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| 1 | Ankylosing spondylitis: etiology, pathogenesis, and treatments显示文摘Ankylosing spondylitis(AS), a common type of spondyloarthropathy, is a chronic inflammatory autoimmune disease that mainly affects spine joints, causing severe, chronic pain;additionally, in more advanced cases, it can cause spine fusion. Significant progress in its pathophysiology and treatment has been achieved in the last decade. Immune cells and innate cytokines have been suggested to be crucial in the pathogenesis of AS, especially human leukocyte antigen(HLA)?B27 and the interleukin?23/17 axis.However, the pathogenesis of AS remains unclear. The current study reviewed the etiology and pathogenesis of AS, including genome-wide association studies and cytokine pathways. This study also summarized the current pharmaceutical and surgical treatment with a discussion of future potential therapies. | Wei Zhu Xuxia He Kaiyuan Cheng Linjie Zhang Di Chen Xiao Wang Guixing Qiu Xu Cao Xisheng Weng | 2019 | Bone Research2019，7，3： | 30 |
| 2 | Aerodynamic Modeling and Parameter Estimation from QAR Data of an Airplane Approaching a High-altitude Airport显示文摘Aerodynamic modeling and parameter estimation from quick accesses recorder (QAR) data is an important technical way to analyze the effects of highland weather conditions upon aerodynamic characteristics of airplane. It is also an essential content of flight accident analysis. The related techniques are developed in the present paper, including the geometric method for angle of attack and sideslip angle estimation, the extended Kalman filter associated with modified Bryson-Frazier smoother (EKF-MBF) method for aerodynamic coefficient identification, the radial basis function (RBF) neural network method for aerodynamic modeling, and the Delta method for stability/control derivative estimation. As an application example, the QAR data of a civil airplane approaching a high-altitude airport are processed and the aerodynamic coefficient and derivative estimates are obtained. The estimation results are reasonable, which shows that the developed techniques are feasible. The causes for the distribution of aerodynamic derivative estimates are analyzed. Accordingly, several measures to improve estimation accuracy are put forward. | WANG Qing WU Kaiyuan ZHANG Tianjiao KONG Yi'nan QIAN Weiqi | 2012 | Chinese Journal of Aeronautics2012，25，3： | 19 |
| 3 | The cross talk between long, non-coding RNAs and microRNAs in gastric cancer显示文摘胃的癌症是最普通的恶意的疾病之一并且仍然是世界范围的癌症相关的死亡的第二个领先的原因。尽管大努力在过去的十年期间被作了便于胃的癌症的早察觉和治疗,预后是还没令人满意的,胃的癌症致病的内在的分子的机制充分没被理解。同时,非编码的 RNA 在调整各种各样的生物、病理学的过程作为关键播放器被建立了,例如房间周期前进,改变的染色质,基因抄写,并且 posttranscriptional 处理。而且,众多的研究也在非编码的 RNA 的不同种类之中揭示了复杂相互影响;因此,在长非编码的 RNA (lncRNAs ) 和 microRNAs (miRNAs ) 之间跨规定开始出现了。这次 lncRNAmiRNA 十字谈话,在最近的年里吸引了增加的注意,包括胃的癌症涉及很多人的疾病。在这评论,我们总结在 lncRNAs 和 miRNAs 之间的相互作用的最近的研究进步,加亮他们对提供为癌症诊断和治疗的新奇途径的胃的癌症的发展和前进的影响。 | Kaiyuan Deng Hao Wang Xiaoqiang Guo Jiazeng Xia | 2016 | Acta Biochimica et Biophysica Sinica2016，48，2： | 16 |
| 4 | Policy and Management of Carbon Peaking and Carbon Neutrality:A Literature Review显示文摘The vision of reaching a carbon peak and achieving carbon neutrality is guiding the low-carbon transition of China’s socioeconomic system.Currently,a research gap remains in the existing literature in terms of studies that systematically identify opportunities to achieve carbon neutrality.To address this gap,this study comprehensively collates and investigates 1105 published research studies regarding carbon peaking and carbon neutrality.In doing so,the principles of development in this area are quantitively analyzed from a space–time perspective.At the same time,this study traces shifts and alterations in research hotspots.This systematic review summarizes the priorities and standpoints of key industries on carbon peaking and carbon neutrality.Furthermore,with an emphasis on five key management science topics,the scientific concerns and strategic demands for these two carbon emission-reduction goals are clarified.The paper ends with theoretical insights on and practical countermeasures for actions,priority tasks,and policy measures that will enable China to achieve a carbon-neutral future.This study provides a complete picture of the research status on carbon peaking and carbon neutrality,as well as the research directions worth investigating in this field,which are crucial to the formulation of carbon peak and carbon neutrality policies. | Yi-Ming Wei Kaiyuan Chen Jia-Ning Kang Weiming Chen Xiang-Yu Wang Xiaoye Zhang | 2022 | Engineering2022，8，7： | 14 |
