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| 1 | Enhanced secondary pollution offset reduction of primary emissions during COVID-19 lockdown in China显示文摘To control the spread of the 2019 novel coronavirus(COVID-19),China imposed nationwide restrictions on the movement of its population(lockdown)after the Chinese New Year of 2020,leading to large reductions in economic activities and associated emissions.Despite such large decreases in primary pollution,there were nonetheless several periods of heavy haze pollution in eastern China,raising questions about the well-established relationship between human activities and air quality.Here,using comprehensive measurements and modeling,we show that the haze during the COVID lockdown was driven by enhancements of secondary pollution.In particular,large decreases in NOx emissions from transportation increased ozone and nighttime NO_(3)radical formation,and these increases in atmospheric oxidizing capacity in turn facilitated the formation of secondary particulate matter.Our results,afforded by the tragic natural experiment of the COVID-19 pandemic,indicate that haze mitigation depends upon a coordinated and balanced strategy for controlling multiple pollutants. | Xin Huang Aijun Ding Jian Gao Bo Zheng Derong Zhou Ximeng Qi Rong Tang Jiaping Wang Chuanhua Ren Wei Nie Xuguang Chi Zheng Xu Liangduo Chen Yuanyuan Li Fei Che Nini Pang Haikun Wang Dan Tong Wei Qin Wei Cheng Weijing Liu Qingyan Fu Baoxian Liu Fahe Chai Steven JDavis Qiang Zhang Kebin He | 2021 | National Science Review2021，8，2： | 47 |
| 2 | Green fluorescent protein (GFP) transgenic pig produced by somatic cell nuclear transfer显示文摘Transgenic somatic cell nuclear transfer is a very promising route for producing transgenic farm ani-mals. Research on GFP transgenic pigs can provide useful information for breeding transgenic pigs, human disease models and human organ xenotransplantation. In this study, a liposomal transfection system was screened and transgenic embryos were reconstructed by nuclear transfer of GFP positive cells into enucleated in vitro matured oocytes. The development of reconstructed embryos both in vitro and in vivo was observed, and GFP expression was determined. The results showed that porcine fe-tal-derived fibroblast cells cultured with 4.0 μL/mL liposome and 1.6 μg/mL plasmid DNA for 6 h re-sulted in the highest transfection rate (3.6%). The percentage of GFP reconstructed embryos that de-veloped in vitro to the blastocyst stage was 10%. Of those the GFP positive percentage was 48%. Re-constructed transgenic embryos were transferred to 10 recipients. 5 of them were pregnant, and 3 de-livered 6 cloned piglets in which 4 piglets were transgenic for the GFP as verified by both GFP protein expression and GFP DNA sequence analysis. The percentage of reconstructed embryos that resulted in cloned piglets was 1.0%; while the percentage of piglets that were transgenic was 0.7%. This is the first group of transgenic cloned pigs born in China, marking a great progress in Chinese transgenic cloned pig research. | LIU ZhongHua SONG Jun WANG ZhenKun TIAN JiangTian KONG QingRan ZHENG Zhong YIN Zhi GAO Li MA HaiKun SUN Shuang LI YuTian WANG HongBin R S PRATHER | 2008 | Chinese Science Bulletin2008，53，7： | 8 |
| 3 | Optical observations of LIGO source GW 170817 by the Antarctic Survey Telescopes at Dome A,Antarctica显示文摘The LIGO detection of gravitational waves(GW) from merging black holes in 2015 marked the beginning of a new era in observational astronomy. The detection of an electromagnetic signal from a GW source is the critical next step to explore in detail the physics involved. The Antarctic Survey Telescopes(AST3),located at Dome A, Antarctica, is uniquely situated for rapid response time-domain astronomy with its continuous night-time coverage during the austral winter. We report optical observations of the GW source(GW 170817) in the nearby galaxy NGC 4993 using AST3. The data show a rapidly fading transient at around 1 day after the GW trigger, with the i-band magnitude declining from 17:23 ± 0:13 magnitude to 17:72 ± 0:09 magnitude in ~1:8 h. The brightness and time evolution of the optical transient associated with GW 170817 are broadly consistent with the predictions of models involving merging binary neutron stars. We infer from our data that the merging process ejected about ~10^(-2) solar mass of radioactive material at a speed of up to 30% the speed of light. | lei hu xuefeng wu igor andreoni michael c.b.ashley jeff cooke xiangqun cui fujia du zigao dai bozhong gu yi hu haiping lu xiaoyan li zhengyang li ensi liang liangduan liu bin ma zhaohui shang tianrui sun n.b.suntzeff charling tao syed a.uddin lifan wang xiaofeng wang haikun wen di xiao jin xu ji yang shihai yang xiangyan yuan hongyan zhou hui zhang jilin zhou zonghong zhu | 2017 | Science Bulletin2017，62，21： | 6 |
