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| 1 | Blocking FSH inhibits hepatic cholesterol biosynthesis and reduces serum cholesterol显示文摘Menopause is associated with dyslipidemia and an increased risk of cardio-cerebrovascular disease.The classic view assumes that the underlying mechanism of dyslipidemia is attributed to an insufficiency of estrogen.In addition to a decrease in estrogen, circulating follicle-stimulating hormone (FSH)levels become elevated at menopause.In this study,we find that blocking FSH reduces serum cholesterol via inhibiting hepatic cholesterol biosynthesis.First,epidemiological results show that the serum FSH levels are positively correlated with the serum total cholesterol levels,even after adjustment by considering the effects of serum estrogen,in addition,the prevalence of hypercholesterolemia is significantly higher in peri-menopausal women than that in premenopausal women.Furthermore,we generated a mouse model of FSH elevation by intraperitoneally injecting exogenous FSH into ovariectomized (OVX)mice,in which a normal level of estrogen (E2)was maintained by exogenous supplementation. Consistently,the results indicate that FSH,independent of estrogen,increases the serum cholesterol level in this mouse model. Moreover,blocking FSH signaling by anti-FSHβ antibody or ablating the FSH receptor (FSHR)gene could effectively prevent hypercholesterolemia induced by FSH injection or high-cholesterol diet feeding.Mechanistically,FSH,via binding to hepatic FSHRs, activates the Gi2α/β-arrestin-2/Akt pathway and subsequently inhibits the binding of FoxO1 with the SREBP-2 promoter,thus preventing FoxO1 from repressing SREBP-2 gene transcription.This effect,in turn,results in the upregulation of SREBP-2,which drives HMGCR nascent transcription and de novo cholesterol biosynthesis,leading to the increase of cholesterol accumulation.This study uncovers that blocking FSH signaling might be a new strategy for treating hypercholesterolemia during menopause, particularly for women in peri-menopause characterized by FSH elevation only. | Yanjing Guo Meng Zhao Tao Bo Shizhan Ma Zhongshang Yuan Wenbin Chen Zhao He Xu Hou Jun Liu Zhenhai Zhang Qiang Zhu Qiangxiu Wang Xiaoyan Lin Zhongli Yang Min Cui Lu Liu Yujie Li Chunxiao Yu Xiaoyi Qi Qian Wang Haiqing Zhang Qingbo Guan Lifang Zhao Shimeng Xuan Huili Yan Yanliang Lin Li Wang Qihang Li Yongfeng Song Ling Gao Jiajun Zhao | 2019 | Cell Research2019，29，2： | 16 |
| 2 | Spatial distribution of heavy metals(Cu, Pb, Zn, and Cd)in sediments of a coastal wetlands in eastern Fujian, China显示文摘We investigated the spatial distribution(horizontal and vertical concentrations) of copper(Cu),lead(Pb), zinc(Zn), and cadmium(Cd) in five wetland types(mudflat, aquaculture wetland, water area, farmland wetland and mangrove) from three areas(Ningde, Fuding,and Xiapu), China. Cu concentrations in five wetland types descended in the order: farm wetland, mudflat, aquaculture,water area and mangrove. Pb concentrations decreased in the order: aquaculture, mangrove, farm wetland, mudflat,and water area. Zn content decreased in the order: farm wetland, water area, aquaculture, mudflat and mangrove,and Cd content decreased as follows: mangrove, aquaculture, water area, mudflat, and farm wetland. Comparison of the concentrations of the same heavy metals in different areas showed that the highest Cu(63.75 mg kg^-1) and Zn(152.32 mg kg^-1) concentrations occurred in Ningde coastal wetlands; Pb(110.58 mg kg^-1) and Cd(2.81 mg kg^-1) contents were highest in Fuding wetlands,and the average contents of all heavy metals were very low in Xiapu wetlands. Examination of the vertical distribution showed that the Cu content was high in all mudflat layers;Pb and Cd concentrations were highest in aquaculture and mangrove wetlands, respectively, and Zn content was highest in farm wetlands. The spatial distribution of Cu and Zn contents for different areas decreased as follows:Ningde [ Fuding [ Xiapu, for Pb and Cd were most concentrated in Fuding coastal wetlands. Concentrations of Zn and Cu were highly correlated, while Zn and Cu were not significantly correlated with Pb. | Lili Zhao Weibin You Haiqing Hu Wei Hong Xiaojuan LIAO Shihong Xiao Ren Wang Jinbiao Cai Xuncheng Fan Yong Tan Dongjin He | 2015 | Journal of Forestry Research2015，26，3： | 8 |
