|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Artemisinin analogue SM934 ameliorates DSS- induced mouse ulcerative colitis via suppressing neutrophils and macrophages显示文摘 | Yu-xi YAN Mei-juan SHAO Qing QI Yan-sheng XU Xiao-qian YANG Feng-hua ZHU Shi-jun HE Pei-lan HE Chun-lan FENG Yan-wei WU Heng LI Wei TANG Jian-ping ZUO | 2018 | Acta Pharmacologica Sinica2018，39，10： | 32 |
| 2 | Effects of Pinus massoniana bark extract on cell proliferation and apoptosis of human hepatoma BEL-7402 cells显示文摘AIM: To study the effects of Pinus massoniana bark extract (PMBE) on cell proliferation and apoptosis of human hepatoma BEL-7402 cells and to elucidate its molecular mechanism.METHODS: BEL-7402 cells were incubated with various concentrations (20-200 μg/mL) of PMBE for different periods of time. After 48 h, cell proliferation was determined by 3-(4,5-dimethyl-thiazolyl-2)-2,5-diphenyl tetrazolium bromide (MTT) assay. Apoptosis was evaluated by morphological observation, agarose gel electrophoresis,and flow cytometry analysis. Possible molecular mechanisms were primarily explored through immunohistochemical staining.RESULTS: PMBE (20-200 μg/mL) significantly suppressed BEL-7402 cell proliferation in a time- and dose-dependent manner. After treatment of BEL-7402 cells with 160 μg/mL PMBE for 24, 48, or 72 h, a typical apoptotic 'DNA ladder'was observed using agarose gel electrophoresis. Nuclear condensation and boundary aggregation or split, apoptotic bodies were seen by fluorescence and electron microscopy.Sub-G1 curves were displayed by flow cytometry analysis.PMBE decreased the expression levels of Bcl-2 protein in a time-dependent manner after treatment of cells with 160 μg/mL PMBE.CONCLUSION: PMBE suppresses proliferation of BEL-7402 cells in a time- and dose-dependent manner and induces cell apoptosis by possibly downregulating the expression of the bcl-2 gene. | Ying-Yu Cui Heng Xie Kang-Biao Qi Yan-Ming He Jin-Fa Wang | 2005 | World Journal of Gastroenterology2005，11，34： | 10 |
| 3 | EFFECTS OF VITAMIN D RECEPTOR GENE POLYMORPHISMS ON SUSCEPTIBILITY TO TYPE 1 DIABETES MELLITUS显示文摘Objective To investigate the influence of vitamin D receptor (VDR) gene polymorphisms on susceptibility to type 1 diabetes mellitus (T1DM) in the Chinese Han population. Method One hundred and thirty-six Chinese Han people, including 54 T1DM patients and 82 unrelated healthy subjects as control were genotyped by polymerase chain reaction-restriction fragment length polymorphism for three restriction sites in the VDR gene, which were ApaI, TaqI, and BamI. Results The frequency of B allele of BsmI site in VDR gene was significantly higher in T1DM patients than in healthy subjects (P = 0.033) while no difference was found between the two groups in the distribution of ApaI and TaqI polymorphisms. Conclusion The BsmI polymorphism of VDR gene may be associated with the susceptibility to T1DM in the Chinese Han population of Beijing. | Xin-hua Xiao Zhe-long Liu Heng Wang Qi Sun Wen-hui Li Guo-hua Yang Qiu-ying Liu | 2006 | Chinese Medical Sciences Journal2006，21，2： | 8 |