| 5 | Prognostic implications of epidermal growth factor receptor variant Ⅲ expression and nuclear translocation in Chinese human gliomas显示文摘Objective: To determine the prognostic implications and clinical significance of epidermal growth factor receptor variant Ⅲ(EGFRvⅢ) expression and EGFRvⅢ nuclear translocation in Chinese human gliomas.Methods: We retrospectively examined EGFRvⅢ expression and EGFRvⅢ nuclear translocation using immunohistochemistry in specimens of 240 Chinese patients with glioma, including 84 World Health Organization(WHO) II gliomas, 84 WHO Ⅲ gliomas and 72 glioblastomas(WHO IV). Factors that correlated with EGFRvⅢ and EGFRvⅢ nuclear translocation expression were analyzed by the Chi-square test. Kaplan-Meier methodology and Cox regression were used for the survival analysis.Results: Log-rank tests showed that patient age, Karnofsky performance scale(KPS) score, tumor grade,EGFRvⅢ expression, EGFRvⅢ nuclear translocation, 1 p/19 q codeletion, isocitrate dehydrogenase(IDH)mutation, Ki-67 labeling index and O6-methylguanine-DNA methyltransferase(MGMT) status(P<0.05) were significantly correlated with overall survival(OS) time. Multivariate Cox regression analysis revealed that patient age, tumor grade, EGFRvⅢ nuclear translocation, 1 p/19 q codeletion, and IDH mutation(P<0.05) were significantly correlated with OS. Patients with a high level of EGFRvⅢ nuclear translocation(≥7%) had both significantly shorter OS [hazard ratio(HR): 1.920, 95% confidence interval(95% CI): 1.228-3.003, P=0.004] and progression-free survival(PFS) times(HR: 1.661, 95% CI: 1.116-2.471, P=0.012) than those with a low level of EGFRvⅢ nuclear translocation(<7%).Conclusions: A high level of EGFRvⅢ nuclear translocation in glioma is an independent factor indicating a poor prognosis, but EGFRvⅢ expression is not an independent clinical prognostic factor. The level of EGFRvⅢ nuclear translocation maybe a novel and crucial prognostic biomarker in glioma. | Kaiyuan Yang Xiaohui Ren Liyuan Tao Peipei Wang Haihui Jiang Li Shen Yiming Zhao Yong Cui Mingxiao Li Song Lin | 2019 | Chinese Journal of Cancer Research2019，31，1： | 8 |
| 6 | Inverse design of digital nanophotonic devices using the adjoint method显示文摘A high-efficiency inverse design of'digital'subwavelength nanophotonic devices using the adjoint method is proposed.We design a single-mode 3dB power divider and a dual-mode demultiplexer to demonstrate the efficiency of the proposed inverse design approach,called the digitized adjoint method,for single-and dual-object optimization,respectively.The optimization comprises three stages:1)continuous variation for an'analog'pattern;2)forced permittivity biasing for a'quasi-digital'pattern;and 3)a multilevel digital pattern.Compared with the conventional brute-force method,the proposed method can improve design efficiency by about five times,and the performance optimization can reach approximately the same level.The method takes advantages of adjoint sensitivity analysis and digital subwavelength structure and creates a new way for the efficient and high-performance design of compact digital subwavelength nanophotonic devices,which could overcome the efficiency bottleneck of the brute-force method,which is restricted by the number of pixels of a digital pattern,and improve the device performance by extending a conventional binary pattern to a multilevel one. | KAIYUAN WANG XINSHU REN WEIJIE CHANG LONGHUI LU DEMING LIU MINMING ZHANG | 2020 | Photonics Research2020，8，4： | 7 |
