|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | SDF-1/CXCR4 axis modulates bone marrow mesenchymal stem cell apoptosis, migration and cytokine secretion显示文摘Bone marrow mesenchymal stem cells(MSCs)are considered as a promising cell source to treat the acute myocardial infarction.However,over 90%of the stem cells usually die in the first three days of transplantation.Survival potential,migration ability and paracrine capacity have been considered as the most important three factors for cell transplantation in the ischemic cardiac treatment.We hypothesized that stromal-derived factor-1(SDF-1)/CXCR4 axis plays a critical role in the regulation of these processes.In this study,apoptosis was induced by exposure of MSCs to H2O2 for 2 h.After re-oxygenation,the SDF-1 pretreated MSCs demonstrated a significant increase in survival and proliferation.SDF-1 pretreatment also enhanced the migration and increased the secretion of pro-survival and angiogenic cytokines including basic fibroblast growth factor and vascular endothelial growth factor.Western blot and RT-PCR demonstrated that SDF-1 pretreatment significantly activated the pro-survival Akt and Erk signaling pathways and up-regulated Bcl-2/Bax ratio.These protective effects were partially inhibited by AMD3100,an antagonist of CXCR4.We conclude that the SDF-1/CXCR4 axis is critical for MSC survival,migration and cytokine secretion. | Xiaolei Liu Biyan Duan Zhaokang Cheng Xiaohua Jia Lina Mao Hao Fu Yongzhe Che Lailiang Ou Lin Liu Deling Kong | 2011 | Protein & Cell2011，2，10： | 53 |
| 2 | Differences in Organic C Mineralization Between Aerobic and Submerged Conditions in Paddy Soils of Southern Jiangsu Province,China显示文摘Moisture regime plays a crucial role in the mineralization of soil organic carbon(SOC).In this paper,the dynamics of SOC mineralization in typical paddy soils of Changshu,Jiangsu Province,China,was investigated by incubation test in laboratory.The differences in SOC mineralization under aerobic and submerged conditions of paddy soils were also studied.Results showed that the daily mineralization of SOC under different moisture regimes was significantly different in the whole incubation period,at the beginning of the incubation,it decreased quickly under aerobic condition,but increased rapidly under submerged condition,and both remained constant after 10 d of incubation.The differences in SOC mineralization were found to be mainly at the beginning period of the incubation and decreased along with the incubation time.Thus,the difference was not significantly different at the later incubation period.The respiration intensity,daily and cumulative mineralization of SOC under aerobic condition was 2.26-19.11,0.96-2.41,and 0.96-2.41 times than those under submerged condition,respectively.Statistic analyses showed that the higher the contents of microbial biomass carbon and nitrogen,the more significant difference in respiration intensity between aerobic and submerged conditions,but the higher the contents of microbial biomass nitrogen and dissolved organic carbon,the more significant difference in daily mineralization of SOC between the two conditions.The decrease in soil microbial activity under submerged condition was the main reason leading to the decrease in respiration intensity,but the decrease in SOC mineralization was also correlated with the changes in dissolved organic carbon over the whole incubation period. | HAO Rui-jun LI Zhong-pei CHE Yu-ping | 2011 | Agricultural Sciences in China2011，10，9： | 13 |
| 3 | Consensus by Chinese Expert Panel on Chlamydia trachomatis-Resistant and Chlamydia trachomatis-Persistent Infection显示文摘 | Man-Li Qi Yuan-Li Guo Qian-Qiu Wang Xiang-Sheng Chen Jian-De Han Xiao-Hong Su Wen-Hui Lun Hao Cheng Jin-Hua Xu Hong-Qing Tian Li Che Zhi-Yuan Ya Wen-Li Feng Juan Jiang Ping-Yu Zhou Xian-Biao Zo Hong-Hui Xu Wei-Min Shi Jun Liu Lin Zhu Quan-Zhong Liu | 2017 | Chinese Medical Journal2017，，23： | 7 |
