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| 1 | Prostate cancer identification: quantitative analysis of T2-weighted MR images based on a back propagation artificial neural network model显示文摘Computer-aided diagnosis(CAD) systems have been proposed to assist radiologists in making diagnostic decisions by providing helpful information. As one of the most important sequences in prostate magnetic resonance imaging(MRI), image features from T2-weighted images(T2WI) were extracted and evaluated for the diagnostic performances by using CAD. We extracted 12 quantitative image features from prostate T2-weighted MR images. The importance of each feature in cancer identification was compared in the peripheral zone(PZ) and central gland(CG), respectively. The performance of the computer-aided diagnosis system supported by an artificial neural network was tested. With computer-aided analysis of T2-weighted images, many characteristic features with different diagnostic capabilities can be extracted. We discovered most of the features(10/12) had significant difference(P<0.01) between PCa and non-PCa in the PZ, while only five features(sum average, minimum value, standard deviation, 10 th percentile, and entropy) had significant difference in CG. CAD prediction by features from T2 w images can reach high accuracy and specificity while maintaining acceptable sensitivity. The outcome is convictive and helpful in medical diagnosis. | ZHAO Kai WANG ChengYan HU Juan YANG XueDong WANG He LI FeiYu ZHANG XiaoDong ZHANG Jue WANG XiaoYing | 2015 | Science China(Life Sciences)2015，58，7： | 16 |
| 2 | Quantitative analysis of diffusion-weighted magnetic resonance images:differentiation between prostate cancer and normal tissue based on a computer-aided diagnosis system显示文摘Diffusion-weighted imaging(DWI) is considered to be one of the dominant modalities used in prostate cancer(PCa) detection and the assessment of lesion aggressiveness,especially for peripheral zone(PZ) PCa.Computer-aided diagnosis(CAD),which is capable of automatically extracting and evaluating image features,can integrate multiple parameters and improve the detection of PCa.In this study,13 quantitative image features were extracted from DWI by CAD,and diagnostic efficacy was analyzed in both the PZ and transition zone(TZ).The results demonstrated that there was a significant difference(P<0.05) between PCa and non-PCa for nine of the 13 features in the PZ and five of the 13 features in the TZ.Besides,the prediction outcome of CAD had a strong correlation with the DWI scores that were graded by experienced radiologists according to the Prostate Imaging-Reporting and Data System Version 2(PI-RADS v2). | Ge Gao Chengyan Wang Xiaodong Zhang Juan Hu Xuedong Yang He Wang Jue Zhang Xiaoying Wang | 2017 | Science China(Life Sciences)2017，60，1： | 13 |
| 3 | Comparative analyses of leaf anatomy of dicotyledonous species in Tibetan and Inner Mongolian grasslands显示文摘Knowledge of the leaf anatomy of grassland plants is crucial for understanding how these plants adapt to the environment. Tibetan alpine grasslands and Inner Mongolian temperate grasslands are two major grassland types in northern China. Tibetan alpine grasslands occur in high-altitude regions where the low temperatures limit plant growth. Inner Mongolian temperate grasslands are found in arid regions where moisture is the limiting factor. Few comparative studies concerning the leaf anatomy of grassland plants of the Tibetan Plateau and Inner Mongolian Plateau have been conducted. We examined leaf characteristics at 71 sites and among 65 species, across the alpine grasslands of the Tibetan Plateau and the temperate grasslands of the Inner Mongolian Plateau. We compared the leaf structures of plants with different life forms and taxonomies, and their adaptation to arid or cold environments. We explored relationships among leaf features and the effects of climatic factors (i.e., growing season temperature and precipitation) on leaf characteristics. Our results showed that (i) there were significant differences in leaf anatomy between Tibetan alpine and Inner Mongolian temperate grasslands. Except for mesophyll cell density, the values obtained for thickness of leaf tissue, surface area and volume of mesophyll cells were larger on the Tibetan Plateau than on the Inner Mongolian Plateau. (ii) Within the same family or genus, leaf anatomy showed significant differences between two regions, and trends were consistent with those