| 4 | In Situ Coupling Strategy for Anchoring Monodisperse Co_9S_8 Nanoparticles on S and N Dual?Doped Graphene as a Bifunctional Electrocatalyst for Rechargeable Zn–Air Battery显示文摘An in situ coupling strategy to prepare Co_9S_8/S and N dual?doped graphene composite(Co_9S_8/NSG) has been proposed. The key point of this strategy is the function?oriented design of organic compounds. Herein, cobalt porphyrin derivatives with sulfo groups are employed as not only the coupling agents to form and anchor Co_9S_8 on the graphene in situ, but also the heteroatom?doped agent to generate S and N dual?doped graphene. The tight coupling of multiple active sites endows the composite materials with fast electrochemical kinetics and excellent stability for both oxygen reduction reaction(ORR) and oxygen evolution reaction(OER). The obtained electrocatalyst exhibits better activity parameter(ΔE = 0.82 V) and smaller Tafel slope(47.7 mV dec^(-1) for ORR and 69.2 mV dec^(-1) for OER) than commercially available Pt/C and RuO_2. Most importantly, as electrocatalyst for rechargeable Zn–air battery, Co_9S_8/NSG displays low charge–discharge voltage gap and outstanding long?term cycle stability over 138 h compared to Pt/C–RuO_2. To further broaden its application scope, a homemade all?solid?state Zn–air battery is also prepared, which displays good charge–discharge performance and cycle performance. The function?oriented design of N_4?metallomacrocycle derivatives might open new avenues to strategic construction of high?performance and long?life multifunctional electrocatalysts for wider electro?chemical energy applications. | Qi Shao Jiaqi Liu Qiong Wu Qiang Li Heng?guo Wang Yanhui Li Qian Duan | 2019 | Nano-Micro Letters2019，11，1： | 8 |
| 5 | Mitosis-specific acetylation tunes Ran effector binding for chromosome segregation显示文摘在房间期间,分割要求忠诚有丝分裂的锭子汇编和染色体分离的基因信息的稳定的传播。运用了 GTPase 戏在有丝分裂的锭子汇编的一个关键角色。然而,在锭子的 Ran-GTP 的一个化学坡度的产生怎么被联合到有丝分裂的 translational 以后修正,从来没被描绘过。这里,我们解决了复杂结构与核苷酸版本因素 Mog1 跑了并且描出一个新奇有丝分裂特定的调整 acetylation 的 Ran-Mog1 相互作用在染色体分离期间。我们的指导结构的功能的分析表明那 Mog1 与 RCC1 竞争为以一种 GTP/GDP-dependent 方式变有约束力。生物化学的描述表明了那 Mog1 固定跑阻止 RCC1 有约束力、随后的 GTP 装载。令人惊讶地,跑了是 TIP60 的真正的底层,并且由 TIP60 的 Lys134 的 acetylation 解放 Mog1 从在有丝分裂期间变有约束力。重要地,这个得到 acetylation 的开关对 RCC1 变有约束力支持 Ran-GTP 的高水平,它为染色体排列是必要的。这些结果建立一以前 TIP60 由调节在提供 Ran-GTP 水平的 homeostatic 控制的规章的机制运用了的 uncharacterized 为在有丝分裂的染色体分离的受动器绑定。 | Xiaoling Bao Heng Liu Xing Liu Ke Ruan Yonshui Zhang Zhiyong Zhang Qi Hu Ying Liu Saima Akram Jiahai Zhang Qingguo Gong Wenwen wang Xiao Yuan Jian-Li Lingli Zhao Zhen Dou Ruijun Tian Xuebiao Yao Jihui Wu Yunyu Shi | 2018 | Journal of Molecular Cell Biology2018，10，1： | 8 |
