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| 1 | Evaluating the suitability of TRMM satellite rainfall data for hydrological simulation using a distributed hydrological model in the Weihe River catchment in China显示文摘这研究的目的到份量上评估热带降雨测量有雨计量器数据并且进一步的使命(TRMM ) 数据到使用驱使一个分布式的时间变体获得模型(DTVGM ) 在中国在半潮湿的 Weihe 河集水执行水文学模拟的这个 TRMM 数据。在模拟前,比较与一 10 年(20012010 ) 设置的每日的雨计量器数据表明在每日的时间步, TRMM 降雨数据擅长比降雨极端捕获雨出现和吝啬的值。在每月的时间规模上,在 TRMM 和雨计量器降雨数据之间的好线性关系被发现,与决心系数 R < 啜 class= “ a-plus-plus ” > 为个人在 0.78 和 0.89 之间变化的 2 驻扎。每日的水文学过程上的数据的七年( 20012007 )的随后的模拟结果证实 DTVGM 什么时候由雨计量器数据校准了,比什么时候由 TRMM 数据校准更好表现,但是 TRMM 数据驾驶的模拟的性能比在每月的时间规模上由计量器数据开车的好。结果因此建议 TRMM 降雨数据对在学习的每月的流速及流水量模拟更合适区域,和那当为水平衡部件的刻度和结果的效果也被考虑时, TRMM 3B42-V7 产品有潜力表现很好在类似的盆。 | ZHAO Haigen | 2015 | Journal of Geographical Sciences2015，25，2： | 12 |
| 2 | Synthesis and biological evaluation of 8-substituted berberine derivatives as novel anti-mycobacterial agents显示文摘Tuberculosis(TB)is a disease which kills two million people every year and infects over one-third of the world's population.Eighteen new 8-substituted berberine derivatives were synthesized and evaluated for their anti-mycobacterial activities against M ycobacterium tuberculosis(M.tuberculosis)strain H_(37)Rv.Among these compounds,compound 6i was the most effective antitubercular agent with an MIC of 1.0μg/mL.Most importantly,compound 6i also exhibited a potent effect against clinically isolated rifampicin-and isoniazid-resistant M.tuberculosis strains,suggesting a different mode of action from the current drugs.Therefore,it shows potential for the development of new anti-TB agents. | Yanxiang Wang Haigen Fu Yinghong Li Jiandong Jiang Danqing Song | 2012 | Acta Pharmaceutica Sinica B2012，2，6： | 4 |
| 3 | Study on Virtual Assembly for Satellite Based on Augmented Reality显示文摘Assembly activities are a very important part of the production processof large and complex equipment. In order to solve the huge resource problemof large and complex equipment assembly process, this paper proposes a virtualassembly for satellite.Microsoft’s latest holographic glasses HoloLens2 is used asa display facility, and Unity3D is applied to develop a satellite part assembly scenebased on augmented reality (AR) technology. Voice input and gaze in the MixedReality Toolkit (MRTK), provided by Microsoft, are adopted in the developmentscenario to enable users to interact with virtual models in a more natural way.Finally, the development scenario has been tested in a small space. The resultsshow its validity and good performance. | Jie Du Yong Wang Haigen Yang | 2021 | 国际计算机前沿大会会议论文集2021，，1： | 0 |
| 4 | Discovery of small-molecule activators of nicotinamide phosphoribosyltransferase(NAMPT)and their preclinical neuroprotective activity显示文摘The decline of nicotinamide adenine dinucleotide(NAD)occurs in a variety of human pathologies including neurodegeneration.NAD-boosting agents can provide neuroprotective benefits.Here,we report the discovery and development of a class of potent activators(NATs)of nicotinamide phosphoribosyltransferase(NAMPT),the rate-limiting enzyme in the NAD salvage pathway.We obtained the crystal structure of NAMPT in complex with the NAT,which defined the allosteric action of NAT near the enzyme active site.The optimization of NAT further revealed the critical role of K189 residue in boosting NAMPT activity.NATs effectively increased intracellular levels of NAD and induced subsequent metabolic and transcriptional reprogramming.Importantly,NATs exhibited strong neuroprotective efficacy in a mouse model of chemotherapy-induced peripheral neuropathy(CIPN)without any overt toxicity.These findings demonstrate the potential of NATs in the treatment of neurodegenerative diseases or conditions associated with NAD level decline. | Hong Yao Minghui Liu Leibo Wang Yumeng Zu Chou Wu Chenyu Li Ruoxi Zhang Haigen Lu Feifei Li Shuang Xi Shuangquan Chen Xuanyu Gu Tianya Liu Jie Cai Shirong Wang Maojun Yang Guo-Gang Xing Wei Xiong Lan Hua Yefeng Tang Gelin Wang | 2022 | Cell Research2022，32，6： | 0 |
