|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Bird diversity and waterbird habitat preferences in relation to wetland restoration at Dianchi Lake, south-west China显示文摘Background:Restoration projects have been implemented worldwide to mitigate the adverse effects of the loss and degradation of wetland habitats.Much research has been carried out on the impacts on birds of wetland restoration and management projects in China. Studies have mainly investigated central or coastal wetlands,while inland wetlands in remote areas have been much less studied. We focused on examining the response of wild birds to wetland restoration in Dianchi Lake,south-west China. Methods: The line transect method was performed at 26 sampling plots.Three of these were in the city,and to acquire all wild bird data 23 plots were located every 2-8 km along the shore of Dianchi Lake, between December 2011 and November 2013.We collected all related bird records by searching the available literature, articles, newspapers and records of birdwatchers to compare species variation before and after implementation of wetland restoration.To measure the relationships between waterbird assemblages and habitat structures, we used canonical correspondence analysis (CCA) to pair the main matrix of bird assemblages with a second matrix of habitat variables. Results: We recorded 182 bird species belonging to 51 families and 17 orders. Of the species, 42 were new records for Kunming City and 20 were new records for Yunnan Province. Ten waterbird species were found to have disappeared from the shore of Dianchi Lake.CCA results indicated that waterbirds could be divided into four categories based on their habitat preference:synanthropic (wintering gulls), special habitat (shorebirds),semi-natural (wintering coots and ducks) and disturbance-tolerant (resident) species.Conclusions:Our study is the first to consider the entire wild bird community throughout the year and discuss the species variation before and after wetland restoration projects launched for Dianchi Lake.Distinct habitat requirements of different waterbird groups were detected in our study,suggesting different types of restoration and management should be implemented. | Kang Luo Zhaolu Wu Haotian Bai Zijiang Wang | 2019 | Avian Research2019，10，3： | 9 |
| 2 | Erythrocyte membrane-camouflaged carrier-free nanoassembly of FRET photosensitizer pairs with high therapeutic efficiency and high security for programmed cancer synergistic phototherapy显示文摘Phototherapy has been intensively investigated as a non-invasive cancer treatment option.However,its clinical translation is still impeded by unsatisfactory therapeutic efficacy and severe phototoxicity.To achieve high therapeutic efficiency and high security,a nanoassembly of Forster Resonance Energy Transfer(FRET)photosensitizer pairs is developed on basis of dual-mode photosensitizer co-loading and photocaging strategy.For proof-of-concept,an erythrocyte-camouflaged FRET pair co-assembly of chlorine e6(Ce6,FRET donor)and 1,1′-dioctadecyl-3,3,3′,3′-tetramethylindotricarbocyanine iodide(DiR,FRET acceptor)is investigated for breast cancer treatment.Notably,Ce6 in the nanoassemby is quenched by DiR and could be unlocked for photodynamic therapy(PDT)only when DiR is photobleached by 808-nm laser.As a result,Ce6-caused phototoxicity could be well controlled.Under cascaded laser irradiation(808-660 nm),tumor-localizing temperature rise following laser irradiation on DiR not only induces tumor cell apoptosis but also facilitates the tumor penetration of NPs,relieves tumor hypoxia,and promotes the PDT efficacy of Ce6.Such FRET pair-based nanoassembly provides a new strategy for developing multimodal phototherapy nanomedicines with high efficiency and good security. | Xuanbo Zhang Jianchen Xiong Kaiyuan Wang Han Yu Bingjun Sun Hao Ye Zhiqiang Zhao Ning Wang Yuequan Wang Shenwu Zhang Wutong Zhao Haotian Zhang Zhonggui He Cong Luo Jin Sun | 2021 | Bioactive Materials2021，6，8： | 4 |