| 6 | Beneficial effects of a diabetes specific formula on insulin sensitivity and free fatty acid in patients with type 2 diabetes mellitus显示文摘背景这未来的、使随机化的、控制研究被设计调查糖尿病的效果特定的公式(Diason 低 energy:313.8 kJ/100 ml ) 与一个标准公式相比,在在类型 2 糖尿病患者的胰岛素敏感,浆液 C 肽,浆液类脂化合物和免费的丰满的酸(船边交货) 上。2 名糖尿病患者完成了学习的总共 71 类型的方法。Enteral 公式作为营养的唯一的来源口头上地被给这些题目 6 天。静脉的血样品(0.5,1,2,3 个小时) 在 75 g 以后在 day-7 被收集口头的葡萄糖忍耐测试(OGTT ) ,在标准测试饭(1673.6 kJ ) 以后并且在 6 天也以后的白天 1 测试糖尿病特定的公式或一个标准公式。血浆葡萄糖,浆液胰岛素, C 肽和类脂化合物是。测量。在干预时期以后结果,糖尿病特定的公式在 0.5 小时( P0.05 )和 1 个小时( P0.01 )在血葡萄糖集中导致了显著地更低的饭后的上升;血浆葡萄糖( P=0.05 )的显著地更低的山峰高度;在 0.5 小时( P0.01 )的显著地更低的血浆胰岛素集中, 1 个小时( P0.01 )和 2 个小时( P0.01 );并且与控制相比的一座显著地更低的血浆胰岛素山峰;OGTT 和标准测试饭(P0.05 ) 在在糖尿病以后的曲线下面的 .The 葡萄糖和胰岛素区域与标准公式相比的特定的公式显著地更低。C 肽水平在 6 天公式比作 75 g OGTT 的两营养以后是更低的,然而并非与标准混合的饭不同。两个公式是井 toleraled。在摘要的结论糖尿病有相对高的 monounsaturated 的特定的公式丰满的酸和高度多,纤维比例显著地改进了 glycemic 控制。在这上,胰岛素敏感(HOMA ) 显著地被改进并且可以直接因此在长期的复杂并发症上改进影响。疾病特定的公式应该因此是被糖尿病患者和 hyperglycemic 病人需要营养的支持要过去常的比较喜欢的选择。 | LI Yu-xiu ZENG Jing-bo YU Kang SUN Qi LIU Qiu-ying QIN Wei ZHANG Qian YU Jian-chun WANG Heng | 2008 | Chinese Medical Journal2008，，8： | 8 |
| 7 | The localization of type 2 diabetes susceptibility gene loci in northern Chinese Han families显示文摘We conducted a genome-wide scan, in which 358 well distributed fluorescent dye-labeled microsatellite marker sets were applied in 32 Chinese Han type 2 diabetes families from Northern China to search for the susceptibility gene loci. The data collected from screening all the chromosomes of genome were genotyped by using genescan and genotyping software, then, parametric and non-parametric multipoint test, and affected sib-pair analysis as well, were used to analyze the data. We identified some susceptibility gene loci residing in chromosomes 1,12,18,20, respectively, or precisely, located around D1S214, D1S207, D1S218, D1S235, D12S336, D18S61 and D20S118. The comparison of this result with those from other regions and races reflected the complexity and heterogeneity of type 2 diabetes. | ZHAO Jinying WANG Heng XIONG Momiao HUANG Wei ZUO Jin CHEN Zhu QIANG Boqin SUN Qi LI Yuxiu LIU Qiuying DU Weinan CHEN Jialun DING Wei YUAN Wentao ZHAO Yang XU Hongyan JIN Li FANG Fude | 2000 | Chinese Science Bulletin2000，45，19： | 8 |
| 8 | RELATIONSHIP BETWEEN HEMOGLOBIN A1C AND BLOOD GLUCOSE THROUGHOUT THE DAY IN WELL-GLYCEMIC-CONTROLLED MEDICAL NUTRITION THERAPY ALONE TYPE 2 DIABETIC PATIENTS显示文摘Objective To investigate the relationship between glycosylated hemoglobin A1c (HbA1c) and blood glucose levels of eight different points throughout the day in well-glycemic-controlled medical nutrition therapy (MNT) alone type 2 diabetic patients. Methods Data were collected as capillary blood glucose value of eight different sample points among sixteen observing days in thirty MNT alone type 2 diabetic patients. The correlation between HbA1c and capillary blood glucose value was evaluated by Pearson’s correlation method. Results The r-values between HbA1c and capillary blood glucose of 3:00, 6:00, and bedtime (22:00-23:00) were 0.81, 0.79, and 0.78, respectively(P<0.001). The best correlation was found between the mean value of 8-point blood glucose value throughout the day and HbA1c (r=0.84, P<0.001). Conclusion Fasting blood glucose and postabsorptive blood glucose have better correlations with HbA1c compared with other points in this group of well-glycemic-controlled MNT alone type 2 diabetic patients. | Wen-hui Li Xin-hua Xiao Qi Sun Guo-hua Yang Heng Wang | 2006 | Chinese Medical Sciences Journal2006，21，2： | 6 |