| 4 | Gasdermin E-derived caspase-3 inhibitors effectively protect mice from acute hepatic failure显示文摘Programmed cell death(PCD),including apoptosis,apoptotic necrosis,and pyroptosis,is involved in various organ dysfunction syndromes.Recent studies have revealed that a substrate of caspase-3,gasdermin E(GSDME),functions as an effector for pyroptosis;however,few inhibitors have been reported to prevent pyroptosis mediated by GSDME.Here,we developed a class of GSDME-derived inhibitors containing the core structure of DMPD or DMLD.Ac-DMPD-CMK and Ac-DMLD-CMK could directly bind to the catalytic domains of caspase-3 and specifically inhibit caspase-3 activity,exhibiting a lower IC50 than that of Z-DEVD-FMK.Functionally,Ac-DMPD/DMLD-CMK substantially inhibited both GSDME and PARP cleavage by caspase-3,preventing apoptotic and pyroptotic events in hepatocytes and macrophages.Furthermore,in a mouse model of bile duct ligation that mimics intrahepatic cholestasis-related acute hepatic failure,Ac-DMPD/DMLD-CMK significantly alleviated liver injury.Together,this study not only identified two specific inhibitors of caspase-3 for investigating PCD but also,more importantly,shed light on novel lead compounds for treating liver failure and organ dysfunctions caused by PCD. | Wan-feng Xu Quan Zhang Chu-jie Ding Hui-yong Sun Yuan Che Hai Huang Yun Wang Jia-wei Wu Hai-ping Hao Li-juan Cao | 2021 | Acta Pharmacologica Sinica2021，42，1： | 7 |
| 5 | Intelligent metasurface imager and recognizer显示文摘There is an increasing need to remotely monitor people in daily life using radio-frequency probe signals.However,conventional systems can hardly be deployed in real-world settings since they typically require objects to either deliberately cooperate or carry a wireless active device or identification tag.To accomplish complicated successive tasks using a single device in real time,we propose the simultaneous use of a smart metasurface imager and recognizer,empowered by a network of artificial neural networks(ANNs)for adaptively controlling data flow.Here,three ANNs are employed in an integrated hierarchy,transforming measured microwave data into images of the whole human body,classifying specifically designated spots(hand and chest)within the whole image,and recognizing human hand signs instantly at a Wi-Fi frequency of 2.4 GHz.Instantaneous in situ full-scene imaging and adaptive recognition of hand signs and vital signs of multiple non-cooperative people were experimentally demonstrated.We also show that the proposed intelligent metasurface system works well even when it is passively excited by stray Wi-Fi signals that ubiquitously exist in our daily lives.The reported strategy could open up a new avenue for future smart cities,smart homes,human-device interaction interfaces,health monitoring,and safety screening free of visual privacy issues. | Lianlin Li Ya Shuang Qian Ma Haoyang Li Hanting Zhao Menglin Wei Che Liu Chenglong Hao Cheng-Wei Qiu Tie Jun Cui | 2019 | Light(Science & Applications)2019，8，1： | 5 |
| 6 | Effects of dietary valine supplementation during late gestation on the reproductive performance and mammary gland development of gilts显示文摘Background:Mammary gland development during late gestation in gilts is a major factor that alters the composition of colostrum and growth performance of piglets.Plasma valine is taken up and metabolized extensively by the mammary gland;however,the effects of valine on mammary gland development during late gestation are still unclear.Thirty primiparous gilts were divided into three treatment groups(n=10)and received one of the three diets starting on day 75 of gestation until the day of farrowing.The total dietary valine to lysine ratio of the three diets was 0.63(LV),0.73(MV),and 0.93(HV),respectively.Results:Dietary valine supplementation during late gestation did not affect(P>0.05)the litter size