| 3 | Intercalibration of international and domestic ^(40)Ar/^(39)Ar dating standards显示文摘Four international standards, Ga1550, MMhb-1, Lp-6, Bern 4M, and one domestic standard BT-1 have been intercalibrated. The repeated measurements on MMhb-1 with different mass demonstrate that MMhb-1 is inhomogeneous in age and its average age is 519.8 Ma. The results of Bern 4M and Lp-6 reflect that they have an invariable value of 40Ar*/39Ark (F) and the ages we obtained are consensus with their K-Ar age: Lp-6=127.7Ma; Bern 4M=18.2 Ma. Analyses of BT-1 age spectra, Ca/K and Cl/K spectra as well as inverse isochrons indicate that the sample is homogeneous and invariable and keeps close chemically, with its trapped argon isotope composition close to the at- mosphere. The dating results show that age values are reproducible and steady, total fusion age, step-heating age, plateau age and isochron age are in accord with each other within the error range (2σ). Therefore, we recommend 28.7 Ma as the calibrated age of BT-1. We also discuss the variation in neutron flux gradients of Beijing 49-2 reactor. It was found that the neutron flux gradient varies considerably, and more monitors (standard samples) are needed to fix the trend of variation. The coefficient of the 49-2 reactor that transfers the ratio of production rate of 37ArCa/39ArK into Ca/K ratio is 1.78. This is different from that reported earlier, 2.0, which may be caused by the reconstruction of the reactor. | WANG Fei HE Huaiyu ZHU Rixiang SANG Haiqing WANG Yinglan YANG Liekun | 2006 | Science China Earth Sciences2006，49，5： | 6 |
| 4 | Laser step-heating ^(40)Ar/^(39)Ar dating on young volcanic rocks显示文摘An attempt was made to use CO_2 laser step-heating method to date the late Pleistocene basaltic groundmass (DF-2) from Tengchong volcanic field. Among the fourteen heating steps, ten define a good inverse isochron (MSWD = 1.4) with an age of 32.2 ± 7.1 ka (2 σ).The inverse isochron also shows that the initial argon isotopic ratio is 297.1±2.0 (2σ) which is the same as the atmospheric argon at the 2σ error level. Study indicates that it is a useful means to date young volcanic groundmass with low K content by using CO_2 laser step-heating ^(40)Ar/^(39)Ar method. | WANG Fei HE Huaiyu ZHU Rixiang YANG Liekun SANG Haiqing WANG Yinglan | 2006 | Chinese Science Bulletin2006，51，23： | 4 |
| 5 | An infrastructure with user-centered presentation data model for integrated management of materials data and services显示文摘With scientific research in materials science becoming more data intensive and collaborative after the announcement of the Materials Genome Initiative,the need for modern data infrastructures that facilitate the sharing of materials data and analysis tools is compelling in the materials community.In this paper,we describe the challenges of developing such infrastructure and introduce an emerging architecture with high usability.We call this architecture the Materials Genome Engineering Databases(MGED).MGED provides cloud-hosted services with features to simplify the process of collecting datasets from diverse data providers,unify data representation forms with user-centered presentation data model,and accelerate data discovery with advanced search capabilities.MGED also provides a standard service management framework to enable finding and sharing of tools for analyzing and processing data.We describe MGED’s design,current status,and how MGED supports integrated management of shared data and services. | Shilong Liu Yanjing Su Haiqing Yin Dawei Zhang Jie He Haiyou Huang Xue Jiang Xuan Wang Haiyan Gong Zhuang Li Hao Xiu Jiawang Wan Xiaotong Zhang | 2021 | npj Computational Materials2021，，1： | 4 |
