4篇
您的检索式：作者名="Handong Su"
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| 1 | Site-specific transfer of chromosomal segments and genes in wheat engineered chromosomes显示文摘Recently, engineered minichromosomes have been produced using a telomere-mediated truncation technique in some plants. However, the study on transferring genes to minichromosomes is very limited.Here, telomere-mediated truncation was successfully performed in common wheat(Triticum aestivum)to generate stable truncated chromosomes accompanied by a relatively high frequency of chromosomal rearrangements. After the cross between transgenic parents, a promoter-less DsRed gene in a chromosome from one parent was transferred to another chromosome from the other parent at the site behind a maize ubiquitin promoter via the Cre/lox system. DsRed transcripts and red fluorescent proteins were detected in the recombinant plants. In one such seedling, transgenic signals were detected at the centric terminus of chromosome 4D and the distal terminus of chromosome 3A. Clear translocations could be detected at the transgenic loci of these two chromosomes. Intriguingly, signals of centric-specific sequences were co-localized with the translocated D-group chromosomal segment in the terminal region of chromosome 3A. Our results indicate that the Cre/lox system induces the gene swapping to the target chromosome and non-homologous chromosomal recombination simultaneously. These approaches could offer a platform to transfer large DNA fragments or even terminal chromosomal segments to other chromosomes of the natural genome. | Jing Yuan Qinghua Shi Xiang Guo Yalin Liu Handong Su Xianrui Guo Zhenling Lv Fangpu Han | 2017 | Journal of Genetics and Genomics2017，44，11： | 0 |
| 2 | 中国新诊断胶质母细胞瘤患者实际治疗方案与Stupp方案的一致性比较显示文摘目的评估中国新诊断胶质母细胞瘤(glioblastoma multiforme,GBM)患者实际接受的治疗方案与指南推荐的Stupp方案的一致性。方法纳入202例新诊断GBM患者,评估实际接受的治疗方案与Stupp方案一致的患者比例,以及不符合Stupp方案的原因。结果研究发现,仅15.8%的GBM患者接受了与Stupp方案一致的治疗。治疗方案的不一致主要是由于同步放化疗阶段替莫唑胺剂量>75 mg/m^(2)(58/120;48.3%)和治疗持续时间<42 d(84/120;70.0%),以及辅助治疗阶段替莫唑胺剂量<150 mg/m^(2)(89/101;88.1%)。接受符合Stupp方案治疗的患者的中位总生存期(27.09 vs 18.21个月)和无进展生存期(14.27 vs 12.10个月)更长。结论需要提高中国GBM患者实际接受的治疗方案与Stupp方案的一致性。 | Yu Wang Jianmin Zhang Wenbin Li Taipeng Jiang Songtao Qi Zhongping Chen Jingbo Kang Lei Huo Yunjie Wang Qichuan Zhuge Guodong Gao Yuping Wu Hua Feng Gang Zhao Xiaopeng Yang Hui Zhao Yirong Wang Hui Yang Dezhi Kang Jun Su Liang Li Chuanlu Jiang Gang Li Yongming Qiu Weimin Wang Handong Wang Zaihua Xu Liwei Zhang Renzhi Wang 吴劲松(翻译/校对) | 2022 | 癌症2022，41，8： | 0 |
| 3 | Recent advances in plant centromere biology显示文摘The centromere, which is one of the essential parts of a chromosome, controls kinetochore formation and chromosome segregation during mitosis and meiosis. While centromere function is conserved in eukaryotes, the centromeric DNA sequences evolve rapidly and have few similarities among species. The histone H3 variant CENH3(CENP-A in human), which mostly exists in centromeric nucleosomes, is a universal active centromere mark in eukaryotes and plays an essential role in centromere identity determination. The relationship between centromeric DNA sequences and centromere identity determination is one of the intriguing questions in studying centromere formation. Due to the discoveries in the past decades, including 'neocentromeres' and 'centromere inactivation', it is now believed that the centromere identity is determined by epigenetic mechanisms. This review will present recent progress in plant centromere biology. | FENG Chao LIU YaLin SU HanDong WANG HeFei BIRCHLER James HAN FangPu | 2015 | Science China(Life Sciences)2015，58，3： | 0 |
| 4 | Synergistic Effect of Nitrogen/Phosphorus Co-Doping and Molybdenum Carbide Induced Electron Redistribution of Carbon Layer to Boost Hydrogen Evolution Reaction显示文摘The development of highly efficient non-precious-metal-based electrocatalysts for the hydrogen evolution reaction is imperative for promoting the large-scale application of electrochemical water splitting.Herein,nitrogen/phosphorus co-doped carbon nanorods encapsulated Mo_(2)C nanoparticles(Mo_(2)C@PNc)have been prepared by pre-phosphating treatment in combination of the coordination with polydopamine and the subsequent pyrolysis.The phosphating temperature has a significant effect on the content of phosphorus within the resultant Mo_(2)C@PNC,and the optimal catalyst delivers superior HER activity with the low overpotential of 104 mV at a current density of 10 mAcm^(-2) and good stability for 8 h,which has been theoretically demonstrated to originate from the synergistic effect between P doping and Mo_(2)C induced electron redistribution of nitrogen-doped carbon layer. | Jiamin Xiao Peng Li Yanyan Sun Heng Liu Javid Khan Handong Zhang Han Zhou Yaqiong Su Shuangyin Wang Lei Han | 2024 | Chinese Journal of Chemistry2024，42，1： | 0 |
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