN Yao WANG Yandong TANG Haibin YU | 2016 | Science China(Information Sciences)2016，59，5： | 1 |
| 14 | Origin of strong and narrow localized surface plasmon resonance of copper nanocubes显示文摘Inexpe nsive copper nano particles are generally thought to possess weak and broad localized surface plasm on resonance(LSPR).The,present experimental and theoretical studies show that tailoring the Cu nanoparticle to a cubic shape results in a single intense,narrow,and asymmetric LSPR line shape,which is even superior to round-shaped gold nanoparticles.In this study,the dielectric function of copper is decomposed into an interband transition component and a free-electron component.This allows interband transition-induced plasmon damping to be visualized both spectrally and by surface polarization charges.The results reveal that the LSPR of Cu nanocubes originates from the comer mode as it is spectrally separated from the interb and transitions.In additi on,the interband tran sitions lead to severe damping of the local electromagnetic field but the cubic corner LSPR mode survives.Cu nanocubes display an extinction coefficient comparable to the dipole mode of a gold nanosphere with the same volume and show a larger local electromagnetic field enhancement These results will guider-development of in expensive plasmonic copper-based nano materials. | Peng Zheng Haibin Tang Botong Liu Sujan Kasani Ling Huang Nianqiang Wu | 2019 | Nano Research2019，12，1： | 1 |
| 15 | Propagation properties of hollow sinh-Gaussian beams through fractional Fourier transform optical systems显示文摘 | Bin Tang ShengBao Jiang Chun Jiang Haibin Zhu | 2014 | Optics and Laser Technology2014，，： | 1 |
| 16 | Pulsed Thrust Measurements Using Electromagnetic Calibration Techniques显示文摘 | Haibin Tang Chenbo Shi Xin'ai Zhang | 2011 | Review of Scientific Instrument2011，82，： | 1 |
| 17 | Near-infrared fluorescent labeled CGRRAGGSC peptides for optical imaging of IL-11Rα in athymic mice bearing tumor xenografts显示文摘The interleukin-11(IL-11)and the IL-11 receptorα-subunit(IL-11Rα)have been demonstrated to regulate the invasion and proliferation of tumor cells.Our study intends to evaluate a noninvasive imaging of IL-11Rαexpression in breast tumors using near-infrared(NIR)fluorescent dye Cy7-labeled IL-11 mimic peptide CGRRAGGSC.This work evaluated the IL-11Rαexpression of breast tumor cells and the binding status of this peptide to IL-11Rαin vitro and in vivo by using Western blotting,immunofluorescence staining and near-infrared fluorescence imaging.Our biochemical study showed that IL-11Rαwas overexpressed in breast tumor cells(MCF-7).The cell-binding assay demonstrated specific binding of peptide CGRRAGGSC to MCF-7 cells in vitro.In vivo imaging results showed that NIR fluorescent signals of Cy7-CGRRAGGSC were selectively accumulated in tumor and metabolic organs.While in the blocking experiment,free CGRRAGGSC obviously blocked the concentration of the Cy7-CGRRAGGSC in the tumors.These results suggested that IL-11Rαmay be used as a potential target for noninvasive imaging in IL-11Rαoverexpressed tumors.Furthermore,the imaging agent of near-infrared fluorescent dye Cy7-labeled CGRRAGGSC is suitable for IL-11Rαexpression imaging study in vivo. | Tiannv Li Jin Sun Yao Hu Min Yang Haibin Shi Lijun Tang | 2019 | The Journal of Biomedical Research2019，33，6： | 1 |
| 18 | Blockade of store-operated Ca 2+ entry inhibits hepatocarcinoma cell migration and invasion by regulating focal adhesion turnover显示文摘 | Ning Yang Ying Tang Fang Wang Haibin Zhang Dan Xu Yafeng Shen Shuhan Sun Guangshun Yang | 2012 | Cancer Letters2012，，： | 1 |
| 19 | Human HAND1 inhibits the conversion of cholesterol to steroids in trophoblasts显示文摘Steroidogenesis from cholesterol in placental trophoblasts is fundamentally involved in the establishment and maintenance of pregnancy.The transcription factor gene heart and neural crest derivatives expressed1(Hand1)promotes differentiation of mouse trophoblast giant cells.However,the role of HAND1 in human trophoblasts remains unknown.Here,we report that HAND1 inhibits human trophoblastic progesterone(P4)and estradiol(E2)from cholesterol through downregulation of the expression of steroidogenic enzymes,including aromatase,P450 cholesterol side-chain cleavage enzyme(P450 scc),and 3β-hydroxysteroid dehydrogenase type 1(3β-HSD1).Mechanically,although HAND1 inhibits transcription of aromatase by directly binding to aromatase gene promoter,it restrains transcription of P450 scc by upregulation of the methylation status of P450 scc gene promoter through its binding to ALKBH1,a demethylase.Unlike aromatase and P450 scc,HAND1 decreases 3β-HSD1 m RNA levels by the reduction of its RNA stability through binding to and subsequent destabilizing protein Hu R.Finally,HAND1 suppresses circulating P4 and E2 levels derived from JEG-3 xenograft and attenuates uterine response to P4 and E2.Thus,our results uncover a hitherto uncharacterized role of HAND1 in the regulation of cholesterol metabolism in human trophoblasts,which may help pinpoint the underlying mechanisms involved in supporting the development and physiological function of the human placenta. | Haibin Zhu Qianlei Ren Ziyi Yan Shouying Xu Jiahao Luo Ximei Wu Chao Tang | 2022 | Journal of Genetics and Genomics2022，49，4： | 1 |
| 20 | Responsive Dual-Targeting Exosome as a Drug Carrier for Combination Cancer Immunotherapy显示文摘Recently,combination immunotherapy,which incorporates the activation of the immune system and inhibition of immune escape,has been proved to be a new powerful strategy for more efficient tumor suppression compared to monotherapy.However,the major challenge is how to integrate multiple immune drugs together and efficiently convey these drugs to tumor sites.Although a variety of nanomaterials have been exploited as carriers for targeting tumor issues and the delivery of multiple drugs,their potential toxicity,immune rejection,and stability are still controversial for clinical application.Here,we proposed endogenic exosomes as drug carriers to deliver two antibodies acting as tumor-targeting molecules and block checkpoint inhibitors with specific response to the tumor microenvironment and costimulatory molecules for further improvement of therapeutic effect.The versatile exosomes exhibit excellent biocompatibility and provide a combination immunotherapy platform with synergistic advantages of activation of immune response and inhibition of immune escape. | Yuanyuan Fan Yingshun Zhou Meng Lu Haibin Si Lu Li Bo Tang | 2021 | Research2021，，1： | 1 |
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