| 6 | Constant Volume Spray Auto-ignition Study of Alkanes显示文摘Spray auto-ignition experiments were carried out in a constant volume combustion chamber for some pure alkanes(n-paraffins with different chain length, cyclohexane, n-butyl cyclohexane, and isooctane) and blends of n-decane with Standard Blended Fuel(isooctane/n-heptane) and product gasoline. Test results showed that the reaction activity of n-paraffins was relatively high. Meanwhile, the auto-ignition characteristics differed significantly with the molecular structures of alkanes. Adding different volume fractions of n-decane to Standard Blended Fuel and product gasoline could improve the fuel reaction activity at varying degree. Finally, functional groups effects were used to simulate the relationship between the molecular topology and the auto-ignition quality. | Wang Jun Yang He Song Haiqing Tian Huayu Wang Pengfei | 2019 | China Petroleum Processing & Petrochemical Technology2019，21，1： | 4 |
| 7 | Comparisons of OCO-2 satellite derived XCO_(2)with in situ and modeled data over global ocean显示文摘Atmospheric CO_(2)is one of key parameters to estimate air-sea CO_(2)flux.The Orbiting Carbon Observatory-2(OCO-2)satellite has observed the column-averaged dry-air mole fractions of global atmospheric carbon dioxide(XCO_(2))since 2014.In this study,the OCO-2 XCO_(2)products were compared between in-situ data from the Total Carbon Column Network(TCCON)and Global Monitoring Division(GMD),and modeling data from CarbonTracker2019 over global ocean and land.Results showed that the OCO-2 XCO_(2)data are consistent with the TCCON and GMD in situ XCO_(2)data,with mean absolute biases of 0.25×10^(-6)and 0.67×10^(-6),respectively.Moreover,the OCO-2 XCO_(2)data are also consistent with the CarbonTracker2019 modeling XCO_(2)data,with mean absolute biases of 0.78×10^(-6)over ocean and 1.02×10^(-6)over land.The results indicated the high accuracy of the OCO-2 XCO_(2)product over global ocean which could be applied to estimate the air-sea CO_(2)flux. | Siqi Zhang Yan Bai Xianqiang He Haiqing Huang Qiangkun Zhu Fang Gong | 2021 | Acta Oceanologica Sinica2021，40，4： | 3 |
| 8 | AGRICULTURAL GREEN DEVELOPMENT TO ACHIEVE FOOD SECURITY AND CARBON REDUCTION IN THE CONTEXT OF CHINA'S DUAL CARBON GOALS显示文摘The agricultural sector,a major source of greenhouse gas emissions,and emissions from agriculture must be reduced substantially to achieve carbon(C)neutrality.Based on a literature analysis and other research results,this study investigated the effects and prospects of C reduction in agricultural systems under different scenarios(i.e.,methods and approaches)in the context of China's dual C goals,as those working in the agricultural sector have yet to reach a consensus on how to move forward.Different views,standards,and countermeasures were analyzed to provide a reference for agricultural action supporting China's C neutrality goal. | Yulong YIN Kai HE Zhong CHEN Yangyang LI Fengling REN Zihan WANG Yingcheng WANG Haiqing GONG Qichao ZHU Jianbo SHEN Xuejun LIU Zhenling CUI | 2023 | Frontiers of Agricultural Science and Engineering2023，10，2： | 2 |
| 9 | A ratiometric fluorescent probe for the detection of hypochlorous acid in living cells and zebra fish with a long wavelength emission显示文摘A ratiometric fluorescence probe,NClO,for the rapid and selective detection of HClO had been designed and synthesized based on a 1,8-naphthalimide derivative.Probe NClO displayed a red emission(λmax=615 nm).In the presence of HClO,the solution of probe NClO gave off a strong green fluorescence(λem,max=520 nm)with a rapid response(within seconds).This probe had been applied to image HClO in living cells and zebra fish. | Haiqing Xiong Long He Yun Zhang Jingpei Wang Xiangzhi Song Zhaoguang Yang | 2019 | Chinese Chemical Letters2019，30，5： | 2 |
| 10 | 显示文摘 | Wang Haixia Xu Haiqing He Tianhou | 2005 | phys star sol (a)2005，202，14： | 1 |