| 9 | Atomic Fe-Zn dual-metal sites for high-efficiency pH-universal oxygen reduction catalysis显示文摘An effective electrocatalyst being highly active in all pH range for oxygen reduction reaction(ORR)is crucial for energy conversion and storage devices.However,most of the high-efficiency ORR catalysis was reported in alkaline conditions.Herein,we demonstrated the preparation of atomically dispersed Fe-Zn pairs anchored on porous N-doped carbon frameworks(Fe-Zn-SA/NC),which works efficiently as ORR catalyst in the whole pH range.It achieves high half-wave potentials of 0.78,0.85 and 0.72 V in 0.1 M HClO4,0.1 M KOH and 0.1 M phosphate buffer saline(PBS)solutions,respectively,as well as respectable stability.The performances are even comparable to Pt/C.Furthermore,when assembled into a Zn-air battery,the high power density of 167.2 mWcm−2 and 120 h durability reveal the feasibility of Fe-Zn-SA/NC in real energy-related devices.Theoretical calculations demonstrate that the superior catalytic activity of Fe-Zn-SA/NC can be contributed to the lower energy barriers of ORR at the Fe-Zn-N6 centers.This work demonstrates the potential of Fe-Zn pairs as alternatives to the Pt catalysts for efficient catalytic ORR and provides new insights of dual-atom catalysts for other energy conversion related catalytic reactions. | Jie Xu Shuhua Lai Defeng Qi Min Hu Xianyun Peng Yifan Liu Wei Liu Guangzhi Hu Heng Xu Fan Li Chao Li Jia He Longchao Zhuo Jiaqiang Sun Yuan Qiu Shusheng Zhang Jun Luo Xijun Liu | 2021 | Nano Research2021，14，5： | 6 |
| 10 | EFFECTS OF GLUCAGON ON ISLET β CELL FUNCTION IN PATIENTS WITH DIABETES MELLITUS显示文摘Objective To evaluate islet β cell response to intravenous glucagon(a non-glucose secretagogue)stimulation in diabetes mellitus.Methods Nineteen patients with type 1 diabetes(T1D)and 131 patients with type 2 diabetes(T2D)were recruited in this study.T2D patients were divided into two groups according to therapy:36 cases treated with insulin and 95 cases treated with diet or oral therapy.The serum C-peptide levels were determined at fasting and six minutes after intravenous injection of 1 mg of glucagon.Results Both fasting and 6-minute post-glucagon-stimulated C-peptide levels in T1D patients were significantly lower than those of T2D patients(0.76±0.36 ng/mL vs.1.81±0.78 ng/mL,P<0.05;0.88±0.42 ng/mL vs.3.68±0.98 ng/mL,P<0.05).In T1D patients,the C-peptide level after injection of glucagon was similar to the fasting level.In T2D,patients treated with diet or oral drug had a significantly greater fasting and stimulated C-peptide level than those patients received insulin therapy(2.45±0.93 ng/mL vs.1.61±0.68 ng/mL,P<0.05;5.26±1.24 ng/mL vs.2.15±0.76 ng/mL,P<0.05).The serum C-peptide level after glucagon stimulation was positively correlated with C-peptide levels at fasting in all three groups(r=0.76,P<0.05).Conclusions The 6-minute glucagon test is valuable in assessing the function of islet β cell in patients with diabetes mellitus.It is helpful for diagnosis and treatment of diabetes mellitus. | Tong Wang Xin-hua Xiao Wen-hui Li Heng Wang Qi Sun Tao Yuan Guo-hua Yang | 2008 | Chinese Medical Sciences Journal2008，23，2： | 5 |