and weight at farrowing;however,the piglet weight and average daily gain at weaning were linearly increased(P<0.05)as the dietary valine increased.The highest piglet weight at weaning was observed when the gilts were provided the HV diet.Dietary valine supplementation linearly elevated(P<0.05)protein,fat and solids-not-fat and some free amino acids content in colostrum.The concentration of prolactin in plasma of gilts was linearly increased in response to valine supplementation at days 1 and 10 of lactation(P<0.05).Furthermore,with increasing dietary valine allowance,a linear increase(P<0.05)was observed in the area of the lumen of alveolus and the content of DNA,RNA,and total protein in the mammary tissues at day 1 of lactation.Moreover,the protein expression of cyclin D1,p-mTOR,p-S6,and p-4EBP1 was also linearly increased(P<0.05)in the mammary tissue at day 1 of lactation.However,no difference(P>0.05)was observed in the indices related to mammary development and the mTOR signaling pathway at day 21 of lactation.Conclusion:The results revealed that increasing the total dietary valine to lysine ratio to 0.93 during late gestation significantly enhances the piglet weight and average daily gain at weaning probably due to improved development of mammary gland. | Long Che Mengmeng Xu Kaiguo Gao Li Wang Xuefen Yang Xiaolu Wen Hao Xiao Zongyong Jiang | 2020 | Journal of Animal Science and Biotechnology2020，11，2： | 4 |
| 7 | Subtyping of type A influenza by sequencing the variable regions of HA gene specifically amplified with RT-PCR显示文摘The outbreak of a novel influenza A(H1N1) virus across the globe poses a threat to human health.It is of paramount importance to develop a rapid,reliable and inexpensive diagnostic procedure.Based on the bioinformatic information from public database,primers specific for influenza A virus surface protein haemagglutinin(HA) of several subtypes(including H1,H2,H3,H5,H7 and H9) were designed.Primer-specific PCR products were subjected to sequencing for accurately distinguishing H1 and H3 subtypes from others.This sequencing-based detection method will not only be applied to rapid detection and simultaneous subtype identification of new influenza A virus H1N1,but also provide the strategies to monitor other new types ofinfluenza virus with explosive potential. | YAN An DING GuoHui ZHOU ZhenFeng DONG Hui ZHANG YaKun ZHU Lei HE YunGang ZHANG GuoQing LI YiXue SUN Bing HUANG Zhong LAN Ke JIN Li WANG HongYan WANG XiaoNing YANG Zhong ZHONG Yang DAI JianXin GUO YaJun WANG Hao CHE XiaoYan WU Fan YUAN ZhenGan ZHANG Xi CAO ZhiWei ZHOU XiaoNong ZHOU JiaHai MA ZhiYong TONG GuangZhi ZHAO GuoPing JIN WeiRong XIONG Hui | 2009 | Chinese Science Bulletin2009，54，13： | 3 |
| 8 | The mutation network for the hemagglutinin gene from the novel influenza A (H1N1) virus显示文摘A mutation network for the hemagglutinin gene(HA) of the novel type A(H1N1) influenza virus was constructed.Sequence homology analysis indicated that one HA sequence type from the viruses mainly isolated from Mexico was likely the original type in this epidemic.Based on the 658A and 1408T mutations in HA,the viruses evolving into this epidemic were divided into three categories,the Mexico,the transitional and the New York type.The three groups of viruses presented distinctive clustering features in their geographic distributions. | HE YunGang DING GuoHui BIAN Chao HUANG Zhong LAN Ke SUN Bing WANG XueCai LI YiXue WANG HongYan WANG XiaoNing YANG Zhong ZHONG Yang JIN WeiRong XIONG Hui DAI JianXin GUO YaJun WANG Hao CHE XiaoYan WU Fan YUAN ZhenAn ZHANG Xi CAO ZhiWei ZHOU XiaoNong ZHOU JiaHai MA ZhiYong TONG GuangZhi ZHAO GuoPing JIN Li | 2009 | Chinese Science Bulletin2009，54，13： | 3 |
