|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Matrix metalloproteinases contribute to kidney fibrosis in chronic kidney diseases显示文摘Matrix metalloproteinases(MMPs) are members of the neutral proteinase family. They were previously thought to be anti-fibrotic because of their ability to degrade and remodel of extracellular matrix. However, recent studies have shown that MMPs are implicated in initiation and progression of kidney fibrosis through tubular cell epithelial–mesenchymal transition(EMT) as well as activation of resident fibroblasts, endothelial-mesenchymal transition(Endo MT) and pericyte-myofibroblast transdifferentiation. Interstitial macrophage infiltration has also been shown to correlate with the severity of kidney fibrosis in various chronic kidney diseases. MMPs secreted by macrophages, especially MMP-9, hasbeen shown by us to be profibrotic by induction of tubular cells EMT. EMT is mainly induced by transforming growth factor-β(TGF-β). However, MMP-9 was found by us and others to be up-regulated by TGF-β1 in kidney tubular epithelial cells and secreted by activated macrophages, resulting in EMT and ultimately kidney fibrosis. Therefore, MMP-9 may serve as a potential therapeutic target to prevent kidney fibrosis in chronic kidney disease. This review, by a particular focus on EMT, seeks to provide a comprehensive understanding of MMPs, especially MMP-9, in kidney fibrosis. | Hong Zhao Yanting Dong Xinrui Tian Thian Kui Tan Zhuola Liu Ye Zhao Yun Zhang David CH Harris Guoping Zheng | 2013 | World Journal of Nephrology2013，2，3： | 21 |
| 2 | Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2)显示文摘 | Bentley SD Chater KF Cerdeno-Tarraga AM Challis GL Thomson NR James KD Harris DE Quail MA Kieser H Harper D Bateman A Brown S Chandra G Chen CW Collins M Cronin A Fraser A Goble A Hidalgo J Hornsby T Howarth S Huang CH Kieser T Larke L Murphy L Oliver K O | | 0，，： | 1 |
| 3 | Iron accumulation in humanchronic renal disease显示文摘 | Nankivell BJ Boadle RA Harris CH | 1992 | Am J Kid Dis1992，20，3： | 1 |
| 4 | Light speed reduction to 17 meters per second in an ultracold atomic gas 显示文摘 | Hau LV Harris SE Dutton Z Behroozi CH | 1999 | Nature1999，397，： | 1 |
| 5 | Tissue interactions and antlerogenesis : new findings revealed by a xenograft approach 显示文摘 | LI CH Y HARRIS A J SUT'FIE J M | 2001 | J Exp Zool2001，290，1： | 1 |
| 6 | Early clinical experiences from students' perspectives: A qualitative study of narratives 显示文摘 | Dyrbye LN Harris 1 Rohren CH | 2007 | Acad Med2007，82，10： | 1 |
| 7 | Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2)显示文摘 | Bentley SD Chater KF Cerdeno-Tarraga AM Challis GL Thomson NR James KD Harris DE Quail MA Kieser H Harper D Bateman A Brown S Chandra G Chen CW Collins M Cronin A Fraser A Goble A Hidalgo J Hornsby T Howarth S Huang CH Kieser T Larke L Murphy L Oliver K O | | 0，，： | 1 |
| 8 | Asymmetric Information, Incentives and Intrafirm Resource Allocation 显示文摘 | HARRIS M CH KRIEBEL A RAVIV | 1982 | Management Science1982，，28： | 1 |
| 9 | Relation between the method of detection of initial breast carcinoma and the method of detection of subsequent lpsilateral local recurrence and contralateral breast carcinoma显示文摘 | Chen CH Orel SG Harris EER | 2003 | Cancer2003，98，8： | 1 |
| 10 | Asymmetric Information,Incentives and Inrafirm Resource Allocation显示文摘 | Harris M Kriebel CH Raviv R | 1982 | Management Science1982，28，6： | 1 |
| 11 | 强化与标准血压控制对痴呆的影响:随机临床试验显示文摘目前还没有有效的治疗方法来降低轻度认知障碍和痴呆的风险。该文旨在探讨强化血压控制对老年痴呆风险的影响。研究人员在美国和波多黎各102个地点对年龄≥50岁有高血压但无糖尿病或脑卒中史的成人进行随机临床试验。于2010年11月8日开始,于2015年8月20日提前停止,获得其主要观察指标(复合心血管事件)和全因死亡率的数据。认知观察指标随访的最后日期为2018年7月22日。 | 刘青 叶鹏 Williamson JD Pajewski NM Auchus AP Bryan RN Chelune G Cheung AK Cleveland ML Coker LH Crowe MG Cushman WC Cutler JA Davatzikos C Desiderio L Erus G Fine LJ Gaussoin SA Harris D Hsieh MK Johnson KC Kimmel PL Tamura MK Launer LJ Lerner AJ Lewis CE Martindale-Adams J Moy CS Nasrallah IM Nichols LO Oparil S Ogrocki PK Rahman M Rapp SR Reboussin DM Rocco MV Sachs BC Sink KM Still CH Supiano MA Snyder JK Wadley VG Walker J Weiner DE Whelton PK Wilson VM Woolard N Wright JT Jr Wright CB | 2019 | 中华高血压杂志2019，27，4： | 1 |
| 12 | Meta-analysis of antibiotic prophylaxis in endoscopic retrograde cholangiopancreatography 显示文摘 | Harris A Chan CH Torres-Viera C | 1999 | Endoscopy1999，31，： | 1 |
| 13 | Factors affecting the proynosis of bruchialplexus insuries显示文摘 | Rorabeck CH Harris WR | 1981 | J Bone Joint snrg(Br)1981，63，3： | 1 |
| 14 | Asymmetric Information,Incentives,and Intrafirm Resource Allceation显示文摘 | Harris M Kriebel CH Raviv A | 1982 | Management Science1982，，28： | 1 |
| 15 | CGRP immunoreactivity and NADPH- diaphorase in afferent nerves of the rat penis显示文摘 | McNeill DL Papka RE Harris CH | 1992 | Peptides1992，13，6： | 1 |
| 16 | Hyperprolinemia:clinical and biochemical family study显示文摘 | Woody NC Snyder CH Harris JA | 1969 | Pediatrics1969，44，4： | 1 |
| 17 | Iron accumulation in human chronic renal disease显示文摘 | Nankivell BJ Boadle RA Harris CH | 1992 | Am J Kid Dis1992，20，3： | 1 |
| 18 | A tumor-suppressing function in the epithelial adhesion protein Trask显示文摘 | Spassov DS Wong CH Harris G | 2012 | Oncogene2012，31，4： | 1 |
| 19 | A modified silver staining protocol for visualized of protein compatible with matrix-assisted laser desorption/ionization and electrospray ionization mass spectrometry 显示文摘 | Yan JX Wait R Berkelman T Harry RA Westbrook JA Wheeler CH | 2000 | Elecrophoresis2000，21，17： | 1 |
| 20 | Hepatic epithelioid hemangioendothelioma:sonographic,CT,and MR imaging appearances显示文摘 | Lyburn ID Torreggiani WC Harris AC Zwirewich CV Buckley AR Davis JE Chung SW Scudamore CH Ho SG | | 0，，05： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员