| 11 | Ozone vertical variations during a typhoon derived from the OMI observations and reanalysis data显示文摘Typhoon is considered to play a key role in the dynamical exchange processes taking place between the troposphere and stratosphere.In this paper,the impact of typhoon on the ozone distribution in the upper troposphere and middle stratosphere is investigated using ozone profiles measured by Aura’s Ozone Monitoring Instrument and meteorological fields from reanalysis data.During the passage of Typhoon Hai-Tang in 2005 over the western North Pacific,low values of ozone column above 200 hPa and ozone mixing ratio between the upper troposphere and the middle stratosphere(from 200 to 50 hPa)are observed right above the typhoon’s track,a result due to the strong upward propagation of air associated with overshooting convection in typhoon.A comparative analysis of different stages of Hai-Tang suggests that in the region where typhoon has higher intensity the troposphere-to-stratosphere transport is enhanced.These results indicated that the typhoon has a significant impact on the ozone variation in the upper troposphere and the middle stratosphere. | FU YunFei XIAN Tao Lü DaRen LIU GuoSheng HENG ZhiWei SUN Liang LIU Qi WANG Yu YANG YuanJian | 2013 | Chinese Science Bulletin2013，58，32： | 5 |
| 12 | Changes in energy metabolism in the quadriceps femoris after a single bout of acute exhaustive swimming in rats: a 31p-magnetic resonance spectroscopy study显示文摘 | Sun Yingwei Pan Shinong Chen Zhian Zhao Heng Ma Ying Zheng Liqiang Li Qi Deng Chunbo Fu Xihu Lu Zaiming Guo Qiyong | 2014 | Chinese Medical Journal2014，，5： | 5 |
| 13 | The heterogeneity of islet autoantibodies and the progression of islet failure in type 1 diabetic patients显示文摘Type 1 diabetes mellitus is heterogeneous in many facets. The patients suffered from type 1 diabetes present several levels of islet function as well as variable number and type of islet-specific autoantibodies. This study was to investigate prevalence and heterogeneity of the islet autoantibodies and clinical phenotypes of type 1 diabetes mellitus; and also discussed the process of islet failure and its risk factors in Chinese type 1 diabetic patients. A total of 1,291 type 1 diabetic patients were enrolled in this study. Demographic information was collected. Laboratory tests including mixed-meal tolerance test, human leukocyte antigen alleles, hemoglobin A1 c, lipids, thyroid function and islet autoantibodies were conducted. The frequency of islet-specific autoantibody in newly diagnosed T1 DM patients(duration shorter than half year) was 73% in East China. According to binary logistic regressions, autoantibody positivity, longer duration and lower Body Mass Index were the risk factors of islet failure. As the disease developed, autoantibodies against glutamic acid decarboxylase declined as well as the other two autoantibodies against zinc transporter 8 and islet