| 3 | Synergistic osteogenic and angiogenic effects of KP and QK peptides incorporated with an injectable and self-healing hydrogel for efficient bone regeneration显示文摘Irregular defects generated by trauma or surgery in orthopaedics practice were usually difficult to be fitted by the preformed traditional bone graft substitute. Therefore, the injectable hydrogels have attracted an increasing interest for bone repair because of their fittability and mini-invasivity. However, the uncontrollable spreading or mechanical failures during its manipulation remain a problem to be solved. Moreover, in order to achieve vascularized bone regeneration, alternatives of osteogenic and angiogenic growth factors should be adopted to avoid the problem of immunogenicity and high cost. In this study, a novel injectable self-healing hydrogel system (GMO hydrogel) loaded with KP and QK peptides had been developed for enhancing vascularized regeneration of small irregular bone defect. The dynamic imine bonds between gelatin methacryloyl and oxidized dextran provided the GMO hydrogel with self-healing and shear-thinning abilities, which led to an excellent injectability and fittability. By photopolymerization of the enclosed GelMA, GMO hydrogel was further strengthened and thus more suitable for bone regeneration. Besides, the osteogenic peptide KP and angiogenic peptide QK were tethered to GMO hydrogel by Schiff base reaction, leading to desired releasing profiles. In vitro, this composite hydrogel could significantly improve the osteogenic differentiation of BMSCs and angiogenesis ability of HUVECs. In vivo, KP and QK in the GMO hydrogel demonstrated a significant synergistic effect in promoting new bone formation in rat calvaria. Overall, the KP and QK loaded GMO hydrogel was injectable and self-healing, which can be served as an efficient approach for vascularized bone regeneration via a minimally invasive approach. | Runze Li Chen Zhou Jun Chen Haotian Luo Ruoyu Li Danying Chen Xuenong Zou Weicai Wang | 2022 | Bioactive Materials2022，7，12： | 2 |
| 4 | Experimental study on the shear performance of quasi-NPR steel bolted rock joints显示文摘Quasi-NPR(negative Poisson’s ratio)steel is a new type of super bolt material with high strength,high ductility,and a micro-negative Poisson’s effect.This material overcomes the contrasting characteristics of the high strength and high ductility of steel and it has significant energy-absorbing characteristics,which is of high value in deep rock and soil support engineering.However,research on the shear resistance of quasi-NPR steel has not been carried out.To study the shear performance of quasi-NPR steel bolted rock joints,indoor shear tests of bolted rock joints under different normal stress conditions were carried out.Q235 steel and#45 steel,two representative ordinary bolt steels,were set up as a control group for comparative tests to compare and analyze the shear strength,deformation and instability mode,shear energy absorption characteristics,and bolting contribution of different types of bolts.The results show that the jointed rock masses without bolt reinforcement undergo brittle failure under shear load,while the bolted jointed rock masses show obvious ductile failure characteristics.The shear deformation ca-pacity of quasi-NPR steel is more than 3.5 times that of Q235 steel and#45 steel.No fracture occurs in the quasi-NPR steel during large shear deformation and it can provide stable shear resistance.However,the other two types of control bolts become fractured under the same conditions.Quasi-NPR steel has significant energy-absorbing characteristics under shear load and has obvious advantages in terms of absorbing the energy released by shear deformation of jointed rock masses as compared with ordinary steel.In particular,the shear force plays a major role in resisting the shear deformation of Q235 steel and#45 steel,therefore,fracture failure occurs under small bolt deformation.However,the axial force of quasi-NPR steel can be fully exerted when resisting joint shear deformation;the steel itself does not break when large shear deformation occurs,and the supporting effect of the jointed rock mass is effectively guaranteed. | Manchao He Shulin Ren Haotian Xu Senlin Luo Zhigang Tao Chun Zhu | 2023 | Journal of Rock Mechanics and Geotechnical Engineering2023，15，2： | 1 |
| 5 | Clinical Evaluation of Three Incision Size–Dependent Phacoemulsification Systems显示文摘 | Lixia Luo Haotian Lin Mingguang He Nathan Congdon Ye Yang Yizhi Liu | 2012 | American Journal of Ophthalmology2012，，5： | 1 |
