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| 1 | Clinical challenges in neoadjuvant immunotherapy for non-small cell lung cancer显示文摘Immune checkpoint inhibitors(ICIs),a type of immunotherapy,have become one of the most important therapeutic options for first-and second-line treatment of advanced non-small cell lung cancer(NSCLC).Recent clinical studies have shown that immunotherapy can offer substantial survival benefits to patients with early-stage or resectable advanced NSCLC.However,considering the importance of timing when using ICIs and their associated adverse events(AEs),the advantages and disadvantages of using these agents need to be weighed carefully when deciding the use of a combined treatment.In addition,the inconsistency between imaging assessment and pathological results poses further challenges to the evaluation of efficacy of neoadjuvant immunotherapy.It is also important to develop new methodologies and discover suitable biomarkers that can be used to evaluate survival outcomes of immunotherapy and identify patients who would benefit the most from this treatment.In this review,we aimed to summarize previous results of ongoing clinical trials on neoadjuvant immunotherapy for lung cancer and discuss the challenges and future perspectives of this therapeutic approach in the treatment of resectable NSCLC. | Hanfei Guo Wenqian Li Lei Qian Jiuwei Cui | 2021 | Chinese Journal of Cancer Research2021，33，2： | 5 |
| 2 | Paleoclimatic indication of X-ray fluorescence core-scanned Rb/Sr ratios: A case study in the Zoige Basin in the eastern Tibetan Plateau显示文摘The X-ray fluorescence(XRF)core-scanned Rb/Sr ratios of lake sediments have been widely used as a proxy for chemical weathering intensity and past climate change.However,some factors could affect Rb/Sr ratios,causing misinterpretation and limiting its application.In this study,we present a high-resolution XRF core-scanned Rb/Sr record of core ZB13-C1 from the Zoige Basin in the eastern Tibetan Plateau.To validate its application,we correlated this record with the chemical index of alteration(CIA)and other paleoclimatic proxies.Our results showed that(1)the core-scanned Rb/Sr ratios and CIA were reliable proxies of chemical weathering intensity in fine-grained sedimentary sequences;(2)the low values of corescanned Rb/Sr ratios and CIA were significantly correlated with high total organic carbon content,arboreal pollen content,carbonate content,and C/N ratios,confirming its reliability as a proxy for the Asian summer monsoon intensity;(3)the corescanned Rb/Sr ratios at core depths of 25–0.3 and 56–47 m were unable to reliably reflect chemical weathering intensity due to both the grain-size effect and the low test accuracy.Our study highlights the need for mutual verification of multiple indicators before accurately applying Rb/Sr as a paleoclimatic proxy in other similar study areas. | Hanfei YANG Yan ZHAO Qiaoyu CUI Weihe REN Quan LI | 2021 | Science China Earth Sciences2021，64，1： | 5 |
| 3 | Experimental study on liquid/solid phase change for cold energy storage of Liquefied Natural Gas (LNG) refrigerated vehicle显示文摘 | Hongbo Tan Yanzhong Li Hanfei Tuo | 2010 | Energy2010，，35： | 1 |
| 4 | Experimental study on liquid/solid phase change for cold energy storage of Liquefied Natural Gas(LNG)refrigerated vehicle显示文摘 | Hongbo Tan Yanzhong Li Hanfei Tuo | 2010 | Energy2010，35，： | 1 |
| 5 | Highly Stretchable and Permeable Conductors Based on Shrinkable Electrospun Fiber Mats显示文摘Wearable on-skin electrodes or conductors should be vapor permeable,strain-insensitive,isotropically stretchable and stable under cyclic stretching.Various strategies have been proposed to prepare the required conductors up to now;however,it is a challenge to fabricate them with above properties in a simple manner.In this paper,a highly permeable and stretchable conductor based on electrospun fluorine rubber fiber mat is reported.The fibers are pre-stretched in electric field during electrospinning,and they shrink isotropically by~35-40%in area after being detached from the substrate.The obtained fiber mat conductor demonstrates high stretchability up to~170%,and the resistance changes only 0.8 under 60%strain,which is superior to many other strain-insensitive conductors.The conductor possesses high stability,no cracks or structure damage are observed after washing and cyclic stretching.Moreover,the conductor is vapor permeable with a water vapor transmission rate of~850 g m−2 day−1,which is comparable to the normal water evaporation in ambient conditions,indicating that it would not disturb the sweat evaporation when being used on skin.The conductor is successfully used as stretchable yarns and electromyography(EMG)electrodes,showing high reliability in E-textiles and on-skin applications. | Qingsong Li Chen Ding Wei Yuan Ruijie Xie Xiaomeng Zhou Yang Zhao Mei Yu Zijian Yang Jing Sun Qiong Tian Fei Han Hanfei Li Xinping Deng Guanglin Li Zhiyuan Liu | 2021 | Advanced Fiber Materials2021，3，5： | 1 |