| 4 | Trending IC design directions in 2022显示文摘For the non-stop demands for a better and smarter society, the number of electronic devices keeps increasing exponentially;and the computation power, communication data rate, smart sensing capability and intelligence are always not enough. Hardware supports software, while the integrated circuit(IC) is the core of hardware. In this long review paper, we summarize and discuss recent trending IC design directions and challenges, and try to give the readers big/cool pictures on each selected small/hot topics. We divide the trends into the following six categories, namely, 1) machine learning and artificial intelligence(AI) chips, 2) communication ICs, 3) data converters, 4) power converters, 5) imagers and range sensors, 6) emerging directions. Hope you find this paper useful for your future research and works. | Chi-Hang Chan Lin Cheng Wei Deng Peng Feng Li Geng Mo Huang Haikun Jia Lu Jie Ka-Meng Lei Xihao Liu Xun Liu Yongpan Liu Yan Lu Kaiming Nie Dongfang Pan Nan Qi Sai-Weng Sin Nan Sun Wenyu Sun Jiangtao Xu Jinshan Yue Milin Zhang Zhao Zhang | 2022 | Journal of Semiconductors2022，43，7： | 3 |
| 5 | VMStore: Distributed storage system for multiple virtual machines显示文摘Desktop virtualization is a very hot concept in both industry and academic communities. Since virtualized desktop system is based on multiple virtual machines (VM), it is necessary to design a distributed storage system to manage the VM images. In this paper, we design a distributed storage system, VMStore, by taking into account three important characteristics: high performance VM snapshot, booting optimization from multiple images and redundancy removal of images data. We adopt a direct index structure of blocks for VM snapshots to speed up VM booting performance significantly; provide a distribute storage structure with good bandwidth scalability by dynamically changing the number of storage nodes; and propose a data preprocessing strategy with intelligent object partitioning techniques, which would eliminate duplication more effectively. Performance analysis for VMStore focuses on two metrics: the speedup of VM booting and the overhead of de-duplication. Experimental results show the efficiency and effectiveness of VMStore. | LIAO XiaoFei LI He JIN Hai HOU HaiXiang JIANG Yue & LIU HaiKun | 2011 | Science China(Information Sciences)2011，54，6： | 3 |
| 6 | Enrichment characteristics and exploration directions of deep shale gas of Ordovician-Silurian in the Sichuan Basin and its surrounding areas,China显示文摘The enrichment characteristics of deep shale gas in the Ordovician Wufeng-Silurian Longmaxi formations in the Sichuan Basin and its surrounding areas are investigated through experiments under high temperature and high pressure,including petrophysical properties analyses,triaxial stress test and isothermal adsorption of methane experiment.(1)The deep shale reservoirs drop significantly in porosity and permeability compared with shallower shale reservoirs,and contain mainly free gas.(2)With higher deviatoric stress and axial strain,the deep shale reservoirs have higher difficulty fracturing.(3)Affected by structural location and morphology,fracture characteristics,geofluid activity stages and intensity,deep shale gas reservoirs have more complicated preservation conditions.(4)To achieve the commercial development of deep shale gas reservoirs,deepening geological understanding is the basis,and exploring reservoir simulation technology befitting the geological features is the key.(5)The siliceous shale and limestone-bearing siliceous shale in the Metabolograptus persculptus-Parakidograptus acuminatus zones(LM1-LM3 graptolite zones)are the high-production intervals for deep shale gas and the most favorable landing targets for horizontal drilling.Deeps water areas such as Jiaoshiba,Wulong,Luzhou and Changning with deep shale reservoirs over 10 m thickness are the most favorable areas for deep shale gas enrichment.It is recommended to carry out exploration and development practice in deep-water shale gas areas deposited deep with burial depth no more than 5000 m where the geological structure is simple and the shale thickness in the LM1-LM3 graptolite zone is greater than 10 m.It is better to increase the lateral length of horizontal wells,and apply techniques including high intensity of perforations,large volume of proppant,far-field and near-wellbore diversions to maximize the stimulated deep reservoir volume. | NIE Haikuan LI Pei DANG Wei DING Jianghui SUN Chuanxiang LIU Mi WANG Jin DU Wei ZHANG Peixian LI Donghui SU Haikun | 2022 | Petroleum Exploration and Development2022，49，4： | 3 |