antigen 2. The decrease of autoantibodies was positively correlated with aggressive beta cell destruction. Autoantibodies can facilitate the identification of classic T1 DM from other subtypes and predict the progression of islet failure. As there were obvious heterogeneity in autoantibodies and clinical manifestation in different phenotypes of the disease, we should take more factors into consideration when identifying type 1 diabetes mellitus. | Jin Liu Lingling Bian Li Ji Yang Chen Heng Chen Yong Gu Bingqin Ma Wei Gu Xinyu Xu Yun Shi Jian Wang Dalong Zhu Zilin Sun Jianhua Ma Hui Jin Xing Shi Heng Miao Bing Xin Yan Zhu Zhenwen Zhang Ruifang Bu Lan Xu Guangde Shi Wei Tang Wei Li Dongmei Zhou Jun Liang Xingbo Cheng Bimin Shi Jixiang Dong Ji Hu Chen Fang Shao Zhong Weinan Yu Weiping Lu Chenguang Wu Li Qian Jiancheng Yu Jialin Gao Xiaoqiang Fei Qingqing Zhang Xueqin Wang Shiwei Cui Jinluo Cheng Ning Xu Guofeng Wang Guoqing Han Chunrong Xu Yun Xie Minmin An Wei Zhang Zhixiao Wang Yun Cai Qi Fu Yu Fu Shuai Zheng Fan Yang Qingfang Hu Hao Dai Yu Jin Zheng Zhang Kuanfeng Xu Yifan Li Jie Shen Hongwen Zhou Wei He Xuqin Zheng Xiao Han Liping Yu Jinxiong She Mei Zhang Tao Yang | 2016 | Science China(Life Sciences)2016，59，9： | 5 |
| 14 | Chip formation dependence of machining velocities in nano-scale by molecular dynamics simulations显示文摘In this study, molecular dynamics simulations were carried out to study the effect of machining velocities on the mechanism of chip formation in nano-metric copper. A wide range of cutting velocities was performed from 10 to 2000 m/s, and the microstructure's evolution from a crystalline state to an amorphous state was studied. At the low machining velocity, dislocations were generated from the surface in front of the tool, and the immobile dislocation deduced by the cross slip of dislocation was observed. At the high machining velocity, no crystal dislocation nucleated, but instead disorder atoms were found near the tool. Temperature near the tool region increased with the increasing machining velocities, and the temperature had an important effect on the phase transition of the crystal structure. | SU Hao TANG Qi Heng | 2014 | Science China(Technological Sciences)2014，57，12： | 5 |
| 15 | (5R)-5-hydroxytriptolide ameliorates anti-glomerular basement membrane glomerulonephritis in NZW mice by regulating Fcγ receptor signaling显示文摘(5R )-5-hydroxytriptolide (LLDT-8 ) 是作为治疗自体免疫的疾病的一个有希望的候选人被识别了并且被显示了在对待鼠科的导致骨胶原的关节炎和豺狼座肾炎有效的新奇 triptolide 类似物。在现在的学习,我们在鼠科的 anti-glomerular 地下室膜(GBM ) 调查了治疗学的效果和 LLDT-8 的行动的可能的机制 glomerulonephritis 模型。NZW 老鼠与兔子 anti-GBM 浆液被注射(500 L, ip ) 。鼠标口头上地与 LLDT-8 被对待(0.125 mg/kg,每隔一天) 或积极控制氢化尼松(2 mg/kg 每天) 为 14 d。血和尿样品以及怒气和肾纸巾为分析被收集。LLDT-8 处理没影响老鼠反兔子抗体的产生。LLDT-8 显著地在 glomerulonephritis 老鼠颠倒了确定的 proteinuria,改进肾的组织病理学说和稀释肾的机能障碍。而且, LLDT-8 在显著地减少的 C3 和 IgG 免职证实的肾禁止了发炎,减少病原的 cytokines TNF- , IL-6, IL-17,和 IFN- 的层次,并且减少在肾的相关 chemokine 表示和白血球渗入。而且, LLDT-8 治疗显著地在肾和脾增加了 FcRIIB 的表示。另外,处理在肾受动器房间的表面上恢复了 FcRIIB 的减少的表示, CD11b + 房间,并且防碍 FcR 依赖的发信号的、特别调停 FcRIIB 的下游的 kinases,例如 BTK。这些结果证明 LLDT-8 改善由调整发信号的 Fc 受体的 anti-GBM glomerulonephritis。 | Qing QI Heng LI Ze-min LIN Xiao-qian YANG Feng-hua ZHU Yu-ting LIU Mei-juan SHAO Lu-yao ZHANG Yan-sheng XU Yu-xi YAN Lan-lan SUN Shi-jun HE Wei TANG Jian-ping ZUO | 2018 | Acta Pharmacologica Sinica2018，39，1： | 4 |