| 7 | Effect of fertilization patterns on the assemblage of weed communities in an upland winter wheat field显示文摘Aims Understanding the response of farmland weed community assembly to fertilization is important for designing better nutrient management strategies in integrated farmland ecological systems.Many studies have focused on weed characteristics,mainly crop–weed competition responses to fertilization or weed communities alone.However,weed community assembly in association with crop growth is poorly understood in the agroecosystems,but is important for the determination of integrated weed management.Biodiversity promotes ecosystem productivity in the grassland,but whether it applies to the agroecosystems is unclear.Based on an 11-year field experiment,the cumulative effects of different fertilization patterns on the floristic composition and species diversity of farmland weed communities along with wheat growth in a winter wheat–soybean rotation were investigated.Methods The field trial included five fertilization patterns with different combinations of N,P and K fertilizers.Species composition and diversity of weed communities,aboveground plant biomass and nutrient accumulation of weeds and winter wheat,light penetration to the ground surface and wheat yield were measured at each plot in 2009 and 2010.Multivariate analysis,regression and analysis of variance were used to analyze the responses of these parameters to the different fertilization treatments.Important Findings Four dominant weeds(Galium aparine L.,Veronica persica Poir.,Vicia sativa L.and Geranium carolinianum L.)accounted for~90%of the total weed density in the 2 years of experimental duration.The residual weed community assembly was influenced primarily by topsoil available nutrients in the order P>N>K.Competition for nutrients and solar radiation between crops and weeds was the main indirect effect of fertilization on the changes in weed community composition and species diversity.The indices of species diversity(species richness,Shannon–Wiener,Pielou and Simpson indices)showed significant linear relationships with wheat yield.The balanced fertilization treatment was more efficient at inhibiting the potential growth of weeds because of solar radiation being intercepted by wheat.These results support the conclusion that wheat yield is favored by balanced fertilization,whereas the weed community is favored by PK fertilization in terms of density and diversity.However,the negative effects on wheat yield may be compromised by simultaneous positive effects of weed communities in the fertilization treatments,for instance,the NP and NK treatments,which are intermediate in terms of increasing wheat production and to a level maintaining a diverse community. | Leilei Tang Kaiyuan Wan Chuanpeng Cheng Ruhai Li Daozhong Wang Junfeng Pan Yong Tao Juan Xie Fang Chen | 2014 | Journal of Plant Ecology2014，7，1： | 6 |
| 8 | Optical meta-waveguides for integrated photonics and beyond显示文摘The growing maturity of nanofabrication has ushered massive sophisticated optical structures available on a photonic chip.The integration of subwavelength-structured metasurfaces and metamaterials on the canonical building block of optical waveguides is gradually reshaping the landscape of photonic integrated circuits,giving rise to numerous metawaveguides with unprecedented strength in controlling guided electromagnetic waves.Here,we review recent advances in meta-structured waveguides that synergize various functional subwavelength photonic architectures with diverse waveguide platforms,such as dielectric or plasmonic waveguides and optical fibers.Foundational results and representative applications are comprehensively summarized.Brief physical models with explicit design tutorials,either physical intuition-based design methods or computer algorithms-based inverse designs,are cataloged as well.We highlight how meta-optics can infuse new degrees of freedom to waveguide-based devices and systems,by enhancing light-matter interaction strength to drastically boost device performance,or offering a versatile designer media for manipulating light in nanoscale to enable novel functionalities.We further discuss current challenges and outline emerging opportunities of this vibrant field for various applications in photonic integrated circuits,biomedical sensing,artificial intelligence and beyond. | Yuan Meng Yizhen Chen Longhui Lu Yimin Ding Andrea Cusano Jonathan A.Fan Qiaomu Hu Kaiyuan Wang Zhenwei Xie Zhoutian Liu Yuanmu Yang Qiang Liu Mali Gong Qirong Xiao Shulin Sun Minming Zhang Xiaocong Yuan Xingjie Ni | 2021 | Light(Science & Applications)2021，10，12： | 6 |