| 7 | A Preliminary Study on SSR Molecular Markers of White Character of Capsicum显示文摘In this study,Paprika 247 with milk white fruit at marketable maturity stage as male parent and capsicum 246 with green fruit at marketable maturity stage as female parent were selected as experimental materials to screen SSR molecular markers closely related to white fruit character,so as to lay a foundation for the use of SSR technique for molecular marker-assisted breeding and provide reference for breeding of new white capsicum germplasms and varieties. 360 pairs of SSR primers were screened in total,and among them,3 pairs of primers( ES-89,ES-292,ES-296) exhibited remarkable polymorphic differences. This study will provide a basis for next QTL mapping. | Yijia KE Tongguang LIU Haikun JIANG Peng CHEN Xia WANG Fanru ZHOU Yuelei WU Ling FANG Qian ZHANG | 2018 | Agricultural Biotechnology2018，7，3： | 2 |
| 8 | Live virtual ma- chine migration via asynchronous replication and state synchroniza- tion 显示文摘 | LIU HAIKUN JIN HAI LIAO XIAOFEI | 2011 | IEEE Transactions on Parallel and Distributed Systems2011，22，12： | 1 |
| 9 | Efficient Agrobucterium tumefuciens-mediated transformation of soybean using an embryonic tip regeneration system显示文摘 | Liu Haikun Yang Chao Wet Zhiming | 2004 | Planta2004，219，6： | 1 |
| 10 | Structure and luminescence properties of color-tunable phosphor Sr_(2)La_(3)(SiO_(4))_(3)F:Tb^(3+),Sm^(3+)显示文摘A series of single-phase and color-tunable phosphors Sr_(2)La_(3)(SiO_(4))_(3)F:0.15Tb^(3+),xSm^(3+)(SLSOF:0.15Tb^(3+),xSm^(3+)) was prepared using solid-state route.The X-ray diffraction(XRD) was used to characterize the phase of the as-prepared samples.The synthesized phosphors have apatite-type structure without other impurities.Sm^(3+) and Tb^(3+) ions substitute La^(3+) into the lattice and form a single-phase solid solution.The elements are evenly distributed in the sample according to the scanning electron microscopy(SEM) results.The crystal structure of the host phosphor was refined by the Rietveld method.The optical properties were studied in detail by investigation of the luminescence and diffuse spectra,fluorescence decay curves and energy transfer efficiency.The phosphor color can be changed from green(0.29,0.48) to yellow/orange and red(0.57,0.42) via adjusting the doping ratio of Sm^(3+).The SLSOF:0.15Tb^(3+),xSm^(3+)phosphors can emit typical multicolor light such as green,yellow,orange and red with gradually increasing Sm^(3+)doping concentration.All results indicate the occurrence of the energy transfer which results in the color-tunable properties of the phosphors. | Haikun Liu Kun Nie Yuanyuan Zhang Lefu Mei Dina V.Deyneko Xiaoxue Ma | 2023 | Journal of Rare Earths2023，41，9： | 1 |
| 11 | The improvement of moisture resistance and thermal stability of Ca3SiO4Cl2:Eu^2+ phosphor coated with SiO2 显示文摘 | ZHUANG Jiaqing XIA Zhiguo LIU Haikun | 2011 | Appl Surf Sci2011，257，9： | 1 |
| 12 | Simulation of soil water dynamics in a Caragana intermedia woodland in Huangfuchuan watershed显示文摘 | Jia Haikun Liu Yinghui Xu Xia | 2007 | Frontiers of Forestry in China2007，2，2： | 1 |
| 13 | Molecular diversity and biogeography of benthic microeukaryotes in temperate seagrass(Zostera japonica)systems of northern China显示文摘The productivity and health of seagrass depend on the combined inputs of nutrients from the water and sediments in which they grow and the microbiota with which they live intimately.However,little is known about the composition and diversity pattern of single-celled benthic eukaryotes in seagrass meadows.Here,we investigated how the structure and diversity of the benthic microeukaryotic community vary with respect to season,location,and seagrass colonization,by applying 18S rRNA gene amplicon sequencing for 96 surface sediment samples that were collected from three different seagrass habitats through four seasons.We found that benthic microeukaryotic communities associated with seagrass Zostera japonica exhibited remarkable spatial and seasonal variations,as well as differences between vegetated and unvegetated sediments.Diatoms and dinoflagellates predominated in the benthic microeukaryotic communities,but they were inversely correlated and displaced each other as the dominant microbial group in different seasons or habitats.Mucoromycota was more prevalent in vegetated sediments,whereas Lobulomycetales and Chytridiales had higher proportions in unvegetated sites.Total organic carbon and total organic nitrogen were the most important environmental factors in driving the microeukaryotic assemblages and diversity.Our study expands the available knowledge on the biogeographic distribution patterns and niche preferences for benthic microeukaryotes in seagrass systems. | Pengyuan Liu Haikun Zhang Yanyu Sun Caixia Wang Xiaoke Hu | 2022 | Acta Oceanologica Sinica2022，41，11： | 1 |