| 9 | Fusagerins A–F,New Alkaloids from the Fungus Fusarium sp.显示文摘Fusagerins A–F(1–6),six new alkaloids including a unique one with the rare a-(N-formyl)carboxamide moiety(1),a hydantoin(imidazolidin-2,4-dione)derivative(2),and four fungerin analogues(3–6),were isolated from the crude extract of the fungus Fusarium sp.,together with the known compound fungerin(7).Compound 2 was isolated as a racemate and further separated into two enantiomers on a chiral HPLC column.The structures of 1–6 were determined mainly by NMR experiments,and the absolute configuration of 1 and 2 was assigned by electronic circular dichroism(ECD)calculations.Compound 7 showed antibacterial activity against Staphylococcus aureus and Streptococcus pneumoniae,and weak cytotoxicity against the T24 cells. | Hao Wen Yan Li Xingzhong Liu Wencai Ye Xinsheng Yao Yongsheng Che | 2015 | Natural Products and Bioprospecting2015，5，4： | 2 |
| 10 | Boosting oxygen reduction activity of spinel CoFe2O4 by strong interaction with hierarchical nitrogen-doped carbon nanocages显示文摘The unique hierarchical nitrogen-doped carbon nanocages(h NCNC) are used as a new support to homogeneously immobilize spinel Co Fe_2O_4 nanoparticles by a facile solvothermal method. The so-constructed hierarchical Co Fe_2O_4/h NCNC catalyst exhibits a high oxygen reduction activity with an onset potential of0.966 V and half-wave potential of 0.819 V versus reversible hydrogen electrode, far superior to the corresponding 0.846 and 0.742 V for its counterpart of Co Fe_2O_4/h CNC with undoped hierarchical carbon nanocages(h CNC) as the support, which locates at the top level for spinel-based catalysts to date.Consequently, the Co Fe_2O_4/h NCNC displays the superior performance to the Co Fe_2O_4/h CNC, when used as the cathode catalysts in the home-made Al-air batteries. X-ray photoelectron spectroscopy characterizations reveal the more charge transfer from Co Fe_2O_4 to h NCNC than to h CNC, indicating the stronger interaction between Co Fe_2O_4 and h NCNC due to the nitrogen participation. The enhanced interaction and hierarchical morphology favor the high dispersion and modification of electronic states for the active species as well as the mass transport during the oxygen reduction process, which plays a significant role in boosting the electrocatalytic performances. In addition, we noticed the high sensitivity of O 1 s spectrum to the particle size and chemical environment for spinel oxides, which is used as an indicator to understand the evolution of ORR activities for all the Co Fe_2O_4-related contrast catalysts. Accordingly,the well-defined structure-performance relationship is demonstrated by the combination of experimental characterizations with theoretical calculations. This study provides a promising strategy to develop efficient, inexpensive and durable oxygen reduction electrocatalysts by tuning the interaction between spinel metal oxides and the carbon-based supports. | Hao Fan Lijun Yang Yu Wang Xiali Zhang Qingsong Wu Renchao Che Meng Liu Qiang Wu Xizhang Wang Zheng Hu | 2017 | Science Bulletin2017，62，20： | 2 |
| 11 | Ginsenosides synergize with mitomycin C in combating human non-small cell lung cancer by repressing Rad51-mediated DNA repair显示文摘为癌症治疗的一个助手在动物模特儿和临床的应用被报导了的人参摘录的使用,而是它的分子的机制充分没被阐明。Mitomycin C (MMC ) , anticancer 抗菌素为非小的房间肺癌(NSCLC ) 在治疗用作首要或第二线的政体,当独自使用了时,引起严肃的不利反应。由在 vitro 并且在 vivo 实验使用,这里,我们为 NSCLC 为最佳的治疗向证据提供全部的人参皂甙摘录(TGS ) 当与 MMC 的相对低的集中在联合使用了时,它显著地在 vitro 对 NSCLC A549 和 PC-9 房间提高了导致 MMC 的 cytotoxicity。一个 NSCLC 异种皮移植老鼠模型被用来证实在里面有 MMC 的 TGS 的联合的 vivo synergistic 效果。进一步的调查表明 TGS 能显著地颠倒导致 MMC 的 S 阶段房间周期拘捕并且禁止调停 Rad51 的 DNA 损坏修理,它被 phospho-MEK1/2, phospho-ERK1/2 和 Rad51 蛋白质和 Rad51 的 translocation 的 TGS on the levels 的禁止的效果响应 MMC 从细胞质证实到原子核。在摘要,我们的结果证明 TGS 能有效地在 vitro 并且在 vivo 对 NSCLC 房间提高 MMC 的 cytotoxicity,从而揭示 TGS 的新奇辅助 anticancer 机制。有 TGS 和 MMC 罐头的联合治疗显著地降低 MMC 的要求的集中并且能进一步减少副作用的风险,建议为 NSCLC 病人的一种更好的治疗选择。 | Min ZHAO Dan-dan WANG Yuan CHE Meng-qiu WU Qing-ran LI Chang SHAO Yun WANG Li-juan CAO Guang-ji WANG Hai-ping HAO | 2018 | Acta Pharmacologica Sinica2018，39，3： | 2 |