| 9 | Research on practical power system stability analysis algorithm based on modified SVM显示文摘Stable and safe operation of power grids is an important guarantee for economy development.Support Vector Machine(SVM)based stability analysis method is a significant method started in the last century.However,the SVM method has several drawbacks,e.g.low accuracy around the hyperplane and heavy computational burden when dealing with large amount of data.To tackle the above problems of the SVM model,the algorithm proposed in this paper is optimized from three aspects.Firstly,the gray area of the SVM model is judged by the probability output and the corresponding samples are processed.Therefore the clustering of the samples in the gray area is improved.The problem of low accuracy in the training of the SVM model in the gray area is improved,while the size of the sample is reduced and the efficiency is improved.Finally,by adjusting the model of the penalty factor in the SVM model after the clustering of the samples,the number of samples with unstable states being misjudged as stable is reduced.Test results on the IEEE 118-bus test system verify the proposed method. | Kaiyuan Hou Guanghui Shao Haiming Wang Le Zheng Qiang Zhang Shuang Wu Wei Hu | 2018 | Protection and Control of Modern Power Systems2018，3，1： | 5 |
| 10 | Erythrocyte membrane-camouflaged carrier-free nanoassembly of FRET photosensitizer pairs with high therapeutic efficiency and high security for programmed cancer synergistic phototherapy显示文摘Phototherapy has been intensively investigated as a non-invasive cancer treatment option.However,its clinical translation is still impeded by unsatisfactory therapeutic efficacy and severe phototoxicity.To achieve high therapeutic efficiency and high security,a nanoassembly of Forster Resonance Energy Transfer(FRET)photosensitizer pairs is developed on basis of dual-mode photosensitizer co-loading and photocaging strategy.For proof-of-concept,an erythrocyte-camouflaged FRET pair co-assembly of chlorine e6(Ce6,FRET donor)and 1,1′-dioctadecyl-3,3,3′,3′-tetramethylindotricarbocyanine iodide(DiR,FRET acceptor)is investigated for breast cancer treatment.Notably,Ce6 in the nanoassemby is quenched by DiR and could be unlocked for photodynamic therapy(PDT)only when DiR is photobleached by 808-nm laser.As a result,Ce6-caused phototoxicity could be well controlled.Under cascaded laser irradiation(808-660 nm),tumor-localizing temperature rise following laser irradiation on DiR not only induces tumor cell apoptosis but also facilitates the tumor penetration of NPs,relieves tumor hypoxia,and promotes the PDT efficacy of Ce6.Such FRET pair-based nanoassembly provides a new strategy for developing multimodal phototherapy nanomedicines with high efficiency and good security. | Xuanbo Zhang Jianchen Xiong Kaiyuan Wang Han Yu Bingjun Sun Hao Ye Zhiqiang Zhao Ning Wang Yuequan Wang Shenwu Zhang Wutong Zhao Haotian Zhang Zhonggui He Cong Luo Jin Sun | 2021 | Bioactive Materials2021，6，8： | 4 |
| 11 | Understanding the electrode reaction process of dechlorination of 2,4-dichlorophenol over Ni/Fe nanoparticles: Effect of pH and 2,4-dichlorophenol concentration显示文摘Herein,with the exploitation of iron and nickel electrodes,the 2,4-dichlorophenol(2,4-DCP)dechlorinating processes at the anode and cathode,respectively,were separately studied via various electrochemical techniques(e.g.,Tafel polarization,linear polarization,electrochemical impedance spectroscopy).With this in mind,Ni/Fe nanoparticles were prepared by chemical solution deposition,and utilized to test the dechlorination activities of 2,4-DCP over a bimetallic system.For the iron anode,the results showed that higher 2,4-DCP concentration and solution acidity aggravated the corrosion within the electrode.The charge transfer resistance(Rct)values of the iron electrode were 703,473,444,and 437Ω·cm2 for the initial 2,4-DCP concentrations of0,20,50,and 80 mg/L,respectively.When the bulk pH of the 2,4-DCP solution varied from 3.0,5.0to 7.0,the corresponding Rct values were 315,376,and 444Ω·cm2,respectively.For the nickel cathode,the reduction current densities on the electrode at-0.75 V(vs.saturated calomel electrode)were 80,106,and 111μA/cm2,for initial 2,4-DCP concentrations of 40,80,and125 mg/L.The dechlorination experiments demonstrated that when the initial pH of the solution was 7.0,5.0,and 3.0,the dechlorination percentage of 2,4-DCP by Ni/Fe nanoparticles was 62%,69%,and 74%,respectively,which was in line with the electrochemical experiments.10 wt.