| 6 | Strategies for Video Producers to Tell Their Good Stories Under the 5W Model of Communication显示文摘In recent years,with the rise of video media such as YouTube and Tik Tok,the short video creation industry has emerged.How to spread China's excellent culture and how to“tell a good Chinese story”have become a hot concern.Using the 5W Model of Communication as a framework for analysis,this paper selects Chinese short videos with high popularity on YouTube as the object of the study.Studies found that the success of these videos was associated with five factors in the process of communication,which are communication main forces,communication content,communication channels,communication audience,and audience effects.Through theoretical and data analysis,the study concluded five strategies in video production to help promote Intercultural communication. | Wenqian Hong Yixuan Jiang Rui Wen Wenyu Chen Nan Lou Jinxuan Deng Jiayun Li Hanfei Li Dan Ye | 2024 | 教育技术与创新2024，6，1： | 0 |
| 7 | Organic Memristor Based on High Planar Cyanostilbene/Polymer Composite Films显示文摘Organic memristors with low power consumption,fast write/erasure speed,and complementary metal-oxide-semiconductor(CMOS)compatibility have attracted tremendous attention to mimic biological synapses to realize neuromorphic computation in recent years.In this paper,organic resistive switching memory(ORSM)based on(Z)-3-(naphthalen-2-yl)-2-(4-nitrophenyl)acrylonitrile(NNA)and polymer poly(N-vinylcarbazole)(PVK)composite film was prepared by spin-coating method.Device performance based on NNA:PVK composite films with different mass fractions of NNA were systematically investigated.The ORSM based on PVK:40%(mass fraction)NNA composite film exhibited non-volatile and bipolar memory properties with a switching ratio(Ion/Ioff)of 24.1,endurance of 68 times and retention time of 104 s,a“SET”voltage(Vset)of−0.55 V and a“RESET”voltage(Vreset)of 2.35 V.The resistive switching was ascribed to the filling and vacant process of the charge traps induced by NNA and the inherent traps in PVK bulk.The holes trapping and de-trapping process occurred when the device was applied with a negative or positive bias,which caused the transforming of the conductive way of charges,that is the resistive behaviors in the macroscopic.This study provides a promising platform for the fabrication of ORSM with high performance. | ZHAO Jinjin LI Wei WANG Xuechen WEI Xiao ZHU Huiwen QU Wenshan MEN Dandan GAO Zhixiang WEI Bin GAO Hanfei WU Yuchen | 2023 | Chemical Research in Chinese Universities2023，39，1： | 0 |
| 8 | Coexisting opportunities and challenges:In which scenarios can minimal/measurable residual disease play a role in advanced non-small cell lung cancer?显示文摘Curative therapy was not previously available for patients with advanced non-small cell lung cancer(NSCLC);thus,the concept of minimal/measurable(or molecular)residual disease(MRD)was not applicable to these patients.However,advances in targeted and immunotherapy have revolutionized the treatment landscape for patients with advanced NSCLC,with emerging evidence of long-term survival and even the hope of complete remission(CR)by imaging examination.The latest research shows that patients with oligometastatic lung cancer can benefit from local treatment.After removing the lesions,the choice of follow-up therapy and monitoring of the lesions could remain uncertain.MRD plays a role in identifying early-stage NSCLC patients with high risks of recurrence and determining adjuvant therapy after radical treatment.In recent years,evidence has been accumulating regarding the use of circulating cell-free tumor DNA(ctDNA)to assess MRD in solid tumors.This study discussed the possible applications of ctDNA-based MRD monitoring in advanced NSCLC and described the current challenges and unresolved problems in the application of MRD in advanced NSCLC. | Hanfei Guo Wenqian Li Bin Wang Neifei Chen Lei Qian Jiuwei Cui | 2021 | Chinese Journal of Cancer Research2021，33，5： | 0 |
| 9 | High-quality Fagopyrum esculentum genome provides insights into the flavonoid accumulation among different tissues and self-incompatibility显示文摘Common buckwheat(Fagopyrum esculentum)and Tartary buckwheat(Fagopyrum tataricum),the two most widely cultivated buckwheat species,differ greatly in flavonoid content and reproductive mode.Here,we report the first high-quality and chromosome-level genome assembly of common buckwheat with 1.2 Gb.Comparative genomic analysis revealed that common buckwheat underwent a burst of long terminal repeat retrotransposons insertion accompanied by numerous large chromosome rearrangements after divergence from Tartary buckwheat.Moreover,multiple gene families involved in stress tolerance and flavonoid biosynthesis such as multidrug and toxic compound extrusion(MATE)and chalcone synthase(CHS)underwent significant expansion in buckwheat,especially in common buckwheat.Integrated multi-omics analysis identified high expression of catechin biosynthesis-related genes in flower and seed in common buckwheat and high expression of rutin biosynthesis-related genes in seed in Tartary buckwheat as being important for the differences in flavonoid type and content between these buckwheat species.We also identified a candidate key rutindegrading enzyme gene(Ft8.2377)that was highly expressed in Tartary buckwheat seed.In addition,we identified a haplotype-resolved candidate locus containing many genes reportedly associated with the development of flower and pollen,which was potentially related to self-incompatibility in common buckwheat.Our study provides important resources facilitating future functional genomics-related research of flavonoid biosynthesis and selfincompatibility in buckwheat. | Qiang He Dan Ma Wei Li Longsheng Xing Hongyu Zhang Yu Wang Cailian Du Xuanzhao Li Zheng Jia Xiuxiu Li Jianan Liu Ze Liu Yuqing Miao Rui Feng Yang Lv Meijia Wang Hongwei Lu Xiaochen Li Yao Xiao Ruyu Wang Hanfei Liang Qinghong Zhou Lijun Zhang Chengzhi Liang Huilong Du | 2023 | Journal of Integrative Plant Biology2023，65，6： | 0 |