of whole species. (iii) Leaf anatomy of woody and herbaceous plants also showed significant differences between the regions. Except for mesophyll cell density, the values obtained for the thickness of leaf tissue, and the surface area and volume of mesophyll cells were larger in herbaceous than in woody plants. (iv) Leaf anatomical traits changed accordingly. Total leaf thickness, thicknesses of lower and upper epidermal cells, and surface area and volume of mesophyll cells were positively correlated, while mesophyll cell density was negatively associated with those traits. (v) Growing season temperature had stronger effects on leaf anatomy than growing season precipitation. Although the communities in Tibetan and Inner Mongolian grasslands were similar in appearance, leaf anatomy differed; this was probably due to the combined effects of evolutionary adaptation of plants to environment and environmental stress induced by climatic factors. | MA JianJing JI ChengJun HAN Mei ZHANG TingFang YAN XueDong HU Dong ZENG Hui HE JinSheng | 2012 | Science China(Life Sciences)2012，55，1： | 12 |
| 4 | Salivary mycobiome dysbiosis and its potential impact on bacteriome shifts and host immunity in oral lichen planus显示文摘The biodiversity of the mycobiome,an important component of the oral microbial community,and the roles of fungal–bacterial and fungal–immune system interactions in the pathogenesis of oral lichen planus (OLP) remain largely uncharacterized.In this study,we sequenced the salivary mycobiome and bacteriome associated with OLP.First,we described the dysbiosis of the microbiome in OLP patients,which exhibits lower levels of fungi and higher levels of bacteria.Significantly higher abundances of the fungi Candida and Aspergillus in patients with reticular OLP and of Alternaria and Sclerotiniaceae_unidentified in patients with erosive OLP were observed compared to the healthy controls.Aspergillus was identified as an “OLP-associated” fungus because of its detection at a higher frequency than in the healthy controls.Second,the co-occurrence patterns of the salivary mycobiome–bacteriome demonstrated negative associations between specific fungal and bacterial taxa identified in the healthy controls,which diminished in the reticular OLP group and even became positive in the erosive OLP group.Moreover,the oral cavities of OLP patients were colonized by dysbiotic oral flora with lower ecological network complexity and decreased fungal–Firmicutes and increased fungal–Bacteroidetes sub-networks.Third,several keystone fungal genera (Bovista,Erysiphe,Psathyrella,etc.) demonstrated significant correlations with clinical scores and IL-17 levels.Thus,we established that fungal dysbiosis is associated with the aggravation of OLP.Fungal dysbiosis could alter the salivary bacteriome or may reflect a direct effect of host immunity,which participates in OLP pathogenesis. | Yan Li Kun Wang Bo Zhang Qichao Tu Yufei Yao Bomiao Cui Biao Ren Jinzhi He Xin Shen Joy D.Van Nostrand Jizhong Zhou Wenyuan Shi Liying Xiao Changqing Lu Xuedong Zhou | 2019 | International Journal of Oral Science2019，11，3： | 8 |
| 5 | Dealumination and desilication for Al-rich HZSM-5 zeolite via steam-alkaline treatment and its application in methanol aromatization显示文摘The hierarchical HZSM-5 was prepared via dealumination and desilication of commercial Al-rich HZSM-5, and characterized by X-ray diffraction, 27Al magic-angle spinning nuclear magnetic resonance, inductively coupled plasma mass spectrometry, scanning electron microscope, transmission electron microscope, N2 adsorption-desorption, NH3 temperature-programmed desorption, performed thermogravimetric and Raman spectrum. The results showed that partial framework of HZSM-5 was removed after steam treatment at 0.15 MPa, 500℃ for 3 h. HZSM-5 with high specific surface area and much mesoporosity was obtained by the subsequent alkaline treatment. The regulation of acid quantity was achieved by altering the concentration of alkaline. Dealumination and desilication of Al-rich HZSM-5 zeolites became more effective using a combination of steam and alkaline treatments than using alkaline treatment alone. Methanol aromatization reaction was employed to evaluate the catalytic performance of treated HZSM-5 at 0.15 MPa, 450℃ and MHSV of 1.5 h^-1. The results indicated that after steam treatment, HZSM-5 further treated with 0.2 mol/L NaOH exhibits the best catalytic performance: the selectivity of aromatics reached 42.1% and the lifetime of catalyst attained 212 h, which are much better than untreated HZSM-5. | Yuehua Fang Fan Yang Xuan He Xuedong Zhu | 2019 | Frontiers of Chemical Science and Engineering2019，13，3： | 5 |
