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| 1 | Neuroprotective effects of daidzein on focal cerebral ischemia injury in rats显示文摘Daidzein, a plant extract, has antioxidant activity. It is hypothesized, in this study, that daidzein exhibits neuroprotective effects on cerebral ischemia. Rat models of middle cerebral artery occlusion were intraperitoneally administered daidzein. Biochemical and immunohistochemical tests showed that superoxide dismutase and nuclear respiratory factor 1 expression levels in the brain tissue decreased after ischemia and they increased obviously after daidzein administration; malondialdehyde level and apoptosis-related cysteine peptidase caspase-3 and caspase-9 immunoreactivity in the brain tissue increased after ischemia and they decreased obviously after daidzein administration. Hematoxylin-eosin staining and luxol fast blue staining results showed that intraperitoneal administration of daidzein markedly alleviated neuronal damage in the ischemic brain tissue. These findings suggest that daidzein exhibits neuroprotective effects on ischemic brain tissue by decreasing oxygen free radical production, which validates the aforementioned hypothesis. | Adem Bozkurt Aras Mustafa Guven Tar?k Akman Adile Ozkan Halil Murat Sen Ugur Duz Y?ld?ray Kalkan Coskun Silan Murat Cosar | 2015 | Neural Regeneration Research2015，10，1： | 4 |
| 2 | The predictive value of triglyceride-glucose index for in-hospital and one-year mortality in elderly non-diabetic patients with ST-segment elevation myocardial infarction显示文摘BACKGROUND Triglyceride-glucose(TyG)index,a reliable marker of insulin resistance,was associated with cardiovascular morbidity and mortality.This study aimed to evaluate the predictive value of TyG index for mortality in elderly non-diabetic pa-tients with ST-segment elevation myocardial infarction(STEMI).METHODS In total,430 non-diabetic patients aged over 65 years with STEMI were consecutively included.The TyG index was calculated by using the following formula:TyG index=ln(fasting triglyceride×fasting glucose/2).The 5-item modified frailty index score was utilized to determine comorbidities.Patients were divided into three groups based on TyG index tertiles.RESULTS Patients included into high TyG index tertile were male and had higher body mass index,glucose,triglyceride,low-density lipoprotein cholesterol,5-item modified frailty index and GRACE risk score;and had low systolic blood pressure,estim-ated glomerular filtration rate and left ventricular ejection fraction.A one-unit increase in TyG index was associated with 3.03 ex-tra cases per 1000 person-day for in-hospital mortality and 0.29 extra cases per 1000 person-day for long-term mortality.There was a non-linear relationship between TyG index and the risk of mortality with an increased risk above 8.5 for TyG index.Kaplan-Meier survival curves revealed that patients in high TyG index tertile had higher in-hospital and long-term mortality rates than those in low TyG index tertile.CONCLUSIONS This was the first study to demonstrate that the TyG index could predict in-hospital and long-term mortality in elderly non-diabetic STEMI patients. | FaysalŞaylık TufanÇınar Murat Selçuk İbrahim Halil Tanboğa | 2022 | Journal of Geriatric Cardiology2022，19，8： | 3 |
| 3 | Syringaldehyde exerts neuroprotective effect on cerebral ischemia injury in rats through anti-oxidative and anti-apoptotic properties显示文摘There are few studies on the neuroprotective effects of syringaldehyde in a rat model of cerebral ischemia. The study aimed to elucidate the mechanisms underlying the neuroprotective effects of syringaldehyde on ischemic brain cells. Rat models of cerebral ischemia were intraperitoneally administered syringaldehyde. At 6 and 24 hours after syringaldehyde administration, cell damage in the brain of cerebral ischemia rats was obviously reduced, superoxide dismutase activity and nuclear respiratory factor 1 expression in the brain tissue were markedly increased, malondiadehyde level was obviously decreased, apoptosis-related cysteine peptidase caspase-3 and-9 immunoreactivity was obviously decreased, and neurological function was markedly improved. These findings suggest that syringaldehyde exerts neuroprotective effects on cerebral ischemia injury through anti-oxidation and anti-apoptosis. | Aras Adem Bozkurt Guven Mustafa Akman Tar?k Ozkan Adile Sen Halil Murat K?l?coglu Mesut Kalkan Y?ld?ray Silan Coskun Cosar Murat | 2014 | Neural Regeneration Research2014，9，21： | 2 |