| 12 | GmFtsH25 overexpression increases soybean seed yield by enhancing photosynthesis and photosynthates显示文摘Increasing plant photosynthetic capacity is a promising approach to boost yields,but it is particularly challenging in C3crops,such as soybean(Glycine max(L.)Merr.).Here,we identified GmFtsH25,encoding a member of the filamentation temperature-sensitive protein H protease family,as a major gene involved in soybean photosynthesis,using linkage mapping and a genome-wide association study.Overexpressing GmFtsH25 resulted in more grana thylakoid stacks in chloroplasts and increased photosynthetic efficiency and starch content,while knocking out GmFtsH25 produced the opposite phenotypes.GmFtsH25 interacted with photosystem I light harvesting complex 2(GmLHCa2),and this interaction may contribute to the observed enhanced photosynthesis.GmFtsH25 overexpression lines had superior yield traits,such as yield per plant,compared to the wild type and knockout lines.Additionally,we identified an elite haplotype of GmFtsH25,generated by natural mutations,which appears to have been selected during soybean domestication.Our study sheds light on the molecular mechanism by which GmFtsH25 modulates photosynthesis and provides a promising strategy for improving the yields of soybean and other crops. | Li Wang Yuming Yang Zhongyi Yang Wenlong Li Dezhou Hu Huilian Yu Xiao Li Hao Cheng Guizhen Kan Zhijun Che Dan Zhang Hengyou Zhang Hui Wang Fang Huang Deyue Yu | 2023 | Journal of Integrative Plant Biology2023，65，4： | 2 |
| 13 | Structure modeling and spatial epitope analysis for HA protein of the novel H1N1 influenza virus显示文摘In recent months,a novel influenza virus H1N1 broke out around the world.With bioinformatics technology,the 3D structure of HA protein was obtained,and the epitope residues were predicted with the method developed in our group for this novel flu virus.58 amino acids were identified as potential epitope residues,the majority of which clustered at the surface of the globular head of HA protein.Although it is located at the similar position,the epitope of HA protein for the novel H1N1 flu virus has obvious differences in the electrostatic potential compared to that of HA proteins from previous flu viruses. | WU Di XU TianLei SUN Jing DAI JianXin DING GuoHui HE YunGang ZHOU ZhengFeng XIONG Hui DONG Hui JIN WeiRong BIAN Chao JIN Li WANG HongYan WANG XiaoNing YANG Zhong ZHONG Yang WANG Hao CHE XiaoYan HUANG Zhong LAN Ke SUN Bing WU Fan YUAN ZhenAn ZHANG Xi ZHOU XiaoNong ZHOU JiaHai MA ZhiYong TONG GuangZhi GUO YaJun ZHAO GuoPing LI YiXue CAO ZhiWei | 2009 | Chinese Science Bulletin2009，54，13： | 2 |
| 14 | Improving the efficiency of magnetic coupling energy transfer byetching fractal patterns in the shielding metals显示文摘Thin metal sheets are often located in the coupling paths of magnetic coupling energy transfer(MCET) systems. Eddy currents in the metals reduce the energy transfer efficiency and can even present safety risks. This paper describes the use of etched fractal patterns in the metals to suppress the eddy currents and improve the efficiency. Simulation and experimental results show that this approach is very effective. The fractal patterns should satisfy three features, namely, breaking the metal edge, etching in the high-intensity magnetic field region, and etching through the metal in the thickness direction. Different fractal patterns lead to different results. By altering the eddy current distribution, the fractal pattern slots reduce the eddy current losses when the metals show resistance effects and suppress the induced magnetic field in the metals when the metals show inductance effects. Fractal pattern slots in multilayer high conductivity metals(e.g., Cu) reduce the induced magnetic field intensity significantly. Furthermore, transfer power, transfer efficiency, receiving efficiency, and eddy current losses all increase with the increase of the number of etched layers. These results can benefit MCET by efficient energy transfer and safe use in metal shielded equipment. | Qing-feng LI Shao-bo CHE Wei-ming WANG Hong-wei HAO Lu-ming LI | 2016 | Frontiers of Information Technology & Electronic Engineering2016，17，1： | 2 |