| 11 | Application of image texture for the sorting of tea categories using multi-spectral imaging technique and support vector machine显示文摘 | Di Wu Haiqing Yang Xiaojing Chen Yong He Xiaoli Li | 2008 | Journal of Food Engineering2008，，4： | 1 |
| 12 | Establishment of a hyperspectral evaluation model of ocean color satellite-measured reflectance显示文摘The accuracy of the satellite-measured reflectance is a key question for data processing and oceanographic applications.A hyperspectral satellite remote sensing reflectance evaluation model(HRSREM) was developed to evaluate the accuracy of the satellite measured reflectance.The model can compute the total reflectance at the top of the atmosphere(TOA) according to observation conditions of satellites,based on a radiative transfer model with the consideration of multiple scattering effects and atmospheric absorption effects.The performance of the HRSREM model was examined by Gordon's algorithms,showing that the relative errors of the Rayleigh scattering reflectance and the aerosol scattering reflectance are less than 2%.The model can also compute the sky reflectance which can be validated by in-situ measurements.The two sky reflectances match well with a spectral average error of 5.4%.The relative error of the total reflectance of the model,verified by sea-viewing wide field-of-view sensor(SeaWiFS) data,is about 3.5%.Therefore,the total reflectances at TOA,computed by the model,can be taken as reference values to evaluate the accuracy of satellite reflectances.The model was used to evaluate the accuracy of the hypersptral satellite(Hyperion) remote sensing data.The Hyperion reflectance matches the total reflectance of HRSREM very well at visible and near-infrared bands with an average error of 7.3%,while the status of calibration coefficients at shortwave infrared bands are not stable with a large spectral average error of 63.5%.The reflectance evaluation of a moderate resolution imaging spectrometer(CMODIS) data indicated that relative errors are large,especially at near-infrared bands with relative errors more than 100%.The calibration coefficients of CMODIS,obtained from laboratory measurements,are not reliable.The CMODIS data should be recalibrated for oceanographic applications.The performance of the HRSREM model is effective in evaluating satellite data and its algorithms can be easily modified in order to evaluate the accuracy of other ocean color satellite sensors. | MAO ZhiHua CHEN JianYu HUANG HaiQing HE XianQiang GONG Fang | 2010 | Science China(Information Sciences)2010，53，9： | 1 |
| 13 | Effect of impact force on Ti-10 Mo alloy powder compaction by high velocity compaction technique显示文摘 | Dil Faraz Khan Haiqing Yin He Li Zainul Abideen Asadullah Xuanhui Qu Mujtaba Ellahi | 2013 | Materials and Design2013，，： | 1 |
| 14 | Ortho-(1-phenylvinyl)benzyl glycosides: Ether-type glycosyl donors for the efficient synthesis of both O-glycosides and nucleosides显示文摘Both O-glycosides and nucleosides are essential biomolecules with important roles in a variety of biological processes.Chemical synthesis of both O-glycosides and nucleosides is a scalable and reliable method to develop new therapeutic agents and decipher their functions.However,the efficient synthesis of both O-glycosides and nucleosides remains one of long-standing challenges in chemical synthesis.In particular,ether-type glycosyl donors are rarely developed to achieve the efficient synthesis of both O-glycosides and nucleosides due to the stronger conditions required for breaking of the glycosidic C–O bond.Here we report that ortho-(1-phenylvinyl)benzyl glycosides are new ether-type donors for efficient synthesis of both O-glycosides and nucleosides under mild reaction conditions.This glycosylation method enables glycosylation with both alcoholic acceptors and nucleobases with a variety of reactive functionalities.Furthermore,the latent-active synthesis of glycans and the efficient synthesis of nucleosides antibiotics have also been successfully demonstrated in the current glycosylation protocol,thereby representing an important step toward streamlining the chemical synthesis of both O-glycosides and nucleosides. | Penghua Li Haiqing He Lili Xu Yingying Huang Zixi Chen Yunqin Zhang Rui Yang Guozhi Xiao | 2020 | Green Synthesis and Catalysis2020，1，2： | 1 |