| 6 | Integration of phospholipid-drug complex into self-nanoemulsifying drug delivery system to facilitate oral delivery of paclitaxel显示文摘Self-nanoemulsifying drug delivery system(SNEDDS) has emerged as a promising platform to improve oral absorption of drugs with poor solubility and low permeability. However,large polarity molecules with insufficient lipid solubility,such as paclitaxel(PTX),would suffer from inferior formulation of SNEDDS due to poor compatibility. Herein,phospholipid-drug complex(PLDC) and SNEDDS were integrated into one system to facilitate oral delivery of PTX. First,PTX was formulated into PLDC in response to its inferior physicochemical properties. Then,the prepared PLDC was further formulated into SNEDDS by integrating these two drug delivery technologies into one system(PLDC-SNEDDS). After PLDC-SNEDDS dispersed in aqueous medium,nanoemulsion was formed immediately with an average particle size of ~30 nm. Furthermore,the nanomulsion of PLDC-SNEDDS showed good colloidal stability in both HCl solution(0.1 mol/l,p H 1.0) and phosphate buffer solution(PBS,p H 6.8). In vivo,PTX-PLDC-SNEDDS showed distinct advantages in terms of oral absorption efficiency,with a3.42-fold and 2.13-fold higher bioavailability than PTX-PLDC and PTX solution,respectively.Our results suggest that the integration of PLDC into SNEDDS could be utilized to facilitate the oral delivery of hydrophobic drugs with large polarity. | Dawei Ding Bingjun Sun Weiping Cui Qin Chen Xuanbo Zhang Haotian Zhang Zhonggui He Jin Sun Cong Luo | 2019 | Asian Journal of Pharmaceutical Sciences2019，14，5： | 1 |
| 7 | Precisely engineering a dual-drug cooperative nanoassembly for proteasome inhibition-potentiated photodynamic therapy显示文摘Photodynamic therapy(PDT) has been widely investigated for cancer therapy. The intracellular accumulation of reactive oxygen species(ROS)-damaged protein facilitates tumor cell apoptosis. However, there is growing evidence that the ubiquitin-proteasome pathway(UPP) significantly impedes PDT by preventing the enrichment of ROS-damaged proteins in tumor cells. To tackle this challenge, we report a facile dual-drug nanoassembly based on the discovery of an interesting co-assembly of bortezomib(BTZ, a proteasome inhibitor) and pyropheophorbide a(PPa) for proteasome inhibition-mediated PDT sensitization.The precisely engineered nanoassembly with the optimal dose ratio of BTZ and PPa demonstrates multiple advantages, including simple fabrication, high drug co-loading efficiency, flexible dose adjustment,good colloidal stability, long systemic circulation, favorable tumor-specific accumulation, as well as significant enrichment of ROS-damaged proteins in tumor cells. As a result, the cooperative nanoassembly exhibits potent synergistic antitumor activity in vivo. This study provides a novel dual-drug engineering modality for multimodal cancer treatment. | Fujun Yang Qingyu Ji Rui Liao Shumeng Li Yuequan Wang Xuanbo Zhang Shenwu Zhang Haotian Zhang Qiming Kan Jin Sun Zhonggui He Bingjun Sun Cong Luo | 2022 | Chinese Chemical Letters2022，33，4： | 1 |
| 8 | Deciphering the Role of Fluoroethylene Carbonate towards Highly Reversible Sodium Metal Anodes显示文摘Sodium metal anodes(SMAs)sufer from extremely low reversibility(<20%)in carbonate based clectrolytes-this piece of knowledge gained from previous studics has ruled out the application of carbonate solvents for sodium metal batteries.Here,we overturn this conclusion by incorporating fluoroethylene carbonate(FEC)as cosolvent that renders a Na plating/stripping fficiency of>95%with conventional NaPF。salt at a regular concentration(1.0M).The peculiar role of FEC is firstly.unraveled via its involvement into the solvation structure,where a threshold FEC concentration with a coordination number>1.2 is needed in guaranteeing high Na reversibility over the long-term.Specifially,by incorporating an average number of 1.2 FEC molecules into the primary Na*solvation sheath,lowest unoccupied molecular orbital(LUMO)levels of such Nat-FEC solvates undergo further decrease,with spin electrons residing either on the O=C 0(O)moiety of FEC or sharing between Na*and its C=:O bond,which ensures a prior FEC decomposition in passivating the Na surface against other carbonate molecules.Further,by adopting cryogenic tranmission electron microscopy(cryo-TEM),we found that the Na filaments grow into substantially larger diameter from-400nm to>1 pum with addition of FEC upon the threshold value.A.highly crstalline and much thiner(-40 nm)slid-electrolyte interphase(SED)is consequently observed to uniformly wrap the Na surface,in contrast to the severely corroded Na as retrieved from the blank electrolyte.The potence of FEC is further demonstrated in a series of'corrosive solvents'such as ethy!l acetate(EA)。trimethyl phosphate(TMP),and actonitrile(AN)enabling highly reversible SMAs in the otherwise unusable solvent systems. | Xueying Zheng Suting Weng Wei Luo Bo Chen Xiao Zhang Zhenyi Gu Haotian Wang Xiaolu Ye Xuyang Liu Liqiang Huang Xinglong Wu Xuefeng Wang Yunhui Huang | 2022 | Research2022，，2： | 1 |