%Ni loading into Ni/Fe bimetal was affordable and gave a good dechlorination efficiency of 2,4-DCP,and fortunately the Ni/Fe nanoparticles remained comparatively stable in the dechlorination processes at pH 3.0. | Kaiyuan Zheng Yuqiao Song Xu Wang Xin Li Xuhui Mao Dihua Wang | 2019 | Journal of Environmental Sciences2019，31，10： | 2 |
| 12 | Borate-Modified,Flame-Retardant Paper Packaging Materials for Archive Conservation显示文摘Paper packaging materials like cardboards are widely used to protect archives which are a major kind of cultural relics.Unfortunately,paper is a combustible material,and thus exploring environment-friendly flame retardant for paper-based archive packaging material plays an important role.Herein,boric acid,borax and disodium octaborate are used to modify the craft paper-based packaging materials for archive conservation to improve fire safety.The modified craft paper exhibits much higher flame retardancy than the pristine one dose based on vertical burning tests,without much influence on mechanical properties such as tensile strength and elongation at break.Thermogravimetric analysis(TGA),scanning electron microscope(SEM),and X-ray photoelectron spectroscopy(XPS)reveal that porous glass structure is formed during the combustion,because thermal decomposition of boric acid,borax and disodium octaborate will produce porous glassy matter as B_(2)O_(3).The porous glass covers the paper surface as an insulating layer which retards the further pyrolysis and combustion,resulting in a denser carbon layer.Our study provides a robust way to reduce the fire hazard of the archive packaging material by applying environment-friendly boron-based fire retardants. | Juanli Wang Ming Cao Jiaxin Li Kaiyuan Li Xiaolian Chao Bingjie Mai Yuhu Li Jing Cao | 2022 | Journal of Renewable Materials2022，10，4： | 2 |
| 13 | Colonization of endophyte Acremonium sp. D212 in Panax notoginseng and rice mediated by auxin and jasmonic acid显示文摘Endophytic fungi can be beneficial to plant growth. However, the molecular mechanisms under-lying colonization of Acremonium spp. remain unclear. In this study, a novel endophytic Acremonium strain was isolated from the buds of Panax notoginseng and named Acremonium sp. D212. The Acremonium sp. D212 could colonize the roots of P. notoginseng, enhance the resistance of P. notoginseng to root rot disease, and promote root growth and saponin bio-synthesis in P. notoginseng. Acremonium sp. D212 could secrete indole-3-acetic acid (IAA) and jasmonic acid (JA), and inoculation with the fungus increased the endogenous levels of IAA and JA in P. noto-ginseng. Colonization of the Acremonium sp. D212 in the roots of the rice line Nipponbare was dependent on the concentration of methyl jasmonate (MeJA) (2–15μmol/L) and 1-naphthalenacetic acid (NAA) (10–20μmol/L). Moreover, the roots of the JA signaling-defective coi1-18 mutant were colonized by Acremonium sp. D212 to a lesser degree than those of the wild-type Nipponbare and miR393b-overexpressing lines, and the colonization was res-cued by MeJA but not by NAA. It suggests that the cross-talk between JA signaling and the auxin biosynthetic pathway plays a crucial role in the colonization of Acremonium sp. D212 in host plants. | Li Han Xuan Zhou Yiting Zhao Shusheng Zhu Lixia Wu Yunlu He Xiangrui Ping Xinqi Lu Wuying Huang Jie Qian Lina Zhang Xi Jiang Dan Zhu Chongyu Luo Saijie Li Qian Dong Qijing Fu Kaiyuan Deng Xin Wang Lei Wang Sheng Peng Jinsong Wu Weimin Li JiǐíFriml Youyong Zhu Xiahong He Yunlong Du | 2020 | Journal of Integrative Plant Biology2020，62，9： | 2 |