| 15 | Superconductivity in One-atomic-layer Metal Films显示文摘Superconductivity is a peculiar quantum phenomenon which originates from the pairing of conduction electrons, followed by phase coherent condensation. Since the discovery by K. Onnes in 1911, superconductivity has been one of the hottest topics in physics for an entire century, and still attracts people's great interest. One of the intriguing issues is | ZHANG Tong CHENG Peng LI Wenjuan SUN Yujie WANG Guang ZHU Xiegang HE Ke WANG Lili MA Xucun CHEN Xi WANG Yayu LIU Ying LIN Haiqing JIA Jinfeng XUE Qikun | 2011 | Bulletin of the Chinese Academy of Sciences2011，25，4： | 1 |
| 16 | VEGF-B prevents excessive angiogenesis by inhibiting FGF2/FGFR1 pathway显示文摘Although VEGF-B was discovered as a VEGF-A homolog a long time ago,the angiogenic effect of VEGF-B remains poorly understood with limited and diverse findings from different groups.Notwithstanding,drugs that inhibit VEGF-B together with other VEGF family members are being used to treat patients with various neovascular diseases.It is therefore critical to have a better understanding of the angiogenic effect of VEGF-B and the underlying mechanisms.Using comprehensive in vitro and in vivo methods and models,we reveal here for the first time an unexpected and surprising function of VEGF-B as an endogenous inhibitor of angiogenesis by inhibiting the FGF2/FGFR1 pathway when the latter is abundantly expressed.Mechanistically,we unveil that VEGF-B binds to FGFR1,induces FGFR1/VEGFR1 complex formation,and suppresses FGF2-induced Erk activation,and inhibits FGF2-driven angiogenesis and tumor growth.Our work uncovers a previously unrecognized novel function of VEGF-B in tethering the FGF2/FGFR1 pathway.Given the anti-angiogenic nature of VEGF-B under conditions of high FGF2/FGFR1 levels,caution is warranted when modulating VEGF-B activity to treat neovascular diseases. | Chunsik Lee Rongyuan Chen Guangli Sun Xialin Liu Xianchai Lin Chang He Liying Xing Lixian Liu Lasse DJensen Anil Kumar Harald FLanger Xiangrong Ren Jianing Zhang Lijuan Huang Xiangke Yin JongKyong Kim Juanhua Zhu Guanqun Huang Jiani Li Weiwei Lu Wei Chen Juanxi Liu Jiaxin Hu Qihang Sun Weisi Lu Lekun Fang Shasha Wang Haiqing Kuang Yihan Zhang Geng Tian Jia Mi Bi-Ang Kang Masashi Narazaki Aaron Prodeus Luc Schoonjans David MOrnitz Jean Gariepy Guy Eelen Mieke Dewerchin Yunlong Yang Jing-Song Ou Antonio Mora Jin Yao Chen Zhao Yizhi Liu Peter Carmeliet Yihai Cao Xuri Li | 2023 | Signal Transduction and Targeted Therapy2023，8，9： | 0 |
| 17 | Influence of Ethanol Addition on the Spray Auto-ignition Properties of Gasoline and Its Relationship with Octane Number显示文摘In this study,the spray auto-ignition properties of binary primary reference fuels(PRFs)of 2,2,4-trimethylpentane and n-heptane with different research octane numbers(RONs)were measured according to the industry standard NB/SH/T 6035 to determine their ignition delay times at various initial temperatures.Furthermore,the auto-ignition properties were investigated after blending the PRFs with various amounts of ethanol.The results revealed a very good correlation between the derived cetane number and the RON for the PRFs in both the presence and absence of ethanol.In addition,a concept of ignition delay sensitivity was developed for ethanol-containing fuels that exhibited a close relationship with the octane sensitivity,which is defined as the RON minus the motor octane number(MON).Finally,the developed method was applied to conveniently estimate the RON and MON values of several ethanol-containing fuels by simply measuring their auto-ignition properties. | Wang Jun Yang He Hu Xiaoming Song Haiqing Zhang Ran Tian Huayu | 2022 | China Petroleum Processing & Petrochemical Technology2022，24，2： | 0 |