| 4 | A longterm experiment to study the role of mulches in the physiology and macro-nutrition of strawberry grown under water stress显示文摘 | Halil K A D Cengiz K B David H C | 2001 | Australian Journal of Agricul- tural Research2001，52，9： | 1 |
| 5 | First trimester markers for the prediction of pre-eclampsia in women with a-priori high risk显示文摘 | halil A Cowans NJ Spencer K otal | 2010 | Uitrasound Obstet Gynecol2010，35，67： | 1 |
| 6 | A Comparative Analysis ofMachine Learning Systems for Measuring the Impact of Knowl-edge Management Practices 显示文摘 | Dursun D Halil Z Cemil K | 2013 | Decision Support Systems2013，54，2： | 1 |
| 7 | The influ- ence of water deficit onvegetative growth, phys- iology, fruit yield and quality in eggplants显示文摘 | Halil K Cengiz K Ismail T A S | 2001 | J Plant Physiol2001，27，34： | 1 |
| 8 | Computer simulation of gas generation and transport in landfills Ⅰ: Quasi-steady-state condition显示文摘 | MEHRDAD H HALIL I K THEODORE T T | 2002 | Chemical Engineering Science2002，57，13： | 1 |
| 9 | Advanced Age Is Associated with Endothelial Dysfunction in Healthy Elderly Subjects显示文摘 | Yavuz B B Yavuz B Sener Dede D Cankurtaran M Halil M Ulger Z Nazli N Kabakci G Aytemir K Tokgozoglu L Oto A Ariogul S | 2008 | Gerontology2008，，3： | 1 |
| 10 | Lp(a) lipoprotein and lipids in patients with rheumatoid arthritis: serum levels and relationship to inflammation显示文摘 | Dursun Dursuno?lu Harun Evrengül Bülent Polat Halil Tanr?verdi Veli ?obankara Asuman Kaftan Mustafa K?l?? | 2005 | Rheumatology International2005，，4： | 1 |
| 11 | Appendicolithiasis cau- sing diagnostic dilemma: a rare cause of acute appendicitis 显示文摘 | ZAFER T BURHAN K HALIL E | 2008 | Ulus Travma Acil Cerrahi Derg2008，14，4： | 1 |
| 12 | Viability of microbial mass in a submerged membrane bioreactor显示文摘 | Halil H Cumali K Ayhan U 2002 | 2002 | Desalination2002，150，： | 1 |
| 13 | Adaptive control if nonlinear systems using networks显示文摘 | K halil K H | 1992 | International Journal of Control1992，55，6： | 1 |
| 14 | The Day of the Week Effect on Stock Market Volatility and Volume: International Evidence 显示文摘 | Halil K B Hakan | 2003 | Review of Financial Economics2003，，12： | 1 |
| 15 | First trime- ster maternal serum placental protein 13 for the predicttion of preeelampsia in women with a priorhigh risk显示文摘 | Halil A Cowans N J Spencer K | 2009 | Prenat Diagn2009，29，8： | 1 |
| 16 | A microwave-assisted route for the solid-state synthesis of lead pyrophosphate, Pb2 P2 O7 显示文摘 | Halil G Figen K | 2005 | Journal of materials science2005，40，24： | 1 |
| 17 | Peroral CT enterography with lactulose solution:preliminary observations显示文摘 | Halil A Omer E Mustafa K | | 0，，： | 1 |
| 18 | Neutrophil activation, protein oxidation and ceruloplasmin levels in children with Henoch-Sch?nlein purpura显示文摘 | Ayd?n Ece Selvi Kelek?i A?k?n Hekimo?lu Halil Kocamaz Hasan Bal?k ?lyas Yolba? ?zcan Erel | 2007 | Pediatric Nephrology2007，，8： | 1 |
| 19 | Use and utility of an-kle-brachial index in patients with diabetes 显示文摘 | Potier L AbiK halil Mohammedi K | 2011 | Eur J Vase EndovascSurg2011，41，1： | 1 |
| 20 | Improved of cathode perfor- mance of LiFePO4/C composite using different carboxylic acids as carbon sources for lithium-ion batteries 显示文摘 | HALIL H G SA H FATMA K | 2010 | Ionics2010，16，： | 1 |
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