| 6 | DYNAMIC CHARACTERISTIC ANALY-SIS OF PRECISE LONG STROKE LINEAR MOTOR WITH AIR-BEARING IN OPTICAL LITHOGRAPHY显示文摘Dynamic characteristic is presented by identifying the model and the dynamic parameters of a precise long stroke linear motor (PLSLM) with the air-bearing in optical lithography.The PLSLM is supported by air-bearing on the stator,and is driven by on-board two large linear motors in a cross-configuration.Firstly,a model of the PLSLM is established by finite element method (FEM). Secondly,based on the model,the natural frequencies and model shapes are discussed.And the contribution of each active mode is evaluated by computing the modal participation factors (MPF), which indicates the major vibration direction.Furthermore,by the experimental modal analysis,the experimental results are in agreement with simulation results,which it is sure that the FEM is reasonable.What′s more,comparing with the effects on the frequency due to the air-bearing stiffness, the relations of the natural frequencies with the air-bearing stiffness are found.It is found that the frequency response curve is fluctuant with the air-bearing stiffness in each direction.Finally,it is conclusion that the natural frequency of the PLSLM is largely affected by the air-bearing stiffness variety.This research is contributed to the dynamic characteristics resulted from the air-bearing stiffness.Further work will include better optimization on the dynamic parameter in the controller design through the control algorithm for the precise long stroke motor. | CHEN Xuedong YU Xianzhong HE Xueming YAN Tianhong | 2008 | Chinese Journal of Mechanical Engineering2008，21，2： | 4 |
| 7 | Shumian capsule(舒眠胶囊) improves symptoms of sleep mood disorder in convalescent patients of Corona Virus Disease 2019显示文摘OBJECTIVE:To evaluate the clinical effectiveness of Shumian capsule(舒眠胶囊)in improving the symptoms of insomnia,anxiety,depression,and other symptoms of convalescent patients of COVID-19.METHODS:Totally 200 patients were collected and randomly divided into experiment group(n=100)and control group(n=100).The control group was treated with Shumian capsule simulator,and the experiment group was treated with Shumian capsule.The improvement of TCM symptom score,the total effective rate and symptom disappearance rate of TCM symptoms in the two groups before and after treatment were observed,and the clinical effect was evaluated.RESULTS:One week after treatment,the scores of anxiety symptoms in the experiment group were significantly different from those in the control group(P<0.05),but there was no significant difference in the scores of insomnia and depression between the experiment group and the control group(P>0.05).There was no significant difference in the total effective rate and disappearance rate of TCM symptoms of insomnia,anxiety and depression between the experiment group and the control group(P>0.05).After 2 weeks of treatment,the scores of insomnia,anxiety,depression and the total effective rate of TCM symptoms in the experiment group were significantly different from those in the control group(P<0.05).There was no significant difference in the disappearance rate of insomnia,anxiety and depression between the experiment group and the control group(P>0.05).There were no significant differences in heart rate,respiration,systolic blood pressure and diastolic blood pressure between the experiment group and the control group(P>0.05).CONCLUSION:Shumian capsule can significantly improve the symptoms of insomnia,anxiety and depression in COVID-19’s convalescent patients with sleep and mood disorders. | LI Li AN Xuedong ZHANG Qing TAO Junxiu HE Jing CHEN Yun LI Kejian LIU Ru GUO Juan ZHANG Hao TONG Xiaolin BA Yuanming | 2021 | Journal of Traditional Chinese Medicine2021，41，6： | 4 |