| 18 | Novel Method for Evaluating the Aging of Aviation Turbine Engine Oils via High-Temperature Bearing Deposit Tests显示文摘Aviation turbine engine oils require excellent thermal-oxidative stability because of their high-temperature environments.High-temperature bearing deposit testing is a mandatory method for measuring the thermal-oxidative performance of aviation lubricant oils,and the relevant apparatus was improved in the present study.Two different commercial aviation turbine engine oils were tested,one with standard performance(known as the SL oil)and the other with high thermal stability,and their thermal-oxidative stability characteristics were evaluated.After 100 h of high-temperature bearing testing,the SL oil was analyzed by using various analytical techniques to investigate its thermal-oxidative process in the bearing test,with its thermal-oxidative degradation mechanism also being discussed.The results indicate that the developed high-temperature bearing apparatus easily meets the test requirements of method 3410.1 in standard FED-STD-791D.The viscosity and total acid number(TAN)of the SL oil increased with the bearing test time,and various deposits were produced in the bearing test,with the micro-particles of the carbon deposits being sphere-like,rod-like,and sheet-like in appearance.The antioxidant additives in the oil were consumed very rapidly in the first 30 h of the bearing test,with N-phenyl-1-naphthylamine being consumed faster than dioctyldiphenylamine.Overall,the oil thermal-oxidative process involves very complex physical and chemical mechanisms. | Hao Lichun Yang He Song Haiqing Zhou Yunfan He Jingjian Liang Yuxiang | 2024 | China Petroleum Processing & Petrochemical Technology2024，26，1： | 0 |
| 19 | Single-cell protein-DNA interactomics and multiomics tools for deciphering genome regulation显示文摘The emergence of single-cell genomic and transcriptomic sequencing accelerates the development of single-cell epigenomic technologies,providing an unprecedented opportunity for decoding cell fate decisions largely encoded in the epigenome.Recent advances in single-cell multimodality epigenomic technologies facilitate directly interrogating the reg-ulatory relationship between multi-layer molecular information in the same cell.In this review,we discuss recent progress in development of single-cell multimodality epigenomic technologies and applications in elucidating cellular diversifications in development and diseases,with a focus on protein-DNA interactomics and regulatory links between epigenome and tran-scriptome.Further,we provide perspective on the future direction of single-cell multiomics tool development as well as challenges facing ahead. | Haiqing Xiong Runyu Wang Aibin He | 2023 | National Science Open2023，2，3： | 0 |
| 20 | Effects of Gasoline with Ester Additives on the Swelling Behavior of Rubbers显示文摘In this study, gasoline was blended with dimethyl carbonate, ethyl acetate or methyl acetate respectively with four different volume fraction, i.e. 1%, 3%, 5% and 10%. The nitrile-butadiene rubber (NBR), fluorocarbon rubber (FKM), and Silastic were prepared for the immersion tests. To assess the performance of the three ester additives, the changes in the weight and volume of these three elastomers during the immersion tests with different gasoline samples were studied. The results showed that gasoline blended with the ester additives could lead to serious swelling problem for the elastomer materials which were widely used in the vehicle manufacture industry. The seal ability of elastomer materials would also be impaired by being exposed in the ester additives-gasoline blending for a long time. | Wang Pengfei Yang He Song Haiqing Zhang Jianrong | 2018 | China Petroleum Processing & Petrochemical Technology2018，20，1： | 0 |
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