| 14 | Oxidation-strengthened disulfide-bridged prodrug nanoplatforms with cascade facilitated drug release for synergetic photochemotherapy显示文摘One of the major barriers in utilizing prodrug nanocarriers for cancer therapy is the slow release of parent drug in tumors.Tumor cells generally display the higher oxidative level than normal cells,and also displayed the heterogeneity in terms of redox homeostasis level.We previously found that the disulfide bond-linkage demonstrates surprising oxidationsensitivity to form the hydrophilic sulfoxide and sulphone groups.Herein,we develop oxidation-strengthened prodrug nanosystem loaded with pyropheophorbide a(PPa)to achieve light-activatable cascade drug release and enhance therapeutic efficacy.The disulfide bond-driven prodrug nanosystems not only respond to the redox-heterogeneity in tumor,but also respond to the exogenous oxidant(singlet oxygen)elicited by photosensitizers.Once the prodrug nanoparticles(NPs)are activated under irradiation,they would undergo an oxidative self-strengthened process,resulting in a facilitated drug cascade release.The IC50 value of the PPa@PTX-S-S NPs without irradiation was 2-fold higher than those of NPs plus irradiation.In vivo,the PPa@PTX prodrug NPs display prolonged systemic circulation and increased accumulation in tumor site.The PPa@PTXS-S NPs showed much higher efficiency than free PTX or the PPa@PTX-C-C NPs to suppress the growth of 4 T1 tumors.Therefore,this novel oxidation-strengthened disulfide-bridged prodrug-nanosystem has a great potential in the enhanced efficacy of cancer synergetic photochemotherapy. | Bin Yang Lin Wei Yuequan Wang Na Li Bin Ji Kaiyuan Wang Xuanbo Zhang Shenwu Zhang Shuang Zhou Xiaohui Yao Hang Song Yusheng Wu Haotian Zhang Qiming Kan Tao Jin Jin Sun | 2020 | Asian Journal of Pharmaceutical Sciences2020，15，5： | 2 |
| 15 | Hopkinson Effect in Soft Magnetic Materials显示文摘The μi-T curves of the alloy Fe73.5 Cu1 Nb3 Si13.5 B9 in the amorphous state and in the nanocrystalline state have been investigated. For comparison, μi-T curves of the other two kinds of typical soft magnetic alloys also have been measured. It was found that a sharp Hopkinson peak appeared at the Curie point for each amorphous and crystalline alloy but there was no Hopkinson peak for the nanocrystalline alloy at the Curie point of the residual amorphous phase. This phenomenon has been explained in terms of the characteristic temperature dependence of the effective magnetic anisotropy. | Kaiyuan HE, Hui XU, Zhi WANG and Lizhi CHENG (Department of Materials Science and Engineering, Northeastern University, Shenyang 110006, China) | 2000 | Journal of Materials Science & Technology2000，16，2： | 2 |
| 16 | JUDICIAL ADJUDICATION RULES AND ENLIGHTENMENT ON THE CASE SERIES OF ADMINISTRATIVE DISPUTES OVER THE TRADEMARK OF "QIAODAN"显示文摘In the process of interest balancing and value selecting in the theoretical research and practice of the Intellectual Property Law,the proper balance between the judicial policy and value of'stringent judicial protection'and'balancing of interest'should be seriously taken into account.One of the typical representatives is the interest dispute and balance between the obligee of the prior right | Tao Kaiyuan Wang Chuang Xia Junli Wang Yanfang Du Weike Liu Jiajia | 2017 | China Legal Science2017，5，2： | 1 |
| 17 | 显示文摘 | He Shuli He Kaiyuan Wang Z Cheng Lizhi and Fu Yujun | 1997 | Chin Phys Lett1997，14，6： | 1 |
| 18 | How do Cats Resist Landing Injury:Insights into the Multi-level Buffering Mechanism显示文摘When humans jump down from a high position,there is a risk of serious injury to the lower limbs.However,cats can jump down from the same heights without any injury because of their excellent ability to attenuate impact forces.The present study aims to investigate the macro/micro biomechanical features of paw pads and limb bones of cats,and the coordination control of joints during landing,providing insights into how cats protect themselves from landing injury.Accordingly,histological analysis,radiological analysis,finite element method,and mechanical testing were performed to investigate the mechanical properties,microstructure,and biomechanical response of the pads and limb bones.In addition,using a motion capture system,the kinematic/kinetic data during landing were analysed based on inverse dynamics.The results show that the pads and limb bones are major contributors to non-impact-injuries,and cats actively couple their joints to adjust the parameters of movement to dissipate the higher impact.Therefore,the paw pads,limb bones,and coordinated joints complement each other and constitute a multi-level buffering mechanism,providing the cat with the sophisticated shock absorption system.This biomechanical analysis can accordingly provide biological inspiration for new approaches to prevent human lower limb injuries. | Xueqing Wu Baoqing Pei Yuyang Pei Wei Wang Yan Hao Kaiyuan Zhou | 2020 | Journal of Bionic Engineering2020，17，3： | 1 |