| 5 | Evolution and development of potent monobactam sulfonate candidate IMBZ18g as a dual inhibitor against MDR Gram-negative bacteria producing ESBLs显示文摘A series of new monobactam sulfonates is continuously synthesized and evaluated for their antimicrobial efficacies against Gram-negative bacteria.Compound 33a(IMBZ18G)is highly effective in vitro and in vivo against clinically intractable multi-drug-resistant(MDR)Gram-negative strains,with a highly druglike nature.The checkerboard assay reveals its significant synergistic effect withβ-lactamase inhibitor avibactam,and the MIC values against MDR enterobacteria were reduced up to 4—512folds.X-ray co-crystal and chemoproteomic assays indicate that the anti-MDR bacteria effect of 33a results from the dual inhibition of the common PBP3 and some class A and Cβ-lactamases.Accordingly,preclinical studies of 33a alone and 33a-avibactam combination as potential innovative candidates are actively going on,in the treatment ofβ-lactamase-producing MDR Gram-negative bacterial infections. | Zhiwen Li Zhihao Guo Xi Lu Xican Ma Xiukun Wang Rui Zhang Xinxin Hu Yanxiang Wang Jing Pang Tianyun Fan Yonghua Liu Sheng Tang Haigen Fu Jingpu Zhang Yinghong Li Xuefu You Danqing Song | 2023 | Acta Pharmaceutica Sinica B2023，13，7： | 0 |
| 6 | China Biodiversity Observation Network for better global sustainability developments显示文摘Biodiversity is undergoing unprecedented changes characterized by long-term,complex,and lagging consequences[1].Understanding the dynamic changes of biodiversity is essential for the conservation of biodiversity[2].Biodiversity monitoring is periodic measurements of biodiversity within a given area,such as data collection regarding the structure and function of ecosystems,the composition and distribution of species,and environmental factors.Based on the collected data,analyses could be performed to determine the trends of biodiversity change and potential drivers and assist in the evaluation of conservation effectiveness and decision-making[2,3]. | Jianfeng Yi Fangzhou Ma Jiaqi Li Wei Liu Yun Cao Yaqiong Wan Chenbin Wang Mengmeng Chen Dandan Yu Haigen Xu | 2022 | Eco-Environment & Health2022，1，4： | 0 |
| 7 | Multidimensional diversity of bird communities across spatial variation of land cover in Zoige on the eastern Qinghai-Tibetan Plateau显示文摘Background:Spatial variation of land cover can result in the changes of community similarities and biotic homog-enization,whereby the increasing similarity would reduce the adaptive capacity of biotic assemblages to further disturbance,and degenerate ecosystem services they offer.However,it remains scarce to integrate multidimensional diversity for unveiling how variations in land cover may influence the patterns and processes of biotic homogeniza-tion in the Anthropocene.In this study,we examined how spatial variation of land cover could alter taxonomic,phy-logenetic and functional homogenization of bird communities simultaneously in a compound ecosystem of Zoige Marsh on the eastern Qinghai-Tibetan Plateau.Acting as the largest alpine marsh and peatland in the world,Zoige Marsh has undergone great changes in the land cover pattern due to climate change and anthropogenic activities.Methods:We conducted transect surveys for bird communities over six years(2014‒2019)during breeding sea-sons in four main land cover types(meadow,woodland,village and marsh),representing the spatial variation of land covers in the study area.We compared multidimensional diversity(taxonomic,phylogenetic and functional diver-sity)among land covers to assess the effects of spatial variation in land cover type on bird communities,particularly whether this variation has homogenized biotic communities.Results:Bird communities during breeding seasons were different and complementary in the four land covers.Taxonomic,phylogenetic and functional similarities were significantly lower in meadow than in the other three types,i.e.woodland,village and marsh.However,when we controlled for the effects of taxonomic similarities,the pattern of phylogenetic similarities almost reversed,with the highest standardized effect