| 16 | Association between four adipokines and insulin sensitivity in patients with obesity, type 1 or type 2 diabetes mellitus,and in the general Chinese population显示文摘背景 Hyperinsulinemic euglycemic 夹钳是标准答案评估胰岛素 sensitity ,但是在试着发现其他的指示物反映胰岛素 sensitivity.To 的 clinic.We 使用太复杂、昂贵评估在四 adipokines 之间的协会, adiponectin , leptin , resistin 和肿瘤坏死因素--(TNF-)与胰岛素敏感,我们使用了 hyperinsulinemic euglycemic 夹钳与肥胖和类型 1 或类型 2 diabete 在中国病人测试胰岛素敏感在不同的组之间的变化的比较被变化分析分析) .Compared 到控制(用多重比较双向 Dunnett t 测试),仅仅 leptin 水平同时从四个不同的组在四 adipokines 显示出重要差别( P 0.001 )在不同 adipokines 和 M 或 M/I 价值之间的 .The 协会分析也证明仅仅 leptin 否定地与 M 相关( r=-0.64 , P 0.001 )或 M/I 价值( r=-0.56 , P0.001 );仅仅在另外的三 adipokines 和 M 或 M/I values.Conclusion 之间没有关系 leptin 与 M 或 M/I values.Therefore 被联系, leptin 可能是胰岛素抵抗的度和伴随的疾病的风险的预兆的因素之一。 | YUAN Tao ZHAO Wei-gang SUN Qi FU Yong DONG Ying-yue DONG Ya-xiu YANG Guo-hua WANG Heng | 2010 | Chinese Medical Journal2010，，15： | 4 |
| 17 | Greenhouse gas emissions from a constructed wetland for municipal sewage treatment显示文摘The fluxes of greenhouse gases (methane and nitrous oxide) emission from a constructed wetland in the Eastern China as municipal sewage treatment were measured from June 1999 to August 2000 by the closed chamber method. The constructed wetland for municipal sewage treatment is a significant source of methane, up to 976 6×10 6 g CH 4/a, which was emitted from the constructed wetland with the area of 495000 m 2 and wastewater loading rate of 12000 m 3/d. Its daily mean methane flux reached 5 22 g CH 4/(m 2·d), 250 times as much as that in natural wetland in the same latitude region. 227 8 mg CH 4 was produced from the treatment of 1 liter wastewater, up to 700—1000 times as much as that in the secondary treatment. The emission of nitrous oxide from the constructed wetland is not higher than that from secondary treatment of wastewater, only 0 07 mgN 2O/L. | TAI Pei dong 1, LI Pei jun 1 , SUN Tie heng 1, HE Yao wu 1, ZHOU Qi xing 1 GONG Zong qiang 1, Motoyuki Mizuochi 2, Yuhei Inamori 2 (1 Institute of Applied Ecology, Chinese Academy of Sciences, Shenyang 110015, China. 2 National Insti | 2002 | Journal of Environmental Sciences2002，14，1： | 3 |
| 18 | Structural basis of Zika virus helicase in recognizing its substrates显示文摘Zika 的最近的爆炸爆发病毒(ZIKV ) 感染在南方和中美洲和加勒比海被报导了。与 ZIKV 感染联系的新生的头小畸型已经引起了国际担心的一种公共健康紧急情况。没有特定的疫苗或药当前是可得到的治疗 ZIKV 感染。ZIKV helicase,在病毒的 RNA 复制起一个枢轴的作用,是为治疗的一个吸引人的目标。我们决定了 ZIKV helicase-ATP-Mn 2+ 和 ZIKV helicase-RNA 的水晶结构。这是到 ATP 的任何 flavivirus helicase 界限的第一结构。有相关 flavivirus helicases 的比较证明了尽管在活跃地点的批评 P 环在不同种类之中有可变符合构造,认出 ATP/Mn 2+ 采用一个相同模式。ZIKV helicase-RNA 的结构表明了在 RNA 绑定之上,马达领域的旋转能引起重要 conformational 变化。惊人地,尽管 ZIKV 和登革热病毒(DENV ) apo-helicases 份额为 RNA 绑定保存了残余,他们在为 RNA 识别的不同单个模式的马达域旋转结果的不同礼貌。它建议 flavivirus helicases 能发展了一台保存引擎为 RNA 放松,而是不同马达领域旋转从 nucleoside triphosphate 把化学能变换成机械精力在可变 RNA 识别的结果适应单个病毒的复制的模式。 | Hongliang Tian Xiaoyun Ji Xiaoyun Yang Zhongxin Zhang zuoku Lu Kailin Yang Cheng Chen Qi Zhao Heng Chi Zhongyu Mu Wei Xie Zefang Wang Huiqiang Lou Haitao Yang Zihe Rao | 2016 | Protein & Cell2016，7，8： | 3 |