| 14 | The ubiquitin ligase Pelil inhibits ICOS and thereby Tfh-mediated immunity显示文摘T follicular helper(Tfh)cells are crucial for regulating autoimmune inflammation and protective immunity against viral infection.However,the molecular mechanism controlling Tfh cell differentiation is poorly understood.Here,through two mixed bone marrow chimeric experiments,we identified Peli1,a T cell-enriched E3 ubiquitin ligase,as an intrinsic regulator that inhibits Tfh cell differentiation.Peli1 deficiency significantly promoted c-Rel-mediated inducible T-cell costimulator(ICOS)expression,and PELI1 mRNA expression was negatively associated with ICOS expression on human CD4^(+)T cells.Mechanistically,increased ICOS expression on Peli1-KO CD4^(+)T cells enhanced the activation of PI3K-AKT signaling and thus suppressed the expression of Klf2,a transcription factor that inhibits Tfh differentiation.Therefore,reconstitution of Klf2 abolished the differences in Tfh differentiation and germinal center reaction between WT and Peli1-KO cells.As a consequence,Peli1-deficient CD4^(+)T cells promoted lupus-like autoimmunity but protected against H1N1 influenza virus infection in mouse models.Collectively,our findings established Peli1 as a critical negative regulator of Tfh differentiation and indicated that targeting Peli1 may have beneficial therapeutic effects in Tfhrelated autoimmunity or infectious diseases. | Xinfang Huang Shumeng Hao Junli Liu Yuanyuan Huang Manman Liu Chunyuan Xiao Yan Wang Siyu Pei Tao Yu Jing Xu Haikun Wang Dongfang Dai Xiao Su Yichuan Xiao | 2021 | Cellular & Molecular Immunology2021，18，4： | 1 |
| 15 | Efficient Agrobacterium tumefaciens-mediated transformation of soybeans using an embryonic tip regeneration system显示文摘 | Liu Haikun Yang Chao Wei Zhiming | 2004 | Planta2004，219，6： | 1 |
| 16 | Porosity, permeability and rock mechanics of Lower Silurian Longmaxi Formation deep shale under temperature-pressure coupling in the Sichuan Basin, SW China显示文摘To investigate the porosity, permeability and rock mechanics of deep shale under temperature-pressure coupling, we selected the core samples of deep shale from the Lower Silurian Longmaxi Formation in the Weirong and Yongchuan areas of the Sichuan Basin for porosity and permeability experiments and a triaxial compression and sound wave integration experiment at the maximum temperature and pressure of 120 ℃ and 70 MPa. The results show that the microscopic porosity and permeability change and the macroscopic rock deformation are mutually constrained, both showing the trend of steep and then gentle variation. At the maximum temperature and pressure, the porosity reduces by 34%–71%, and the permeability decreases by 85%–97%. With the rising temperature and pressure, deep shale undergoes plastic deformation in which organic pores and clay mineral pores are compressed and microfractures are closed, and elastic deformation in which brittle mineral pores and rock skeleton particles are compacted. Compared with previous experiments under high confining pressure and normal temperature,the experiment under high temperature and high pressure coupling reveals the effect of high temperature on stress sensitivity of porosity and permeability. High temperature can increase the plasticity of the rock, intensify the compression of pores due to high confining pressure, and induce thermal stress between the rock skeleton particles, allowing the reopening of shale bedding or the creation of new fractures along weak planes such as bedding, which inhibits the decrease of permeability with the increase of temperature and confining pressure. Compared with the triaxial mechanical experiment at normal temperature, the triaxial compression experiment at high temperature and high pressure demonstrates that the compressive strength and peak strain of deep shale increase significantly due to the coupling of temperature and pressure. The compressive strength is up to 435 MPa and the peak strain exceeds 2%, indicating that high temperature is not conducive to fracture initiation and expansion by increasing rock plasticity. Lithofacies and mineral composition have great impacts on the porosity, permeability and rock mechanics of deep shale. Shales with different lithologies are different in the difficulty and extent of brittle failure. The stress-strain characteristics of rocks under actual geological conditions are key support to the optimization of reservoir stimulation program. | SUN Chuanxiang NIE Haikuan SU Haikun DU Wei LU Ting CHEN Yalin LIU Mi LI Jingchang | 2023 | Petroleum Exploration and Development2023，50，1： | 1 |
| 17 | The improvement of moisture resistance and thermal stability of Ca3Si O4Cl2:Eu2+phosphor coated with Si O2显示文摘 | ZHUANG Jiaqing XIA Zhiguo LIU Haikun | 2011 | Applied Surface Science2011，251，9： | 1 |