| 9 | Biogas residue biochar integrated with phosphate from its ash for the effective recovery of nutrients from piggery biogas slurry显示文摘Magnesium ammonium phosphate(MAP)precipitation generally requires an external phosphorus source to increase the recovery of NH_(4)^(+)-N from biogas slurry.However,P-rich piggery biogas residue has been ignored as a phosphorus source.In this study,biogas residue was carbonized into biogas residue biochar(BRC),followed by acid leaching to synthesize functionalized BRC and release PO_(4)^(3−)-P from its ash as the phosphorus source.The effects of different acids on the leaching efficiency and morphological changes of P in BRC were investigated,and NH_(4)^(+)-N and PO_(4)^(3−)-P in the biogas slurry were recovered with functionalized BRC and MAP precipitation.The results showed that oxalic acid-hydrochloric acid mixed acid could leach more than 96%of P in BRC,while weakening the inhibitory effect of Ca^(2+)on MAP precipitation.The BRC was mainly composed of inorganic P,and most nonapatite IP and apatite P(Ca_(3)(PO_(4))2)were leached during acid leaching,with the latter more easily leached.Under optimal recovery conditions,the method had a significant recovery effect on NH_(4)^(+)-N(96.4%)and PO_(4)^(3−)-P(99.3%)in biogas slurry.The recovery of NH_(4)^(+)-N and PO_(4)^(3−)-P by functionalized BRC was mainly through chemical precipitation(forming NH_(4)MgPO_(4)·H_(2)O precipitate)while bonding with-OH,C=O and C-H functional groups.The final recovery product was also a BRC-based slow-release N-P fertilizer rich in struvite.This study solved the disposal problems of P-rich biogas residue and N-rich biogas slurry while providing an innovative technology for the resource utilization of faecal sewage at pig farms. | Zifeng Luo Hongping Wen Haotian Zhang Yunliang Li Xueyi Mai Yulong Zhang Jinjin Wang Yongtao Li Zhen Zhang | 2022 | Biochar2022，4，1： | 1 |
| 10 | Unbiased transcriptomic analyses reveal distinet effects of immune deficiency in CNS function with and without injury显示文摘The mammalian central nervous system (CNS) is considered an immune privileged system as it is separated from the periphery by the blood brain barrier (BBB). Yet, immune functions have been postulated to heavily influence the functional state of the CNS, especially after injury or during neurodegeneration. There is controversy regarding whether adaptive immune responses are beneficial or detrimental to CNS injury repair. In this study, we utilized immunocompromised SCID mice and subjected them to spinal cord injury (SCI). We analyzed motor function, electrophysiology, histochemistry, and performed unbiased RNA-sequencing. SCID mice displayed improved CNS functional recovery compared to WT mice after SCI. Weighted gene-coexpression network analysis (WGCNA) of spinal cord transcriptomes revealed that SCID mice had reduced expression of immune function-related genes and heightened expression of neural transmission-related genes after SCI, which was confirmed by immunohistochemical analysis and was consistent with better functional recovery. Transcriptomic analyses also indicated heightened expression of neurotransmission-related genes before injury in SCID mice, suggesting that a steady state of immune-deficiency potentially led to CNS hyper-connectivity. Consequently, SCID mice without injury demonstrated worse performance in Morris water maze test. Taken together, not only reduced inflammation after injury but also dampened steady-state immune function without injury heightened the neurotransmission program, resulting in better or worse behavioral outcomes respectively. This study revealed the intricate relationship between immune and nervous systems, raising the possibility for therapeutic manipulation of neural function via immune modulation. | Dandan Luo Weihong Ge Xiao Hu Chen Li Chia-Ming Lee Liqiang Zhou Zhourui Wu Juehua Yu Sheng Lin Jing Yu Wei Xu Lei Chen Chong Zhang Kun Jiang Xingfei Zhu Haotian Li Xinpei Gao Yanan Geng Bo Jing Zhen Wang Changhong Zheng Rongrong Zhu Qiao Yan Quan Lin Keqiang Ye Yi E. Sun Liming Cheng | 2019 | Protein & Cell2019，10，8： | 1 |