| 15 | Accuracy assessment of four cloud-free snow cover products over the Qinghai-Tibetan Plateau显示文摘Four up-to-date daily cloud-free snow products–IMS(InteractiveMultisensor Snow products),MOD-SSM/I(combination of the MODIS andSSM/I snow products),MOD-B(Blending method basing on the MODISsnow cover products)and TAI(Terra–Aqua–IMS)–with high-resolutionsover the Qinghai-Tibetan Plateau(QTP)were comprehensively assessed.Comparisons of the IMS,MOD-SSM/I,MOD-B and TAI cloud-free snowproducts against meteorological stations observations over 10 snowseasons(2004–2013)over the QTP indicated overall accuracies of 76.0%,89.3%,92.0%and 92.0%,respectively.The Khat values of the IMS,MODSSM/I,MOD-B and TAI products were 0.084,0.463,0.428 and 0.526,respectively.The TAI products appear to have the best cloud-removalability among the four snow products over the QTP.Based on theassessment,an I-TAI(Improvement of Terra–Aqua–IMS)snow productwas proposed,which can improve the accuracy to some extent.However,the algorithms of the MODIS series products show instabilitywhen identifying wet snow and snow under forest cover over the QTP.The snow misclassification is an important limitation of MODIS snowcover products and requires additional improvements. | Xiaohua Hao Siqiong Luoa Tao Che Jian Wang Hongyi Li Liyun Dai Xiaodong Huang Qisheng Feng | 2019 | International Journal of Digital Earth2019，12，4： | 2 |
| 16 | Unimodal productivity-biodiversity relationship along the gradient of multidimensional resources across Chinese grasslands显示文摘Resources can affect plant productivity and biodiversity simultaneously and thus are key drivers of their relationships in addition to plant-plant interactions.However,most previous studies only focused on a single resource while negle cting the nature of resource multidimensionality.Here we integrated four essential resources for plant growth into a single metric of resource diversity(RD)to investigate its effects on the productivity-biodiversity relationship(PBR)across Chinese grasslands.Results showed that habitats differing in RD have different PBRs—positive in low-resource habitats,but neutral in medium-and high-resource ones—while collectively,a weak positive PBR was observe d.However,when excluding direct effects of RD on productivity and biodiversity,the PBR in high-resource habitats became negative,which leads to a unimodal instead of a positive PBR along the RD gradient.By integrating resource effects and changing plant-plant interactions into a unified framework with the RD gradient,our work contributes to uncovering underlying me chanisms for inconsistent PBRs at large scales. | Yanfen Wang Jianqing Du Zhe Pang Yali Liu Kai Xue Yann Hautier Biao Zhang Li Tang Lili Jiang Baoming Ji Xingliang Xu Jing Zhang Ronghai Hu Shutong Zhou Fang Wang Rongxiao Che Di Wang Chaoting Zhou Xiaoyong Cui Nico Eisenhauer Yanbin Hao | 2022 | National Science Review2022，9，12： | 2 |
| 17 | Haze trends over the capital cities of 31 provinces in China, 1981–2005显示文摘 | Huizheng Che Xiaoye Zhang Yang Li Zijiang Zhou John J. Qu Xianjun Hao | 2009 | Theoretical and Applied Climatology (-)2009，，3： | 1 |
| 18 | DRES:Dynamic Range Encoding Scheme for TCAM Coprocessors显示文摘 | Che Hao Wang Zhijun Zheng Kai | 2008 | IEEE Transactions on Computer2008，57，6： | 1 |
| 19 | Carbachol on rat burn shock when early oral rehydration and gastric emptying of blood flow显示文摘 | HU S HAO B CHE J W | 2007 | Med2007，32，11： | 1 |
| 20 | DRES: Dynamic Range Encoding Scheme for TCAM Coprocessors显示文摘 | Che Hao Wang Zhijun Zheng Kai at al | 2008 | IEEE Transactions on Computers2008，57，7： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员