| 19 | Determination of chlorogenic acid by flow injection irreversible biamperometry显示文摘A flow injection irreversible biamperometric method for the determination of chlorogenic acid is described.The proposedmethod is based on the electrochemical oxidation of chlorogenic acid at pretreated platinum electrode and the reduction ofpermanganate at another electrode to form an irreversible biamperometric detection system.Under the external potential difference(△E)of 0 V,in the 0.05 mol/L sulfuric acid,chlorogenic acid can be determined over the range 0.8-120 mg/L with a samplemeasurement frequency of 80 samples/h.The detection limit is 0.18 mg/L.The proposed method exhibits the satisfactoryreproducibility with a relative standard derivation(R.S.D.)of 2.21%for 19 successive determinations of 40 mg/L. | Li Jun Li Qi Feng Chen Lai Bo Yu Zhao Heng Zhong Jun Feng Hao Cheng Hong Xing Kong Jian Ling Wu | 2007 | Chinese Chemical Letters2007，18，4： | 3 |
| 20 | A collaborative strategy for enhanced reduction of Cr(Ⅵ) by Fe(0) in the presence of oxalate under sunlight:Performance and mechanism显示文摘Nanometer-size zero-valent iron(NZVI)is an efficient reducing agent,but its surface is easily passivated with an oxide layer,leading to reaction inefficiency.In our study,oxalate(OA)was introduced into this heterogeneous system of NZVI,which could form ferrioxalate complexes with the NZVI surface-bound Fe3+and dissolved Fe3+in the solution.Photolysis of ferrioxalate complexes can facilitate the generation of Fe2+from Fe3+and CO2·-radical,both species have strong reduction capacity.Hence,a'photo-oxalate-Fe(0)'system through sunlight induction was established,which not only prohibited the formation of a surface passivation layer,but also displayed a synergetic mechanism of ferrioxalate photolysis to enhance reduction,exhibiting remarkably higher degradation activity(several times faster)toward the model pollutant Cr(Ⅵ)than the mechanism with NZVI alone.Factor tests suggested that both NZVI dosage and OA content markedly affected the reduction rate.Low pH was beneficial to the reduction efficiency.Moreover,recyclability experiment showed that the reduction rate decreased from 0.21706 to 0.03977 min-1 after three cycles of reuse due to the NZVI losing reaction activity generally,but the system still maintained considerable reduction capacity.Finally,a mechanism was revealed whereby NZVI would transform to Fe oxides after the exhaustion of its reductive power,and the photolysis of ferrioxalate to promote the cycling of iron species played the predominant role in providing extra reduction ability.These features confirm that introduction of OA into Cr(Ⅵ)reduction by NZVI through sunlight induction is advantageous and promising. | Qi Zhou Yang Li Heng Yang Yun Gao | 2020 | Journal of Environmental Sciences2020，32，4： | 3 |
您所在的机构暂未开通此部分的功能，请联系管理员