| 10 | Review of intelligent diagnosis methods for imaging gland cancer based on machine learning显示文摘Gland cancer is a high-incidence disease that endangers human health,and its early detection and treatment require efficient,accurate,and objective intelligent diagnosis methods.In recent years,the advent of machine learning techniques has yielded satisfactory results in intelligent gland cancer diagnosis based on clinical images,significantly improving the accuracy and efficiency of medical image interpretation while reducing the workload of doctors.The focus of this study is to review,classify,and analyze intelligent diagnosis methods for imaging gland cancer based on machine learning and deep learning.This paper briefly introduces some basic imaging principles of multimodal medical images,such as the commonly used computed tomography(CT),magnetic resonance imaging(MRI),ultrasound(US),positron emission tomography(PET),and pathology.In addition,the intelligent diagnosis methods for imaging gland cancer were further classified into supervised learning and weakly supervised learning.Supervised learning consists of traditional machine learning methods,such as K-nearest neighbor algorithm(KNN),support vector machine(SVM),and multilayer perceptron,and deep learning methods evolving from convolutional neural network(CNN).By contrast,weakly supervised learning can be further categorized into active learning,semisupervised learning,and transfer learning.State-of-the-art methods are illustrated with implementation details,including image segmentation,feature extraction,and optimization of classifiers.Their performances are evaluated through indicators,such as accuracy,precision,and sensitivity.In conclusion,the challenges and development trends of intelligent diagnosis methods for imaging gland cancer were addressed and discussed. | Han JIANG Wenjia SUN Hanfei GUO Jiayuan ZENG Xin XUE Shuai LI | 2023 | Virtual Reality & Intelligent Hardware2023，5，4： | 0 |
| 11 | Chlorine-substituted chiral 2D perovskite microwires with enhanced lattice rigidity for sensitive circularly polarized light detection显示文摘Chiral two-dimensional(2D) perovskites offer numerous attractive features for optoelectronics owing to their soft, deformable lattices and a high degree of chemical tunability. While tremendous advances have been made in perovskite-based direct circularly polarized light(CPL) detection, the low circular polarization anisotropy factor and sensitivity of those photodetectors arising from large lattice distortion still limit practical applications. Herein, chiral 2D perovskite-based single-crystalline microwire arrays with enhanced circular dichroism(CD) absorption are fabricated with the synergy of the capillary-bridgeconfined assembly method and chlorine-substituted phenethylamine(Cl-MBA). Compared with phenethylamine(MBA)-inserted perovskites, the smaller lattice distortion and increased halogen–halogen interaction within Cl–MBA-inserted perovskites strengthen lattice rigidity and weaken electron–phonon coupling to improve carrier transport and thermal stability, resulting in high-performance CPL photodetectors with an anisotropy factor of 0.25, responsivity exceeding 95.7±9.3 A W^(-1)and detectivity exceeding(3.05±0.30)×10^(13)Jones. This work opens a new perspective to modulate circular polarization sensitivity and will be helpful to realize promising implementations in quantum computation and communication. | Meng Yuan Yuchen Qiu Yingjie Zhao Yuyan Zhao Hui Li Xiao Wei Gaosong Chen Jiangang Feng Hanfei Gao Jinjin Zhao Jiahui Zhao Lei Jiang Yuchen Wu | 2023 | Science China Chemistry2023，66，12： | 0 |
| 12 | UOUU:User-Object Distance and User-User Distance Combined Method for Collaboration Task显示文摘Augmented reality superimposes digital information onto objects in the physical world and enables multi-user collaboration.Despite that previous proxemic interaction research has explored many applications of user-object distance and user-user distance in an augmented reality context,respectively,and combining both types of distance can improve the efficiency of users’perception and interaction with task objects and collaborators by providing userswith insight into spatial relations of user-task object and user-user,less is concerned about howthe two types of distances can be simultaneously adopted to assist collaboration tasks acrossmulti-users.To fulfill the gap,we present UOUU,the user-object distance and user-user distance combined method for dynamically assigning tasks across users.We conducted empirical studies to investigate how the method affected user collaboration tasks in terms of collaboration occurrence and overall task efficiency.The results show that the method significantly improves the speed and accuracy of the collaboration tasks as well as the frequencies of collaboration occurrences.The study also confirms the method’s effects on stimulating collaboration activities,as the UOUU method has effectively reduced the participants’perceived workload and the overall moving distances during the tasks.Implications for generalising the use of the method are discussed. | Xiangdong Li Pengfei Wang Hanfei Xia Yuting Niu | 2023 | Computer Modeling in Engineering & Sciences2023，，9： | 0 |
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