| 18 | Learning dynamic dependency network structure with time lag显示文摘Characterizing and understanding the structure and the evolution of networks is an important problem for many different fields. While in the real-world networks, especially the spatial networks, the influence from one node to another tends to vary over both space and time due to the different space distances and propagation speeds between nodes. Thus the time lag plays an essential role in interpreting the temporal causal dependency among nodes and also brings a big challenge in network structure learning.However most of the previous researches aiming to learn the dynamic network structure only treat the time lag as a predefined constant, which may miss important information or include noisy information if the time lag is set too small or too large. In this paper, we propose a dynamic Bayesian model with adaptive lags(DBAL)which simultaneously integrates two usually separate tasks, i.e., learning the dynamic dependency network structure and estimating time lags, within one unified framework. Specifically, we propose a novel weight kernel approach for time series segmenting and sampling via leveraging samples from adjacent segments to avoid the sample scarcity. Besides, an effective Bayesian scheme cooperated with reversible jump Markov chain Monte Carlo(RJMCMC) and expectation propagation(EP) algorithm is proposed for parameter inference. Extensive empirical evaluations are conducted on both synthetic and two real-world datasets,and the results demonstrate that our proposed model is superior to the traditional methods in learning the network structure and the temporal dependency. | Sizhen DU Guojie SONG Haikun HONG Dong LIU | 2018 | Science China(Information Sciences)2018，61，5： | 0 |
| 19 | Construction of apricot variety search engine based on deep learning显示文摘Apricot has a long history of cultivation and has many varieties and types. The traditional variety identification methods are timeconsuming and labor-consuming, posing grand challenges to apricot resource management. Tool development in this regard will help researchers quickly identify variety information. This study photographed apricot fruits outdoors and indoors and constructed a dataset that can precisely classify the fruits using a U-net model (F-score:99%), which helps to obtain the fruit's size, shape, and color features. Meanwhile, a variety search engine was constructed, which can search and identify variety from the database according to the above features. Besides, a mobile and web application (ApricotView) was developed, and the construction mode can be also applied to other varieties of fruit trees.Additionally, we have collected four difficult-to-identify seed datasets and used the VGG16 model for training, with an accuracy of 97%, which provided an important basis for ApricotView. To address the difficulties in data collection bottlenecking apricot phenomics research, we developed the first apricot database platform of its kind (ApricotDIAP, http://gffzz2a5b87b2dfb54266hv90qnko056vo69uc.ffgz.tsg.suse.edu.cn/) to accumulate, manage, and publicize scientific data of apricot. | Chen Chen Lin Wang Huimin Liu Jing Liu Wanyu Xu Mengzhen Huang Ningning Gou Chu Wang Haikun Bai Gengjie Jia Tana Wuyun | 2024 | Horticultural Plant Journal2024，10，2： | 0 |
| 20 | HMvisor:dynamic hybrid memory management for virtual machines显示文摘Emerging non-volatile memory(NVM) technologies promise high density, low cost and dynamic random access memory(DRAM)-like performance, at the expense of limited write endurance and high write energy consumption. It is more practical to use NVM combining with the traditional DRAM. However, the hybrid memory management such as page migration becomes more challenging in a virtualization environment because virtual machines(VMs) are unaware of the memory heterogeneity. In this paper, we propose HMvisor, a hypervisor and VM coordinated hybrid memory management mechanism to better utilize DRAM and NVM resources. HMvisor exposes the memory heterogeneity to VMs by mapping virtual NUMA nodes to different physical NUMA nodes. We propose a lightweight and efficient page migration mechanism by decoupling page hotness tracking from page migration. HMvisor performs those operations in the hypervisor and VMs separately, without disrupting the execution of VMs. We also propose a memory resource trading policy to adjust the capacity of DRAM and NVM for each VM, with the monetary cost unchanged. We implement our prototype system based on QEMU/KVM and evaluate it with several benchmarks. Experimental results show that HMvisor can reduce 50% of write traffic to NVM with less than 5% performance overhead. Moreover, the hybrid memory adjustment scheme in HMvisor can significantly improve application performance by up to 30×. | Dang YANG Haikun LIU Hai JIN Yu ZHANG | 2021 | Science China(Information Sciences)2021，64，9： | 0 |
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