| 11 | Modularly engineered prodrug-nanoassemblies for cancer therapy:Nonpharmacological moiety dominating delivery fates显示文摘Self-engineered small-molecule prodrug-nanoassemblies have emerged as promising nanomedicines for cancer treatment.Modular design of prodrug molecules is crucial to guarantee the favorable assembly stability,tumor-specific prodrug activation,and satisfactory antitumor effect.However,too much attention has been paid to the pharmacophores and chemical linkages in prodrug molecules while neglects the vital roles of nonpharmacological moieties.Herein,we found that iso-carbon fatty acids with different number,position,and cis-trans configuration of double bonds dramatically affect the nanoassembly feature and drug delivery fates of thioether-linked paclitaxel prodrug-nanoassemblies.Particularly,the number and cis-trans configuration of double bonds in fatty acid moieties not only dominate the self-assembly ability and colloidal stability of prodrugs,but also exert significant influences on the pharmacokinetics,prodrug activation,and antitumor activity of prodrug-nanoassemblies.Finally,oleic acid with one cis double bond stands out as the optimal nonpharmacological moiety for thioether-linked paclitaxel prodrugnanoassemblies.This study elucidates the crucial roles of nonpharmacological moieties in prodrugs,and provides new insights into the modular design of prodrug-based nanomedicines for cancer therapy. | Yuequan Wang Qian Qiu Rui Liao Xinhui Wang Ziran Zhou Xuanbo Zhang Haotian Zhang Zhonggui He Shenwu Zhang Cong Luo Jin Sun | 2023 | Nano Research2023，16，1： | 0 |
| 12 | A Monochromophoric Approach to Succinct Ratiometric Fluorescent Probes without Probe-Product Crosstalk显示文摘Ratiometric probes facilitate quantitative studies via self-calibration and are cherished for bioimaging.Often,a small probe-product spectral separation leads to crosstalk,but the rational development of ratiometric probes with zero probe-product crosstalk remains challenging.Harnessing the recent progress on photophysical modulation of xanthenoid fluorochromes,we propose a powerful and versatile probe design principle,that is,“bridging-group modification,”and developed totalROX,a robust probe for monitoring the total cellular oxidative capacity. | Kai Xin Xinxing Li Yinghua Guo Youhuan Zhong Jungang Wang Haotian Yang Jie Zhao Chunlei Guo Yunxia Huang Zuhai Lei Yi-Lun Ying Xiao Luo Haolu Wang Xuhong Qian Wen Yang Xiaowen Liang Youjun Yang | 2021 | CCS Chemistry2021，3，8： | 0 |
| 13 | Multifunctional properties of a polar spin chain compound[N(C_(3)H_(7))_(4)][Cu(C_(8)H_(4)NO_(4))]·H_(2)O exhibiting both one-dimensional magnetism and nonlinear optical activity显示文摘Functional materials with multiple properties are urgent to be explored to reach high requirements for applications nowadays.In this work,a new multifunctional one-dimensional(1D)chain compound[N(C_(3)H_(7))_(4)][Cu(ohpma)]·H_(2)O 1(ohpma=deprotonated N-(2-hydoxyphenyl)oxamic acid)exhibiting both 1D antiferromagnetic and nonlinear optical properties,which are both originated from the same polar[Cu(C_(8)H_(4)NO_(4))]magnetic units,has been successfully synthesized by evaporation at room temperature.Bis-polydentate nature of the(ohpma)3−ligand with constrained tridentate and bidentate coordination sites conducts Cu^(2+)ions coordinating in different geometries and forms 1D chains along the c axis,which are further separated by the[N(C_(3)H_(7))_(4)]+cations.And the 1D magnetic chains further exhibit noncentrosymmetric polar arrangement.Nonlinear optical study shows polar compound 1 exhibits a discernible second-harmonic generation(SHG)efficiency and the calculation of the partial density of states indicates that the SHG efficiency of 1 is mainly originated from the polar[Cu(C_(8)H_(4)NO_(4))]magnetic units.Moreover,magnetic susceptibility shows a broad maximum around 70 K with strong intrachain interaction of J/k B=−113.0 K but no long-range order is observed down to 2 K,suggesting that 1 shows a good 1D magnetism.Both good 1D magnetism and SHG activity suggest that 1 could be as a potential multifunctional material,particularly. | Ang Li Yanhong Wang Haotian Tian Alimujiang Yalikun Yves Journaux Min Luo Hongcheng Lu | 2024 | Chinese Chemical Letters2024，35，2： | 0 |
您所在的机构暂未开通此部分的功能，请联系管理员