size(SES)phylogenetic similarity in meadow;and we found no significant difference in SES functional similarity among land covers.Conclusions:Our results suggest that spatial variation of land cover can play a crucial role in regulating multiple dimensions of bird diversity in Zoige Marsh.The findings indicate that taxonomic,phylogenetic and functional homogenization of bird communities may differently response to the variation of land covers.It thus highlights not only the relative roles of different land covers in maintaining biodiversity and community structures of birds,but also the urgency of retarding ecosystem degradations on the eastern Qinghai-Tibetan Plateau. | Aichun Xu Maojun Zhong Ke Tang Xiaoyi Wang Chen Yang Haigen Xu Jianfeng Yi Wei Liu Chunlan Zhang Junhua Hu | 2021 | Avian Research2021，12，2： | 0 |
| 8 | Review for Porcine Reproductive and Respiratory Syndrome Virus显示文摘Abstract Porcine reproductive and respiratory syndrome(PRRS)is the severest disease of pigs worldwide,caused by a highly genetically diverse RNA virus,called Porcine reproductive and respiratory syndrome virus(PRRSV).The research summarized the genome characteristics of PRRSV particles and the most updated knowledge of structure protein function,and introduced the intellectual of PRRSV transmission and host immune response,which is very important for prevention and control for PRRS.A report showed that mass vaccination can stabilize the immunity of the entire herd,and this is the first required step for a PRRS eradication plan.However,the attenuated live vaccines may not achieve a valid prevention.The final goal of the EU project is to develop new generation,efficacious and safe maker vaccines that can be adapted to temporary changes and geographical differences.Robinson reported that broadly antibodies could neutralize all rapidly evolving typeⅠand typeⅡviruses,while further studies are expected to elucidate mechanisms of neutralizing antibody production and maturation and to investigate conserved epitope targets of cross-neutralization in this rapidly evolving virus. | Tao XING Xingxing YU Jun ZHANG Hongfei ZHANG Haigen WANG Guangsheng ZHOU Min ZHANG Chuanmin LIU Jingui LI | 2017 | Agricultural Science & Technology2017，18，1： | 0 |
| 9 | Combinatory action of VEGFR2 and MAP kinase pathways maintains endothelial-cell integrity显示文摘血容器通常坚持说 stereotyped 腔直径和他们的稳定的结构为脉管的功能是关键的。然而,很,很少对控制容器直径的维护和 endothelial 房间的正直的分子的机制被知道。我们由一条化学遗传途径在 zebrafish 胚胎调查了这个问题。小分子图书馆用实时 Tg 被屏蔽(kdrl : GRCFP ) endothelial 房间是的转基因的在胚胎明确地用 GFP 标记的 zn1 。由在腔形成以后在胚胎的血容器的形态学和功能上分析混合物的效果, PP1,一个通常认为的 Src kinase 禁止者,明确地由打断 endothelial 房间正直减少脉管的腔尺寸作为有能力被识别。禁止的效果不由于因为象几个 VEGFR 禁止者一样的另一 Src 禁止者和 Src morpholino 没能生产类似的显型,表明抑制的 Src 或一般 VEGF。在介绍 22 代表性的哺乳动物的 kinases 的一块面板并且调查出版数据以后,我们选择了一些可能的新候选人。这些候选人 kinase 禁止者的 Combinational 分析证实 PP1 由禁止 VEGFR2 和地图 kinase 小径导致了 endothelial 倒塌。更重要地,二临床上同意的药 Dasatinib 和 Sunitinib 的组合使用生产了一样的显型。这是第一研究阐明用化学遗传控制 endothelial 完整的维护的小径来临,显示那 endothelial 正直被 VEGFR2 和地图 kinase 小径的联合行动控制。我们的结果也在循环系统上建议二 anticancer 药的联合的可能的副作用。 | Hanbing Zhong Danyang Wang Nan Wang Yesenia Rios Haigen Huang Song Li Xinrong Wu Shuo Lin | 2011 | Cell Research2011，21，7： | 0 |
| 10 | Research on Route Optimization of Battlefield Collection Equipment Based on Improved Ant Algorithm显示文摘Accurate battlefield collection plays a crucial role in the end of thewar. How to effectively improve the ability of accurate battlefield collection hasbecome a hot issue of research. However, the existing support force is limited. Tosolve the problem, an improved ant algorithm is applied to the path optimizationproblem of battlefield collection equipment. A model for solving the collectionpath optimization problem of battlefield collection vehicles was designed, andan example was used to simulate calculations. The final results show that thealgorithm is effective and practical,which improves the army’s ability to accuratelycollect equipment in the modern battlefield. | Haigen Yang Wang Sun Xiao Fu Gang Li Luyang Li | 2021 | 国际计算机前沿大会会议论文集2021，，1： | 0 |
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