| 8 | Shugan Jieyu capsule(舒肝解郁胶囊) improve sleep and emotional disorder in coronavirus disease 2019 convalescence patients: a randomized, double-blind, placebo-controlled trial显示文摘OBJECTIVE: To evaluate the efficacy of the Shugan Jieyu capsule(舒肝解郁胶囊) on improving sleep and emotional disorder during Coronavirus disease 2019(COVID-19) convalescence. METHODS: We conducted a randomized, double-blind, placebo-controlled trial, and recruit 200 COVID-19 convalescence patients and then divide the subjects into two groups respectively: the experimental group(n = 100) and the control group(n = 100). Patients in the control group were given doses as a placebo, while those in the experimental group were given Shugan Jieyu capsule.The investigators mainly observed the differences between the two groups before and after treatment in terms of the rate of reduction and the rate of efficiency in Hamilton Depression Scale(HAMD-17) total scores from baseline, and recorded the scores of Hamilton Anxiety Scale(HAMA), Patient Health Questionnaire-15(PHQ-15), Insomnia Severity Index(ISI) and Treatment Emergent Symptom Scale at 2 week, the 4 week and the 6 week respectively after treatment, and compared the differences between the groups. And the occurrence of adverse events was recorded. RESULTS: After 6-week treatment, there were statistically significant differences in the rate of reduction as well as efficiency in HAMD-17 scores, HAMA Total Scores, PHQ-15 Score, ISI Score from baseline in the experimental group and control group(P < 0.05). There were 4 adverse events in the experimental group and 1 in the control group. CONCLUSION: Shugan Jieyu capsule could significantly improve sleep and emotional disorder in patients during COVID-19 convalescence. | AN Xuedong ZHANG Qing TAO Junxiu LI Li CHEN Yun LI Kejian HE Jing LIU Ru GUO Juan ZHANG Jia ZHU Hui LIAN Fengmei LI Xiaodong | 2022 | Journal of Traditional Chinese Medicine2022，42，5： | 2 |
| 9 | Wireless Strain Measurement Based on a Microstrip Patch Antenna显示文摘Wireless interrogation of a rectangular microstrip patch antenna for strain measurement is investigated by simulations.To analyze the antenna performance,a microstrip line-feeding patch antenna at 10 GHz is designed.A patch antenna wirelessly fed by a horn is proposed to measure the strain.The direction information of strain detected by the patch antenna is also considered.The strain can be detected both in the width and length directions.It is shown that the strain can be measured wirelessly using a standard horn antenna.This kind of wireless strain-sensing technique offers significant potential for wireless structural health monitoring(SHM),especially for high-end equipment. | Song Guorong Sun Tingting Lu Yan Yan Tianting Wang Xuedong He Cunfu Wu Bin | 2017 | Transactions of Nanjing University of Aeronautics and Astronautics2017，34，5： | 2 |
| 10 | The effect of the recess shape on performance analysis of the gas-lubricated bearing in optical li-thography显示文摘 | Chen Xuedong He Xueming | | 0，，11： | 1 |
| 11 | Tribological behaviours of PVD TiN and TiCN coatings in artificial seawater显示文摘 | Lei Shan Yongxin Wang Jinlong Li He Li Xuedong Wu Jianmin Chen | 2013 | Surface & Coatings Technology2013，，： | 1 |
| 12 | The effect of the recess shape on performance analysis of the gas-lubricated bearing in optical lithography 显示文摘 | Chen Xuedong He Xueming | 2006 | Tribology international2006，，39： | 1 |
| 13 | Mutation breeding by ion implantation显示文摘 | Yu Zengliang Deng Jianguo He Jianjun HuoYuping Wu Yuejin Wang Xuedong Lui Guifu | 1991 | Nuclear Instruments and Methods in Physics Research1991，5960，： | 1 |
| 14 | The effect of the recess shape on performance analysis of the gas-lubricated bearing in opti- cal lithography 显示文摘 | Chen Xuedong He Xueming | 2006 | Tribology lnternatiomd2006，39，11： | 1 |
| 15 | The effect of the recess shape on performance analysis of the gas lubricated bearing in optical lithography显示文摘 | CHEN Xuedong HE Xueming | 2006 | Tribology International2006，39，11： | 1 |
| 16 | The dynamic analysis of the gas lubricated stage in optical lithography显示文摘 | He Xueming Chen Xuedong | 2007 | International Journal of Advanced Manufacturing Technology2007，32，910： | 1 |
| 17 | The effect of the recess shape on performance analysis of the gas-lubricated bearing in optical li- thography显示文摘 | Chen Xuedong He Xueming | 2006 | Tribology International2006，39，4： | 1 |
| 18 | The dynamic analysis of the gas lubricated stage in optical lithography显示文摘 | He Xueming Chen Xuedong | 2007 | Advanced Manufacturing Technology2007，32，9： | 1 |
| 19 | The effect of the recess shape on performance analysis of the gas - lubricated bearing in optical lithography 显示文摘 | Chen Xuedong He Xueming | 2006 | Tribology international2006，39，11： | 1 |
| 20 | Portfolio choice under cu- mulative prospect theory: An analytical treatment显示文摘 | He Xuedong Zhou Xunyu | 2011 | Management Science2011，57，2： | 1 |
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