| 19 | WIP1 promotes cancer stem cell properties by inhibiting p38 MAPK in NSCLC显示文摘Cancer stem cells(CSCs)are a small population of stem cell-like cancer cells that can initiate tumors in vivo,and are the major source of cancer initiation,relapse,and drug resistance.We previously reported that the p38 MAPK,through its downstream effectors MK2 and HSP27,suppressed CSC properties by downregulating the expression of transcription factors that mediate stemness in non-small-cell lung cancer(NSCLC)cells,and that despite unaltered total expression of total p38 proteins,the levels of activated p38 were reduced in NSCLC tissues.However,the mechanism underlying the reduced levels of activated p38 in NSCLC is unknown.In this study,we identified WIP1,a p38 phosphatase frequently overexpressed in cancer,as a suppressor of p38 in a pathway that regulates CSC properties in NSCLC.Increased WIP1 expression correlated with reduced levels of activated p38,and with increased levels of a CSC marker in NSCLC tissues.Further investigation revealed that WIP1 promoted stemness-related protein expression and CSC properties by inhibiting p38 activity in NSCLC cells.WIP1 inhibitors are currently under development as anticancer drugs based on their ability to reactivate p53.We found that a WIP1 inhibitor suppressed stemness-related protein expression and CSC properties by activating p38 in NSCLC cells in vitro and in vivo.These studies have identified the WIP1–p38–MK2–HSP27 cascade as a novel signaling pathway that,when altered,promotes CSC properties in NSCLC development,and have defined novel mechanisms underlying the oncogenic activity of WIP1 and the anticancer efficacy of WIP1 inhibitors. | Kaiyuan Deng Liang Liu Xiaoming Tan Zhen Zhang Jianjun Li Yang Ou Xin Wang Shuang Yang Rong Xiang Peiqing Sun | 2020 | Signal Transduction and Targeted Therapy2020，5，1： | 1 |
| 20 | Morphine-3-glucuronide upregulates PD-L1 expression via TLR4 and promotes the immune escape of non-small cell lung cancer显示文摘Objective:Patients with cancer pain are highly dependent on morphine analgesia,but studies have shown a negative correlation between morphine demand and patient outcomes.The long-term use of morphine may result in abnormally elevated serum morphine-3-glucuronide(M3G)levels.Hence,the effects of M3G on tumor progression are worth studying.Methods:The effects of M3G on PD-L1 expressions in human non-small cell lung cancer(NSCLC)cell lines were first evaluated.Activation of TLR4 downstream pathways after M3G treatment was then determined by Western blot.The effects of M3G on human cytotoxic T lymphocytes(CTL)cytotoxicity and INF-γrelease was also detected.Finally,the LLC murine lung adenocarcinoma cell line were used to establish a murine lung cancer model,and the effects of M3G on tumor growth and metastasis were determined.Results:M3G promoted the expressions of PD-L1 in the A549 and H1299 cell lines in a TLR4-dependent manner(P<0.05).M3G activated the PI3 K and the NFκB signaling pathways,and this effect was antagonized by a TLR4 pathway inhibitor.A PI3 K pathway inhibitor reversed the M3G-mediated PD-L1 upregulation.M3G inhibited the cytotoxicity of CTL on A549 cells and decreased the level of INF-γ.Repeated M3G intraperitoneal injections promoted LLC tumor growth and lung metastasis through the upregulation of tumor expressed PD-L1 and the reduction of CTL in the tumor microenvironment.Conclusions:M3G specifically activated TLR4 in NSCLC cells and upregulated PD-L1 expression through the PI3 K signaling pathway,thereby inhibiting CTL cytotoxicity and finally promoting tumor immune escape. | Kaiyuan Wang Jian Wang Ting Liu Wenwen Yu Nan Dong Chen Zhang Wenbin Xia Feng Wei Lili Yang Xiubao Ren | 2021 | Cancer Biology & Medicine2021，18，1： | 1 |
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